TY - JOUR AU - Bagoly, Zsuzsa AU - Hajas, Orsolya AU - Urbancsek, Réka AU - Kiss, Alexandra AU - Fiak, Edit AU - Sarkady, Ferenc AU - Tóth, Noémi Klára AU - Orbán-Kálmándi, Rita Angéla AU - Kovács, Kitti Bernadett AU - Nagy, László Tibor AU - Nagy, Attila Csaba AU - Kappelmayer, János AU - Csiba, László AU - Csanádi, Zoltán TI - Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 9 PY - 2020 IS - 9 PG - 13 SN - 2077-0383 DO - 10.3390/jcm9093050 UR - https://m2.mtmt.hu/api/publication/31610168 ID - 31610168 LA - English DB - MTMT ER - TY - JOUR AU - Hajas, Orsolya AU - Bagoly, Zsuzsa AU - Tóth, Noémi Klára AU - Urbancsek, Réka AU - Kiss, Alexandra AU - Kovács, Kitti Bernadett AU - Sarkady, Ferenc AU - Nagy, Attila Csaba AU - Vargáné Oláh, Anna AU - Nagy, László Tibor AU - Clemens, Marcell AU - Csiba, László AU - Csanádi, Zoltán TI - Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques JF - CARDIOLOGY RESEARCH AND PRACTICE J2 - CARDIOL RES PRAC VL - 2020 PY - 2020 PG - 8 SN - 2090-0597 DO - 10.1155/2020/1570483 UR - https://m2.mtmt.hu/api/publication/31143304 ID - 31143304 N1 - 281437 LA - English DB - MTMT ER - TY - JOUR AU - Kattula, Sravya AU - Bagoly, Zsuzsa AU - Tóth, Noémi Klára AU - Muszbek, László AU - Wolberg, Alisa S. TI - The factor XIII-A Val34Leu polymorphism decreases whole blood clot mass at high fibrinogen concentrations JF - JOURNAL OF THROMBOSIS AND HAEMOSTASIS J2 - J THROMB HAEMOST VL - 18 PY - 2020 IS - 4 SP - 885 EP - 894 PG - 10 SN - 1538-7933 DO - 10.1111/jth.14744 UR - https://m2.mtmt.hu/api/publication/31143253 ID - 31143253 LA - English DB - MTMT ER - TY - JOUR AU - Bagoly, Zsuzsa AU - Szegedi, István AU - Orbán-Kálmándi, Rita Angéla AU - Tóth, Noémi Klára AU - Csiba, László TI - Markers of Coagulation and Fibrinolysis Predicting the Outcome of Acute Ischemic Stroke Thrombolysis Treatment: A Review of the Literature JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 10 PY - 2019 PG - 13 SN - 1664-2295 DO - 10.3389/fneur.2019.00513 UR - https://m2.mtmt.hu/api/publication/30766995 ID - 30766995 AB - Intravenous administration of recombinant tissue plasminogen activator (rt-PA) has been proven to be safe and effective in the treatment of acute ischemic stroke. Little is known, however, why this treatment is less effective in some patients while in others life-threatening side-effects, e.g., symptomatic intracerebral hemorrhage might occur. Clinical failure of thrombolysis related to absent or partial recanalization or reocclusion as well as hemorrhagic complications of thrombolysis are possibly related to hemostatic events. Data on markers of coagulation and/or fibrinolysis in acute stroke patients are numerous and may provide indications regarding therapy outcomes. Better understanding of the hemostatic and fibrinolytic system during rt-PA therapy might be clinically useful and ultimately might lead to an improvement in the efficacy or safety of this treatment. Studies on thrombus composition retrieved from cerebral arteries may also advance our knowledge and provide a key to improve acute stroke therapy. Here we provide a comprehensive review on a wide range of factors and markers of coagulation and fibrinolysis that have been studied in the context of thrombolysis outcome in ischemic stroke patients. Moreover, a brief summary is given on the most recent research on thrombus composition having a potential influence on outcomes. LA - English DB - MTMT ER - TY - JOUR AU - Szekely, EG AU - Kovács, Katalin Réka AU - Bereczky, Zsuzsanna AU - Katona, Éva AU - Mezei, Zoltán András AU - Nagy, Attila Csaba AU - Tóth, Noémi Klára AU - Berényi, Ervin László AU - Muszbek, László AU - Csiba, László AU - Bagoly, Zsuzsa TI - Low factor XIII levels after intravenous thrombolysis predict short-term mortality in ischemic stroke patients JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 8 PY - 2018 IS - 1 PG - 9 SN - 2045-2322 DO - 10.1038/s41598-018-26025-z UR - https://m2.mtmt.hu/api/publication/3385993 ID - 3385993 N1 - Funding Agency and Grant Number: National Office for Research and Technology [PD111929, K109712, K113097]; Hungarian Academy of Sciences (MTA-DE Cerebrovascular and Neurodegenerative Research Group); New National Excellence Program of The Ministry of Human Capacities [UNKP-17-4-III-DE-381]; European Union; European Regional Development Fund; Hungarian Academy of Sciences; Lajos Szodoray Prize; [GINOP 2.3.2-15-2016-00048] Funding text: This work was supported by the National Office for Research and Technology (PD111929 and K109712, K113097), by the Hungarian Academy of Sciences (MTA-DE Cerebrovascular and Neurodegenerative Research Group), by the UNKP-17-4-III-DE-381 New National Excellence Program of The Ministry of Human Capacities and the GINOP 2.3.2-15-2016-00048 project, co-financed by the European Union and the European Regional Development Fund. Z. Bagoly is the recipient of Janos Bolyai fellowship of Hungarian Academy of Sciences and Lajos Szodoray Prize. The authors would like to thank Prof. Janos Kappelmayer for providing the opportunity of routine sample testing and all involved personnel of the University of Debrecen, Department of Laboratory Medicine for helpful technical assistance. AB - In this observational study we investigated whether levels of factor XIII (FXIII) and its major polymorphisms affect the outcome of thrombolysis by recombinant tissue plasminogen activator (rtPA) in acute ischemic stroke (AIS) patients. Study cohort included 132 consecutive AIS patients undergoing i.v. thrombolysis within 4.5 h of symptom onset. Blood samples taken on admission, immediately after and 24 h after therapy were analyzed for FXIII activity and antigen levels. FXIII-A p.Val34Leu, p.Tyr204Phe, FXIII-B p.His95Arg and intron K(IVS11 + 144) polymorphisms were genotyped. Neurological deficit was assessed using the National Institutes of Health Stroke Scale. Intracranial hemorrhage was classified according to ECASSII criteria. Long-term functional outcome was defined at 3 months post-event by the modified Rankin scale. FXIII levels showed a gradual decrease immediately after thrombolysis and 24 h later, which was not related to therapy-associated bleeding. In a multiple logistic regression model, a FXIII level in the lowest quartile 24 h post-lysis proved to be an independent predictor of mortality by 14 days post-event (OR:4.95, 95% CI:1.31-18.68, p < 0.05). No association was found between the investigated FXIII polymorphisms and therapeutic outcomes. In conclusion, our findings indicate that FXIII levels 24 h after thrombolysis might help to identify patients at increased risk for short-term mortality. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Noémi Klára AU - Székely , Edina Gabriella AU - Kovács, Katalin Réka AU - Sarkady, F AU - Nagy, Orsolya AU - Lánczi, LI AU - Berényi, E AU - Fekete, Klára AU - Fekete, István AU - Csiba, László AU - Bagoly, Zsuzsa TI - Elevated factor VIII and von Willebrand factor levels predict unfavorable outcome in stroke patients treated with intravenous thrombolysis JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 8 PY - 2018 PG - 10 SN - 1664-2295 DO - 10.3389/fneur.2017.00721 UR - https://m2.mtmt.hu/api/publication/3328941 ID - 3328941 N1 - 246576 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Noémi Klára AU - Csanádi, Zoltán AU - Hajas, Orsolya AU - Kiss, Alexandra AU - Nagy-Baló, Edina AU - Kovács, Kitti Bernadett AU - Sarkady, Ferenc AU - Muszbek, László AU - Bereczky, Zsuzsanna AU - Csiba, László AU - Bagoly, Zsuzsa TI - Intracardiac hemostasis and fibrinolysis parameters in patients with atrial fibrillation JF - BIOMED RESEARCH INTERNATIONAL J2 - BIOMED RES INT VL - 2017 PY - 2017 PG - 10 SN - 2314-6133 DO - 10.1155/2017/3678017 UR - https://m2.mtmt.hu/api/publication/3227929 ID - 3227929 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Noémi Klára AU - Bagoly, Zsuzsa AU - Csanádi, Zoltán AU - Kiss, Alexandra AU - Nagy-Baló, Edina AU - Kovacs, KB AU - Muszbek, László AU - Bereczky, Zsuzsanna AU - Csiba, L TI - Local parameters of hemostasis activation in the fibrillating atrium JF - JOURNAL OF THROMBOSIS AND HAEMOSTASIS J2 - J THROMB HAEMOST VL - 13 PY - 2015 IS - Suppl 2 SP - 785 EP - 785 PG - 1 SN - 1538-7933 DO - 10.1111/jth.12993 UR - https://m2.mtmt.hu/api/publication/2977994 ID - 2977994 LA - English DB - MTMT ER -