@article{MTMT:35416385,
	title = {Gibberellic Acid (GA3): a Versatile Chiral Building Block for Syntheses of Pharmaceutical Agents},
	url = {https://m2.mtmt.hu/api/publication/35416385},
	author = {Khdar, Zein Alabdeen and Le Minh, Tam and Szakonyi, Zsolt},
	doi = {10.1002/cbdv.202401823},
	journal-iso = {CHEM BIODIVERS},
	journal = {CHEMISTRY & BIODIVERSITY},
	volume = {22},
	unique-id = {35416385},
	issn = {1612-1872},
	abstract = {Gibberellic acid (GA3), an ent‐kaurene tetracyclic diterpene, has been considered to be a chiral pool for the chemical transformation of significant heterocyclic compounds. This chiral pool continues to influence modern synthetic chemistry as an inexpensive and versatile starting material since it is widely applied in agriculture. This review focuses on the stereoselective syntheses of bioactive agents with pharmaceutical potency prepared from Gibberellic acid.},
	year = {2025},
	eissn = {1612-1880},
	orcid-numbers = {Le Minh, Tam/0000-0002-8296-887X; Szakonyi, Zsolt/0000-0003-2432-8409}
}

@article{MTMT:35577548,
	title = {Aminodiols, aminotetraols and 1,2,3-triazoles based on allo-gibberic acid: stereoselective syntheses and antiproliferative activities},
	url = {https://m2.mtmt.hu/api/publication/35577548},
	author = {Khdar, Zein Alabdeen and Le Minh, Tam and Schelz, Zsuzsanna and Zupkó, István and Szakonyi, Zsolt},
	doi = {10.1039/D4RA07334G},
	journal-iso = {RSC ADV},
	journal = {RSC ADVANCES},
	volume = {14},
	unique-id = {35577548},
	issn = {2046-2069},
	abstract = {Various allo -gibberic acid modifications yielded aminodiols, aminotetraols, and triazoles. N -naphthyl aminotetraols and di- or tetrahydroxy triazoles with a diaminopyrimidine moiety showed optimal antiproliferative activity.},
	year = {2024},
	eissn = {2046-2069},
	pages = {36698-36712},
	orcid-numbers = {Le Minh, Tam/0000-0002-8296-887X; Schelz, Zsuzsanna/0000-0002-8519-4830; Zupkó, István/0000-0003-3243-5300; Szakonyi, Zsolt/0000-0003-2432-8409}
}

@article{MTMT:34577084,
	title = {Stereoselective synthesis and antiproliferative activity of allo-gibberic acid-based 1,3-aminoalcohol regioisomers},
	url = {https://m2.mtmt.hu/api/publication/34577084},
	author = {Khdar, Zein Alabdeen and Le Minh, Tam and Schelz, Zsuzsanna and Zupkó, István and Szakonyi, Zsolt},
	doi = {10.1039/D3MD00665D},
	journal-iso = {RSC MED CHEM},
	journal = {RSC MEDICINAL CHEMISTRY},
	volume = {15},
	unique-id = {34577084},
	abstract = {A new library of allo -gibberic acid-based aminoalcohol regioisomers was synthesised stereoselectively starting from commercially available gibberellic acid, which yields allo -gibberic acid under mild acidic conditions. The successful formation of hydroxymethyl...},
	year = {2024},
	eissn = {2632-8682},
	pages = {874-887},
	orcid-numbers = {Le Minh, Tam/0000-0002-8296-887X; Schelz, Zsuzsanna/0000-0002-8519-4830; Zupkó, István/0000-0003-3243-5300; Szakonyi, Zsolt/0000-0003-2432-8409}
}

@CONFERENCE{MTMT:35198104,
	title = {Allogibberic acid based 1,3-aminoalcohol regioisomers:stereoselective synthesis and biological applications},
	url = {https://m2.mtmt.hu/api/publication/35198104},
	author = {Khdar, Zein Alabdeen},
	booktitle = {XV. Clauder Ottó Emlékverseny 2023},
	unique-id = {35198104},
	year = {2023},
	pages = {38-38}
}

@article{MTMT:33087002,
	title = {Stereoselective Synthesis and Application of Gibberellic Acid-Derived Aminodiols},
	url = {https://m2.mtmt.hu/api/publication/33087002},
	author = {Khdar, Zein Alabdeen and Le Minh, Tam and Schelz, Zsuzsanna and Zupkó, István and Szakonyi, Zsolt},
	doi = {10.3390/ijms231810366},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33087002},
	issn = {1661-6596},
	abstract = {A series of gibberellic acid-based aminodiols was designed and synthesized from commercially available gibberellic acid. Exposure of gibberellic acid to hydrochloric acid under reflux conditions resulted in aromatization followed by rearrangement to form allo-gibberic acid. The key intermediate, ethyl allo-gibberate, was prepared according to literature methods. Epoxidation of key intermediate and subsequent ring-opening of the corresponding epoxide with different nucleophiles resulted in N-substituted aminodiols. The regioselective ring closure of N-benzyl-substituted aminodiol with formaldehyde was also investigated. All aminodiol derivatives were well characterized using modern spectroscopic techniques and evaluated for their antiproliferative activity against a panel of human cancer cell lines. In addition, structure–activity relationships were examined by assessing substituent effects on the aminodiol systems. The results indicated that aminodiols containing aromatic rings on their nitrogen substituents displayed significant cytotoxic effects. Among these agents, N-naphthylmethyl-substituted aminodiols were found to be the most potent candidates in this series. One of these molecules exhibited a modest cancer selectivity determined by non-cancerous fibroblast cells. A docking study was also made to exploit the observed results.},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Le Minh, Tam/0000-0002-8296-887X; Schelz, Zsuzsanna/0000-0002-8519-4830; Zupkó, István/0000-0003-3243-5300; Szakonyi, Zsolt/0000-0003-2432-8409}
}

@article{MTMT:32925656,
	title = {Design, synthesis, evaluation of new 3-acetylisoxazolines and their hybrid analogous as anticancer agents: In vitro and in silico analysis},
	url = {https://m2.mtmt.hu/api/publication/32925656},
	author = {Fawzi, Mourad and Oubella, Ali and Bimoussa, Abdoullah and Bamou Zahra, Fatima and Khdar, Zein Alabdeen and Auhmani, Aziz and Riahi, Abdelkhalek and Robert, Anthony and Morjani, Hamid and Itto, My Youssef Ait},
	doi = {10.1016/j.compbiolchem.2022.107666},
	journal-iso = {COMPUT BIOL CHEM},
	journal = {COMPUTATIONAL BIOLOGY AND CHEMISTRY},
	volume = {98},
	unique-id = {32925656},
	issn = {1476-9271},
	year = {2022},
	eissn = {1476-928X}
}

@article{MTMT:32874321,
	title = {New 1,3,4-thiadiazoles derivatives: synthesis, antiproliferative activity, molecular docking and molecular dynamics},
	url = {https://m2.mtmt.hu/api/publication/32874321},
	author = {Bimoussa, Abdoullah and Oubella, Ali and Bamou Zahra, Fatima and Khdar, Zein Alabdeen and Fawzi, Mourad and Laamari, Yassine and Ait Itto, My Youssef and Morjani, Hamid and Auhmani, Aziz},
	doi = {10.4155/fmc-2022-0016},
	journal-iso = {FUTURE MED CHEM},
	journal = {FUTURE MEDICINAL CHEMISTRY},
	volume = {14},
	unique-id = {32874321},
	issn = {1756-8919},
	year = {2022},
	eissn = {1756-8927},
	pages = {881-897}
}