@article{MTMT:34535462, title = {Antimicrobial and antioxidant activity of encapsulated tea polyphenols in chitosan/alginate-coated zein nanoparticles: a possible supplement against fish pathogens in aquaculture}, url = {https://m2.mtmt.hu/api/publication/34535462}, author = {Fabrikov, Dmitri and Varga, Ágnes Timea and García, María Carmen Vargas and Bélteky, Péter and Kozma, Gábor and Kónya, Zoltán and López Martínez, Josefa L. and Barroso, Fernando and Sánchez-Muros, María José}, doi = {10.1007/s11356-024-32058-x}, journal-iso = {ENVIRON SCI POLLUT R}, journal = {ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH}, volume = {31}, unique-id = {34535462}, issn = {0944-1344}, abstract = {Regulation of antibiotic use in aquaculture calls for the emergence of more sustainable alternative treatments. Tea polyphenols (GTE), particularly epigallocatechin gallate (EGCG), have various biological activities. However, tea polyphenols are susceptible to degradation. In this work, EGCG and GTE were encapsulated in zein nanoparticles (ZNP) stabilized with alginate (ALG) and chitosan (CS) to reduce the degradation effect. ALG-coated ZNP and ALG/CS-coated ZNP encapsulating EGCG or GTE were obtained with a hydrodynamic size of less than 300 nm, an absolute ζ -potential value >30 mV, and an encapsulation efficiency greater than 75%. The antioxidant capacity of the encapsulated substances, although lower than that of the free ones, maintained high levels. On the other hand, the evaluation of antimicrobial activity showed greater efficiency in terms of growth inhibition for ALG/CS-ZNP formulations, with average overall values of around 60%, reaching an inhibition of more than 90% for Photobacterium damselae . These results support encapsulation as a good strategy for tea polyphenols, as it allows maintaining significant levels of antioxidant activity and increasing the potential for antimicrobial activity, in addition to increasing protection against sources of degradation.}, year = {2024}, eissn = {1614-7499}, pages = {13673-13687}, orcid-numbers = {Fabrikov, Dmitri/0000-0001-5048-4232; Kozma, Gábor/0000-0003-2033-0720; Kónya, Zoltán/0000-0002-9406-8596} } @article{MTMT:33917149, title = {Fabrication and characterization of a bifunctional zinc oxide/multiwalled carbon nanotube/ poly(3,4-ethylenedioxythiophene): polystyrene sulfonate composite thin film}, url = {https://m2.mtmt.hu/api/publication/33917149}, author = {Papp, Ibolya Zita and Szerlauth, Adél and Szűcs, Tímea and Bélteky, Péter and Perez, Juan Fernando Gomez and Kónya, Zoltán and Kukovecz, Ákos}, doi = {10.1016/j.tsf.2023.139908}, journal-iso = {THIN SOLID FILMS}, journal = {THIN SOLID FILMS}, volume = {778}, unique-id = {33917149}, issn = {0040-6090}, year = {2023}, eissn = {1879-2731}, orcid-numbers = {Papp, Ibolya Zita/0000-0001-9202-9035; Kónya, Zoltán/0000-0002-9406-8596; Kukovecz, Ákos/0000-0003-0716-9557} } @article{MTMT:33003489, title = {Functionalized Mesoporous Silica Nanoparticles for Drug-Delivery to Multidrug-Resistant Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/33003489}, author = {Igaz, Nóra and Bélteky, Péter and Kovács, Dávid and Papp, Csaba Gergő and Rónavári, Andrea and Szabó, Diána and Gácser, Attila and Kónya, Zoltán and Csontné Kiricsi, Mónika}, doi = {10.2147/IJN.S363952}, journal-iso = {INT J NANOMED}, journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE}, volume = {17}, unique-id = {33003489}, issn = {1176-9114}, abstract = {Background: Multidrug resistance is a common reason behind the failure of chemotherapy. Even if the therapy is effective, serious adverse effects might develop due to the low specificity and selectivity of antineoplastic agents. Mesoporous silica nanoparticles (MSNs) are promising materials for tumor-targeting and drug-delivery due to their small size, relatively inert nature, and extremely large specific surfaces that can be functionalized by therapeutic and targeting entities. We aimed to create a fluorescently labeled MSN-based drug-delivery system and investigate their internalization and drug-releasing capability in drug-sensitive MCF-7 and P-glycoprotein-overexpressing multidrug-resistant MCF-7 KCR cancer cells.Methods and Results: To track the uptake and subcellular distribution of MSNs, particles with covalently coupled red fluorescent Rhodamine B (RhoB) were produced (RhoB@MSNs). Both MCF-7 and MCF-7 KCR cells accumulated a significant amount of RhoB@MSNs. The intracellular RhoB@MSN concentrations did not differ between sensitive and multidrug-resistant cells and were kept at the same level even after cessation of RhoB@MSN exposure. Although most RhoB@MSNs resided in the cytoplasm, significantly more RhoB@MSNs co-localized with lysosomes in multidrug-resistant cells compared to sensitive counterparts. To examine the drug-delivery capability of these particles, RhoB@Rho123@MSNs were established, where RhoB-functionalized nanoparticles carried green fluorescent Rhodamine 123 (Rho123) -a P-glycoprotein substrate - as cargo within mesopores. Significantly higher Rho123 fluorescence intensity was detected in RhoB@Rho123@MSN-treated multidrug-resistant cells than in free Rho123-exposed counterparts. The exceptional drug-delivery potential of MSNs was further verified using Mitomycin C (MMC)-loaded RhoB@MSNs (RhoB@MMC@MSNs). Exposures to RhoB@MMC@MSNs significantly decreased the viability not only of drug-sensitive but of multidrug-resistant cells and the elimination of MDR cells was significantly more robust than upon free MMC treatments.Conclusion: The efficient delivery of Rho123 and MMC to multidrug-resistant cells via MSNs, the amplified and presumably prolonged intracellular drug concentration, and the consequently enhanced cytotoxic effects envision the enormous potential of MSNs to defeat multidrug-resistant cancer.}, year = {2022}, eissn = {1178-2013}, pages = {3079-3096}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Papp, Csaba Gergő/0000-0003-4450-0667; Rónavári, Andrea/0000-0001-7054-0975; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:32724347, title = {Design Principles and Insights into the Liquid-Phase Exfoliation of Alpha-MoO3 for the Production of Colloidal 2D Nano-inks in Green Solvents}, url = {https://m2.mtmt.hu/api/publication/32724347}, author = {Crisci, Matteo and Dolcet, Paolo and Yang, Jijin and Salerno, Marco and Bélteky, Péter and Kukovecz, Ákos and Lamberti, Francesco and Agnoli, Stefano and Osella, Silvio and Gross, Silvia and Gatti, Teresa}, doi = {10.1021/acs.jpcc.1c09221}, journal-iso = {J PHYS CHEM C}, journal = {JOURNAL OF PHYSICAL CHEMISTRY C}, volume = {126}, unique-id = {32724347}, issn = {1932-7447}, year = {2022}, eissn = {1932-7455}, pages = {404-415}, orcid-numbers = {Dolcet, Paolo/0000-0001-9583-9375; Kukovecz, Ákos/0000-0003-0716-9557; Lamberti, Francesco/0000-0003-1720-8038; Agnoli, Stefano/0000-0001-5204-5460; Osella, Silvio/0000-0001-8541-1914; Gross, Silvia/0000-0003-1860-8711; Gatti, Teresa/0000-0001-5343-8055} } @mastersthesis{MTMT:32861860, title = {Különböző méretű és felületi borítottságú ezüst nanorészecskék aggregációjának és toxicitásának kapcsolata bioreleváns körülmények között [Aggregation behavior of silver nanoparticles in varying sizes and surface capping under biorelevant conditions and its effect on nanoparticle toxicity]}, url = {https://m2.mtmt.hu/api/publication/32861860}, author = {Bélteky, Péter}, doi = {10.14232/phd.10974}, publisher = {SZTE}, unique-id = {32861860}, year = {2021} } @article{MTMT:32724422, title = {Large Cation Engineering in Two-Dimensional Silver–Bismuth Bromide Double Perovskites}, url = {https://m2.mtmt.hu/api/publication/32724422}, author = {Schmitz, Fabian and Horn, Jonas and Dengo, Nicola and Sedykh, Alexander E. and Becker, Jonathan and Maiworm, Elena and Bélteky, Péter and Kukovecz, Ákos and Gross, Silvia and Lamberti, Francesco and Müller-Buschbaum, Klaus and Schlettwein, Derck and Meggiolaro, Daniele and Righetto, Marcello and Gatti, Teresa}, doi = {10.1021/acs.chemmater.1c01182}, journal-iso = {CHEM MATER}, journal = {CHEMISTRY OF MATERIALS}, volume = {33}, unique-id = {32724422}, issn = {0897-4756}, year = {2021}, eissn = {1520-5002}, pages = {4688-4700}, orcid-numbers = {Sedykh, Alexander E./0000-0003-2650-5173; Kukovecz, Ákos/0000-0003-0716-9557; Gross, Silvia/0000-0003-1860-8711; Lamberti, Francesco/0000-0003-1720-8038; Gatti, Teresa/0000-0001-5343-8055} } @article{MTMT:32131688, title = {Polyvinyl-Pyrrolidone-Coated Silver Nanoparticles—The Colloidal, Chemical, and Biological Consequences of Steric Stabilization under Biorelevant Conditions}, url = {https://m2.mtmt.hu/api/publication/32131688}, author = {Rónavári, Andrea and Bélteky, Péter and Boka, Eszter and Zakupszky, Dalma and Igaz, Nóra and Szerencsés, Bettina and Pfeiffer, Ilona and Kónya, Zoltán and Csontné Kiricsi, Mónika}, doi = {10.3390/ijms22168673}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {32131688}, issn = {1661-6596}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Igaz, Nóra/0000-0003-1580-4397; Pfeiffer, Ilona/0000-0003-0680-7596; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:31982606, title = {Are Smaller Nanoparticles Always Better? Understanding the Biological Effect of Size-Dependent Silver Nanoparticle Aggregation Under Biorelevant Conditions}, url = {https://m2.mtmt.hu/api/publication/31982606}, author = {Bélteky, Péter and Rónavári, Andrea and Zakupszky, Dalma and Boka, Eszter and Igaz, Nóra and Szerencsés, Bettina and Pfeiffer, Ilona and Vágvölgyi, Csaba and Csontné Kiricsi, Mónika and Kónya, Zoltán}, doi = {10.2147/IJN.S304138}, journal-iso = {INT J NANOMED}, journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE}, volume = {16}, unique-id = {31982606}, issn = {1176-9114}, year = {2021}, eissn = {1178-2013}, pages = {3021-3040}, orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Igaz, Nóra/0000-0003-1580-4397; Pfeiffer, Ilona/0000-0003-0680-7596; Vágvölgyi, Csaba/0000-0003-0009-7773; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Kónya, Zoltán/0000-0002-9406-8596} } @article{MTMT:31611326, title = {Mechanochemical synthesis of the NiSn, CuSn bimetallic and NiCuSn trimetallic nanocomposites using various types of additives}, url = {https://m2.mtmt.hu/api/publication/31611326}, author = {Siposné Musza, Katalin and Szabados, Márton and Ádám, Anna Adél and Bélteky, Péter and Kónya, Zoltán and Kukovecz, Ákos and Sipos, Pál Miklós and Pálinkó, István}, doi = {10.1016/j.jssc.2020.121756}, journal-iso = {J SOLID STATE CHEM}, journal = {JOURNAL OF SOLID STATE CHEMISTRY}, volume = {293}, unique-id = {31611326}, issn = {0022-4596}, year = {2021}, eissn = {1095-726X}, orcid-numbers = {Szabados, Márton/0000-0002-7588-335X; Kónya, Zoltán/0000-0002-9406-8596; Kukovecz, Ákos/0000-0003-0716-9557; Sipos, Pál Miklós/0000-0003-1407-0950; Pálinkó, István/0000-0002-8508-309X} } @inproceedings{MTMT:31821559, title = {A felületi stabilizáció mechanizmusának szerepe az ezüst nanorészecskék aggregációs viselkedésére bioreleváns körülmények között}, url = {https://m2.mtmt.hu/api/publication/31821559}, author = {Bélteky, Péter and Zakupszky, Dalma and Boka, Eszter and Rónavári, Andrea and Kónya, Zoltán}, booktitle = {XLIII. Kémiai Előadói Napok - Előadás összefoglalók}, unique-id = {31821559}, year = {2020}, pages = {.}, orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Kónya, Zoltán/0000-0002-9406-8596} }