@article{MTMT:36176123, title = {Relationship between physical condition and academic performance in rural Romanian schoolchildren}, url = {https://m2.mtmt.hu/api/publication/36176123}, author = {Holló, Filoména and Salamon, Pál Attila and Bodor, Zsolt and Miklóssy, Ildikó and Orbán, Kálmán Csongor and Albert, Beáta}, doi = {10.17979/sportis.2025.11.1.11205}, journal-iso = {SPORTIS}, journal = {SPORTIS-SCIENTIFIC TECHNICAL JOURNAL OF SCHOOL SPORT PHYSICAL EDUCATION AND PSYCHOMOTRICITY}, volume = {11}, unique-id = {36176123}, issn = {2386-8333}, abstract = {This study explored the relationship between body mass index (BMI) and motor skills among 5th to 8th-grade boys aged 11-14 in a rural public elementary school. Conducted in a demographically diverse school with a consistent curriculum, the research minimized external variables. BMI was determined according to international guidelines, and motor competencies were assessed using standardized tests (50-meter sprint, 1000-meter run, standing long jump, sit-up test, plank test). Cognitive tests included the Stroop Test and Digital Symbol Test. Results revealed a significant negative correlation between higher BMI and motor skills, indicating that higher BMI scores were associated with lower motor test performance. This finding highlights the detrimental impact of higher BMI on physical performance and emphasizes the importance of preventive measures and early interventions to address adolescent obesity. The study underscores the need to understand the link between physical fitness and body composition to develop effective educational and health programs. Further research is necessary to clarify causal relationships and design tailored interventions to improve motor skills and prevent childhood obesity. In addition, future studies should explore gender differences and their potential effects on academic performance and cognitive development to gain a more comprehensive understanding of the factors influencing physical and cognitive outcomes.}, year = {2025}, eissn = {2386-8333}, pages = {1-25}, orcid-numbers = {Bodor, Zsolt/0000-0003-1386-6957} } @article{MTMT:35434014, title = {Development of a Mammalian Cell Line for Stable Production of Anti-PD-1}, url = {https://m2.mtmt.hu/api/publication/35434014}, author = {Csató-Kovács, Erika and Salamon, Pál Attila and Fikó-Lászlo, Szilvia and Kovács, Krisztina and Koka, Alice and András-Korodi, Mónika and Antal, Emőke and Brumă, Emília and Tőrsők, Brigitta and Gudor, Szilárd and Miklóssy, Ildikó and Orbán, Kálmán Csongor and Albert, Csilla and Bálint, Emese-Éva and Albert, Beáta}, doi = {10.3390/antib13040082}, journal-iso = {ANTIBODIES}, journal = {ANTIBODIES}, volume = {13}, unique-id = {35434014}, abstract = {Background/Objectives: Immune checkpoint blockade, particularly targeting the programmed cell death 1 (PD-1) receptor, is a promising strategy in cancer immunotherapy. The interaction between PD-1 and its ligands, PD-L1 and PD-L2, is crucial in immune evasion by tumors. Blocking this interaction with monoclonal antibodies like Nivolumab can restore anti-tumor immunity. This study aims to develop a stable expression system for Nivolumab-based anti-PD-1 in the Chinese Hamster Ovary (CHO) DG44 cell line using two different expression vector systems with various signal sequences. Methods: The heavy chain (HC) and light chain (LC) of Nivolumab were cloned into two expression vectors, pOptiVEC and pcDNA3.3. Each vector was engineered with two distinct signal sequences, resulting in the creation of eight recombinant plasmids. These plasmids were co-transfected into CHO DG44 cells in different combinations, allowing for the assessment of stable antibody production. Results: Both pOptiVEC and pcDNA3.3 vectors were successful in stably integrating and expressing the Nivolumab-based anti-PD-1 antibody in CHO DG44 cells. This study found that the choice of signal sequence significantly influenced the quantity of antibodies produced. The optimization of production conditions further enhanced antibody yield, indicating the potential for large-scale production. Conclusions: This study demonstrates that both pOptiVEC and pcDNA3.3 expression systems are effective for the stable production of Nivolumab-based anti-PD-1 in CHO DG44 cells. Signal sequences play a critical role in determining the expression levels, and optimizing production conditions can further increase antibody yield, supporting future applications in cancer immunotherapy.}, year = {2024}, eissn = {2073-4468}, orcid-numbers = {Salamon, Pál Attila/0000-0002-6803-1212; Miklóssy, Ildikó/0000-0002-8037-7216; Orbán, Kálmán Csongor/0000-0002-7509-748X; Albert, Csilla/0000-0001-6882-6691} } @{MTMT:36112616, title = {Az iskolákban fertőzést okozó gyakori baktériumok és vírusok}, url = {https://m2.mtmt.hu/api/publication/36112616}, author = {Bálint, Emese-Éva and Salamon, Pál Attila and Mara, Gyöngyvér and Klementina-Imelda, Ilkei}, booktitle = {INDEHEP E-KÉZIKÖNYV : Innovatív digitális tananyagfejlesztés a felsőoktatásban}, unique-id = {36112616}, year = {2024}, pages = {178-192} } @{MTMT:36115473, title = {Common bacteria and viruses causing infections in schools. A brief overview}, url = {https://m2.mtmt.hu/api/publication/36115473}, author = {Bálint, Emese-Éva and Salamon, Pál Attila and Mara, Gyöngyvér and Klementina-Imelda, Ilkei}, booktitle = {Innovative Digital Curriculum Development in Higher Education}, unique-id = {36115473}, year = {2024}, pages = {173-186} } @{MTMT:36123855, title = {Bežné baktérie a vírusy spôsobujúce infekcie v školskom prostredí. Stručný prehľad.}, url = {https://m2.mtmt.hu/api/publication/36123855}, author = {Bálint, Emese-Éva and Salamon, Pál Attila and Mara, Gyöngyvér and Klementina-Imelda, Ilkei}, booktitle = {Inovatívne digitálne uebné osnovy Vývoj vo vysokobkolskom vzdelávaní}, unique-id = {36123855}, year = {2024}, pages = {176-189} } @{MTMT:36132654, title = {Prieten sau dușman? Microbiomul uman și rolul său în sănătate}, url = {https://m2.mtmt.hu/api/publication/36132654}, author = {Mara, Gyöngyvér and Klementina-Imelda, Ilkei and Bálint, Emese-Éva and Salamon, Pál Attila}, booktitle = {Dezvoltarea curriculumului digital în învățământul superior Indehep E-Handbook - IHEB}, unique-id = {36132654}, year = {2024}, pages = {193-208} } @CONFERENCE{MTMT:36323761, title = {EMT, XXX. Nemzetközi Vegyészkonferencia, 2024. okt. 23 – 26, Kolozsvár. Kobalt komplexek hatása a Staphylococcus aureus és Bacillus cereus fejlődésére (Effect of Cobalt Complexes on the Development of Staphylococcus Aureus and Bacillus Cereus)}, url = {https://m2.mtmt.hu/api/publication/36323761}, author = {FERENCZ, BORÓKA and Salamon, Pál Attila and Várhelyi, Csaba, ifj. and PAPP, JUDIT}, booktitle = {XXX. Nemzetközi Vegyészkonferencia}, unique-id = {36323761}, abstract = {A széles körben elterjedt antibiotikum-rezisztens baktériumtörzsek megjelenése egyre nagyobb problémát jelent az orvostudományban, ami arra ösztönzi a kutatókat, hogy olyan vegyületeket szintetizáljanak, amelyek képesek elpusztítani ezeket a törzseket. Az átmeneti fémek mikroorganizmusokra gyakorolt negatív hatása áttörést jelenthet a gyógyászatban a fémtartalmú antibiotikumok terén, és megoldást kínálhat az antibiotikum-rezisztens baktériumtörzsek ellen. Kísérleteink során két kobalt-komplex antimikrobiális hatását vizsgáltuk Staphylococcus aureus és Bacillus cereus baktériumtörzseken.}, keywords = {antibiotikum-rezisztencia, kobalt komplexek, Staphylococcus aureus, Bacillus cereus}, year = {2024}, pages = {117-117} } @article{MTMT:33365403, title = {Structural hierarchy of mechanical extensibility in human von Willebrand factor multimers}, url = {https://m2.mtmt.hu/api/publication/33365403}, author = {Csányi, Mária Csilla and Salamon, Pál Attila and Feller, Tímea and Bozó, Tamás and Hársfalvi, Jolán and Kellermayer, Miklós}, doi = {10.1002/pro.4535}, journal-iso = {PROTEIN SCI}, journal = {PROTEIN SCIENCE}, volume = {32}, unique-id = {33365403}, issn = {0961-8368}, year = {2023}, eissn = {1469-896X}, orcid-numbers = {Csányi, Mária Csilla/0000-0002-7777-4229; Bozó, Tamás/0000-0002-2643-0661; Hársfalvi, Jolán/0000-0001-9940-4846; Kellermayer, Miklós/0000-0002-5553-6553} } @article{MTMT:34109004, title = {THE EFFECT OF SARS-COV-2 VIRUS ON THE ACTIVITY OF THE PANOPTOSIS PATHWAY IN UPPER RESPIRATORY EPITHELIAL CELLS: CORRELATIONS BETWEEN EXPRESSION PATTERNS, AGE, GENDER, AND COMORBIDITIES}, url = {https://m2.mtmt.hu/api/publication/34109004}, author = {Kovács, Zita and Bálint, Emese-Éva and Lászlo, Szilvia and Albert, Beáta and Gyöngyi, Tar and Attila, András and Salamon, Pál Attila}, journal-iso = {ACTA MARISIEN}, journal = {ACTA MARISIENSIS: SERIA MEDICA}, volume = {69}, unique-id = {34109004}, issn = {2668-7755}, year = {2023}, eissn = {2668-7763}, pages = {35-35} } @article{MTMT:34238005, title = {Enhanced Gait Recovery in Chronic Post-COVID-19 Stroke: The Role of Combined Physical Rehabilitation}, url = {https://m2.mtmt.hu/api/publication/34238005}, author = {Fodor, Hunor Pál and Dávid, Hunor and Czont, Attila and Miklóssy, Ildikó and Orbán, Kálmán Csongor and Tar, Gyöngyi and Fodor, Abony and Kovács, Zita and Albert, Beáta and Salamon, Pál Attila}, doi = {10.3390/reports6040051}, journal-iso = {REPORTS-BASEL}, journal = {REPORTS}, volume = {6}, unique-id = {34238005}, abstract = {Background: Rehabilitation programs applied in cases of COVID-19-related stroke should counteract not only the effects of the stroke but also the effects of long-term COVID-19. As the molecular processes underlying these cases are still not fully understood, and evidence-based clinical outcomes are scarcely documented, there is a valid need to gather information and develop rehabilitation strategies for these patients. The risks, already clarified in the case of stroke, need to be assessed taking into account the coincidence of the two diseases. Endothelial injuries and emboli that develop after the hypercoagulable state of COVID-19 may take longer to heal, and complications may occur during exercise. This case study attempts to determine what the rehabilitation of a COVID-19-related stroke patient should include. The participant was a 64-year-old male with ischemic right middle cerebral artery stroke, left-side hemiplegia, and middle cerebral artery stenosis, and the CT showed a well-defined area of hypoattenuation in the basal ganglia territory involving the right lentiform nucleus, the anterior and posterior limbs of the internal capsule, and the dorsal part of the external capsule. His NIHSS score was 14, and he registered 15 points on the Barthel index. The patient had a COVID-19 infection two weeks before the stroke event. Methods: Conventional physical therapy was combined with adaptive ballistic strength training, a high-intensity interval training regimen, and manual treatment for myofascial release throughout the chronic recovery phase. Our primary goals were gait rehabilitation, muscle strengthening, weakness management, as well as spasticity reduction, while three different rehabilitation approaches were adopted in a single rehabilitation program to improve the outcome and long-term functional recovery of the patient. Results: The patient progressed in almost every aspect of the assessment criteria. This combined approach’s main success was improved gait speed, gait quality, and improved cardiovascular fitness. Take-away message: In the case of a stroke caused by COVID-19, where the endothelium cells are compromised, HIIT may be questionable due to the poor vascular condition. Based on our results, the low-volume HIIT approach proved appropriate and effective.}, year = {2023}, eissn = {2571-841X}, orcid-numbers = {Dávid, Hunor/0009-0004-3834-421X; Czont, Attila/0000-0002-6395-1562; Miklóssy, Ildikó/0000-0002-8037-7216; Orbán, Kálmán Csongor/0000-0002-7509-748X} }