@article{MTMT:34791444, title = {Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions}, url = {https://m2.mtmt.hu/api/publication/34791444}, author = {Mardikasari, Sandra Aulia and Katona, Gábor and Sipos, Bence and Pannonhalminé Csóka, Ildikó}, doi = {10.1080/17425247.2024.2341184}, journal-iso = {EXPERT OPIN DRUG DELIV}, journal = {EXPERT OPINION ON DRUG DELIVERY}, unique-id = {34791444}, issn = {1742-5247}, year = {2024}, eissn = {1744-7593}, pages = {1-15}, orcid-numbers = {Mardikasari, Sandra Aulia/0000-0001-6771-0208; Katona, Gábor/0000-0003-1564-4813; Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @CONFERENCE{MTMT:34770795, title = {Development of in situ ionic-sensitive nasal gels of amoxicillin-loaded albumin nanoparticle applying QbD-based optimization for improved local delivery}, url = {https://m2.mtmt.hu/api/publication/34770795}, author = {Mardikasari, Sandra Aulia and Katona, Gábor and Budai-Szűcs, Mária and Sipos, Bence and Orosz, László and Burián, Katalin and Rovó, László and Pannonhalminé Csóka, Ildikó}, booktitle = {VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2024.18}, unique-id = {34770795}, year = {2024}, pages = {18-18}, orcid-numbers = {Mardikasari, Sandra Aulia/0000-0001-6771-0208; Katona, Gábor/0000-0003-1564-4813; Budai-Szűcs, Mária/0000-0001-5187-5702; Sipos, Bence/0000-0002-0131-4728; Burián, Katalin/0000-0003-1300-2374; Rovó, László/0000-0003-1782-1756; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @CONFERENCE{MTMT:34762705, title = {Nasal polymeric nanoparticles for enhanced therapeutic effects}, url = {https://m2.mtmt.hu/api/publication/34762705}, author = {Rajab, Fatima and Sipos, Bence and Pannonhalminé Csóka, Ildikó}, booktitle = {VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2024.50}, unique-id = {34762705}, year = {2024}, pages = {50-50}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @{MTMT:34689121, title = {Nasal polymeric nanoparticles for enhanced therapeutic effects}, url = {https://m2.mtmt.hu/api/publication/34689121}, author = {Rajab, Fatima and Sipos, Bence and Pannonhalminé Csóka, Ildikó}, booktitle = {VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, unique-id = {34689121}, year = {2024}, pages = {50}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @{MTMT:34689116, title = {Investigation of thermosensitive polymeric micelles in scope of nasal drug administration}, url = {https://m2.mtmt.hu/api/publication/34689116}, author = {Sipos, Bence and Pannonhalminé Csóka, Ildikó}, booktitle = {VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, unique-id = {34689116}, year = {2024}, pages = {38}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @{MTMT:34633006, title = {Coating technology in the pharmaceutical industry}, url = {https://m2.mtmt.hu/api/publication/34633006}, author = {Shammout, Hadi and Ludasi, Krisztina and Selenay, Belge and Sipos, Bence and Sovány, Tamás}, booktitle = {VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, unique-id = {34633006}, year = {2024}, pages = {42-42}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Sovány, Tamás/0000-0003-3392-7788} } @article{MTMT:34318204, title = {Preparation and Optimization of Bovine Serum Albumin Nanoparticles as a Promising Gelling System for Enhanced Nasal Drug Administration}, url = {https://m2.mtmt.hu/api/publication/34318204}, author = {Mardikasari, Sandra Aulia and Katona, Gábor and Sipos, Bence and Ambrus, Rita and Pannonhalminé Csóka, Ildikó}, doi = {10.3390/gels9110896}, journal-iso = {GELS-BASEL}, journal = {GELS (BASEL)}, volume = {9}, unique-id = {34318204}, abstract = {Bovine serum albumin (BSA) has been used extensively as a suitable carrier system for alternative drug delivery routes, such as nasal administration. However, the optimization of BSA nanoparticles with respect to their nasal applicability has not been widely studied. The present study focuses on the characterization of BSA nanoparticles prepared using the desolvation method, followed by a gelation process to facilitate intranasal drug delivery. The results demonstrated that the ratio of BSA and the desolvating agent, ethanol, played a critical role in the nanoparticle characteristics of the BSA nanogel matrices (BSA-NGs). Based on the gelling properties, the formulations of BSA-NG 2, BSA-NG 4, and BSA-NG 6 were selected for further investigation. The Raman spectra confirmed that there were no specific changes to the secondary structures of the BSA. The mucoadhesion studies revealed moderately high mucoadhesive properties, with a mucin binding efficiency (MBE) value of around 67%, allowing the dose to avoid elimination due to rapid mucociliary clearance of the nasal passage. Via studying the nexus of the carrier system, BSA-NGs loaded with dexamethasone as a model drug were prepared and evaluated by differential scanning calorimetry (DSC) and thermal gravimetry (TG), ascertaining that no ethanol remained in the samples after the freeze-drying process. Furthermore, the viscosity measurements exhibited moderate viscosity, which is suitable for nasal liquid preparations. The in vitro release studies performed with a simulated nasal electrolyte solution (SNES) medium showed 88.15–95.47% drug release within 4 h. In conclusion, BSA nanoparticle gelling matrices can offer potential, value-added drug delivery carriers for improved nasal drug administration.}, year = {2023}, eissn = {2310-2861}, orcid-numbers = {Mardikasari, Sandra Aulia/0000-0001-6771-0208; Katona, Gábor/0000-0003-1564-4813; Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @article{MTMT:34192255, title = {Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying}, url = {https://m2.mtmt.hu/api/publication/34192255}, author = {Sipos, Bence and Katona, Gábor and Szarvas, Flóra Mária and Budai-Szűcs, Mária and Ambrus, Rita and Pannonhalminé Csóka, Ildikó}, doi = {10.3390/ph16101447}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {16}, unique-id = {34192255}, abstract = {In this present formulation study, vinpocetine-loaded nano-spray-dried polymeric micelles were developed via nano-spray-drying. Three different mucoadhesive excipients were applied in the studies, namely chitosan, hyaluronic acid and hydroxypropyl methylcellulose. In all cases, the formulations had a proper particle size and drug content after drying with spherical morphology and amorphous structure. After rapid dissolution in water, the polymeric micelles had a particle size around 100–130 nm, in monodisperse size distribution. The high encapsulation efficiency (>80%) and high solubilization (approx. 300-fold increase in thermodynamic solubility) contributed to rapid drug release (>80% in the first 15 min) and fast passive diffusion at simulated nasal conditions. The formulated prototype preparations fulfilled the demands of a low-viscosity, moderately mucoadhesive nasal drug delivery system, which may be capable of increasing the overall bioavailability of drugs administered via the auspicious nasal drug delivery route.}, year = {2023}, eissn = {1424-8247}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Katona, Gábor/0000-0003-1564-4813; Budai-Szűcs, Mária/0000-0001-5187-5702; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @article{MTMT:34183774, title = {Optimization and Characterization of Sodium Alginate Beads Providing Extended Release for Antidiabetic Drugs}, url = {https://m2.mtmt.hu/api/publication/34183774}, author = {Sipos, Bence and Benei, Márk and Katona, Gábor and Pannonhalminé Csóka, Ildikó}, doi = {10.3390/molecules28196980}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {34183774}, issn = {1420-3049}, abstract = {The current research is aimed at investigating the relationship between the formulation components and conditions in the case of a binary drug delivery system, where antidiabetic drugs are co-formulated into polymeric micelles embedded in sodium alginate. Compared to chemical modifications of polymers with alginate, our development provides a simpler and scalable formulation process. Our results prove that a multi-level factorial design-based approach can ensure the development of a value-added polymeric micelle formulation with an average micelle size of 123.6 ± 3.1 nm and a monodisperse size distribution, showing a polydispersity index value of 0.215 ± 0.021. The proper nanoparticles were co-formulated with sodium alginate as a biologically decomposing and safe-to-administer biopolymer. The Box–Behnken factorial design ensured proper design space development, where the optimal sodium alginate bead formulation had a uniform, extended-release drug release mechanism similar to commercially available tablet preparations. The main conclusion is that the rapid-burst-like drug release can be hindered via the embedment of nanocarriers into biopolymeric matrices. The thermally stable formulation also holds the benefit of uniform active substance distribution after freeze-drying.}, year = {2023}, eissn = {1420-3049}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Katona, Gábor/0000-0003-1564-4813; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @article{MTMT:34153994, title = {Investigation of drug release and permeability behavior of different species-specific serum albumin nanoparticles}, url = {https://m2.mtmt.hu/api/publication/34153994}, author = {Katona, Gábor and Pannonhalminé Csóka, Ildikó and Sipos, Bence and Gróf, Ilona and A. Deli, Mária and Balogh, György Tibor}, doi = {10.33320/maced.pharm.bull.2023.69.03.022}, journal-iso = {MACED PHARMA BULL}, journal = {MACEDONIAN PHARMACEUTICAL BULLETIN}, volume = {69}, unique-id = {34153994}, issn = {1409-8695}, year = {2023}, eissn = {1857-8969}, pages = {45-46}, orcid-numbers = {Katona, Gábor/0000-0003-1564-4813; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Sipos, Bence/0000-0002-0131-4728} }