TY - JOUR AU - Holló, Filoména AU - Salamon, Pál Attila AU - Bodor, Zsolt AU - Miklóssy, Ildikó AU - Orbán, Kálmán Csongor AU - Albert, Beáta TI - Relationship between physical condition and academic performance in rural Romanian schoolchildren JF - SPORTIS-SCIENTIFIC TECHNICAL JOURNAL OF SCHOOL SPORT PHYSICAL EDUCATION AND PSYCHOMOTRICITY J2 - SPORTIS VL - 11 PY - 2025 IS - 1 SP - 1 EP - 25 PG - 25 SN - 2386-8333 DO - 10.17979/sportis.2025.11.1.11205 UR - https://m2.mtmt.hu/api/publication/36176123 ID - 36176123 AB - This study explored the relationship between body mass index (BMI) and motor skills among 5th to 8th-grade boys aged 11-14 in a rural public elementary school. Conducted in a demographically diverse school with a consistent curriculum, the research minimized external variables. BMI was determined according to international guidelines, and motor competencies were assessed using standardized tests (50-meter sprint, 1000-meter run, standing long jump, sit-up test, plank test). Cognitive tests included the Stroop Test and Digital Symbol Test. Results revealed a significant negative correlation between higher BMI and motor skills, indicating that higher BMI scores were associated with lower motor test performance. This finding highlights the detrimental impact of higher BMI on physical performance and emphasizes the importance of preventive measures and early interventions to address adolescent obesity. The study underscores the need to understand the link between physical fitness and body composition to develop effective educational and health programs. Further research is necessary to clarify causal relationships and design tailored interventions to improve motor skills and prevent childhood obesity. In addition, future studies should explore gender differences and their potential effects on academic performance and cognitive development to gain a more comprehensive understanding of the factors influencing physical and cognitive outcomes. LA - English DB - MTMT ER - TY - JOUR AU - Csató-Kovács, Erika AU - Salamon, Pál Attila AU - Fikó-Lászlo, Szilvia AU - Kovács, Krisztina AU - Koka, Alice AU - András-Korodi, Mónika AU - Antal, Emőke AU - Brumă, Emília AU - Tőrsők, Brigitta AU - Gudor, Szilárd AU - Miklóssy, Ildikó AU - Orbán, Kálmán Csongor AU - Albert, Csilla AU - Bálint, Emese-Éva AU - Albert, Beáta TI - Development of a Mammalian Cell Line for Stable Production of Anti-PD-1 JF - ANTIBODIES J2 - ANTIBODIES VL - 13 PY - 2024 IS - 4 PG - 13 SN - 2073-4468 DO - 10.3390/antib13040082 UR - https://m2.mtmt.hu/api/publication/35434014 ID - 35434014 AB - Background/Objectives: Immune checkpoint blockade, particularly targeting the programmed cell death 1 (PD-1) receptor, is a promising strategy in cancer immunotherapy. The interaction between PD-1 and its ligands, PD-L1 and PD-L2, is crucial in immune evasion by tumors. Blocking this interaction with monoclonal antibodies like Nivolumab can restore anti-tumor immunity. This study aims to develop a stable expression system for Nivolumab-based anti-PD-1 in the Chinese Hamster Ovary (CHO) DG44 cell line using two different expression vector systems with various signal sequences. Methods: The heavy chain (HC) and light chain (LC) of Nivolumab were cloned into two expression vectors, pOptiVEC and pcDNA3.3. Each vector was engineered with two distinct signal sequences, resulting in the creation of eight recombinant plasmids. These plasmids were co-transfected into CHO DG44 cells in different combinations, allowing for the assessment of stable antibody production. Results: Both pOptiVEC and pcDNA3.3 vectors were successful in stably integrating and expressing the Nivolumab-based anti-PD-1 antibody in CHO DG44 cells. This study found that the choice of signal sequence significantly influenced the quantity of antibodies produced. The optimization of production conditions further enhanced antibody yield, indicating the potential for large-scale production. Conclusions: This study demonstrates that both pOptiVEC and pcDNA3.3 expression systems are effective for the stable production of Nivolumab-based anti-PD-1 in CHO DG44 cells. Signal sequences play a critical role in determining the expression levels, and optimizing production conditions can further increase antibody yield, supporting future applications in cancer immunotherapy. LA - English DB - MTMT ER - TY - CHAP AU - Bálint, Emese-Éva AU - Salamon, Pál Attila AU - Mara, Gyöngyvér AU - Klementina-Imelda, Ilkei ED - Szakál, Zoltán ED - Takács, Péter TI - Az iskolákban fertőzést okozó gyakori baktériumok és vírusok T2 - INDEHEP E-KÉZIKÖNYV : Innovatív digitális tananyagfejlesztés a felsőoktatásban PB - Debreceni Egyetem Egészségtudományi Kar CY - Debrecen SN - 9789634906674 PY - 2024 SP - 178 EP - 192 PG - 15 UR - https://m2.mtmt.hu/api/publication/36112616 ID - 36112616 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Bálint, Emese-Éva AU - Salamon, Pál Attila AU - Mara, Gyöngyvér AU - Klementina-Imelda, Ilkei ED - Szakál, Zoltán ED - Takács, Péter TI - Common bacteria and viruses causing infections in schools. A brief overview T2 - Innovative Digital Curriculum Development in Higher Education PB - Debreceni Egyetem Egészségtudományi Kar CY - Debrecen SN - 9789634906605 PY - 2024 SP - 173 EP - 186 PG - 14 UR - https://m2.mtmt.hu/api/publication/36115473 ID - 36115473 LA - English DB - MTMT ER - TY - CHAP AU - Bálint, Emese-Éva AU - Salamon, Pál Attila AU - Mara, Gyöngyvér AU - Klementina-Imelda, Ilkei ED - Szakál, Zoltán ED - Takács, Péter TI - Bežné baktérie a vírusy spôsobujúce infekcie v školskom prostredí. Stručný prehľad. T2 - Inovatívne digitálne uebné osnovy Vývoj vo vysokobkolskom vzdelávaní PB - Debreceni Egyetem Egészségtudományi Kar CY - Debrecen SN - 9789634906650 PY - 2024 SP - 176 EP - 189 PG - 14 UR - https://m2.mtmt.hu/api/publication/36123855 ID - 36123855 LA - Slovak DB - MTMT ER - TY - CHAP AU - Mara, Gyöngyvér AU - Klementina-Imelda, Ilkei AU - Bálint, Emese-Éva AU - Salamon, Pál Attila ED - Szakál, Zoltán ED - Takács, Péter TI - Prieten sau dușman? Microbiomul uman și rolul său în sănătate T2 - Dezvoltarea curriculumului digital în învățământul superior Indehep E-Handbook - IHEB PB - Debreceni Egyetem Egészségtudományi Kar CY - Debrecen SN - 9789634906667 PY - 2024 SP - 193 EP - 208 PG - 16 UR - https://m2.mtmt.hu/api/publication/36132654 ID - 36132654 LA - Romanian DB - MTMT ER - TY - CONF AU - FERENCZ, BORÓKA AU - Salamon, Pál Attila AU - Várhelyi, Csaba, ifj. AU - PAPP, JUDIT TI - EMT, XXX. Nemzetközi Vegyészkonferencia, 2024. okt. 23 – 26, Kolozsvár. Kobalt komplexek hatása a Staphylococcus aureus és Bacillus cereus fejlődésére (Effect of Cobalt Complexes on the Development of Staphylococcus Aureus and Bacillus Cereus) TS - Kobalt komplexek hatása a Staphylococcus aureus és Bacillus cereus fejlődésére (Effect of Cobalt Complexes on the Development of Staphylococcus Aureus and Bacillus Cereus) T2 - XXX. Nemzetközi Vegyészkonferencia PB - Erdélyi Magyar Műszaki Tudományos Társaság (EMT) C1 - Kolozsvár T3 - Nemzetközi Vegyészkonferencia, ISSN 1843-6293 ; 30. PY - 2024 SP - 117 EP - 117 PG - 1 UR - https://m2.mtmt.hu/api/publication/36323761 ID - 36323761 AB - A széles körben elterjedt antibiotikum-rezisztens baktériumtörzsek megjelenése egyre nagyobb problémát jelent az orvostudományban, ami arra ösztönzi a kutatókat, hogy olyan vegyületeket szintetizáljanak, amelyek képesek elpusztítani ezeket a törzseket. Az átmeneti fémek mikroorganizmusokra gyakorolt negatív hatása áttörést jelenthet a gyógyászatban a fémtartalmú antibiotikumok terén, és megoldást kínálhat az antibiotikum-rezisztens baktériumtörzsek ellen. Kísérleteink során két kobalt-komplex antimikrobiális hatását vizsgáltuk Staphylococcus aureus és Bacillus cereus baktériumtörzseken. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csányi, Mária Csilla AU - Salamon, Pál Attila AU - Feller, Tímea AU - Bozó, Tamás AU - Hársfalvi, Jolán AU - Kellermayer, Miklós TI - Structural hierarchy of mechanical extensibility in human von Willebrand factor multimers JF - PROTEIN SCIENCE J2 - PROTEIN SCI VL - 32 PY - 2023 IS - 1 PG - 14 SN - 0961-8368 DO - 10.1002/pro.4535 UR - https://m2.mtmt.hu/api/publication/33365403 ID - 33365403 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Zita AU - Bálint, Emese-Éva AU - Lászlo, Szilvia AU - Albert, Beáta AU - Gyöngyi, Tar AU - Attila, András AU - Salamon, Pál Attila TI - THE EFFECT OF SARS-COV-2 VIRUS ON THE ACTIVITY OF THE PANOPTOSIS PATHWAY IN UPPER RESPIRATORY EPITHELIAL CELLS: CORRELATIONS BETWEEN EXPRESSION PATTERNS, AGE, GENDER, AND COMORBIDITIES JF - ACTA MARISIENSIS: SERIA MEDICA J2 - ACTA MARISIEN VL - 69 PY - 2023 IS - Suppl. 5 SP - 35 EP - 35 PG - 1 SN - 2668-7755 UR - https://m2.mtmt.hu/api/publication/34109004 ID - 34109004 LA - English DB - MTMT ER - TY - JOUR AU - Fodor, Hunor Pál AU - Dávid, Hunor AU - Czont, Attila AU - Miklóssy, Ildikó AU - Orbán, Kálmán Csongor AU - Tar, Gyöngyi AU - Fodor, Abony AU - Kovács, Zita AU - Albert, Beáta AU - Salamon, Pál Attila TI - Enhanced Gait Recovery in Chronic Post-COVID-19 Stroke: The Role of Combined Physical Rehabilitation JF - REPORTS J2 - REPORTS-BASEL VL - 6 PY - 2023 IS - 4 PG - 18 SN - 2571-841X DO - 10.3390/reports6040051 UR - https://m2.mtmt.hu/api/publication/34238005 ID - 34238005 AB - Background: Rehabilitation programs applied in cases of COVID-19-related stroke should counteract not only the effects of the stroke but also the effects of long-term COVID-19. As the molecular processes underlying these cases are still not fully understood, and evidence-based clinical outcomes are scarcely documented, there is a valid need to gather information and develop rehabilitation strategies for these patients. The risks, already clarified in the case of stroke, need to be assessed taking into account the coincidence of the two diseases. Endothelial injuries and emboli that develop after the hypercoagulable state of COVID-19 may take longer to heal, and complications may occur during exercise. This case study attempts to determine what the rehabilitation of a COVID-19-related stroke patient should include. The participant was a 64-year-old male with ischemic right middle cerebral artery stroke, left-side hemiplegia, and middle cerebral artery stenosis, and the CT showed a well-defined area of hypoattenuation in the basal ganglia territory involving the right lentiform nucleus, the anterior and posterior limbs of the internal capsule, and the dorsal part of the external capsule. His NIHSS score was 14, and he registered 15 points on the Barthel index. The patient had a COVID-19 infection two weeks before the stroke event. Methods: Conventional physical therapy was combined with adaptive ballistic strength training, a high-intensity interval training regimen, and manual treatment for myofascial release throughout the chronic recovery phase. Our primary goals were gait rehabilitation, muscle strengthening, weakness management, as well as spasticity reduction, while three different rehabilitation approaches were adopted in a single rehabilitation program to improve the outcome and long-term functional recovery of the patient. Results: The patient progressed in almost every aspect of the assessment criteria. This combined approach’s main success was improved gait speed, gait quality, and improved cardiovascular fitness. Take-away message: In the case of a stroke caused by COVID-19, where the endothelium cells are compromised, HIIT may be questionable due to the poor vascular condition. Based on our results, the low-volume HIIT approach proved appropriate and effective. LA - English DB - MTMT ER -