@CONFERENCE{MTMT:35697218, title = {Nanoszerkezetű Mitomycin-C tartalmú hatóanyag-leadó rendszerek, mint új minimálinvazív kezelési lehetőségek felső légúti heges szűkületekben}, url = {https://m2.mtmt.hu/api/publication/35697218}, author = {Csanády, Miklós ifj. and Mohamed, Abdelgafour and Janovák, László and Rovó, László and Szabó, Diána}, booktitle = {Magyar Fül-Orr-Gége és Fej-Nyaksebész Orvosok Egyesülete 48. Kongresszusa és az MFOE Audiológiai Szekciójának 60. Vándorgyűlése}, unique-id = {35697218}, year = {2024}, pages = {35-35}, orcid-numbers = {Rovó, László/0000-0003-1782-1756} } @article{MTMT:35135372, title = {pH-Triggered Hydrogel Nanoparticles for Efficient Anticancer Drug Delivery and Bioimaging Applications}, url = {https://m2.mtmt.hu/api/publication/35135372}, author = {Amin, Keristina and Imre-Deák, Ágota and Csanády, Miklós ifj. and Szemerédi, Nikoletta and Szabó, Diána and Turcsányi, Árpád and Ungor, Ditta Anita and Spengler, Gabriella and Rovó, László and Janovák, László}, doi = {10.3390/pharmaceutics16070931}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {16}, unique-id = {35135372}, abstract = {In this work, we developed multifunctional hydrogel nanoparticles (NPs) that can encapsulate anticancer drugs and imaging contrast agents as well. Mitomycin C (MMC) and rhodamine B (RB) were selected as models for anticancer drugs and imaging contrasting agents, respectively. Both MMC and RB were linked to the succinated polyvinyl alcohol polymer (PVA-SA). The selected labeled hydrogel NPs ((0.5% RB)-PVA-SA NPs and (1.5% RB)-PVA-SA NPs) improved the RB quantum yield from 29.8% to a minimum of 42.7%. Moreover, they showed higher emission stability compared to free RB when they were repeatedly excited at 554 nm for 2 h. Furthermore, the dye polymeric interactions significantly increased the RB fluorescence lifetime by approximately twofold. All these optical properties pave the way for our labeled hydrogel NPs to be used in imaging-guided therapy. For the labeled MMC-loaded NPs, the MMC-binding efficiency was found to be exceedingly high in all synthesized samples: a minimum of 92% was achieved. In addition, the obtained pH-dependent drug release profiles as well as the cytotoxicity evaluation demonstrated the high potential of releasing MMC under acidic cancerous conditions. Moreover, the in vitro cellular uptake experiment confirmed the accumulation of MMC NPs throughout the cytoplasm.}, year = {2024}, eissn = {1999-4923}, orcid-numbers = {Imre-Deák, Ágota/0000-0002-6781-1727; Ungor, Ditta Anita/0000-0002-7659-0428; Spengler, Gabriella/0000-0001-8085-0950; Rovó, László/0000-0003-1782-1756; Janovák, László/0000-0002-2066-319X} } @article{MTMT:34729015, title = {Új minimálinvazív kezelési lehetőségek jó- és rosszindulatú fül-orr-gégészeti betegségekben nanoszerkezetű hatóanyag-leadó rendszerek alkalmazásával = [New minimally invasive treatment options in benign and malignant otorhinolaryngological diseases using nanostructured drug delivery systems]}, url = {https://m2.mtmt.hu/api/publication/34729015}, author = {Szabó, Diána and Janovák, László and Abdelghafour, Mohamed M. and Takács, Tamás and Csanády, Miklós ifj. and Spengler, Gabriella and Szakács, László and Csanády, Miklós and Rovó, László}, doi = {10.1556/650.2024.32978}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34729015}, issn = {0030-6002}, year = {2024}, eissn = {1788-6120}, pages = {370-378}, orcid-numbers = {Janovák, László/0000-0002-2066-319X; Abdelghafour, Mohamed M./0000-0002-7895-4555; Spengler, Gabriella/0000-0001-8085-0950; Rovó, László/0000-0003-1782-1756} }