TY - JOUR AU - Nagybanyai-Nagy, Blanka AU - Szebeni, Gábor AU - Balogh, Fanni AU - Neuperger, Patricia AU - Oláh, Csaba Zsolt AU - Molnár, Tihamér AU - Schwarcz, Attila AU - Csécsei, Péter TI - Comparative analysis of matrix metalloproteinases and growth factors in aneurysmal and perimesencephalic subarachnoid hemorrhage: Evidence for an aneurysm-driven molecular response JF - JOURNAL OF CLINICAL NEUROSCIENCE J2 - J CLIN NEUROSCI VL - 145 PY - 2026 PG - 8 SN - 0967-5868 DO - 10.1016/j.jocn.2025.111837 UR - https://m2.mtmt.hu/api/publication/36850619 ID - 36850619 LA - English DB - MTMT ER - TY - JOUR AU - Simon, Péter AU - Török, Éva AU - Szalontai, Klára Margit AU - Kari, Beáta AU - Neuperger, Patricia AU - Zavala, Norma AU - Kanizsai, Iván AU - Puskás, László AU - Török, Szilvia AU - Szebeni, Gábor TI - Nutritional Support of Chronic Obstructive Pulmonary Disease JF - NUTRIENTS J2 - NUTRIENTS VL - 17 PY - 2025 IS - 7 PG - 46 SN - 2072-6643 DO - 10.3390/nu17071149 UR - https://m2.mtmt.hu/api/publication/36060676 ID - 36060676 N1 - Funding Agency and Grant Number: National Research, Development, and Innovation Office (NKFI), Hungary [2023-1.1.1-PIACI_FKUSZ-2024-00036, 2020-1.1.6-JOEVOdblac;-2021-00003, 2022-1.2.6-TET-IPARI-TR-2022-00023, 142877 FK22]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00582/22/8] Funding text: This research was funded by the 2023-1.1.1-PIACI_F & Oacute;KUSZ-2024-00036, 2020-1.1.6-JOEV & Odblac;-2021-00003, 2022-1.2.6-TET-IPARI-TR-2022-00023 and 142877 FK22, grant from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00582/22/8 (GS). AB - Background: COPD is a heterogenous disease of the respiratory tract caused by diverse genetic factors along with environmental and lifestyle-related effects such as industrial dust inhalation and, most frequently, cigarette smoking. These factors lead to airflow obstruction and chronic respiratory symptoms. Additionally, the increased risk of infections exacerbates airway inflammation in COPD patients. As a consequence of the complex pathomechanisms and difficulty in treatment, COPD is among the leading causes of mortality both in the western countries and in the developing world. Results: The management of COPD is still a challenge for the clinicians; however, alternative interventions such as smoking cessation and lifestyle changes from a sedentary life to moderate physical activity with special attention to the diet may ameliorate patients’ health. Here, we reviewed the effects of different dietary components and supplements on the conditions of COPD. Conclusions: COPD patients are continuously exposed to heavy metals, which are commonly present in cigarette smoke and polluted air. Meanwhile, they often experience significant nutrient deficiencies, which affect the detoxification of these toxic metals. This in turn can further disrupt nutritional balance by interfering with the absorption, metabolism, and utilization of essential micronutrients. Therefore, awareness and deliberate efforts should be made to check levels of micronutrients, with special attention to ensuring adequate levels of antioxidants, vitamin D, vitamin K2, magnesium, and iron, as these may be particularly important in reducing the risk of COPD development and limiting disease severity. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Renáta AU - Börzsei, Denise AU - Nagy, András Levente AU - Kiss, Viktória Mónika AU - Virág, Zoltán AU - Karcsúné Kis, Gyöngyi AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Bagyánszki, Mária AU - Bódi, Nikolett AU - Barta, Bence Pál AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba TI - Biochemical Insights into the Effects of a Small Molecule Drug Candidate on Imatinib-Induced Cardiac Inflammation JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 26 PY - 2025 IS - 14 PG - 18 SN - 1661-6596 DO - 10.3390/ijms26146661 UR - https://m2.mtmt.hu/api/publication/36244329 ID - 36244329 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office (NKFI), Hungary; University of Szeged Open Access Fund [7844]; [143241 PD]; [142877 FK22] Funding text: This research was funded by the National Research, Development and Innovation Office (NKFI), Hungary, through grants 143241 PD (to R.S.) and 142877 FK22 (to G.J.S.). Open access funding was provided by the University of Szeged Open Access Fund (grant no. 7844 to R.S.). LA - English DB - MTMT ER - TY - JOUR AU - Szebeni, Gábor AU - Gémes, Nikolett AU - Neuperger, Patricia AU - Szabó, Enikő AU - Balog, József Ágoston AU - Honfi, Dániel György AU - Balog, Attila AU - Toldi, Gergely TI - The effect of baricitinib on pSTAT3 levels in IL-6- or IL-15-stimulated PBMCs isolated from patients with SLE JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 16 PY - 2025 PG - 11 SN - 1664-3224 DO - 10.3389/fimmu.2025.1675350 UR - https://m2.mtmt.hu/api/publication/36391088 ID - 36391088 N1 - Funding Agency and Grant Number: National Research, Development, and Innovation Office (NKFI), Hungary [2023-1.1.1-PIACI_FOKUSZ-2024-00036, 142877 FK22]; University of Szeged [IV-134-62-1/2024.SZAOK]; Hungarian Academy of Sciences [BO/00582/22/8]; University of Szeged Open Access Fund [BO/00582/22/8] Funding text: The author(s) declare financial support was received for the research and/or publication of this article. This research was funded by the 2023-1.1.1-PIACI_FOKUSZ-2024-00036 and 142877 FK22 grants from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by the IV-134-62-1/2024.SZAOK, SZAOK-SZBK collaboration grant of the University of Szeged; the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00582/22/8 (GS); and the University of Szeged Open Access Fund (GS). LA - English DB - MTMT ER - TY - JOUR AU - Baráth, Benjámin R AU - Bojcsuk, Dóra AU - Bene, Krisztian AU - Caballero-Sánchez, Noemí AU - Cseh, Tímea AU - de Freitas, João Cr AU - Tzerpos, Petros AU - Toth, Marta AU - Tang, Zhonghua AU - Guller, Seth AU - Krasznai, Zoárd Tibor AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Nagy, Gergely AU - Deli, Tamás AU - Nagy, Laszlo TI - Distinct transcriptional and epigenomic programs define Hofbauer cells in term placenta. JF - JCI INSIGHT J2 - JCI INSIGHT PY - 2025 SN - 2379-3708 DO - 10.1172/jci.insight.195801 UR - https://m2.mtmt.hu/api/publication/36753249 ID - 36753249 AB - Hofbauer cells (HBC) are fetal-derived macrophages located in the placenta that contribute to antimicrobial defense, angiogenesis, tissue remodeling, and metabolic processes within the chorionic villi. Although their roles in placental biology are increasingly recognized, the mechanisms that regulate HBC identity and function are not yet fully defined. This study aimed to define the core transcriptomic and epigenomic features of HBCs in term placentas and to examine their capacity for transcriptional responsiveness and phenotypic variation. Using chromatin accessibility profiling and bulk RNA sequencing, we found that HBCs exhibit a unique gene expression and chromatin accessibility profile compared to other fetal and adult macrophages. We identified a coordinated transcriptional network involving nuclear receptors NR4A1-3, the glucocorticoid receptor (GR), and RFX family members (RFX1, RFX2, RFX5) that appears to shape HBC identity, particularly through pathways linked to lipid metabolism and angiogenesis. Although exploratory in nature, in vitro stimulation studies showed that HBCs exhibited increased transcriptional activity in response to combined IL-4 and RSG treatment, including induction of the lipid transporter CD36. Mass cytometry analysis revealed surface markers indicative of both immature and mature macrophage states. Together, these results indicated that HBCs represent a distinct and diverse macrophage population with specialized and adaptable regulatory program in the human placenta. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Renáta AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória Mónika AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba TI - Therapeutic effect of BGP-15 in the treatment of imatinib-induced cardiotoxicity in a rat model JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 54. évfolyam (1-2) PY - 2024 SP - 263 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/35054510 ID - 35054510 N1 - Poszter szekció előadással LA - English DB - MTMT ER - TY - CONF AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória Mónika AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba AU - Szabó, Renáta ED - Hajdú, Péter TI - A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében T2 - XXVII. Tavaszi Szél Konferencia 2024 - Absztrakt kötet PB - Doktoranduszok Országos Szövetsége (DOSZ) C1 - Budapest SN - 9786156457523 PY - 2024 SP - 651 UR - https://m2.mtmt.hu/api/publication/35054634 ID - 35054634 N1 - Poszter szekció előadással LA - Hungarian DB - MTMT ER - TY - CONF AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória Mónika AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba AU - Szabó, Renáta ED - Pap, Péter László ED - László, Zoltán TI - A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében T2 - 24. Kolozsvári Biológus Napok C1 - Kolozsvár PY - 2024 SP - 48 UR - https://m2.mtmt.hu/api/publication/35054657 ID - 35054657 N1 - Előadás LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ruppert, Zsófia AU - Neuperger, Patricia AU - Rákóczi, Bettina AU - Gémes, Nikolett AU - Dukay, Brigitta AU - Hajdu, Petra AU - Péter, Mária AU - Balogh, Gábor AU - Tiszlavicz, László AU - Vigh, László AU - Török, Zsolt AU - Puskás, László AU - Szebeni, Gábor AU - Tóth, Erzsébet Melinda TI - Characterization of obesity-related diseases and inflammation using single cell immunophenotyping in two different diet-induced obesity models JF - INTERNATIONAL JOURNAL OF OBESITY J2 - INT J OBES (LOND) VL - 48 PY - 2024 IS - 11 SP - 1568 EP - 1576 PG - 9 SN - 0307-0565 DO - 10.1038/s41366-024-01584-6 UR - https://m2.mtmt.hu/api/publication/35133023 ID - 35133023 N1 - Laboratory of Molecular Stress Biology, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary PhD School in Biology, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Core Facility, HUN-REN Biological Research Centre, Szeged, Hungary Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Internal Medicine, Hematology Centre, Faculty of Medicine, University of Szeged, Szeged, H6725, Hungary Export Date: 2 August 2024 CODEN: IJOBD Correspondence Address: Tóth, M.E.; Laboratory of Molecular Stress Biology, Hungary; email: toth.erzsebetmelinda@brc.hu Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Hungary; email: szebeni.gabor@brc.hu A közlemény a Bolyai János Kutatási Ösztöndíj (BO/00582/22/8) segítségével jött létre. AB - Obesity is a growing problem worldwide and a major risk factor for many chronic diseases. The accumulation of adipose tissue leads to the release of significant amounts of pro-inflammatory cytokines and adipokines, resulting in a low-grade systemic inflammation. However, the mechanisms behind the development of obesity-related diseases are not fully understood. Therefore, our study aimed to investigate the pathological changes and inflammatory processes at systemic level and in individual organs in two different diet-induced mouse obesity models. LA - English DB - MTMT ER - TY - THES AU - Neuperger, Patricia TI - Inter- és intratumor heterogenitás egysejt szintű elemzése, valamint a TMEM45A fehérje vizsgálata humán nem-kissejtes tüdő adenokarcinómában PB - Szegedi Tudományegyetem PY - 2024 SP - 77 DO - 10.14232/phd.12214 UR - https://m2.mtmt.hu/api/publication/35797684 ID - 35797684 LA - Hungarian DB - MTMT ER -