@article{MTMT:34498341,
	title = {Az agyi neuronhálózatok szerepe a dementiák kialakulásában: vizsgálati módszereink az optogenetikától a mesterséges intelligenciáig},
	url = {https://m2.mtmt.hu/api/publication/34498341},
	author = {Hangya, Balázs},
	doi = {10.33616/lam.33.0625},
	journal-iso = {LEGE ART MED},
	journal = {LEGE ARTIS MEDICINAE},
	volume = {33},
	unique-id = {34498341},
	issn = {0866-4811},
	abstract = {A Kísérleti Orvostudományi Kutatóintézet Rendszer-Neurobiológia Ku­tatócsoportjában a fő célkitűzésünk a kognitív folyamatok agyi mechanizmusainak jobb megértése. A tanulás, memória, figyelem és döntéshozás idegrendszeri alapjait nemcsak normális körülmények között, hanem kóros állapotokban is vizsgáljuk, különös tekintettel a neurodegeneratív dementiákra, mint az Alzheimer- és a Par­kinson-kór.},
	year = {2023},
	eissn = {2063-4161},
	pages = {625-630}
}

@article{MTMT:34400320,
	title = {Author Correction: The medial septum controls hippocampal supra-theta oscillations},
	url = {https://m2.mtmt.hu/api/publication/34400320},
	author = {Király, Bálint and Domonkos, Andor and Jelitai, Márta and Lopes-dos-Santos, Vítor and Martínez-Bellver, Sergio and Kocsis, Barnabás and Schlingloff, Dániel and Joshi, Abhilasha and Salib, Minas and Fiáth, Richárd and Barthó, Péter and Ulbert, István and Freund, Tamás and Viney, Tim J. and Dupret, David and Varga, Viktor and Hangya, Balázs},
	doi = {10.1038/s41467-023-43190-6},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {14},
	unique-id = {34400320},
	issn = {2041-1723},
	year = {2023},
	eissn = {2041-1723},
	orcid-numbers = {Lopes-dos-Santos, Vítor/0000-0002-1858-0125; Joshi, Abhilasha/0000-0002-0511-3747; Salib, Minas/0000-0001-9938-7978; Fiáth, Richárd/0000-0001-8732-2691; Ulbert, István/0000-0001-9941-9159; Viney, Tim J./0000-0001-6444-1188; Dupret, David/0000-0002-0040-1766}
}

@article{MTMT:34341943,
	title = {Behavioral, neural and ultrastructural alterations in a graded-dose 6-OHDA mouse model of early-stage Parkinson's disease},
	url = {https://m2.mtmt.hu/api/publication/34341943},
	author = {Slézia, Andrea and Hegedüs, Panna and Rusina, Evgeniia and Lengyel, Katalin and Solari, Nicola and Kaszás, Attila and Balázsfi, Diána and Botzanowski, Boris and Acerbo, Emma and Missey, Florian and Williamson, Adam and Hangya, Balázs},
	doi = {10.1038/s41598-023-46576-0},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34341943},
	issn = {2045-2322},
	abstract = {Studying animal models furthers our understanding of Parkinson’s disease (PD) pathophysiology by providing tools to investigate detailed molecular, cellular and circuit functions. Different versions of the neurotoxin-based 6-hydroxydopamine (6-OHDA) model of PD have been widely used in rats. However, these models typically assess the result of extensive and definitive dopaminergic lesions that reflect a late stage of PD, leading to a paucity of studies and a consequential gap of knowledge regarding initial stages, in which early interventions would be possible. Additionally, the better availability of genetic tools increasingly shifts the focus of research from rats to mice, but few mouse PD models are available yet. To address these, we characterize here the behavioral, neuronal and ultrastructural features of a graded-dose unilateral, single-injection, striatal 6-OHDA model in mice, focusing on early-stage changes within the first two weeks of lesion induction. We observed early onset, dose-dependent impairments of overall locomotion without substantial deterioration of motor coordination. In accordance, histological evaluation demonstrated a partial, dose-dependent loss of dopaminergic neurons of substantia nigra pars compacta (SNc). Furthermore, electron microscopic analysis revealed degenerative ultrastructural changes in SNc dopaminergic neurons. Our results show that mild ultrastructural and cellular degradation of dopaminergic neurons of the SNc can lead to certain motor deficits shortly after unilateral striatal lesions, suggesting that a unilateral dose-dependent intrastriatal 6-OHDA lesion protocol can serve as a successful model of the early stages of Parkinson’s disease in mice.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Slézia, Andrea/0000-0002-4528-3169; Hegedüs, Panna/0000-0002-9984-5729}
}

@article{MTMT:34191844,
	title = {LAMMI: mesterséges intelligencia (MI) rovat a LAM-ban – beköszöntô},
	url = {https://m2.mtmt.hu/api/publication/34191844},
	author = {Balkányi, László and Hangya, Balázs},
	journal-iso = {LEGE ART MED},
	journal = {LEGE ARTIS MEDICINAE},
	volume = {33},
	unique-id = {34191844},
	issn = {0866-4811},
	year = {2023},
	eissn = {2063-4161},
	pages = {459-466}
}

@article{MTMT:34188237,
	title = {The medial septum controls hippocampal supra-theta oscillations},
	url = {https://m2.mtmt.hu/api/publication/34188237},
	author = {Király, Bálint and Domonkos, Andor and Jelitai, Márta and Lopes-dos-Santos, Vítor and Martínez-Bellver, Sergio and Kocsis, Barnabás and Schlingloff, Dániel and Joshi, Abhilasha and Salib, Minas and Fiáth, Richárd and Barthó, Péter and Ulbert, István and Freund, Tamás and Viney, Tim J. and Dupret, David and Varga, Viktor and Hangya, Balázs},
	doi = {10.1038/s41467-023-41746-0},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {14},
	unique-id = {34188237},
	issn = {2041-1723},
	abstract = {Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval.},
	keywords = {NEURONS; hippocampus; Theta rhythm; ENTORHINAL CORTEX; Action Potentials; HIPPOCAMPAL; Parvalbumins; CA1 region},
	year = {2023},
	eissn = {2041-1723},
	orcid-numbers = {Király, Bálint/0000-0001-8483-8780; Lopes-dos-Santos, Vítor/0000-0002-1858-0125; Joshi, Abhilasha/0000-0002-0511-3747; Salib, Minas/0000-0001-9938-7978; Fiáth, Richárd/0000-0001-8732-2691; Ulbert, István/0000-0001-9941-9159; Viney, Tim J./0000-0001-6444-1188; Dupret, David/0000-0002-0040-1766}
}

@misc{MTMT:34096335,
	title = {Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience},
	url = {https://m2.mtmt.hu/api/publication/34096335},
	author = {Hegedüs, Panna and Victoria, Lyakhova and Velencei, Anna and Mayer, Márton István and Zelenak, Zsofia and Nyíri, Gábor and Hangya, Balázs},
	unique-id = {34096335},
	year = {2023},
	orcid-numbers = {Hegedüs, Panna/0000-0002-9984-5729}
}

@article{MTMT:33756936,
	title = {A cholinergic auditory pathway},
	url = {https://m2.mtmt.hu/api/publication/33756936},
	author = {Schlingloff, Dániel and Hangya, Balázs and Pinto, Lucas},
	doi = {10.1038/s41593-023-01300-z},
	journal-iso = {NAT NEUROSCI},
	journal = {NATURE NEUROSCIENCE},
	volume = {26},
	unique-id = {33756936},
	issn = {1097-6256},
	year = {2023},
	eissn = {1546-1726},
	pages = {726-728},
	orcid-numbers = {Pinto, Lucas/0000-0002-0471-9317}
}

@article{MTMT:33624175,
	title = {Editorial: The medial septum as a smart clock: New aspects of its function beyond pacemaking.},
	url = {https://m2.mtmt.hu/api/publication/33624175},
	author = {Hangya, Balázs and Varga, Viktor},
	doi = {10.3389/fncir.2022.1093711},
	journal-iso = {FRONT NEURAL CIRCUIT},
	journal = {FRONTIERS IN NEURAL CIRCUITS},
	volume = {16},
	unique-id = {33624175},
	issn = {1662-5110},
	year = {2023},
	eissn = {1662-5110}
}

@article{MTMT:33548218,
	title = {Cholinergic activity reflects reward expectations and predicts behavioral responses},
	url = {https://m2.mtmt.hu/api/publication/33548218},
	author = {Hegedüs, Panna and Tóthné Sviatkó, Katalin and Király, Bálint and Martínez-Bellver, Sergio and Hangya, Balázs},
	doi = {10.1016/j.isci.2022.105814},
	journal-iso = {ISCIENCE},
	journal = {ISCIENCE},
	volume = {26},
	unique-id = {33548218},
	keywords = {Neuroscience; biological sciences; Behavioral neuroscience},
	year = {2023},
	eissn = {2589-0042},
	orcid-numbers = {Hegedüs, Panna/0000-0002-9984-5729; Tóthné Sviatkó, Katalin/0000-0002-5104-0884}
}

@article{MTMT:33123196,
	title = {Investigation of Anxiety- and Depressive-like Symptoms in 4- and 8-Month-Old Male Triple Transgenic Mouse Models of Alzheimer’s Disease},
	url = {https://m2.mtmt.hu/api/publication/33123196},
	author = {Várkonyi, Dorottya and Török, Bibiána and Bodóné Sipos, Eszter and Fazekas, Csilla Lea and Bánrévi, Krisztina and Correia, Pedro and Chaves, Tiago and Farkas, Szidónia and Szabó, Adrienn and Martínez-Bellver, Sergio and Hangya, Balázs and Zelena, Dóra},
	doi = {10.3390/ijms231810816},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33123196},
	issn = {1661-6596},
	abstract = {Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. Approximately 50% of AD patients show anxiety and depressive symptoms, which may contribute to cognitive decline. We aimed to investigate whether the triple-transgenic mouse (3xTg-AD) is a good preclinical model of this co-morbidity. The characteristic histological hallmarks are known to appear around 6-month; thus, 4- and 8-month-old male mice were compared with age-matched controls. A behavioral test battery was used to examine anxiety- (open field (OF), elevated plus maze, light-dark box, novelty suppressed feeding, and social interaction (SI) tests), and depression-like symptoms (forced swim test, tail suspension test, sucrose preference test, splash test, and learned helplessness) as well as the cognitive decline (Morris water maze (MWM) and social discrimination (SD) tests). Acetylcholinesterase histochemistry visualized cholinergic fibers in the cortex. Dexamethasone-test evaluated the glucocorticoid non-suppression. In the MWM, the 3xTg-AD mice found the platform later than controls in the 8-month-old cohort. The SD abilities of the 3xTg-AD mice were missing at both ages. In OF, both age groups of 3xTg-AD mice moved significantly less than the controls. During SI, 8-month-old 3xTg-AD animals spent less time with friendly social behavior than the controls. In the splash test, 3xTg-AD mice groomed themselves significantly less than controls of both ages. Cortical fiber density was lower in 8-month-old 3xTg-AD mice compared to the control. Dexamethasone non-suppression was detectable in the 4-month-old group. All in all, some anxiety- and depressive-like symptoms were present in 3xTg-AD mice. Although this strain was not generally more anxious or depressed, some aspects of comorbidity might be studied in selected tests, which may help to develop new possible treatments.},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Correia, Pedro/0000-0002-4410-9855; Chaves, Tiago/0000-0001-8761-2728}
}