@article{MTMT:37050602, title = {The Role of MRI in the Preoperative Staging of Rectal Cancer : Ten-year Experience from a Single Tertiary Center}, url = {https://m2.mtmt.hu/api/publication/37050602}, author = {Kondor, Ariella Edina and Vereczkei, András and Varga, Péter and Sindler, Dóra Lili and Gowda, Yashwanth Sudheendra and Dergez, Tímea and Garcia, Elisabeth and Csontos, Armand and Faluhelyi, Nándor and Hegedűs, Ivett and Bogner, Barna and Baracs, József}, doi = {10.21873/anticanres.18101}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {46}, unique-id = {37050602}, issn = {0250-7005}, abstract = {Accurate preoperative staging of rectal cancer (CRC) guides treatment decisions, particularly regarding neoadjuvant chemoradiotherapy. Although magnetic resonance imaging (MRI) is recommended for local staging, questions persist regarding whether T stage or circumferential resection margin (CRM) involvement is the stronger predictor of treatment necessity. This study evaluated ten years of institutional experience to determine whether MRI-based CRM assessment provides superior prognostic guidance compared to tumor-node-metastasis (TNM) staging alone.Between March 2014 and July 2023, 659 patients underwent surgery for histologically confirmed rectal adenocarcinoma; 258 received preoperative MRI and computed tomography (CT) imaging. After applying exclusion criteria (neoadjuvant therapy prior to surgery, transanal endoscopic procedures, patient refusal, contraindications), 114 patients undergoing primary surgical resection comprised the study cohort. MRI- and CT-derived T and N stages and CRM involvement were compared with definitive histopathological findings using chi-squared, Fisher's exact, independent t-tests, Mann-Whitney U-tests, and diagnostic accuracy calculations.MRI correctly predicted pathological T (pT) stage in 47.4% of cases versus CT in 48.2% (p=0.895), indicating no significant difference. CT more frequently underestimated T stage (33.3%), whereas MRI more often overestimated (36.8%, p<0.001). MRI demonstrated higher sensitivity for nodal metastasis (74% vs. 62%), although specificity was lower (39.1% vs. 54.7%). Critically, MRI correctly identified all seven patients with pathological circumferential resection margin (pCRM) ≤1 mm (6.14% of cohort), achieving 100% concordance. Local recurrence occurred in nine patients (7.9%) during follow-up; all received primary surgery based on negative mesorectal fascia (MRF) status on MRI.MRI reliably predicts CRM involvement and MRF status, serving as a key determinant for neoadjuvant chemoradiotherapy decisions. In patients with T3 tumors and negative MRF status on MRI, primary resection remains oncologically safe, avoiding unnecessary chemoradiotherapy-related morbidity while maintaining acceptable recurrence rates comparable to literature data.}, keywords = {Magnetic Resonance Imaging; Rectal cancer; Tumor staging; circumferential resection margin; TOTAL MESORECTAL EXCISION; mesorectal fascia}, year = {2026}, eissn = {1791-7530}, pages = {2125-2132} } @article{MTMT:35696301, title = {Early Oral Feeding in Patients Undergoing Upper Gastrointestinal Surgery : A Propensity Score-matching Study}, url = {https://m2.mtmt.hu/api/publication/35696301}, author = {Papp, Csenge and Sindler, Dóra Lili and Palkovics, András and Csontos, Armand and Sándor, Zoltán and Németh, Balázs and Vereczkei, András and Papp, András}, doi = {10.21873/invivo.13832}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {39}, unique-id = {35696301}, issn = {0258-851X}, abstract = {Enhanced recovery after surgery (ERAS) protocol is adopted in clinical practice worldwide, but a lack of evidence for measurable benefits after upper gastrointestinal (GI) surgeries can be detected especially regarding early oral feeding.A propensity score-matching study was conducted at the Department of Surgery of the University of Pécs between January 2020 and December 2023. The study included patients who underwent upper GI cancer surgery and were treated according to an early oral feeding protocol (EOF). Investigational and control groups were analyzed and compared from prospectively collected datasets.We enrolled 72 patients, 36 in the EOF group, and 36 case-matched patients in the traditional late oral feeding (LOF) group. Oral feeding in the EOF group started on an average of 1.94 days postoperatively, while in the LOF group, it began on an average of 5.72 days postoperatively. EOF could reduce the average length of hospital stay. Statistically significant decreases were observed in the EOF group concerning the time until the first bowel movements, and the length of postoperative intravenous fluid therapy. No significant differences were detected regarding mortality, anastomosis insufficiency, inflammation and stricture or seroma formation.Early oral nutritional support positively impacts the recovery of patients following upper GI surgery without increasing mortality or anastomosis insufficiency rates compared to traditional protocols. Significant improvements were observed in quality of life indicators for patients in the early oral feeding group. This approach aligns with ERAS goals and suggests a valuable strategy for postoperative care in upper GI cancer surgeries.}, keywords = {Early oral feeding; ERAS; upper GI surgery; esophageal anastomosis; upper GI tumors}, year = {2025}, eissn = {1791-7549}, pages = {335-339}, orcid-numbers = {Németh, Balázs/0000-0002-4914-9872} } @article{MTMT:34506134, title = {A korai, szájon keresztüli táplálás nem jelent veszélyt a felső tápcsatornai műtétek után : Becsült részvételi valószínűség szerinti párosítási tanulmány}, url = {https://m2.mtmt.hu/api/publication/34506134}, author = {Sindler, Dóra Lili and Papp, Csenge and Csontos, Armand and Szakó, Lajos and Vereczkei, András and Halvax, Péter Ákos and Palkovics, András and Papp, András}, doi = {10.1556/650.2024.32936}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34506134}, issn = {0030-6002}, keywords = {anastomosis; oesophagus; nyelőcső; ERAS; Oral feeding; peroralis táplálás}, year = {2024}, eissn = {1788-6120}, pages = {24-29} } @article{MTMT:35169697, title = {Intraoperative pyloric drainage is unnecessary during esophagectomies: a meta-analysis and systematic review of randomized controlled trials}, url = {https://m2.mtmt.hu/api/publication/35169697}, author = {Csontos, Armand and Németh, Dávid and Szakó, Lajos and Berke, Gergő and Sindler, Dóra Lili and Berki, Dávid and Papp, Csenge and Hegyi, Péter and Vereczkei, András and Papp, András}, doi = {10.3389/pore.2024.1611823}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {30}, unique-id = {35169697}, issn = {1219-4956}, abstract = {Objective: The topic of this meta-analysis is the comparison of gastric conduit esophageal reconstructions with or without pyloroplasty.}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {1532-2807}, orcid-numbers = {Berke, Gergő/0000-0002-7822-2637; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:33754879, title = {Achalasia miatt végzett robotasszisztált laparoszkópos cardiomyotomia és fundoplicatio (Heller–Dor-műtét)}, url = {https://m2.mtmt.hu/api/publication/33754879}, author = {Papp, András and Palkovics, András and Sindler, Dóra Lili and Papp, Csenge and Halvax, Péter Ákos and Czimmer, József and Nagy, Bálint and Vereczkei, András}, doi = {10.1556/650.2023.32748}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {164}, unique-id = {33754879}, issn = {0030-6002}, abstract = {The outcomes of surgical interventions for achalasia treatment improved with the advent of minimally invasive surgery. Robotic-assisted Heller-Dor's (RAHD) procedure established over the last years, provides important advantages to surgeons, such as binocular three-dimensional vision and improvement of fine motor control.Between October and December of 2022, first in Hungary, 3 patients (37-year-old man, 55- and 72-year-old women) underwent RAHD procedure for achalasia at the Clinical Centre of the University of Pécs using the da Vinci Xi system.RAHD procedure was feasible without any particular problems and the postoperative course of all three patients was uneventful. The operation times were 198, 204 and 238 minutes, including 23, 19 and 14 minutes for the setup time of the robot. By the last patient, due to an accompanying hiatal hernia, an additional hiatal reconstruction was also performed. In the first 2 cases, the patients were discharged on the 4th postoperative day, while in the last case, with the additional hiatal reconstruction, the patient was emitted on the 6th postoperative day.There are several published studies about RAHD cardiomyotomy. The general conclusion is that, in experienced hands, RAHD procedure is easy to perform, ensures a meticulous esophageal and gastric myotomy, allowing to visualize and divide each muscle fiber with a significantly lower rate of mucosal perforations. However, by RAHD procedure, the overall costs are higher, including a longer operation time during the learning curve. At the same time, the avoidance of mucosal lacerations and their possible consequences has to be weighed against the higher overall costs.Laparoscopic cardiomyotomy is the first standard upper-gastrointestinal operation where a clear advantage of the use of a surgical robot has been proven. Thus, wherever this equipment is available, it should be preferred for this procedure. Orv Hetil. 2023; 164(14): 542-547.}, keywords = {Heller–Dor cardiomyotomy; Heller–Dor-műtét; RAHD; achalasia cardiae; cardiomyotomia; robotasszisztált műtét; robotic-assisted operation}, year = {2023}, eissn = {1788-6120}, pages = {542-547}, orcid-numbers = {Czimmer, József/0000-0001-7831-3523} } @article{MTMT:34011864, title = {Faster recovery and bowel movement after early oral feeding compared to late oral feeding after upper GI tumor resections: a meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34011864}, author = {Sindler, Dóra Lili and Mátrai, Péter and Szakó, Lajos and Berki, Dávid and Berke, Gergő and Csontos, Armand and Papp, Csenge and Hegyi, Péter and Papp, András}, doi = {10.3389/fsurg.2023.1092303}, journal-iso = {FRONT SURG}, journal = {FRONTIERS IN SURGERY}, volume = {10}, unique-id = {34011864}, issn = {2296-875X}, keywords = {[Meta-analysis]}, year = {2023}, eissn = {2296-875X}, orcid-numbers = {Berke, Gergő/0000-0002-7822-2637; Hegyi, Péter/0000-0003-0399-7259} }