TY - JOUR AU - Gergics, Marin AU - Pham-Dobor, Gréta AU - Nemes, Orsolya AU - Bódis, Beáta AU - Mezősi, Emese AU - Bajnok, László Zoltán TI - AZ APELIN ÉS A KOPEPTIN SZEREPE HUMORÁLIS SZABÁLYOZÁSI ZAVAROKBAN JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 309 EP - 309 PG - 1 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34561215 ID - 34561215 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gergics, Marin AU - Pham-Dobor, Gréta AU - Kurdi, Csilla AU - Montskó, Gergely AU - Mihályi, Krisztina AU - Bánfai, Gábor László AU - Kanizsai, Péter László AU - Kőszegi, Tamás AU - Mezősi, Emese AU - Bajnok, László Zoltán TI - Apelin-13 as a Potential Biomarker in Critical Illness JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 12 PY - 2023 IS - 14 PG - 11 SN - 2077-0383 DO - 10.3390/jcm12144801 UR - https://m2.mtmt.hu/api/publication/34081443 ID - 34081443 N1 - ISSN:2077-0383 AB - The adrenocortical system and copeptin as prognostic markers were intensively investigated in critical illness. The potential predictive power of apelin-13 as a biomarker is largely unknown. We aimed to investigate the prognostic role of apelin-13 in relation to free cortisol, aldosterone, CRH, and copeptin in critically ill patients.In this prospective observational study, 124 critically ill patients (64 men, 60 women, median age: 70 (59-78) years) were consecutively enrolled at the time of admission. All routinely available clinical and laboratory parameters were evaluated and correlated to hormonal changes.Serum apelin-13 was 1161 (617-2967) pg/mL in non-survivors vs. 2477 (800-3531) pg/mL in survivors (p = 0.054). The concentrations of apelin-13 and CRH had strong positive correlations (r = 0.685, p < 0.001) and were significantly higher in surviving non-septic patients (Apelin-13 (pg/mL): 2286 (790-3330) vs. 818 (574-2732) p < 0.05; CRH (pg/mL) 201 (84-317) vs. 89 (74-233) p < 0.05). Apelin-13 and free cortisol were independent determinants of survival in the multivariate Cox regression analysis, while copeptin, CRH, or aldosterone were not.Beyond free cortisol, serum apelin-13 may also help refine prognostic predictions in the early phase of critical illness, especially in non-septic patients. LA - English DB - MTMT ER - TY - JOUR AU - Csenkey, Alexandra AU - Hargitai, Emma AU - Pákai, Eszter AU - Kajtár, Béla AU - Vida, Livia AU - Lőrincz, Aba Tamás AU - Gergics, Marin AU - Vajda, Péter AU - Józsa, Gergő AU - Garami, András TI - Effectiveness of four topical treatment methods in a rat model of superficial partial-thickness burn injury: the advantages of combining zinc-hyaluronan gel with silver foam dressing JF - INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED J2 - INJURY VL - 53 PY - 2022 IS - 12 SP - 3912 EP - 3919 PG - 8 SN - 0020-1383 DO - 10.1016/j.injury.2022.09.062 UR - https://m2.mtmt.hu/api/publication/33127953 ID - 33127953 AB - Background There are several options available for conservative treatment of partial-thickness burns, however, reliable, affordable, and easily obtainable animal testing models are hard to find for the comparison of the different treatment methods. We aimed at developing a preclinical testing model and at comparing four treatment methods for superficial partial-thickness burns. Methods Burn injury was induced in 90 adult male Wistar rats by placing the 130°C hot tip of a commercially obtainable soldering device for 30 s on the clipped skin of the interscapular region at a steady pressure. Skin histology was studied on days 5, 10, and 22 after the induction of the burn injury, on which days, respectively, the ratio of the not epithelialized wound (%), the extent of re-epithelialization (score), and the scar thickness (µm) were assessed. We compared 4 groups: silver-sulfadiazine cream, zinc-hyaluronan gel, silver foam dressing, and the combination of zinc-hyaluronan gel with a silver foam dressing. Results On day 5, the induction of superficial partial-thickness burn injury was confirmed histologically in the rats. The zinc-hyaluronan gel and the combination treatment resulted in a markedly smaller ratio of the non-epithelialized area (29 ± 10% and 28 ± 13%, respectively) than silver-sulfadiazine cream (69 ± 4%; p < 0.01). On day 10, the extent of re-epithelialization was the lowest (∼0.2) in the silver-sulfadiazine cream group, while the other 3 treatments performed significantly better. The combination treatment lead to the maximal score of 2 in all rats, which was higher than in the other 3 treatment groups. On day 22, the scar thickness was the smallest in the combination treatment group (560 ± 42 µm), which was significantly less than in the silver-sulfadiazine cream group (712 ± 38 µm; p < 0.05). Conclusions We designed and histologically confirmed a reproducible method for induction of superficial partial-thickness burns in rats for preclinical testing. In our model, the combination of zinc-hyaluronan gel with silver foam dressing was more effective than either of its components alone or than silver-sulfadiazine cream. LA - English DB - MTMT ER - TY - JOUR AU - Gergics, Marin AU - Pham-Dobor, Gréta AU - Horváth-Szalai, Zoltán AU - Kőszegi, Tamás AU - Mezősi, Emese AU - Bajnok, László Zoltán TI - Secondary hormonal alterations in short-term severe hypothyroidism; in the focus: Apelin and copeptin JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 13 PY - 2022 PG - 9 SN - 1664-2392 DO - 10.3389/fendo.2022.981891 UR - https://m2.mtmt.hu/api/publication/33126288 ID - 33126288 AB - This study aimed to investigate the complex interactions of thyroid hormone, apelin, and copeptin in the fluid-ion homeostasis of patients with severe transitory hypothyroidism.In this prospective observational study, 39 patients (ECOG: 0; 11 men, 28 women, mean age: 50.3 ± 14.9 years) were investigated during short-term severe hypothyroidism due to surgical removal of the thyroid gland and after adequate thyroid replacement therapy. In addition to the routinely available lab tests, copeptin and apelin levels were determined using ELISA.In the hypothyroid state, apelin concentration was lower, while copeptin levels did not differ compared to the euthyroid condition. Apelin showed a positive correlation with copeptin (p = 0.003), sodium (p = 0.002), NT-proBNP (p < 0.001), and fT4 (p < 0.001) and a negative correlation with thyroid-stimulating hormone (TSH) (p < 0.001). In multivariate linear regression models, copeptin and TSH proved to be significant independent predictors of apelin levels, of which TSH had an explanatory power of 48.7%. Aside from apelin, copeptin only correlated with sodium (p = 0.046). Sodium levels were negatively associated with TSH (p = 0.004) and positively with ACTH (p = 0.002) and cortisol (p = 0.047), in addition to copeptin. None of the parameters were independent predictors of serum sodium levels in a multivariate regression model.In short-term severe hypothyroidism, serum apelin level is markedly decreased, which may predispose susceptible patients to hyponatremia, while the level of copeptin is unchanged. TSH and copeptin are independent predictors of apelin concentration, of which TSH is stronger. LA - English DB - MTMT ER - TY - JOUR AU - Ezer, Péter AU - Gergics, Marin AU - Szokodi, István AU - Kónyi, Attila TI - Impact of remote monitoring in heart failure patients with cardiac implantable electronic devices during COVID-19 pandemic: a single center experience JF - JOURNAL OF CARDIOTHORACIC SURGERY J2 - J CARDIOTHORAC SURG VL - 17 PY - 2022 IS - 1 PG - 9 SN - 1749-8090 DO - 10.1186/s13019-022-01963-y UR - https://m2.mtmt.hu/api/publication/33071773 ID - 33071773 AB - Coronavirus disease 2019 (COVID-19) had spread into a pandemic affecting healthcare providers worldwide. Heart failure patients with implanted cardiac devices require close follow-up in-spite of pandemic related healthcare restrictions.Patients were retrospectively registered and clinical outcomes were compared of 61 remote monitored (RMG) versus 71 conventionally (in-office only) followed (CFG) cardiac device implanted, heart failure patients. Follow-up length was 12 months, during the COVID-19 pandemic related intermittent insitutional restrictions. We used a specified heart failure detection algorithm in RMG. This investigation compared worsening heart failure-, arrhythmia- and device related adverse events as primary outcome and heart failure hospitalization rates as secondary outcome in the two patient groups.No significant difference was observed in the primary composite end-point during the first 12 months of COVID-19 pandemic (p = 0.672). In RMG, patients who had worsening heart failure event had relative modest deterioration in heart failure functional class (p = 0.026), relative lower elevation of N terminal-pro BNP levels (p < 0.01) at in-office evaluation and were less hospitalized for worsening heart failure in the first 6 months of pandemic (p = 0.012) compared to CFG patients.Specified remote monitoring alert-based detection algorithm and workflow in device implanted heart failure patients may potentially indicate early worsening in heart failure status. Preemptive adequate intervention may prevent further progression of deteriorating heart failure and thus prevent heart failure hospitalizations. LA - English DB - MTMT ER - TY - JOUR AU - Bartalis, Eszter AU - Gergics, Marin AU - Tinusz, Benedek AU - Földi, Mária AU - Kiss, Szabolcs AU - Németh, Dávid AU - Varjú-Solymár, Margit AU - Szakács, Zsolt AU - Hegyi, Péter AU - Mezősi, Emese AU - Bajnok, László Zoltán TI - Prevalence and Prognostic Significance of Hyponatremia in Patients With Lung Cancer : Systematic Review and Meta-Analysis JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 8 PY - 2021 PG - 19 SN - 2296-858X DO - 10.3389/fmed.2021.671951 UR - https://m2.mtmt.hu/api/publication/32551691 ID - 32551691 AB - Background: The prevalence of hyponatremia is highly variable among patients with lung cancer. However, its prevalence and prognostic significance in subgroups of patients with lung cancer have not yet been evaluated in a meta-analysis. Methods: We have registered our meta-analysis and review protocol to the PROSPERO International Prospective Register of Systematic Reviews, with the following registration number: CRD42020167013. A systematic search was done in the following sources: MEDLINE, Embase, CENTRAL, Web of Science, ClinicalTrials.gov, a WHO Global Health Library. Results: We identified a total of 8,962 potentially eligible studies, and we included 31 articles in our evaluation. The prevalence of hyponatremia in patients with lung cancer varied between 3 and 94.8% with an average of 25% without any significant differences between the following subgroups: histotype, gender, age, Eastern Cooperative Oncology Group (ECOG) state, and the extent of disease. The overall survival (OS) was significantly lower in hyponatremic compared to normonatremic patients at 10 months [RR.59 (95% CI.47-0.74), p < 0.001] and at 20 months [RR.44 (95% CI.33-0.59), p < 0.001], with worse survival rates in non-small cell lung cancer (NSCLC) [RR.27 (95% CI.12-0.44), p < 0.001] than in small cell lung cancer (SCLC) [RR.42 (95% CI.27-0.57), p < 0.001]. If hyponatremia was corrected, OS at 10 months was significantly higher than in the uncorrected hyponatremia group [RR 1.83 (95% CI 1.37-2.44), p < 0.001], but, at 20 months, no statistically significant difference could be found between these subgroups [RR 2.65 (95% CI.94-7.50), p = 0.067]. Conclusions: Patients with lung cancer diagnosed with hyponatremia, especially patients with NSCLC, seem to have significantly lower survival rates than normonatremic patients. If hyponatremia remains uncorrected, the mortality rates might be even higher. LA - English DB - MTMT ER - TY - JOUR AU - Vizvári, Zoltán Ákos AU - Győrfi, Nina Rubina AU - Odry, Ákos AU - Sári, Zoltán AU - Klincsik, Mihály AU - Gergics, Marin AU - Kovács, Levente AU - Dolgosné Kovács, Anita AU - Pál, József AU - Karádi, Zoltán György AU - Odry, Péter AU - Tóth, Attila TI - Physical Validation of a Residual Impedance Rejection Method during Ultra-Low Frequency Bio-Impedance Spectral Measurements JF - SENSORS J2 - SENSORS-BASEL VL - 20 PY - 2020 IS - 17 PG - 20 SN - 1424-8220 DO - 10.3390/s20174686 UR - https://m2.mtmt.hu/api/publication/31410117 ID - 31410117 N1 - Journal Article; Validation Study Funding Agency and Grant Number: [EFOP-3.6.3-VEKOP-16-2017-00009]; [KA-2019-19]; [TUDFO/51757-1/2019-ITM] Funding text: The project has been supported by grants EFOP-3.6.3-VEKOP-16-2017-00009, KA-2019-19 and TUDFO/51757-1/2019-ITM. LA - English DB - MTMT ER - TY - JOUR AU - Pham-Dobor, Gréta AU - Hanák, Lilla AU - Hegyi, Péter AU - Márta, Katalin AU - Párniczky, Andrea AU - Gergics, Marin AU - Sarlós, Patrícia AU - Erőss, Bálint Mihály AU - Mezősi, Emese TI - Prevalence of other autoimmune diseases in polyglandular autoimmune syndromes type II and III JF - JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION J2 - J ENDOCRINOL INVEST VL - 43 PY - 2020 IS - 9 SP - 1327 EP - 1335 PG - 9 SN - 0391-4097 DO - 10.1007/s40618-020-01229-1 UR - https://m2.mtmt.hu/api/publication/31269088 ID - 31269088 AB - Polyglandular autoimmune syndromes (PAS) are complex, heterogeneous disorders in which various autoimmune diseases can occur, affecting both endocrine and non-endocrine organs. In this meta-analysis, the prevalence of associated autoimmune disorders was investigated in PAS II and III.A comprehensive search in MEDLINE and Embase databases identified 479 studies with the keywords of PAS II and PAS III. 18 records containing a total of 1312 patients fulfilled our inclusion criteria (original studies reporting at least 10 cases and containing the combination of other autoimmune disorders) and were selected for further analysis. A meta-analysis of prevalence was performed using the random-effects model with the calculation of 95% confidence intervals (CI). Results of each meta-analysis were displayed graphically using forest plots.Distinction between PAS II and PAS III was made in 842 cases, of which 177 and 665 were PAS II and III (21.1 vs 78.9%), respectively. The prevalence of Hashimoto's thyroiditis was significantly higher than that of Graves's disease (39% [95% CI 17-65%] vs. 4% [95% CI 0-10%], respectively; p = 0.001). In PAS II, Addison's disease (AD) coexisted with AITDs, T1DM or the combination of these conditions in 65, 18 and 10% of cases, respectively. In addition, one other endocrine and five non-endocrine organ-specific autoimmune disorders were reported. In PAS III, two other autoimmune endocrinopathies, six non-endocrine organ-specific, and four systemic autoimmune disorders were found in combination with AITDs.AITDs, T1DM and AD are the most common combinations in PAS, thus screening for these conditions seems to be reasonable. LA - English DB - MTMT ER -