@article{MTMT:34561215, title = {AZ APELIN ÉS A KOPEPTIN SZEREPE HUMORÁLIS SZABÁLYOZÁSI ZAVAROKBAN}, url = {https://m2.mtmt.hu/api/publication/34561215}, author = {Gergics, Marin and Pham-Dobor, Gréta and Nemes, Orsolya and Bódis, Beáta and Mezősi, Emese and Bajnok, László Zoltán}, journal-iso = {MBA}, journal = {MAGYAR BELORVOSI ARCHIVUM}, volume = {76}, unique-id = {34561215}, issn = {0133-5464}, year = {2023}, pages = {309-309}, orcid-numbers = {Mezősi, Emese/0000-0001-9367-3877} } @article{MTMT:34081443, title = {Apelin-13 as a Potential Biomarker in Critical Illness}, url = {https://m2.mtmt.hu/api/publication/34081443}, author = {Gergics, Marin and Pham-Dobor, Gréta and Kurdi, Csilla and Montskó, Gergely and Mihályi, Krisztina and Bánfai, Gábor László and Kanizsai, Péter László and Kőszegi, Tamás and Mezősi, Emese and Bajnok, László Zoltán}, doi = {10.3390/jcm12144801}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {12}, unique-id = {34081443}, abstract = {The adrenocortical system and copeptin as prognostic markers were intensively investigated in critical illness. The potential predictive power of apelin-13 as a biomarker is largely unknown. We aimed to investigate the prognostic role of apelin-13 in relation to free cortisol, aldosterone, CRH, and copeptin in critically ill patients.In this prospective observational study, 124 critically ill patients (64 men, 60 women, median age: 70 (59-78) years) were consecutively enrolled at the time of admission. All routinely available clinical and laboratory parameters were evaluated and correlated to hormonal changes.Serum apelin-13 was 1161 (617-2967) pg/mL in non-survivors vs. 2477 (800-3531) pg/mL in survivors (p = 0.054). The concentrations of apelin-13 and CRH had strong positive correlations (r = 0.685, p < 0.001) and were significantly higher in surviving non-septic patients (Apelin-13 (pg/mL): 2286 (790-3330) vs. 818 (574-2732) p < 0.05; CRH (pg/mL) 201 (84-317) vs. 89 (74-233) p < 0.05). Apelin-13 and free cortisol were independent determinants of survival in the multivariate Cox regression analysis, while copeptin, CRH, or aldosterone were not.Beyond free cortisol, serum apelin-13 may also help refine prognostic predictions in the early phase of critical illness, especially in non-septic patients.}, keywords = {critical illness; CRH; Apelin-13; COPEPTIN; Free cortisol}, year = {2023}, eissn = {2077-0383}, orcid-numbers = {Kanizsai, Péter László/0000-0001-7896-2857; Mezősi, Emese/0000-0001-9367-3877} } @article{MTMT:33127953, title = {Effectiveness of four topical treatment methods in a rat model of superficial partial-thickness burn injury: the advantages of combining zinc-hyaluronan gel with silver foam dressing}, url = {https://m2.mtmt.hu/api/publication/33127953}, author = {Csenkey, Alexandra and Hargitai, Emma and Pákai, Eszter and Kajtár, Béla and Vida, Livia and Lőrincz, Aba Tamás and Gergics, Marin and Vajda, Péter and Józsa, Gergő and Garami, András}, doi = {10.1016/j.injury.2022.09.062}, journal-iso = {INJURY}, journal = {INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED}, volume = {53}, unique-id = {33127953}, issn = {0020-1383}, abstract = {Background There are several options available for conservative treatment of partial-thickness burns, however, reliable, affordable, and easily obtainable animal testing models are hard to find for the comparison of the different treatment methods. We aimed at developing a preclinical testing model and at comparing four treatment methods for superficial partial-thickness burns. Methods Burn injury was induced in 90 adult male Wistar rats by placing the 130°C hot tip of a commercially obtainable soldering device for 30 s on the clipped skin of the interscapular region at a steady pressure. Skin histology was studied on days 5, 10, and 22 after the induction of the burn injury, on which days, respectively, the ratio of the not epithelialized wound (%), the extent of re-epithelialization (score), and the scar thickness (µm) were assessed. We compared 4 groups: silver-sulfadiazine cream, zinc-hyaluronan gel, silver foam dressing, and the combination of zinc-hyaluronan gel with a silver foam dressing. Results On day 5, the induction of superficial partial-thickness burn injury was confirmed histologically in the rats. The zinc-hyaluronan gel and the combination treatment resulted in a markedly smaller ratio of the non-epithelialized area (29 ± 10% and 28 ± 13%, respectively) than silver-sulfadiazine cream (69 ± 4%; p < 0.01). On day 10, the extent of re-epithelialization was the lowest (∼0.2) in the silver-sulfadiazine cream group, while the other 3 treatments performed significantly better. The combination treatment lead to the maximal score of 2 in all rats, which was higher than in the other 3 treatment groups. On day 22, the scar thickness was the smallest in the combination treatment group (560 ± 42 µm), which was significantly less than in the silver-sulfadiazine cream group (712 ± 38 µm; p < 0.05). Conclusions We designed and histologically confirmed a reproducible method for induction of superficial partial-thickness burns in rats for preclinical testing. In our model, the combination of zinc-hyaluronan gel with silver foam dressing was more effective than either of its components alone or than silver-sulfadiazine cream.}, year = {2022}, eissn = {1879-0267}, pages = {3912-3919}, orcid-numbers = {Csenkey, Alexandra/0000-0001-7167-6225; Kajtár, Béla/0000-0001-5551-3709; Lőrincz, Aba Tamás/0000-0002-6705-3292; Garami, András/0000-0003-2493-0571} } @article{MTMT:33126288, title = {Secondary hormonal alterations in short-term severe hypothyroidism; in the focus: Apelin and copeptin}, url = {https://m2.mtmt.hu/api/publication/33126288}, author = {Gergics, Marin and Pham-Dobor, Gréta and Horváth-Szalai, Zoltán and Kőszegi, Tamás and Mezősi, Emese and Bajnok, László Zoltán}, doi = {10.3389/fendo.2022.981891}, journal-iso = {FRONT ENDOCRINOL}, journal = {FRONTIERS IN ENDOCRINOLOGY}, volume = {13}, unique-id = {33126288}, issn = {1664-2392}, abstract = {This study aimed to investigate the complex interactions of thyroid hormone, apelin, and copeptin in the fluid-ion homeostasis of patients with severe transitory hypothyroidism.In this prospective observational study, 39 patients (ECOG: 0; 11 men, 28 women, mean age: 50.3 ± 14.9 years) were investigated during short-term severe hypothyroidism due to surgical removal of the thyroid gland and after adequate thyroid replacement therapy. In addition to the routinely available lab tests, copeptin and apelin levels were determined using ELISA.In the hypothyroid state, apelin concentration was lower, while copeptin levels did not differ compared to the euthyroid condition. Apelin showed a positive correlation with copeptin (p = 0.003), sodium (p = 0.002), NT-proBNP (p < 0.001), and fT4 (p < 0.001) and a negative correlation with thyroid-stimulating hormone (TSH) (p < 0.001). In multivariate linear regression models, copeptin and TSH proved to be significant independent predictors of apelin levels, of which TSH had an explanatory power of 48.7%. Aside from apelin, copeptin only correlated with sodium (p = 0.046). Sodium levels were negatively associated with TSH (p = 0.004) and positively with ACTH (p = 0.002) and cortisol (p = 0.047), in addition to copeptin. None of the parameters were independent predictors of serum sodium levels in a multivariate regression model.In short-term severe hypothyroidism, serum apelin level is markedly decreased, which may predispose susceptible patients to hyponatremia, while the level of copeptin is unchanged. TSH and copeptin are independent predictors of apelin concentration, of which TSH is stronger.}, keywords = {HYPOTHYROIDISM; Apelin; TSH; COPEPTIN; DTC (differentiated thyroid cancer)}, year = {2022}, eissn = {1664-2392}, orcid-numbers = {Mezősi, Emese/0000-0001-9367-3877} } @article{MTMT:33071773, title = {Impact of remote monitoring in heart failure patients with cardiac implantable electronic devices during COVID-19 pandemic: a single center experience}, url = {https://m2.mtmt.hu/api/publication/33071773}, author = {Ezer, Péter and Gergics, Marin and Szokodi, István and Kónyi, Attila}, doi = {10.1186/s13019-022-01963-y}, journal-iso = {J CARDIOTHORAC SURG}, journal = {JOURNAL OF CARDIOTHORACIC SURGERY}, volume = {17}, unique-id = {33071773}, issn = {1749-8090}, abstract = {Coronavirus disease 2019 (COVID-19) had spread into a pandemic affecting healthcare providers worldwide. Heart failure patients with implanted cardiac devices require close follow-up in-spite of pandemic related healthcare restrictions.Patients were retrospectively registered and clinical outcomes were compared of 61 remote monitored (RMG) versus 71 conventionally (in-office only) followed (CFG) cardiac device implanted, heart failure patients. Follow-up length was 12 months, during the COVID-19 pandemic related intermittent insitutional restrictions. We used a specified heart failure detection algorithm in RMG. This investigation compared worsening heart failure-, arrhythmia- and device related adverse events as primary outcome and heart failure hospitalization rates as secondary outcome in the two patient groups.No significant difference was observed in the primary composite end-point during the first 12 months of COVID-19 pandemic (p = 0.672). In RMG, patients who had worsening heart failure event had relative modest deterioration in heart failure functional class (p = 0.026), relative lower elevation of N terminal-pro BNP levels (p < 0.01) at in-office evaluation and were less hospitalized for worsening heart failure in the first 6 months of pandemic (p = 0.012) compared to CFG patients.Specified remote monitoring alert-based detection algorithm and workflow in device implanted heart failure patients may potentially indicate early worsening in heart failure status. Preemptive adequate intervention may prevent further progression of deteriorating heart failure and thus prevent heart failure hospitalizations.}, keywords = {FOLLOW-UP; heart failure; Remote monitoring; COVID-19}, year = {2022}, eissn = {1749-8090} } @article{MTMT:32551691, title = {Prevalence and Prognostic Significance of Hyponatremia in Patients With Lung Cancer : Systematic Review and Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/32551691}, author = {Bartalis, Eszter and Gergics, Marin and Tinusz, Benedek and Földi, Mária and Kiss, Szabolcs and Németh, Dávid and Varjú-Solymár, Margit and Szakács, Zsolt and Hegyi, Péter and Mezősi, Emese and Bajnok, László Zoltán}, doi = {10.3389/fmed.2021.671951}, journal-iso = {FRONT MED}, journal = {FRONTIERS IN MEDICINE}, volume = {8}, unique-id = {32551691}, abstract = {Background: The prevalence of hyponatremia is highly variable among patients with lung cancer. However, its prevalence and prognostic significance in subgroups of patients with lung cancer have not yet been evaluated in a meta-analysis. Methods: We have registered our meta-analysis and review protocol to the PROSPERO International Prospective Register of Systematic Reviews, with the following registration number: CRD42020167013. A systematic search was done in the following sources: MEDLINE, Embase, CENTRAL, Web of Science, ClinicalTrials.gov, a WHO Global Health Library. Results: We identified a total of 8,962 potentially eligible studies, and we included 31 articles in our evaluation. The prevalence of hyponatremia in patients with lung cancer varied between 3 and 94.8% with an average of 25% without any significant differences between the following subgroups: histotype, gender, age, Eastern Cooperative Oncology Group (ECOG) state, and the extent of disease. The overall survival (OS) was significantly lower in hyponatremic compared to normonatremic patients at 10 months [RR.59 (95% CI.47-0.74), p < 0.001] and at 20 months [RR.44 (95% CI.33-0.59), p < 0.001], with worse survival rates in non-small cell lung cancer (NSCLC) [RR.27 (95% CI.12-0.44), p < 0.001] than in small cell lung cancer (SCLC) [RR.42 (95% CI.27-0.57), p < 0.001]. If hyponatremia was corrected, OS at 10 months was significantly higher than in the uncorrected hyponatremia group [RR 1.83 (95% CI 1.37-2.44), p < 0.001], but, at 20 months, no statistically significant difference could be found between these subgroups [RR 2.65 (95% CI.94-7.50), p = 0.067]. Conclusions: Patients with lung cancer diagnosed with hyponatremia, especially patients with NSCLC, seem to have significantly lower survival rates than normonatremic patients. If hyponatremia remains uncorrected, the mortality rates might be even higher.}, keywords = {lung cancer; Hyponatremia; NSCLC; SCLC; SIADH}, year = {2021}, eissn = {2296-858X}, orcid-numbers = {Varjú-Solymár, Margit/0000-0001-6667-6263; Szakács, Zsolt/0000-0002-7035-941X; Hegyi, Péter/0000-0003-0399-7259; Mezősi, Emese/0000-0001-9367-3877} } @article{MTMT:31410117, title = {Physical Validation of a Residual Impedance Rejection Method during Ultra-Low Frequency Bio-Impedance Spectral Measurements}, url = {https://m2.mtmt.hu/api/publication/31410117}, author = {Vizvári, Zoltán Ákos and Győrfi, Nina Rubina and Odry, Ákos and Sári, Zoltán and Klincsik, Mihály and Gergics, Marin and Kovács, Levente and Dolgosné Kovács, Anita and Pál, József and Karádi, Zoltán György and Odry, Péter and Tóth, Attila}, doi = {10.3390/s20174686}, journal-iso = {SENSORS-BASEL}, journal = {SENSORS}, volume = {20}, unique-id = {31410117}, year = {2020}, eissn = {1424-8220}, orcid-numbers = {Kovács, Levente/0000-0002-3188-0800} } @article{MTMT:31269088, title = {Prevalence of other autoimmune diseases in polyglandular autoimmune syndromes type II and III}, url = {https://m2.mtmt.hu/api/publication/31269088}, author = {Pham-Dobor, Gréta and Hanák, Lilla and Hegyi, Péter and Márta, Katalin and Párniczky, Andrea and Gergics, Marin and Sarlós, Patrícia and Erőss, Bálint Mihály and Mezősi, Emese}, doi = {10.1007/s40618-020-01229-1}, journal-iso = {J ENDOCRINOL INVEST}, journal = {JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION}, volume = {43}, unique-id = {31269088}, issn = {0391-4097}, abstract = {Polyglandular autoimmune syndromes (PAS) are complex, heterogeneous disorders in which various autoimmune diseases can occur, affecting both endocrine and non-endocrine organs. In this meta-analysis, the prevalence of associated autoimmune disorders was investigated in PAS II and III.A comprehensive search in MEDLINE and Embase databases identified 479 studies with the keywords of PAS II and PAS III. 18 records containing a total of 1312 patients fulfilled our inclusion criteria (original studies reporting at least 10 cases and containing the combination of other autoimmune disorders) and were selected for further analysis. A meta-analysis of prevalence was performed using the random-effects model with the calculation of 95% confidence intervals (CI). Results of each meta-analysis were displayed graphically using forest plots.Distinction between PAS II and PAS III was made in 842 cases, of which 177 and 665 were PAS II and III (21.1 vs 78.9%), respectively. The prevalence of Hashimoto's thyroiditis was significantly higher than that of Graves's disease (39% [95% CI 17-65%] vs. 4% [95% CI 0-10%], respectively; p = 0.001). In PAS II, Addison's disease (AD) coexisted with AITDs, T1DM or the combination of these conditions in 65, 18 and 10% of cases, respectively. In addition, one other endocrine and five non-endocrine organ-specific autoimmune disorders were reported. In PAS III, two other autoimmune endocrinopathies, six non-endocrine organ-specific, and four systemic autoimmune disorders were found in combination with AITDs.AITDs, T1DM and AD are the most common combinations in PAS, thus screening for these conditions seems to be reasonable.}, keywords = {diabetes mellitus; Meta-analysis; Addison's disease; autoimmune thyroid disease; polyglandular autoimmune syndrome}, year = {2020}, eissn = {1720-8386}, pages = {1327-1335}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Márta, Katalin/0000-0002-2213-4865; Sarlós, Patrícia/0000-0002-5086-9455; Erőss, Bálint Mihály/0000-0003-3658-8427; Mezősi, Emese/0000-0001-9367-3877} }