@article{MTMT:33192543,
	title = {Predictive value of tachycardia for mortality in trauma-related haemorrhagic shock: a systematic review and meta-regression},
	url = {https://m2.mtmt.hu/api/publication/33192543},
	author = {Jávor, Péter János and Hanák, Lilla and Hegyi, Péter and Csonka, Endre and Butt, Edina and Horváth, Tamara and Góg, István and Lukács, Anita and Soós, Alexandra and Rumbus, Zoltán and Pákai, Eszter and Toldi, János and Hartmann, Petra},
	doi = {10.1136/bmjopen-2021-059271},
	journal-iso = {BMJ OPEN},
	journal = {BMJ OPEN},
	volume = {12},
	unique-id = {33192543},
	issn = {2044-6055},
	abstract = {Objectives
		Heart rate (HR) is one of the physiological variables in the early assessment of trauma-related haemorrhagic shock, according to Advanced Trauma Life Support (ATLS). However, its efficiency as predictor of mortality is contradicted by several studies. Furthermore, the linear association between HR and the severity of shock and blood loss presented by ATLS is doubtful. This systematic review aims to update current knowledge on the role of HR in the initial haemodynamic assessment of patients who had a trauma.
		
		Design
		This study is a systematic review and meta-regression that follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations.
		
		Data
		sources EMBASE, MEDLINE, CENTRAL and Web of Science databases were systematically searched through on 1 September 2020.
		
		Eligibility
		criteria Papers providing early HR and mortality data on bleeding patients who had a trauma were included. Patient cohorts were considered haemorrhagic if the inclusion criteria of the studies contained transfusion and/or positive focused assessment with sonography for trauma and/or postinjury haemodynamical instability and/or abdominal gunshot injury. Studies on burns, traumatic spinal or brain injuries were excluded. Papers published before January 2010 were not considered.
		
		Data
		extraction and synthesis Data extraction and risk of bias were assessed by two independent investigators. The association between HR and mortality of patients who had a trauma was assessed using meta-regression analysis. As subgroup analysis, meta-regression was performed on patients who received blood products.
		
		Results
		From a total of 2017 papers, 19 studies met our eligibility criteria. Our primary meta-regression did not find a significant relation (p=0.847) between HR and mortality in patients who had a trauma with haemorrhage. Our subgroup analysis included 10 studies, and it could not reveal a linear association between HR and mortality rate.
		
		Conclusions
		In accordance with the literature demonstrating the multiphasic response of HR to bleeding, our study presents the lack of linear association between postinjury HR and mortality. Modifying the pattern of HR derangements in the ATLS shock classification may result in a more precise teaching tool for young clinicians.},
	year = {2022},
	eissn = {2044-6055},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Horváth, Tamara/0000-0003-4437-9924; Lukács, Anita/0000-0002-0746-8920; Hartmann, Petra/0000-0002-4746-9792}
}

@article{MTMT:32602475,
	title = {Predictive Performance of Serum S100B Versus LDH in Melanoma Patients: a Systematic Review and Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/32602475},
	author = {Janka, Eszter Anna and Várvölgyi, Tünde and Sipos, Zoltán and Soós, Alexandra and Hegyi, Péter and Kiss, Szabolcs and Dembrovszky, Fanni and Csupor, Dezső and Kéringer, Patrik and Pécsi, Dániel and Varjú-Solymár, Margit and Emri, Gabriella},
	doi = {10.3389/fonc.2021.772165},
	journal-iso = {FRONT ONCOL},
	journal = {FRONTIERS IN ONCOLOGY},
	volume = {11},
	unique-id = {32602475},
	issn = {2234-943X},
	abstract = {Currently, no consensus on the use of blood tests for monitoring disease recurrence in patients with resected melanoma exists. The only meta-analysis conducted in 2008 found that elevated serum S100B levels were associated with significantly worse survival in melanoma patients. Serum LDH is an established prognostic factor in patients with advanced melanoma.To compare the discriminative and prognostic ability of serum S100B with that of serum LDH in patients with melanoma.This systematic review and meta-analysis were reported in accordance with the PRISMA Statement. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42019137138).A quantitative analysis of data from 6 eligible studies included 1,033 patients with cutaneous melanoma. The discriminative ability of serum S100B at identifying disease relapse [pooled Area Under the ROC (AUROC) 78.64 (95% CI 70.28; 87.01)] was significantly greater than the discriminative ability of serum LDH [AUROC 64.41 (95% CI 56.05; 7278)] (p=0.013). Ten eligible studies with 1,987 patients were included in the risk of death analysis. The prognostic performance of serum S100B [pooled estimate of adjusted hazard ratio (HR) 1.78 (95% CI 1.38; 2.29)] was independent but not superior to that of serum LDH [HR 1.60 (95% CI 1.36; 2.29)].A relatively small number of articles were eligible and there was considerable heterogeneity across the included studies.Serum biomarkers may provide relevant information on melanoma patient status and should be further researched. Serum S100B is a valid marker for diagnosis of melanoma recurrence.The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42019137138).},
	keywords = {Meta-analysis; S100B; Melanoma; COX; ROC; LDH},
	year = {2021},
	eissn = {2234-943X},
	orcid-numbers = {Janka, Eszter Anna/0000-0003-0724-5281; Sipos, Zoltán/0000-0001-7845-8116; Hegyi, Péter/0000-0003-0399-7259; Dembrovszky, Fanni/0000-0001-6953-3591; Csupor, Dezső/0000-0002-4088-3333; Pécsi, Dániel/0000-0003-0499-6004; Varjú-Solymár, Margit/0000-0001-6667-6263}
}

@article{MTMT:32501761,
	title = {Inflammatory Biomarkers Are Inaccurate Indicators of Bacterial Infection on Admission in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease—A Systematic Review and Diagnostic Accuracy Network Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/32501761},
	author = {Pázmány, Piroska and Soós, Alexandra and Hegyi, Péter and Dohos, Dóra and Kiss, Szabolcs and Szakács, Zsolt and Párniczky, Andrea and Garami, András and Péterfi, Zoltán and Molnár, Zsolt},
	doi = {10.3389/fmed.2021.639794},
	journal-iso = {FRONT MED},
	journal = {FRONTIERS IN MEDICINE},
	volume = {8},
	unique-id = {32501761},
	year = {2021},
	eissn = {2296-858X},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Szakács, Zsolt/0000-0002-7035-941X; Garami, András/0000-0003-2493-0571; Péterfi, Zoltán/0000-0001-9658-153X}
}

@article{MTMT:32468150,
	title = {Efficacy of first-line treatment options in transplant-ineligible multiple myeloma : A network meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/32468150},
	author = {Kiss, Szabolcs and Gede, Noémi and Soós, Alexandra and Hegyi, Péter and Nagy, Bettina and Imrei, Marcell and Czibere, Bernadett and Borbásné Farkas, Kornélia and Hanák, Lilla and Szakács, Zsolt and Erőss, Bálint Mihály and Alizadeh, Hussain},
	doi = {10.1016/j.critrevonc.2021.103504},
	journal-iso = {CRIT REV ONCOL HEMAT},
	journal = {CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY},
	volume = {168},
	unique-id = {32468150},
	issn = {1040-8428},
	abstract = {Despite major therapeutic advances, the rational choice of the most appropriate first-line regimen in newly diagnosed transplant-ineligible multiple myeloma (TIE-MM) is currently undefined.We aimed to identify the most effective first-line treatment for TIE-MM patients.A total of 37 articles, including 34 treatments and 16,681 patients, were included in this Bayesian network meta-analysis. The outcomes of interest were risk ratios (RR) for progression-free survival (PFS) and overall survival (OS).Based on surface under cumulative ranking curve values, daratumumab-bortezomib-melphalan-prednisone (Dara-VMP) and daratumumab-lenalidomide-dexamethasone (Dara-Rd28) showed superiority compared to other combinations regarding 12-, 24-, 36-, and 48-month PFS. Dara-VMP also ranked first for 12-, 24-, 36-, and 48-month OS.Our finding supports the incorporation of daratumumab into first-line regimens. Additionally, these results highlight the relative benefit of incorporating novel agents like monoclonal antibodies, immunomodulatory derivatives, and proteasome inhibitors in combination with the currently existing treatment options.},
	keywords = {SURVIVAL; Meta-analysis; multiple myeloma; first-line; Transplant-ineligible},
	year = {2021},
	eissn = {1879-0461},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Imrei, Marcell/0000-0003-0175-7462; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Szakács, Zsolt/0000-0002-7035-941X; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:32396717,
	title = {Effect of ivabradine in heart failure : a meta-analysis of heart failure patients with reduced versus preserved ejection fraction},
	url = {https://m2.mtmt.hu/api/publication/32396717},
	author = {Tóth, Noémi and Soós, Alexandra and Váradi, Alex and Hegyi, Péter and Tinusz, Benedek and Vágvölgyi, Anna and Orosz, Andrea and Varjú-Solymár, Margit and Polyák, Alexandra Júlia and Varró, András and Farkas, Attila and Nagy, Norbert},
	doi = {10.1139/cjpp-2020-0700},
	journal-iso = {CAN J PHYSIOL PHARM},
	journal = {CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY},
	volume = {99},
	unique-id = {32396717},
	issn = {0008-4212},
	abstract = {In clinical trials of heart failure reduced ejection fraction (HFrEF), ivabradine seemed to be an effective heart rate lowering agent associated with lower risk of cardiovascular death. In contrast, ivabradine failed to improve cardiovascular outcomes in heart failure preserved ejection fraction (HFpEF) despite the significant effect on heart rate. This meta-analysis is the first to compare the effects of ivabradine on heart rate and mortality parameters in HFpEF versus HFrEF. We screened three databases: PubMed, Embase, and Cochrane Library. The outcomes of these studies were mortality, reduction in heart rate, and left ventricular function improvement. We compared the efficacy of ivabradine treatment in HFpEF versus HFrEF. Heart rate analysis of pooled data showed decrease in both HFrEF (-17.646 beats/min) and HFpEF (-11.434 beats/min), and a tendency to have stronger bradycardic effect in HFrEF (p = 0.094) in randomized clinical trials. Left ventricular ejection fraction analysis revealed significant improvement in HFrEF (5.936, 95% CI: [4.199-7.672], p < 0.001) when compared with placebo (p < 0.001). We found that ivabradine significantly improves left ventricular performance in HFrEF, at the same time it exerts a tendency to have improved bradycardic effect in HFrEF. These disparate effects of ivabradine and the higher prevalence of non-cardiac comorbidities in HFpEF may explain the observed beneficial effects in HFrEF and the unchanged outcomes in HFpEF patients after ivabradine treatment.},
	keywords = {Heart Rate; heart failure; Ivabradine; Left ventricular function; heart failure preserved ejection fraction; Heart failure reduced ejection fraction; Insuffisance cardiaque; fonction ventriculaire gauche; fréquence cardiaque; insuffisance cardiaque à fraction d’éjection préservée; insuffisance cardiaque à fraction d’éjection réduite},
	year = {2021},
	eissn = {1205-7541},
	pages = {1159-1174},
	orcid-numbers = {Váradi, Alex/0000-0001-8229-6340; Hegyi, Péter/0000-0003-0399-7259; Vágvölgyi, Anna/0000-0002-8810-700X; Varjú-Solymár, Margit/0000-0001-6667-6263; Varró, András/0000-0003-0745-3603}
}

@article{MTMT:32145922,
	title = {Non-invasive Diagnostic Tests in Cystic Fibrosis-Related Liver Disease : A Diagnostic Test Accuracy Network Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/32145922},
	author = {Martonosi, Ágnes Rita and Soós, Alexandra and Rumbus, Zoltán and Hegyi, Péter and Izsák, Vera Dóra and Pázmány, Piroska and Imrei, Marcell and Váncsa, Szilárd and Szakács, Zsolt and Párniczky, Andrea},
	doi = {10.3389/fmed.2021.598382},
	journal-iso = {FRONT MED},
	journal = {FRONTIERS IN MEDICINE},
	volume = {8},
	unique-id = {32145922},
	abstract = {Background and Aims: Cystic fibrosis-related liver disease (CFLD) is one of the leading causes of morbidity and mortality in cystic fibrosis (CF). Several non-invasive diagnostic methods have been proposed as screening tools for CFLD. Our aim was to rank all available non-invasive modalities for diagnostic performance. Methods: A systematic search was performed in five medical databases to find studies which reported on any single or composite non-invasive diagnostic test (as an index test) compared to the Debray, the EuroCare or the Colombo criteria (as a reference standard). Ranking was carried out with a Bayesian diagnostic test accuracy network meta-analysis based on superiority indices, calculated for pooled sensitivity (Se) and specificity (Sp) with a 95% confidence interval (CI). The study was registered under CRD42020155846 in PROSPERO. Results: Fifteen studies with 15 index tests and a combination of them were included. The New criteria proposed by Koh et al. - which represent a composite diagnostic definition for CFLD including liver biochemistry, ultrasonography, transient elastography and fibrosis markers-had the best performance for detecting CFLD (Se:94%[CI:58-100], Sp:72%[CI:52-84]); while transient elastography (Se:65%[CI:56-74], Sp:88%[CI:84-91]) and a combination of it with a tissue inhibitor of metalloproteinase-4 measurement (Se:78%[CI:30-100], Sp:64%[CI:18-95%]) proved to be the second and third best options, respectively. In the imaging techniques subgroup, transient elastography (Se:66%[CI:57-72], Sp:88%[CI:85-91%]), acoustic radiation force impulse in the right lobe (Se:54%[CI:33-74], Sp:88%[CI:66-96]) and that in the left lobe (Se:55%[CI:23-81], Sp:82%[CI:50-95]) were ranked the highest. Comparing biochemical markers/fibrosis indices, the measurement of the Forns index (Se:72%[CI:25-99], Sp:63%[CI:16-94]), the aspartate aminotransferase-to-platelet ratio (Se:55%[CI:41-68], Sp:83%[CI:66-89]) and alkaline phosphatase (Se:63%[CI:18-93], Sp:64%[CI:19-95]) were ranked the highest. Conclusion: The New criteria show the best diagnostic performance. In clinical practice, transient elastography seems to be a simple, cheap and non-invasive tool, outperforming imaging, biochemical and fibrosis tests for detecting CFLD. Further studies are needed to validate our findings.},
	keywords = {cystic fibrosis; network meta-analysis; Transient elastography; non-invasive diagnostic methods; cystic fibrosis-related liver disease},
	year = {2021},
	eissn = {2296-858X},
	orcid-numbers = {Martonosi, Ágnes Rita/0000-0001-6528-4671; Hegyi, Péter/0000-0003-0399-7259; Imrei, Marcell/0000-0003-0175-7462; Váncsa, Szilárd/0000-0002-9347-8163; Szakács, Zsolt/0000-0002-7035-941X}
}

@{MTMT:32130229,
	title = {Investigation of a common chymotrypsin C (CTRC) polymorphism in chronic pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/32130229},
	author = {Gergő, Berke and Sebastian, Beer and Soós, Alexandra and Amanda, Takáts and Szentesi, Andrea Ildikó and Jonas, Rosendahl and Hegyi, Péter and Németh, Balázs and Hegyi, Eszter},
	booktitle = {Medical Conference for PhD Students and Experts of Clinical Sciences 2021},
	unique-id = {32130229},
	year = {2021},
	pages = {52-52},
	orcid-numbers = {Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259; Németh, Balázs/0000-0001-5338-7577}
}

@article{MTMT:32129643,
	title = {Assessment of clinical data on urocortins and their therapeutic potential in cardiovascular diseases: A systematic review and meta‐analysis},
	url = {https://m2.mtmt.hu/api/publication/32129643},
	author = {Kovács, Dóra Krisztina and Borbásné Farkas, Kornélia and Soós, Alexandra and Hegyi, Péter and Kelava, Leonardo and Eitmann, Szimonetta and Schekk, Anna and Molnár, Zsolt and Erőss, Bálint Mihály and Balaskó, Márta},
	doi = {10.1111/cts.13114},
	journal-iso = {CTS-CLIN TRANSL SCI},
	journal = {CTS-CLINICAL AND TRANSLATIONAL SCIENCE},
	volume = {14},
	unique-id = {32129643},
	issn = {1752-8054},
	year = {2021},
	eissn = {1752-8062},
	pages = {2461-2473},
	orcid-numbers = {Kovács, Dóra Krisztina/0000-0001-5152-2069; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:32071535,
	title = {Minor physical anomalies in bipolar disorder - a meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/32071535},
	author = {Varga, Eszter and Hajnal, András Sándor and Soós, Alexandra and Hegyi, Péter and Kovács, Dóra Krisztina and Borbásné Farkas, Kornélia and Szebényi, Júlia Liza and Mikó, Alexandra and Tényi, Tamás and Herold, Róbert},
	doi = {10.3389/fpsyt.2021.598734},
	journal-iso = {FRONT PSYCHIATRY},
	journal = {FRONTIERS IN PSYCHIATRY},
	volume = {12},
	unique-id = {32071535},
	issn = {1664-0640},
	year = {2021},
	eissn = {1664-0640},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Kovács, Dóra Krisztina/0000-0001-5152-2069; Borbásné Farkas, Kornélia/0000-0002-5349-6527}
}

@article{MTMT:31953672,
	title = {Screening Methods for Diagnosing Cystic Fibrosis-Related Diabetes : A Network Meta-Analysis of Diagnostic Accuracy Studies},
	url = {https://m2.mtmt.hu/api/publication/31953672},
	author = {Izsák, Vera Dóra and Soós, Alexandra and Szakács, Zsolt and Hegyi, Péter and Juhász, Márk Félix and Varannai, Orsolya and Martonosi, Ágnes Rita and Földi, Mária and Kozma, Alexandra and Vajda, Zsolt and Shaw, James Am and Párniczky, Andrea},
	doi = {10.3390/biom11040520},
	journal-iso = {BIOMOLECULES},
	journal = {BIOMOLECULES},
	volume = {11},
	unique-id = {31953672},
	issn = {2218-273X},
	abstract = {Cystic fibrosis-related diabetes (CFRD) has become more common due to higher life expectancy with cystic fibrosis. Early recognition and prompt treatment of CFRD leads to improved outcomes.We performed a network meta-analysis (NMA) in order to identify the most valuable diagnostic metrics for diagnosing CFRD out of available screening tools (index test), using the oral glucose tolerance test as a reference standard. Pooled sensitivity (Se), specificity (Sp), and superiority indices were calculated and used to rank the index tests.A total of 31 articles with 25 index tests were eligible for inclusion. Two-day, continuous glucose monitoring (CGM) ranked the highest (Se: 86% Sp: 76%), followed by glucose measurement from blood capillary samples (Se: 70%, Sp: 82%) and three-day CGM (Se: 96%, Sp: 56%). When we compared the CGM of different durations, two-day CGM performed best (Se: 88%, Sp: 80%), followed by three-day (Se: 96%, Sp: 59%) and six-day CGM (Se: 66%, Sp: 79%).Considering its overall performance ranking, as well as the high sensitivity, two-day CGM appears to be a promising screening test for CFRD.},
	keywords = {cystic fibrosis; oral glucose tolerance test; Continuous glucose monitor; cystic fibrosis-related diabetes},
	year = {2021},
	eissn = {2218-273X},
	orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Hegyi, Péter/0000-0003-0399-7259; Martonosi, Ágnes Rita/0000-0001-6528-4671}
}