TY - JOUR AU - Jávor, Péter János AU - Hanák, Lilla AU - Hegyi, Péter AU - Csonka, Endre AU - Butt, Edina AU - Horváth, Tamara AU - Góg, István AU - Lukács, Anita AU - Soós, Alexandra AU - Rumbus, Zoltán AU - Pákai, Eszter AU - Toldi, János AU - Hartmann, Petra TI - Predictive value of tachycardia for mortality in trauma-related haemorrhagic shock: a systematic review and meta-regression JF - BMJ OPEN J2 - BMJ OPEN VL - 12 PY - 2022 IS - 10 PG - 8 SN - 2044-6055 DO - 10.1136/bmjopen-2021-059271 UR - https://m2.mtmt.hu/api/publication/33192543 ID - 33192543 AB - Objectives Heart rate (HR) is one of the physiological variables in the early assessment of trauma-related haemorrhagic shock, according to Advanced Trauma Life Support (ATLS). However, its efficiency as predictor of mortality is contradicted by several studies. Furthermore, the linear association between HR and the severity of shock and blood loss presented by ATLS is doubtful. This systematic review aims to update current knowledge on the role of HR in the initial haemodynamic assessment of patients who had a trauma. Design This study is a systematic review and meta-regression that follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Data sources EMBASE, MEDLINE, CENTRAL and Web of Science databases were systematically searched through on 1 September 2020. Eligibility criteria Papers providing early HR and mortality data on bleeding patients who had a trauma were included. Patient cohorts were considered haemorrhagic if the inclusion criteria of the studies contained transfusion and/or positive focused assessment with sonography for trauma and/or postinjury haemodynamical instability and/or abdominal gunshot injury. Studies on burns, traumatic spinal or brain injuries were excluded. Papers published before January 2010 were not considered. Data extraction and synthesis Data extraction and risk of bias were assessed by two independent investigators. The association between HR and mortality of patients who had a trauma was assessed using meta-regression analysis. As subgroup analysis, meta-regression was performed on patients who received blood products. Results From a total of 2017 papers, 19 studies met our eligibility criteria. Our primary meta-regression did not find a significant relation (p=0.847) between HR and mortality in patients who had a trauma with haemorrhage. Our subgroup analysis included 10 studies, and it could not reveal a linear association between HR and mortality rate. Conclusions In accordance with the literature demonstrating the multiphasic response of HR to bleeding, our study presents the lack of linear association between postinjury HR and mortality. Modifying the pattern of HR derangements in the ATLS shock classification may result in a more precise teaching tool for young clinicians. LA - English DB - MTMT ER - TY - JOUR AU - Janka, Eszter Anna AU - Várvölgyi, Tünde AU - Sipos, Zoltán AU - Soós, Alexandra AU - Hegyi, Péter AU - Kiss, Szabolcs AU - Dembrovszky, Fanni AU - Csupor, Dezső AU - Kéringer, Patrik AU - Pécsi, Dániel AU - Varjú-Solymár, Margit AU - Emri, Gabriella TI - Predictive Performance of Serum S100B Versus LDH in Melanoma Patients: a Systematic Review and Meta-Analysis JF - FRONTIERS IN ONCOLOGY J2 - FRONT ONCOL VL - 11 PY - 2021 PG - 11 SN - 2234-943X DO - 10.3389/fonc.2021.772165 UR - https://m2.mtmt.hu/api/publication/32602475 ID - 32602475 AB - Currently, no consensus on the use of blood tests for monitoring disease recurrence in patients with resected melanoma exists. The only meta-analysis conducted in 2008 found that elevated serum S100B levels were associated with significantly worse survival in melanoma patients. Serum LDH is an established prognostic factor in patients with advanced melanoma.To compare the discriminative and prognostic ability of serum S100B with that of serum LDH in patients with melanoma.This systematic review and meta-analysis were reported in accordance with the PRISMA Statement. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42019137138).A quantitative analysis of data from 6 eligible studies included 1,033 patients with cutaneous melanoma. The discriminative ability of serum S100B at identifying disease relapse [pooled Area Under the ROC (AUROC) 78.64 (95% CI 70.28; 87.01)] was significantly greater than the discriminative ability of serum LDH [AUROC 64.41 (95% CI 56.05; 7278)] (p=0.013). Ten eligible studies with 1,987 patients were included in the risk of death analysis. The prognostic performance of serum S100B [pooled estimate of adjusted hazard ratio (HR) 1.78 (95% CI 1.38; 2.29)] was independent but not superior to that of serum LDH [HR 1.60 (95% CI 1.36; 2.29)].A relatively small number of articles were eligible and there was considerable heterogeneity across the included studies.Serum biomarkers may provide relevant information on melanoma patient status and should be further researched. Serum S100B is a valid marker for diagnosis of melanoma recurrence.The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42019137138). LA - English DB - MTMT ER - TY - JOUR AU - Pázmány, Piroska AU - Soós, Alexandra AU - Hegyi, Péter AU - Dohos, Dóra AU - Kiss, Szabolcs AU - Szakács, Zsolt AU - Párniczky, Andrea AU - Garami, András AU - Péterfi, Zoltán AU - Molnár, Zsolt TI - Inflammatory Biomarkers Are Inaccurate Indicators of Bacterial Infection on Admission in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease—A Systematic Review and Diagnostic Accuracy Network Meta-Analysis JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 8 PY - 2021 PG - 13 SN - 2296-858X DO - 10.3389/fmed.2021.639794 UR - https://m2.mtmt.hu/api/publication/32501761 ID - 32501761 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Szabolcs AU - Gede, Noémi AU - Soós, Alexandra AU - Hegyi, Péter AU - Nagy, Bettina AU - Imrei, Marcell AU - Czibere, Bernadett AU - Borbásné Farkas, Kornélia AU - Hanák, Lilla AU - Szakács, Zsolt AU - Erőss, Bálint Mihály AU - Alizadeh, Hussain TI - Efficacy of first-line treatment options in transplant-ineligible multiple myeloma : A network meta-analysis JF - CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY J2 - CRIT REV ONCOL HEMAT VL - 168 PY - 2021 PG - 11 SN - 1040-8428 DO - 10.1016/j.critrevonc.2021.103504 UR - https://m2.mtmt.hu/api/publication/32468150 ID - 32468150 AB - Despite major therapeutic advances, the rational choice of the most appropriate first-line regimen in newly diagnosed transplant-ineligible multiple myeloma (TIE-MM) is currently undefined.We aimed to identify the most effective first-line treatment for TIE-MM patients.A total of 37 articles, including 34 treatments and 16,681 patients, were included in this Bayesian network meta-analysis. The outcomes of interest were risk ratios (RR) for progression-free survival (PFS) and overall survival (OS).Based on surface under cumulative ranking curve values, daratumumab-bortezomib-melphalan-prednisone (Dara-VMP) and daratumumab-lenalidomide-dexamethasone (Dara-Rd28) showed superiority compared to other combinations regarding 12-, 24-, 36-, and 48-month PFS. Dara-VMP also ranked first for 12-, 24-, 36-, and 48-month OS.Our finding supports the incorporation of daratumumab into first-line regimens. Additionally, these results highlight the relative benefit of incorporating novel agents like monoclonal antibodies, immunomodulatory derivatives, and proteasome inhibitors in combination with the currently existing treatment options. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Noémi AU - Soós, Alexandra AU - Váradi, Alex AU - Hegyi, Péter AU - Tinusz, Benedek AU - Vágvölgyi, Anna AU - Orosz, Andrea AU - Varjú-Solymár, Margit AU - Polyák, Alexandra Júlia AU - Varró, András AU - Farkas, Attila AU - Nagy, Norbert TI - Effect of ivabradine in heart failure : a meta-analysis of heart failure patients with reduced versus preserved ejection fraction JF - CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY J2 - CAN J PHYSIOL PHARM VL - 99 PY - 2021 IS - 11 SP - 1159 EP - 1174 PG - 16 SN - 0008-4212 DO - 10.1139/cjpp-2020-0700 UR - https://m2.mtmt.hu/api/publication/32396717 ID - 32396717 AB - In clinical trials of heart failure reduced ejection fraction (HFrEF), ivabradine seemed to be an effective heart rate lowering agent associated with lower risk of cardiovascular death. In contrast, ivabradine failed to improve cardiovascular outcomes in heart failure preserved ejection fraction (HFpEF) despite the significant effect on heart rate. This meta-analysis is the first to compare the effects of ivabradine on heart rate and mortality parameters in HFpEF versus HFrEF. We screened three databases: PubMed, Embase, and Cochrane Library. The outcomes of these studies were mortality, reduction in heart rate, and left ventricular function improvement. We compared the efficacy of ivabradine treatment in HFpEF versus HFrEF. Heart rate analysis of pooled data showed decrease in both HFrEF (-17.646 beats/min) and HFpEF (-11.434 beats/min), and a tendency to have stronger bradycardic effect in HFrEF (p = 0.094) in randomized clinical trials. Left ventricular ejection fraction analysis revealed significant improvement in HFrEF (5.936, 95% CI: [4.199-7.672], p < 0.001) when compared with placebo (p < 0.001). We found that ivabradine significantly improves left ventricular performance in HFrEF, at the same time it exerts a tendency to have improved bradycardic effect in HFrEF. These disparate effects of ivabradine and the higher prevalence of non-cardiac comorbidities in HFpEF may explain the observed beneficial effects in HFrEF and the unchanged outcomes in HFpEF patients after ivabradine treatment. LA - English DB - MTMT ER - TY - JOUR AU - Martonosi, Ágnes Rita AU - Soós, Alexandra AU - Rumbus, Zoltán AU - Hegyi, Péter AU - Izsák, Vera Dóra AU - Pázmány, Piroska AU - Imrei, Marcell AU - Váncsa, Szilárd AU - Szakács, Zsolt AU - Párniczky, Andrea TI - Non-invasive Diagnostic Tests in Cystic Fibrosis-Related Liver Disease : A Diagnostic Test Accuracy Network Meta-Analysis JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 8 PY - 2021 PG - 11 SN - 2296-858X DO - 10.3389/fmed.2021.598382 UR - https://m2.mtmt.hu/api/publication/32145922 ID - 32145922 AB - Background and Aims: Cystic fibrosis-related liver disease (CFLD) is one of the leading causes of morbidity and mortality in cystic fibrosis (CF). Several non-invasive diagnostic methods have been proposed as screening tools for CFLD. Our aim was to rank all available non-invasive modalities for diagnostic performance. Methods: A systematic search was performed in five medical databases to find studies which reported on any single or composite non-invasive diagnostic test (as an index test) compared to the Debray, the EuroCare or the Colombo criteria (as a reference standard). Ranking was carried out with a Bayesian diagnostic test accuracy network meta-analysis based on superiority indices, calculated for pooled sensitivity (Se) and specificity (Sp) with a 95% confidence interval (CI). The study was registered under CRD42020155846 in PROSPERO. Results: Fifteen studies with 15 index tests and a combination of them were included. The New criteria proposed by Koh et al. - which represent a composite diagnostic definition for CFLD including liver biochemistry, ultrasonography, transient elastography and fibrosis markers-had the best performance for detecting CFLD (Se:94%[CI:58-100], Sp:72%[CI:52-84]); while transient elastography (Se:65%[CI:56-74], Sp:88%[CI:84-91]) and a combination of it with a tissue inhibitor of metalloproteinase-4 measurement (Se:78%[CI:30-100], Sp:64%[CI:18-95%]) proved to be the second and third best options, respectively. In the imaging techniques subgroup, transient elastography (Se:66%[CI:57-72], Sp:88%[CI:85-91%]), acoustic radiation force impulse in the right lobe (Se:54%[CI:33-74], Sp:88%[CI:66-96]) and that in the left lobe (Se:55%[CI:23-81], Sp:82%[CI:50-95]) were ranked the highest. Comparing biochemical markers/fibrosis indices, the measurement of the Forns index (Se:72%[CI:25-99], Sp:63%[CI:16-94]), the aspartate aminotransferase-to-platelet ratio (Se:55%[CI:41-68], Sp:83%[CI:66-89]) and alkaline phosphatase (Se:63%[CI:18-93], Sp:64%[CI:19-95]) were ranked the highest. Conclusion: The New criteria show the best diagnostic performance. In clinical practice, transient elastography seems to be a simple, cheap and non-invasive tool, outperforming imaging, biochemical and fibrosis tests for detecting CFLD. Further studies are needed to validate our findings. LA - English DB - MTMT ER - TY - CHAP AU - Gergő, Berke AU - Sebastian, Beer AU - Soós, Alexandra AU - Amanda, Takáts AU - Szentesi, Andrea Ildikó AU - Jonas, Rosendahl AU - Hegyi, Péter AU - Németh, Balázs AU - Hegyi, Eszter ED - Csiszár, Beáta ED - Hankó, Csilla ED - Kajos, Luca Fanni ED - Mező, Emerencia TI - Investigation of a common chymotrypsin C (CTRC) polymorphism in chronic pancreatitis T2 - Medical Conference for PhD Students and Experts of Clinical Sciences 2021 PB - University of Pécs, Doctoral Student Association CY - Pécs SN - 9789634296539 PY - 2021 SP - 52 EP - 52 PG - 1 UR - https://m2.mtmt.hu/api/publication/32130229 ID - 32130229 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Dóra Krisztina AU - Borbásné Farkas, Kornélia AU - Soós, Alexandra AU - Hegyi, Péter AU - Kelava, Leonardo AU - Eitmann, Szimonetta AU - Schekk, Anna AU - Molnár, Zsolt AU - Erőss, Bálint Mihály AU - Balaskó, Márta TI - Assessment of clinical data on urocortins and their therapeutic potential in cardiovascular diseases: A systematic review and meta‐analysis JF - CTS-CLINICAL AND TRANSLATIONAL SCIENCE J2 - CTS-CLIN TRANSL SCI VL - 14 PY - 2021 IS - 6 SP - 2461 EP - 2473 PG - 13 SN - 1752-8054 DO - 10.1111/cts.13114 UR - https://m2.mtmt.hu/api/publication/32129643 ID - 32129643 N1 - Funding Agency and Grant Number: Economic Development and Innovation Operational Programme [GINOP-2.3.2-15-2016-00048 -STAY ALIVE, GINOP-2.3.4-15-2020-00010] Funding text: This study was supported by Economic Development and Innovation Operational Programme Grants (GINOP--2.3.2--15-2016--00048 --STAY ALIVE and GINOP-2.3.4--15--2020--00010 Competence Center for Health Data Analysis, Data Utilisation and Smart Device and Technology Development at the University of Pecs). LA - English DB - MTMT ER - TY - JOUR AU - Varga, Eszter AU - Hajnal, András Sándor AU - Soós, Alexandra AU - Hegyi, Péter AU - Kovács, Dóra Krisztina AU - Borbásné Farkas, Kornélia AU - Szebényi, Júlia Liza AU - Mikó, Alexandra AU - Tényi, Tamás AU - Herold, Róbert TI - Minor physical anomalies in bipolar disorder - a meta-analysis JF - FRONTIERS IN PSYCHIATRY J2 - FRONT PSYCHIATRY VL - 12 PY - 2021 PG - 10 SN - 1664-0640 DO - 10.3389/fpsyt.2021.598734 UR - https://m2.mtmt.hu/api/publication/32071535 ID - 32071535 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Izsák, Vera Dóra AU - Soós, Alexandra AU - Szakács, Zsolt AU - Hegyi, Péter AU - Juhász, Márk Félix AU - Varannai, Orsolya AU - Martonosi, Ágnes Rita AU - Földi, Mária AU - Kozma, Alexandra AU - Vajda, Zsolt AU - Shaw, James Am AU - Párniczky, Andrea TI - Screening Methods for Diagnosing Cystic Fibrosis-Related Diabetes : A Network Meta-Analysis of Diagnostic Accuracy Studies JF - BIOMOLECULES J2 - BIOMOLECULES VL - 11 PY - 2021 IS - 4 PG - 15 SN - 2218-273X DO - 10.3390/biom11040520 UR - https://m2.mtmt.hu/api/publication/31953672 ID - 31953672 AB - Cystic fibrosis-related diabetes (CFRD) has become more common due to higher life expectancy with cystic fibrosis. Early recognition and prompt treatment of CFRD leads to improved outcomes.We performed a network meta-analysis (NMA) in order to identify the most valuable diagnostic metrics for diagnosing CFRD out of available screening tools (index test), using the oral glucose tolerance test as a reference standard. Pooled sensitivity (Se), specificity (Sp), and superiority indices were calculated and used to rank the index tests.A total of 31 articles with 25 index tests were eligible for inclusion. Two-day, continuous glucose monitoring (CGM) ranked the highest (Se: 86% Sp: 76%), followed by glucose measurement from blood capillary samples (Se: 70%, Sp: 82%) and three-day CGM (Se: 96%, Sp: 56%). When we compared the CGM of different durations, two-day CGM performed best (Se: 88%, Sp: 80%), followed by three-day (Se: 96%, Sp: 59%) and six-day CGM (Se: 66%, Sp: 79%).Considering its overall performance ranking, as well as the high sensitivity, two-day CGM appears to be a promising screening test for CFRD. LA - English DB - MTMT ER -