TY - JOUR AU - Mardikasari, Sandra Aulia AU - Katona, Gábor AU - Sipos, Bence AU - Pannonhalminé Csóka, Ildikó TI - Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions JF - EXPERT OPINION ON DRUG DELIVERY J2 - EXPERT OPIN DRUG DELIV PY - 2024 SP - 1 EP - 15 PG - 15 SN - 1742-5247 DO - 10.1080/17425247.2024.2341184 UR - https://m2.mtmt.hu/api/publication/34791444 ID - 34791444 LA - English DB - MTMT ER - TY - CONF AU - Mardikasari, Sandra Aulia AU - Katona, Gábor AU - Budai-Szűcs, Mária AU - Sipos, Bence AU - Orosz, László AU - Burián, Katalin AU - Rovó, László AU - Pannonhalminé Csóka, Ildikó TI - Development of in situ ionic-sensitive nasal gels of amoxicillin-loaded albumin nanoparticle applying QbD-based optimization for improved local delivery T2 - VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and RegulatoryAffairs, University of Szeged, Faculty of Pharmacy C1 - Szeged PY - 2024 SP - 18 EP - 18 PG - 1 DO - 10.14232/syrptbrs.2024.18 UR - https://m2.mtmt.hu/api/publication/34770795 ID - 34770795 LA - English DB - MTMT ER - TY - CONF AU - Rajab, Fatima AU - Sipos, Bence AU - Pannonhalminé Csóka, Ildikó TI - Nasal polymeric nanoparticles for enhanced therapeutic effects T2 - VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and RegulatoryAffairs, University of Szeged, Faculty of Pharmacy C1 - Szeged PY - 2024 SP - 50 EP - 50 PG - 1 DO - 10.14232/syrptbrs.2024.50 UR - https://m2.mtmt.hu/api/publication/34762705 ID - 34762705 LA - English DB - MTMT ER - TY - CHAP AU - Rajab, Fatima AU - Sipos, Bence AU - Pannonhalminé Csóka, Ildikó ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Nasal polymeric nanoparticles for enhanced therapeutic effects T2 - VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2024 SP - 50 UR - https://m2.mtmt.hu/api/publication/34689121 ID - 34689121 N1 - Funded by Project no. TKP2021-EGA-32 of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. LA - English DB - MTMT ER - TY - CHAP AU - Sipos, Bence AU - Pannonhalminé Csóka, Ildikó ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Investigation of thermosensitive polymeric micelles in scope of nasal drug administration T2 - VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2024 SP - 38 UR - https://m2.mtmt.hu/api/publication/34689116 ID - 34689116 N1 - Funded by Project no. TKP2021-EGA-32 of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. LA - English DB - MTMT ER - TY - CHAP AU - Shammout, Hadi AU - Ludasi, Krisztina AU - Selenay, Belge AU - Sipos, Bence AU - Sovány, Tamás ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Coating technology in the pharmaceutical industry T2 - VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2024 SP - 42 EP - 42 PG - 68 UR - https://m2.mtmt.hu/api/publication/34633006 ID - 34633006 LA - English DB - MTMT ER - TY - JOUR AU - Mardikasari, Sandra Aulia AU - Katona, Gábor AU - Sipos, Bence AU - Ambrus, Rita AU - Pannonhalminé Csóka, Ildikó TI - Preparation and Optimization of Bovine Serum Albumin Nanoparticles as a Promising Gelling System for Enhanced Nasal Drug Administration JF - GELS (BASEL) J2 - GELS-BASEL VL - 9 PY - 2023 IS - 11 PG - 16 SN - 2310-2861 DO - 10.3390/gels9110896 UR - https://m2.mtmt.hu/api/publication/34318204 ID - 34318204 AB - Bovine serum albumin (BSA) has been used extensively as a suitable carrier system for alternative drug delivery routes, such as nasal administration. However, the optimization of BSA nanoparticles with respect to their nasal applicability has not been widely studied. The present study focuses on the characterization of BSA nanoparticles prepared using the desolvation method, followed by a gelation process to facilitate intranasal drug delivery. The results demonstrated that the ratio of BSA and the desolvating agent, ethanol, played a critical role in the nanoparticle characteristics of the BSA nanogel matrices (BSA-NGs). Based on the gelling properties, the formulations of BSA-NG 2, BSA-NG 4, and BSA-NG 6 were selected for further investigation. The Raman spectra confirmed that there were no specific changes to the secondary structures of the BSA. The mucoadhesion studies revealed moderately high mucoadhesive properties, with a mucin binding efficiency (MBE) value of around 67%, allowing the dose to avoid elimination due to rapid mucociliary clearance of the nasal passage. Via studying the nexus of the carrier system, BSA-NGs loaded with dexamethasone as a model drug were prepared and evaluated by differential scanning calorimetry (DSC) and thermal gravimetry (TG), ascertaining that no ethanol remained in the samples after the freeze-drying process. Furthermore, the viscosity measurements exhibited moderate viscosity, which is suitable for nasal liquid preparations. The in vitro release studies performed with a simulated nasal electrolyte solution (SNES) medium showed 88.15–95.47% drug release within 4 h. In conclusion, BSA nanoparticle gelling matrices can offer potential, value-added drug delivery carriers for improved nasal drug administration. LA - English DB - MTMT ER - TY - JOUR AU - Sipos, Bence AU - Katona, Gábor AU - Szarvas, Flóra Mária AU - Budai-Szűcs, Mária AU - Ambrus, Rita AU - Pannonhalminé Csóka, Ildikó TI - Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 16 PY - 2023 IS - 10 PG - 16 SN - 1424-8247 DO - 10.3390/ph16101447 UR - https://m2.mtmt.hu/api/publication/34192255 ID - 34192255 AB - In this present formulation study, vinpocetine-loaded nano-spray-dried polymeric micelles were developed via nano-spray-drying. Three different mucoadhesive excipients were applied in the studies, namely chitosan, hyaluronic acid and hydroxypropyl methylcellulose. In all cases, the formulations had a proper particle size and drug content after drying with spherical morphology and amorphous structure. After rapid dissolution in water, the polymeric micelles had a particle size around 100–130 nm, in monodisperse size distribution. The high encapsulation efficiency (>80%) and high solubilization (approx. 300-fold increase in thermodynamic solubility) contributed to rapid drug release (>80% in the first 15 min) and fast passive diffusion at simulated nasal conditions. The formulated prototype preparations fulfilled the demands of a low-viscosity, moderately mucoadhesive nasal drug delivery system, which may be capable of increasing the overall bioavailability of drugs administered via the auspicious nasal drug delivery route. LA - English DB - MTMT ER - TY - JOUR AU - Sipos, Bence AU - Benei, Márk AU - Katona, Gábor AU - Pannonhalminé Csóka, Ildikó TI - Optimization and Characterization of Sodium Alginate Beads Providing Extended Release for Antidiabetic Drugs JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 19 PG - 19 SN - 1420-3049 DO - 10.3390/molecules28196980 UR - https://m2.mtmt.hu/api/publication/34183774 ID - 34183774 AB - The current research is aimed at investigating the relationship between the formulation components and conditions in the case of a binary drug delivery system, where antidiabetic drugs are co-formulated into polymeric micelles embedded in sodium alginate. Compared to chemical modifications of polymers with alginate, our development provides a simpler and scalable formulation process. Our results prove that a multi-level factorial design-based approach can ensure the development of a value-added polymeric micelle formulation with an average micelle size of 123.6 ± 3.1 nm and a monodisperse size distribution, showing a polydispersity index value of 0.215 ± 0.021. The proper nanoparticles were co-formulated with sodium alginate as a biologically decomposing and safe-to-administer biopolymer. The Box–Behnken factorial design ensured proper design space development, where the optimal sodium alginate bead formulation had a uniform, extended-release drug release mechanism similar to commercially available tablet preparations. The main conclusion is that the rapid-burst-like drug release can be hindered via the embedment of nanocarriers into biopolymeric matrices. The thermally stable formulation also holds the benefit of uniform active substance distribution after freeze-drying. LA - English DB - MTMT ER - TY - JOUR AU - Katona, Gábor AU - Pannonhalminé Csóka, Ildikó AU - Sipos, Bence AU - Gróf, Ilona AU - A. Deli, Mária AU - Balogh, György Tibor TI - Investigation of drug release and permeability behavior of different species-specific serum albumin nanoparticles JF - MACEDONIAN PHARMACEUTICAL BULLETIN J2 - MACED PHARMA BULL VL - 69 PY - 2023 IS - 03 SP - 45 EP - 46 PG - 2 SN - 1409-8695 DO - 10.33320/maced.pharm.bull.2023.69.03.022 UR - https://m2.mtmt.hu/api/publication/34153994 ID - 34153994 LA - English DB - MTMT ER -