@article{MTMT:36099827,
	title = {Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopulations},
	url = {https://m2.mtmt.hu/api/publication/36099827},
	author = {Gémes, Nikolett and Rónaszéki, Benedek and Modok, Szabolcs and Borbényi, Zita and Földesi, Imre and Trucza, Éva Gabriella and Godza, Blanka and László, Zsuzsanna and Csernus, Balázs and Krenács, László and Bagdi, Enikő and Szabó, Enikő and Puskás, László and Bertagnolo, Valeria and Szebeni, Gábor},
	doi = {10.3389/fimmu.2025.1563386},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {16},
	unique-id = {36099827},
	issn = {1664-3224},
	year = {2025},
	eissn = {1664-3224},
	orcid-numbers = {Rónaszéki, Benedek/0000-0002-7689-9361; Földesi, Imre/0000-0002-3329-8136; Szebeni, Gábor/0000-0002-6998-5632}
}

@article{MTMT:36235342,
	title = {Multiplex immunophenotyping of petients with antiphospholipid syndrome or seropositivity without clinical symptomes},
	url = {https://m2.mtmt.hu/api/publication/36235342},
	author = {Balog, Attila and Kari, Beáta and Kotogány, Edit and Gémes, Nikolett and Honfi, Dániel György and Cselei, N. and Szebeni, Gábor},
	doi = {10.1016/j.ard.2025.06.911},
	journal-iso = {ANN RHEUM DIS},
	journal = {ANNALS OF THE RHEUMATIC DISEASES},
	volume = {84},
	unique-id = {36235342},
	issn = {0003-4967},
	year = {2025},
	eissn = {1468-2060},
	pages = {1543-1543},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632}
}

@article{MTMT:36264592,
	title = {Comprehensive analysis of human keratinocyte interactions with Candida albicans and Candida parapsilosis},
	url = {https://m2.mtmt.hu/api/publication/36264592},
	author = {Novák, Ádám and Zajta, Erik and Csikós, Máté Lajos and Halmos, Emese and Horváth, Márton and Tildy, Orsolya and Szekeres, András and Svorenj, Gergő and Gémes, Nikolett and Szebeni, Gábor and Tóth, Renáta and Gácser, Attila},
	doi = {10.1080/21505594.2025.2532815},
	journal-iso = {VIRULENCE},
	journal = {VIRULENCE},
	volume = {16},
	unique-id = {36264592},
	issn = {2150-5594},
	year = {2025},
	eissn = {2150-5608},
	orcid-numbers = {Zajta, Erik/0000-0001-5258-2506; Szekeres, András/0000-0003-1651-4623; Szebeni, Gábor/0000-0002-6998-5632; Tóth, Renáta/0000-0001-7395-0689}
}

@article{MTMT:36280462,
	title = {The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis},
	url = {https://m2.mtmt.hu/api/publication/36280462},
	author = {Nógrádi, Bernát and Molnár, Kinga and Kristóf, Rebeka and Horváth, Orsolya and Huang, Yu-Ting and Ridgway, Zara and Elicegui, Amaia and Fuertes-Alvarez, Sandra and Alonso-Martin, Sonia and Szebeni, Gábor and Gémes, Nikolett and Ramadan, Abdullah and Smith, Hannah L. and Krizbai, István Adorján and Patai, Roland and Siklós, László and Klivényi, Péter and Chaytow, Helena and Gillingwater, Thomas H.},
	doi = {10.1038/s41467-025-62351-3},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {16},
	unique-id = {36280462},
	year = {2025},
	eissn = {2041-1723},
	orcid-numbers = {Ridgway, Zara/0009-0007-3936-5428; Elicegui, Amaia/0000-0003-4782-6005; Alonso-Martin, Sonia/0000-0002-3254-0365; Szebeni, Gábor/0000-0002-6998-5632; Smith, Hannah L./0000-0003-3670-5881; Klivényi, Péter/0000-0002-5389-3266; Chaytow, Helena/0000-0003-2257-7620; Gillingwater, Thomas H./0000-0002-0306-5577}
}

@article{MTMT:36298925,
	title = {Immune Checkpoint Dysregulation in Aneurysmal Subarachnoid Hemorrhage: A Prospective Study of sCTLA-4 and sPD-L1 as Biomarkers of Symptomatic Vasospasm},
	url = {https://m2.mtmt.hu/api/publication/36298925},
	author = {Várnai, Réka and Szebeni, Gábor and Gémes, Nikolett and Schwarcz, Attila and Molnár, Tihamér and Oláh, Csaba Zsolt and Csécsei, Péter},
	doi = {10.3390/ijms26178228},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {26},
	unique-id = {36298925},
	issn = {1661-6596},
	abstract = {Aneurysmal subarachnoid hemorrhage (aSAH) is a severe stroke subtype often complicated by symptomatic cerebral vasospasm (sVP), contributing to delayed cerebral ischemia and poor outcomes. Immune dysregulation, particularly T-cell imbalances and pro-inflammatory cytokines, is implicated in vasospasm development. Soluble immune checkpoint proteins—CTLA-4 (sCTLA-4) and PD-L1 (sPD-L1)—regulate immune homeostasis and may serve as biomarkers or modulators of inflammation in aSAH. This prospective cohort study included 179 aSAH patients, divided into sVP+ (n = 48) and sVP− (n = 131), plus 50 healthy controls. Serum sCTLA-4 and sPD-L1 levels were measured on days 1, 5, and 9 post-ictus using Luminex xMAP. Associations with clinical outcomes were analyzed using non-parametric statistics and hierarchical clustering. Both sCTLA-4 and sPD-L1 were significantly elevated in sVP+ patients versus sVP− and controls, increasing over time. sCTLA-4 was significantly higher in sVP+ on days 5 (p = 0.001) and 9 (p < 0.001), and sPD-L1 on days 5 and 9 (both p < 0.001). Clustering revealed distinct expression patterns between sVP+ and sVP− groups. Elevated sCTLA-4 and sPD-L1 levels are associated with sVP after aSAH and may serve as biomarkers for early immune dysfunction, offering insights into potential therapeutic targets.},
	year = {2025},
	eissn = {1422-0067},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Molnár, Tihamér/0000-0002-6149-9787; Oláh, Csaba Zsolt/0000-0001-9598-9322}
}

@article{MTMT:36389897,
	title = {Claudin proteins and hemorrhage severity in aneurysmal subarachnoid hemorrhage: Correlation with modified Fisher score but not functional outcome},
	url = {https://m2.mtmt.hu/api/publication/36389897},
	author = {Lenzsér, Gábor and Szebeni, Gábor and Balogh, Fanni and Gémes, Nikolett and Schwarcz, Attila and Csécsei, Péter},
	doi = {10.1007/s10143-025-03829-y},
	journal-iso = {NEUROSURG REV},
	journal = {NEUROSURGICAL REVIEW},
	volume = {48},
	unique-id = {36389897},
	issn = {0344-5607},
	abstract = {Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a critical condition characterized by blood-brain barrier (BBB) disruption. Tight junction proteins, claudin-3 (CLDN3) and claudin-5 (CLDN5), are key regulators of BBB integrity and may serve as biomarkers of hemorrhage severity. Methods: In this prospective cohort study, 200 patients with aSAH were evaluated. Serum CLDN3 and CLDN5 levels were measured on days 1, 5, and 9 post-ictus and compared with healthy and aneurysm-bearing controls. Patients were stratified by modified Fisher Score (mFS), World Federation of Neurosurgical Societies (WFNS) score, and 3-month modified Rankin Scale (mRS). Associations with complications, including delayed cerebral ischemia (DCI) and infection, were also assessed. Results: CLDN3 and CLDN5 levels were significantly elevated in aSAH patients compared to controls ( p  <0.01 and p  <0.0001, respectively), with CLDN5 levels consistently higher than CLDN3 at all time points ( p  <0.0001). CLDN5 levels were consistently higher than CLDN3 at all measured time points, and neither CLDN3 nor CLDN5 showed significant temporal variation between days 1, 5, and 9. Both markers showed significant positive correlation with mFS, with higher levels observed in mFS3 and mFS4 groups ( p  <0.05 to p  <0.0001). No association was found between CLDN3 and 5 levels and WFNS score, 3-month mRS, age, sex, comorbidities, inflammatory markers, or DCI. Conclusion: Elevated serum CLDN3 and especially CLDN5 levels reflect hemorrhage extent and potential BBB disruption in aSAH. Their strong correlation with mFS suggests utility in grading imageological hemorrhagic severity, though not in predicting long-term functional outcomes. CLDN5 emerges as a promising biomarker for early assessment of BBB integrity in neurovascular injury.},
	year = {2025},
	eissn = {1437-2320},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632}
}

@article{MTMT:36391088,
	title = {The effect of baricitinib on pSTAT3 levels in IL-6- or IL-15-stimulated PBMCs isolated from patients with SLE},
	url = {https://m2.mtmt.hu/api/publication/36391088},
	author = {Szebeni, Gábor and Gémes, Nikolett and Neuperger, Patricia and Szabó, Enikő and Balog, József Ágoston and Honfi, Dániel György and Balog, Attila and Toldi, Gergely},
	doi = {10.3389/fimmu.2025.1675350},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {16},
	unique-id = {36391088},
	issn = {1664-3224},
	year = {2025},
	eissn = {1664-3224},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Toldi, Gergely/0000-0003-0178-1243}
}

@article{MTMT:36444224,
	title = {Potential anticancer effects of Peganum harmala in human papillomavirus-related cervical and head and neck cancer cells},
	url = {https://m2.mtmt.hu/api/publication/36444224},
	author = {Abdallah, Hiba Faroug Muddather and Nasibova, Tohfa and Szebeni, Gábor and Gémes, Nikolett and Bózsity-Faragó, Noémi and Minorics, Renáta and Garayev, Eldar and Orhan, Ilkay Erdogan and Herbette, Gaëtan and Schelz, Zsuzsanna and Hohmann, Judit and Zupkó, István},
	doi = {10.3389/fphar.2025.1668827},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {16},
	unique-id = {36444224},
	year = {2025},
	eissn = {1663-9812},
	orcid-numbers = {Abdallah, Hiba Faroug Muddather/0000-0001-8472-330X; Szebeni, Gábor/0000-0002-6998-5632; Minorics, Renáta/0000-0001-9685-813X; Schelz, Zsuzsanna/0000-0002-8519-4830; Hohmann, Judit/0000-0002-2887-6392; Zupkó, István/0000-0003-3243-5300}
}

@article{MTMT:36444923,
	title = {C > U mutations generate immunogenic peptides in SARS-CoV-2},
	url = {https://m2.mtmt.hu/api/publication/36444923},
	author = {Balogh, Gergő Mihály and Koncz, Balázs and Asztalos, Leó and Ari, Eszter and Gémes, Nikolett and Szebeni, Gábor and Papp, Benjamin Tamás and Tóth, Franciska and Papp, Balázs and Pál, Csaba and Manczinger, Máté},
	doi = {10.1038/s41467-025-65251-8},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {16},
	unique-id = {36444923},
	abstract = {The rapid spread of SARS-CoV-2 worldwide has given rise to numerous variants. While the impact of viral mutations on antibody escape has been extensively studied, an unresolved issue concerns how emerging mutations shape HLA-restricted T-cell immune responses. Here, we analyse SARS-CoV-2 genomic variants, showing that 27% of the mutations are C > U transitions, a phenomenon common in human RNA viruses and primarily attributed to APOBEC3 enzyme-driven mutagenesis. We find that this mutation bias generally enhances viral peptide binding to human leukocyte antigen class I (HLA-I) molecules, producing immunogenic epitopes that trigger cytotoxic adaptive immune responses in most individuals across diverse populations. We also identify several HLA-I variants that are especially well-suited for presenting viral epitopes generated by these mutations. Intriguingly, individuals carrying these specific alleles are predominantly located in South and East Asia. Finally, we show that carrying HLA-I molecules that are less likely to bind C > U-induced viral peptides increases risk for severe COVID-19 disease. Our work suggests a link between C > U hypermutation and HLA-I-based presentation of viral epitopes, which may reflect the evolutionary outcome of ancient RNA virus pandemics. More broadly, our findings imply that SARS-CoV-2 diversification leads to ongoing gains of T-cell epitopes despite natural selection favouring immune escape.},
	year = {2025},
	eissn = {2041-1723},
	orcid-numbers = {Ari, Eszter/0000-0001-7774-1067; Szebeni, Gábor/0000-0002-6998-5632; Tóth, Franciska/0009-0005-7338-8231; Manczinger, Máté/0000-0003-0831-9617}
}

@article{MTMT:34840255,
	title = {Identification of immune subsets with distinct lectin binding signatures using multi-parameter flow cytometry: correlations with disease activity in systemic lupus erythematosus},
	url = {https://m2.mtmt.hu/api/publication/34840255},
	author = {Szabó, Enikő and Faragó, Anna and Bodor, Gergely and Gémes, Nikolett and Puskás, László and Kovács, László and Szebeni, Gábor},
	doi = {10.3389/fimmu.2024.1380481},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34840255},
	issn = {1664-3224},
	abstract = {Cell surface glycosylation can influence protein-protein interactions with particular relevance to changes in core fucosylation and terminal sialylation. Glycans are ligands for immune regulatory lectin families like galectins (Gals) or sialic acid immunoglobulin-like lectins (Siglecs). This study delves into the glycan alterations within immune subsets of systemic lupus erythematosus (SLE).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Evaluation of binding affinities of Galectin-1, Galectin-3, Siglec-1, <jats:italic>Aleuria aurantia</jats:italic> lectin (AAL, recognizing core fucosylation), and <jats:italic>Sambucus nigra</jats:italic> agglutinin (SNA, specific for α-2,6-sialylation) was conducted on various immune subsets in peripheral blood mononuclear cells (PBMCs) from control and SLE subjects. Lectin binding was measured by multi-parameter flow cytometry in 18 manually gated subsets of T-cells, NK-cells, NKT-cells, B-cells, and monocytes in unstimulated resting state and also after 3-day activation. Stimulated pre-gated populations were subsequently clustered by FlowSOM algorithm based on lectin binding and activation markers, CD25 or HLA-DR.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Elevated AAL, SNA and CD25<jats:sup>+</jats:sup>/CD25<jats:sup>-</jats:sup> SNA binding ratio in certain stimulated SLE T-cell subsets correlated with SLE Disease Activity Index 2000 (SLEDAI-2K) scores. The significantly increased frequencies of activated AAL<jats:sup>low</jats:sup> Siglec-1<jats:sup>low</jats:sup> NK metaclusters in SLE also correlated with SLEDAI-2K indices. In SLE, activated double negative NKTs displayed significantly lower core fucosylation and CD25<jats:sup>+</jats:sup>/CD25<jats:sup>-</jats:sup> Siglec-1 binding ratio, negatively correlating with disease activity. The significantly enhanced AAL binding in resting SLE plasmablasts positively correlated with SLEDAI-2K scores.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Alterations in the glycosylation of immune cells in SLE correlate with disease severity, which might represent potential implications in the pathogenesis of SLE.},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Kovács, László/0000-0003-4457-1430; Szebeni, Gábor/0000-0002-6998-5632}
}