@article{MTMT:36850619, title = {Comparative analysis of matrix metalloproteinases and growth factors in aneurysmal and perimesencephalic subarachnoid hemorrhage: Evidence for an aneurysm-driven molecular response}, url = {https://m2.mtmt.hu/api/publication/36850619}, author = {Nagybanyai-Nagy, Blanka and Szebeni, Gábor and Balogh, Fanni and Neuperger, Patricia and Oláh, Csaba Zsolt and Molnár, Tihamér and Schwarcz, Attila and Csécsei, Péter}, doi = {10.1016/j.jocn.2025.111837}, journal-iso = {J CLIN NEUROSCI}, journal = {JOURNAL OF CLINICAL NEUROSCIENCE}, volume = {145}, unique-id = {36850619}, issn = {0967-5868}, year = {2026}, eissn = {1532-2653}, orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Molnár, Tihamér/0000-0002-6149-9787} } @article{MTMT:36060676, title = {Nutritional Support of Chronic Obstructive Pulmonary Disease}, url = {https://m2.mtmt.hu/api/publication/36060676}, author = {Simon, Péter and Török, Éva and Szalontai, Klára Margit and Kari, Beáta and Neuperger, Patricia and Zavala, Norma and Kanizsai, Iván and Puskás, László and Török, Szilvia and Szebeni, Gábor}, doi = {10.3390/nu17071149}, journal-iso = {NUTRIENTS}, journal = {NUTRIENTS}, volume = {17}, unique-id = {36060676}, abstract = {Background: COPD is a heterogenous disease of the respiratory tract caused by diverse genetic factors along with environmental and lifestyle-related effects such as industrial dust inhalation and, most frequently, cigarette smoking. These factors lead to airflow obstruction and chronic respiratory symptoms. Additionally, the increased risk of infections exacerbates airway inflammation in COPD patients. As a consequence of the complex pathomechanisms and difficulty in treatment, COPD is among the leading causes of mortality both in the western countries and in the developing world. Results: The management of COPD is still a challenge for the clinicians; however, alternative interventions such as smoking cessation and lifestyle changes from a sedentary life to moderate physical activity with special attention to the diet may ameliorate patients’ health. Here, we reviewed the effects of different dietary components and supplements on the conditions of COPD. Conclusions: COPD patients are continuously exposed to heavy metals, which are commonly present in cigarette smoke and polluted air. Meanwhile, they often experience significant nutrient deficiencies, which affect the detoxification of these toxic metals. This in turn can further disrupt nutritional balance by interfering with the absorption, metabolism, and utilization of essential micronutrients. Therefore, awareness and deliberate efforts should be made to check levels of micronutrients, with special attention to ensuring adequate levels of antioxidants, vitamin D, vitamin K2, magnesium, and iron, as these may be particularly important in reducing the risk of COPD development and limiting disease severity.}, year = {2025}, eissn = {2072-6643}, orcid-numbers = {Kanizsai, Iván/0000-0003-0109-7097; Szebeni, Gábor/0000-0002-6998-5632} } @article{MTMT:36244329, title = {Biochemical Insights into the Effects of a Small Molecule Drug Candidate on Imatinib-Induced Cardiac Inflammation}, url = {https://m2.mtmt.hu/api/publication/36244329}, author = {Szabó, Renáta and Börzsei, Denise and Nagy, András Levente and Kiss, Viktória Mónika and Virág, Zoltán and Karcsúné Kis, Gyöngyi and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Bagyánszki, Mária and Bódi, Nikolett and Barta, Bence Pál and Neuperger, Patricia and Szebeni, Gábor and Varga, Csaba}, doi = {10.3390/ijms26146661}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {26}, unique-id = {36244329}, issn = {1661-6596}, year = {2025}, eissn = {1422-0067}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Bódi, Nikolett/0000-0002-9774-1387; Barta, Bence Pál/0000-0002-5309-8633; Szebeni, Gábor/0000-0002-6998-5632; Varga, Csaba/0000-0002-2678-665X} } @article{MTMT:36391088, title = {The effect of baricitinib on pSTAT3 levels in IL-6- or IL-15-stimulated PBMCs isolated from patients with SLE}, url = {https://m2.mtmt.hu/api/publication/36391088}, author = {Szebeni, Gábor and Gémes, Nikolett and Neuperger, Patricia and Szabó, Enikő and Balog, József Ágoston and Honfi, Dániel György and Balog, Attila and Toldi, Gergely}, doi = {10.3389/fimmu.2025.1675350}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {16}, unique-id = {36391088}, issn = {1664-3224}, year = {2025}, eissn = {1664-3224}, orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Toldi, Gergely/0000-0003-0178-1243} } @article{MTMT:36753249, title = {Distinct transcriptional and epigenomic programs define Hofbauer cells in term placenta.}, url = {https://m2.mtmt.hu/api/publication/36753249}, author = {Baráth, Benjámin R and Bojcsuk, Dóra and Bene, Krisztian and Caballero-Sánchez, Noemí and Cseh, Tímea and de Freitas, João Cr and Tzerpos, Petros and Toth, Marta and Tang, Zhonghua and Guller, Seth and Krasznai, Zoárd Tibor and Neuperger, Patricia and Szebeni, Gábor and Nagy, Gergely and Deli, Tamás and Nagy, Laszlo}, doi = {10.1172/jci.insight.195801}, journal-iso = {JCI INSIGHT}, journal = {JCI INSIGHT}, unique-id = {36753249}, abstract = {Hofbauer cells (HBC) are fetal-derived macrophages located in the placenta that contribute to antimicrobial defense, angiogenesis, tissue remodeling, and metabolic processes within the chorionic villi. Although their roles in placental biology are increasingly recognized, the mechanisms that regulate HBC identity and function are not yet fully defined. This study aimed to define the core transcriptomic and epigenomic features of HBCs in term placentas and to examine their capacity for transcriptional responsiveness and phenotypic variation. Using chromatin accessibility profiling and bulk RNA sequencing, we found that HBCs exhibit a unique gene expression and chromatin accessibility profile compared to other fetal and adult macrophages. We identified a coordinated transcriptional network involving nuclear receptors NR4A1-3, the glucocorticoid receptor (GR), and RFX family members (RFX1, RFX2, RFX5) that appears to shape HBC identity, particularly through pathways linked to lipid metabolism and angiogenesis. Although exploratory in nature, in vitro stimulation studies showed that HBCs exhibited increased transcriptional activity in response to combined IL-4 and RSG treatment, including induction of the lipid transporter CD36. Mass cytometry analysis revealed surface markers indicative of both immature and mature macrophage states. Together, these results indicated that HBCs represent a distinct and diverse macrophage population with specialized and adaptable regulatory program in the human placenta.}, keywords = {MACROPHAGES; immunology; reproductive biology}, year = {2025}, eissn = {2379-3708}, orcid-numbers = {Bojcsuk, Dóra/0000-0001-5091-7237; Szebeni, Gábor/0000-0002-6998-5632; Nagy, Gergely/0000-0002-3273-731X} } @article{MTMT:35054510, title = {Therapeutic effect of BGP-15 in the treatment of imatinib-induced cardiotoxicity in a rat model}, url = {https://m2.mtmt.hu/api/publication/35054510}, author = {Szabó, Renáta and Nagy, András Levente and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória Mónika and Toldi, Éva and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Neuperger, Patricia and Szebeni, Gábor and Varga, Csaba}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {54. évfolyam (1-2)}, unique-id = {35054510}, issn = {0133-5596}, year = {2024}, eissn = {1588-0230}, pages = {263}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Szebeni, Gábor/0000-0002-6998-5632; Varga, Csaba/0000-0002-2678-665X} } @CONFERENCE{MTMT:35054634, title = {A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében}, url = {https://m2.mtmt.hu/api/publication/35054634}, author = {Nagy, András Levente and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória Mónika and Toldi, Éva and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Neuperger, Patricia and Szebeni, Gábor and Varga, Csaba and Szabó, Renáta}, booktitle = {XXVII. Tavaszi Szél Konferencia 2024 - Absztrakt kötet}, unique-id = {35054634}, year = {2024}, pages = {651}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Szebeni, Gábor/0000-0002-6998-5632; Varga, Csaba/0000-0002-2678-665X} } @CONFERENCE{MTMT:35054657, title = {A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében}, url = {https://m2.mtmt.hu/api/publication/35054657}, author = {Nagy, András Levente and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória Mónika and Toldi, Éva and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Neuperger, Patricia and Szebeni, Gábor and Varga, Csaba and Szabó, Renáta}, booktitle = {24. Kolozsvári Biológus Napok}, unique-id = {35054657}, year = {2024}, pages = {48}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Szebeni, Gábor/0000-0002-6998-5632; Varga, Csaba/0000-0002-2678-665X} } @article{MTMT:35133023, title = {Characterization of obesity-related diseases and inflammation using single cell immunophenotyping in two different diet-induced obesity models}, url = {https://m2.mtmt.hu/api/publication/35133023}, author = {Ruppert, Zsófia and Neuperger, Patricia and Rákóczi, Bettina and Gémes, Nikolett and Dukay, Brigitta and Hajdu, Petra and Péter, Mária and Balogh, Gábor and Tiszlavicz, László and Vigh, László and Török, Zsolt and Puskás, László and Szebeni, Gábor and Tóth, Erzsébet Melinda}, doi = {10.1038/s41366-024-01584-6}, journal-iso = {INT J OBES (LOND)}, journal = {INTERNATIONAL JOURNAL OF OBESITY}, volume = {48}, unique-id = {35133023}, issn = {0307-0565}, abstract = {Obesity is a growing problem worldwide and a major risk factor for many chronic diseases. The accumulation of adipose tissue leads to the release of significant amounts of pro-inflammatory cytokines and adipokines, resulting in a low-grade systemic inflammation. However, the mechanisms behind the development of obesity-related diseases are not fully understood. Therefore, our study aimed to investigate the pathological changes and inflammatory processes at systemic level and in individual organs in two different diet-induced mouse obesity models.}, year = {2024}, eissn = {1476-5497}, pages = {1568-1576}, orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587; Szebeni, Gábor/0000-0002-6998-5632} } @mastersthesis{MTMT:35797684, title = {Inter- és intratumor heterogenitás egysejt szintű elemzése, valamint a TMEM45A fehérje vizsgálata humán nem-kissejtes tüdő adenokarcinómában}, url = {https://m2.mtmt.hu/api/publication/35797684}, author = {Neuperger, Patricia}, doi = {10.14232/phd.12214}, publisher = {Universití of Szeged}, unique-id = {35797684}, year = {2024} }