@article{MTMT:36203642,
	title = {Resveratrol Mitigates Inflammation by Modulating Tumor Necrosis Factor-Alpha Receptors (TNFRs) in a 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-Induced Rat Model of Colitis},
	url = {https://m2.mtmt.hu/api/publication/36203642},
	author = {Veszelka, Médea and Hegyközi, József and Almási, Nikoletta and Török, Szilvia and Barta, Bence Pál and Nagy, Izabella and Börzsei, Denise and Bódi, Nikolett and Bagyánszki, Mária and Szabó, Renáta and Varga, Csaba},
	doi = {10.3390/ijms26125779},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {26},
	unique-id = {36203642},
	issn = {1661-6596},
	abstract = {Several substances with antioxidant and anti-inflammatory properties are currently being investigated as potential adjunctive or standalone treatments for inflammatory bowel disease (IBD). One such substance is resveratrol (RES), also known as 3,5,4′-trihydroxy-trans-stilbene, a natural dietary polyphenol with diverse health-promoting effects. In this study, male Wistar–Hannover rats received oral RES supplementation at doses of 5, 10, or 20 mg/kg/day for 28 days. On day 25 colitis was induced using intracolonic administration of 2,4,6-trinitrobenzene sulphonic acid (TNBS). Based on histological and planimetric analysis, the 10 mg/kg dose significantly reduced colonic ulceration and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) expression compared to the TNBS group. Immunohistochemistry also revealed that RES at this dose attenuated the intensity of TNF-α receptors, namely TNFR1 and TNFR2. Furthermore, the concentration of lipocalin-2 (Lcn-2) was significantly elevated in TNBS-induced colitis. In conclusion, our findings suggest that RES may exert its protective effects partly through the modulation of TNF receptor signaling in TNBS-induced colitis.},
	year = {2025},
	eissn = {1422-0067},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Barta, Bence Pál/0000-0002-5309-8633; Bódi, Nikolett/0000-0002-9774-1387; Bagyánszki, Mária/0000-0003-3533-9461; Varga, Csaba/0000-0002-2678-665X}
}

@misc{MTMT:36212911,
	title = {Acute Inflammation-Induced Barrier Dysfunction in a Rat Model of IBD: a Focus on the Gut-Brain Axis},
	url = {https://m2.mtmt.hu/api/publication/36212911},
	author = {Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Nagy, Izabella and Balog, Dóra and Krisztián, Péli and Denise, Börzsei and Renáta, Szabó and Csaba, Varga},
	unique-id = {36212911},
	year = {2025},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272}
}

@misc{MTMT:36212916,
	title = {Lawesson’s reagent ameliorates inflammation via the modulation of inflammatory cytokines and NET formation in TNBS-induced rat colitis},
	url = {https://m2.mtmt.hu/api/publication/36212916},
	author = {Török, Szilvia and Almási, Nikoletta and Szebeni, Gábor and Veszelka, Médea and Nagy, Izabella and Balog, Dóra and Denise, Börzsei and Renáta, Szabó and Csaba, Varga},
	unique-id = {36212916},
	year = {2025},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Szebeni, Gábor/0000-0002-6998-5632}
}

@misc{MTMT:36212981,
	title = {Anti-inflammatory Effect of a Natural Polyphenol, Resveratrol in TNBS-Induced Rat Model of Colitis: the Role of TNFRs},
	url = {https://m2.mtmt.hu/api/publication/36212981},
	author = {Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and József, Hegyközi and Bagyánszki, Mária and Barta, Bence Pál and Bódi, Nikolett and Nagy, Izabella and Papdi, Korinna and Balog, Dóra and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	unique-id = {36212981},
	year = {2025},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Bódi, Nikolett/0000-0002-9774-1387; Varga, Csaba/0000-0002-2678-665X}
}

@misc{MTMT:36217076,
	title = {Akut gyulladás indukálta barrier diszfunkció IBD patkánymodellben: fókuszban a bél-agy tengely},
	url = {https://m2.mtmt.hu/api/publication/36217076},
	editor = {Nagy, Izabella and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Balog, Dóra and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	unique-id = {36217076},
	year = {2025},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272}
}

@CONFERENCE{MTMT:36466318,
	title = {A NARINGIN HEPATOPROTEKTÍV HATÁSÁNAK VIZSGÁLATA NEM ALKOHOLOS ZSÍRMÁJBETEGSÉG (NAFLD) PATKÁNYMODELLBEN},
	url = {https://m2.mtmt.hu/api/publication/36466318},
	author = {Nagy, Izabella and Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and Hegyközi, József and Bagyánszki, Mária and Bódi, Nikolett and Balog, Dóra and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	booktitle = {ERDÉLYI TERMÉSZETTUDOMÁNYI KONFERENCIA 2025},
	unique-id = {36466318},
	year = {2025},
	pages = {26-27}
}

@CONFERENCE{MTMT:34967921,
	title = {Antioxidant Effects of a Hydrogen Sulfide Donor in Experimental Colitis},
	url = {https://m2.mtmt.hu/api/publication/34967921},
	author = {Török, Szilvia and Almási, Nikoletta and Veszelka, Médea and Nagy, Izabella and Balog, Dóra and Péli, Krisztián and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	booktitle = {Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation},
	unique-id = {34967921},
	year = {2024},
	pages = {213},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@CONFERENCE{MTMT:34967922,
	title = {Investigation of the protecitive effect of a bioactive polyphenol in TNBS rat model},
	url = {https://m2.mtmt.hu/api/publication/34967922},
	author = {Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and Bagyánszki, Mária and Barta, Bence Pál and Bódi, Nikolett and Nagy, Izabella and Papdi, Korinna and Balog, Dóra and Szabó, Renáta and Börzsei, Denise and Varga, Csaba},
	booktitle = {Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation},
	unique-id = {34967922},
	abstract = {Inflammatory bowel diseases (IBD) are a group of chronic, incurable diseases of the digestive tract. Chronic inflammation underlies the aetiology of IBD and is closely associated with oxidative/nitrosative stress and a vast generation of reactive oxygen/nitrogen species. Several substances with antioxidant and anti-inflammatory properties are now intensively researched as possible adjunctive or independent treatment options in IBD. Among them, resveratrol (RES), a natural polyphenol is increasingly studied for its possible protective properties against IBD.
		In the present study, we aimed to investigate the anti-inflammatory effects of RES in three different doses. For this reason, RES supplementation was carried out for 28 days per os. A total of 65 male Wistar-Hannover rats were randomly divided into 7 groups: CTRL, EtOH, TNBS, RES: 5, 10, 20 mg/kg, SASP. On the 25th day of the experiment, animals were challenged by intracolonic injection of 2,4,6-trinitrobenzene sulfonic acid (TNBS) to model IBD. Animals were sacrificed on the 29th day of the experiment. The potential anti-inflammatory effect was investigated by enzyme-linked immunosorbent assay (ELISA) and western blot.
		The histological features of the gut wall, especially the tunica mucosa layer showed clearly visible differences in the investigated groups. Based on our histological and planimetric analysis 10 mg/kg dose of RES is considered to be effective and significantly attenuated ulceration of the colon compared to the TNBS group. Furthermore, RES-induced protection at a concentration of 10mg/kg/day was mediated by the modulation of inflammatory parameter, such as myeloperoxidase (MPO). RES supplementation also caused a decrease in inflammation by reducing the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α). In addition, our immunohistochemical findings showed that 10 mg/kg/day of RES attenuated the intensity of TNF-α receptors, TNFR1 and TNFR2 in the colon compared to TNBS. In conclusion, our results indicate the protective effects of RES in acute low-grade inflammation in TNBS rats and suggest that RES may be a promising therapeutic alternative in the treatment of IBD.},
	year = {2024},
	pages = {214-215},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Bódi, Nikolett/0000-0002-9774-1387; Varga, Csaba/0000-0002-2678-665X}
}

@CONFERENCE{MTMT:34967931,
	title = {Acute Inflammation-Induced Barrier Dysfunction in TNBS Rat Colitis: a Focus on The Gut-Brain Axis},
	url = {https://m2.mtmt.hu/api/publication/34967931},
	author = {Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Nagy, Izabella and Balog, Dóra and Péli, Krisztián and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	booktitle = {Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation},
	unique-id = {34967931},
	year = {2024},
	pages = {200},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@CONFERENCE{MTMT:34968228,
	title = {Naringin-Induced Protection in an Experimental NAFLD Rat Model},
	url = {https://m2.mtmt.hu/api/publication/34968228},
	author = {Nagy, Izabella and Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and Bagyánszki, Mária and Barta, Bence Pál and Papdi, Korinna and Balog, Dóra and Péli, Krisztián and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	booktitle = {Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation},
	unique-id = {34968228},
	abstract = {Non-alcoholic fatty liver disease (NAFLD) is a chronic liver ailment, which prevalence has increased significantly in recent decades. NAFLD is associated with high lipid accumulation in hepatocytes and has been associated with obesity. Naringin (NAR), a natural bioflavonoid found in citrus fruits, such as oranges and grapefruit, has anti-hyperglycaemic and antioxidant effects and may reduce hepatic lipid accumulation. Thus, NAR may be a potential treatment for NAFLD. The present study aimed to investigate the effect of NAR in a 45% fat diet (HFD)-induced NAFLD rat model. A total of 47 male Wistar-Hannover rats were divided into 5 groups: 1) control (CTRL), 2) high-fat diet (HFD 45%), 3) carboxymethyl-cellulose (CMC), 4) naringin 40 mg/kg (NAR1 + HFD), 5) naringin 80 mg/kg (NAR2 + HFD). NAR was prepared with a CMC vehicle in the form of suspension and was administered orally by gavage needle daily for 4 weeks.
		Our histopathological results showed that after 12 weeks of HFD, the number of fat droplets increased, liver scaffolds collapsed and wider sinuses were observed. Furthermore, white blood cell count and inflammatory marker levels were also increased in the HFD group compared to the CTRL group, however, 4 weeks of NAR treatment resulted in a decrease at both doses. Our histopathological and biochemical results demonstrated that 4 weeks of NAR treatment had a dose-dependent effect on inflammatory changes.
		Our results demonstrate that 4 weeks of oral administration of NAR is protective against HFD-induced liver damage and thus may be effective in attenuating the progression of NAFLD.},
	year = {2024},
	pages = {208},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Varga, Csaba/0000-0002-2678-665X}
}