@article{MTMT:33928735, title = {Az elektrokemoterápia mérföldkövei [Milestones of electrochemotherapy]}, url = {https://m2.mtmt.hu/api/publication/33928735}, author = {Kis, Erika and Baltás, Eszter and Ócsai, Henriette and Csányi, Ildikó and Ottlakán, Aurél and Lázár, György ifj and Vass, Gábor and Ágoston, Dóra and Rózsa, Petra and Bottyán, Krisztina and Dalmády, Szandra and Nagy, András and Tóth-Molnár, Edit and Oláh, Judit Magdolna}, doi = {10.7188/bvsz.2023.99.2.5}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {33928735}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {116-120}, orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Csányi, Ildikó/0000-0002-0766-5289; Ottlakán, Aurél/0000-0002-7743-7775; Lázár, György ifj/0000-0001-7155-2978; Vass, Gábor/0000-0003-0787-8679; Dalmády, Szandra/0000-0001-7362-5640; Tóth-Molnár, Edit/0000-0001-7989-1616} } @article{MTMT:33041891, title = {Clinical considerations of bleomycin based electrochemotherapy with Variable Electrode Geometry electrodes for inoperable, deep-seated soft tissue sarcomas}, url = {https://m2.mtmt.hu/api/publication/33041891}, author = {Ottlakán, Aurél and Lázár, György ifj and Hideghéty, Katalin and Kószó, Renáta Lilla and Deák , Bence and Nagy, András and Besenyi, Zsuzsanna and Bottyán, Krisztina and Vass, Gábor and Oláh, Judit Magdolna and Kis, Erika}, doi = {10.1016/j.bioelechem.2022.108220}, journal-iso = {BIOELECTROCHEMISTRY}, journal = {BIOELECTROCHEMISTRY}, volume = {148}, unique-id = {33041891}, issn = {1567-5394}, year = {2022}, eissn = {1878-562X}, orcid-numbers = {Ottlakán, Aurél/0000-0002-7743-7775; Lázár, György ifj/0000-0001-7155-2978; Hideghéty, Katalin/0000-0001-7080-2365; Kószó, Renáta Lilla/0000-0002-1958-7839; Besenyi, Zsuzsanna/0000-0001-9115-9620; Vass, Gábor/0000-0003-0787-8679} } @article{MTMT:32490909, title = {Bleomycinalapú elektrokemoterápia lágyrészszarkómák kezelésére Variable Electrode Geometry elektródák használatával}, url = {https://m2.mtmt.hu/api/publication/32490909}, author = {Ottlakán, Aurél and Lázár, György ifj and Oláh, Judit Magdolna and Hideghéty, Katalin and Kószó, Renáta Lilla and Deák , Bence and Nagy, András and Bottyán, Krisztina and Vass, Gábor and Kis, Erika}, journal-iso = {MAGYAR ONKOLÓGIA}, journal = {MAGYAR ONKOLÓGIA}, volume = {65}, unique-id = {32490909}, issn = {0025-0244}, year = {2021}, eissn = {2060-0399}, pages = {47-47}, orcid-numbers = {Ottlakán, Aurél/0000-0002-7743-7775; Lázár, György ifj/0000-0001-7155-2978; Hideghéty, Katalin/0000-0001-7080-2365; Kószó, Renáta Lilla/0000-0002-1958-7839; Vass, Gábor/0000-0003-0787-8679} } @article{MTMT:32163636, title = {Bleomycin Concentration in Patients’ Plasma and Tumors after Electrochemotherapy. A Study from InspECT Group}, url = {https://m2.mtmt.hu/api/publication/32163636}, author = {Groselj, Ales and Bosnjak, Masa and Krzan, Mojca and Kosjek, Tina and Bottyán, Krisztina and Plesnik, Helena and Jamsek, Crt and Cemazar, Maja and Kis, Erika and Sersa, Gregor}, doi = {10.3390/pharmaceutics13091324}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {13}, unique-id = {32163636}, issn = {1999-4923}, year = {2021}, eissn = {1999-4923}, orcid-numbers = {Bosnjak, Masa/0000-0001-7288-6582; Kosjek, Tina/0000-0002-6421-0344; Cemazar, Maja/0000-0002-1418-1928; Sersa, Gregor/0000-0002-7641-5670} } @article{MTMT:31787768, title = {New Treatment Option for Capillary Lymphangioma. Bleomycin-Based Electrochemotherapy of an Infant [Case Report]}, url = {https://m2.mtmt.hu/api/publication/31787768}, author = {Dalmády, Szandra and Csoma, Zsanett and Besenyi, Zsuzsanna and Bottyán, Krisztina and Oláh, Judit Magdolna and Kemény, Lajos and Kis, Erika}, doi = {10.1542/peds.2020-0566}, journal-iso = {PEDIATRICS}, journal = {PEDIATRICS}, volume = {146}, unique-id = {31787768}, issn = {0031-4005}, abstract = {The treatment of microcystic and combined lymphangiomas, especially in the head and neck region, is still a challenge because the lymphangiomas do not respond to conventional therapies and their recurrence rate is high, regardless of the treatment choice. Complete surgical resection is the main treatment of lymphangiomas, but because of localization perioperative complications, such as bleeding, neural damage and airway obstruction are common disadvantages of this method. Bleomycin-based sclerotherapy is another common therapeutic approach, in which the lymphocysts are aspirated, and 25% to 50% of their volumes are replaced with a sclerotisant drug. This is an effective treatment in cases in which the vessels are large enough for an intravascular or intracystic injection, but because of the small size of vessels and cysts, the microcystic and combined lymphangiomas are not suitable for sclerotherapy. Delivery of drugs for treating sclerosis to endothelial cells can be achieved by electroporation (electrochemotherapy), even for capillary malformations. A congenital, rapidly growing combined lymphangioma of the left cervicofacial region was treated with one session of bleomycin-based electrochemotherapy. Seven months after treatment, the growth-corrected target volume decrease was 63% and the dislocation of the trachea and blood vessels previously observed had ceased. We suggest that bleomycin-based electrochemotherapy is a feasible alternative treatment option for capillary malformations.}, year = {2020}, eissn = {1098-4275}, orcid-numbers = {Dalmády, Szandra/0000-0001-7362-5640; Csoma, Zsanett/0000-0003-0376-9061; Besenyi, Zsuzsanna/0000-0001-9115-9620; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:31538357, title = {Botulinum toxin kezelés az esztétikában [Botulinum toxin treatment in aesthetic medicine]}, url = {https://m2.mtmt.hu/api/publication/31538357}, author = {Bottyán, Krisztina and Gaál, Magdolna}, doi = {10.7188/bvsz.2020.96.3.2}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {96}, unique-id = {31538357}, issn = {0006-7768}, year = {2020}, eissn = {2064-261X}, pages = {128-134} } @article{MTMT:31537868, title = {„3 az 1-ben”: atópia, alopecia és psoriasis előfordulása egy gyermekben. [esetismertetés]}, url = {https://m2.mtmt.hu/api/publication/31537868}, author = {Bottyán, Krisztina and Dalmády, Szandra and Kemény, Lajos and Csoma, Zsanett}, journal-iso = {GYERMEKORVOS TOVÁBBKÉPZÉS}, journal = {GYERMEKORVOS TOVÁBBKÉPZÉS}, volume = {19}, unique-id = {31537868}, issn = {1589-0309}, year = {2020}, pages = {61-64}, orcid-numbers = {Dalmády, Szandra/0000-0001-7362-5640; Kemény, Lajos/0000-0002-2119-9501; Csoma, Zsanett/0000-0003-0376-9061} } @article{MTMT:31094270, title = {Electrochemotherapy for advanced cutaneous angiosarcoma: A European register-based cohort study from the International Network for Sharing Practices of electrochemotherapy (InspECT)}, url = {https://m2.mtmt.hu/api/publication/31094270}, author = {Campana, Luca G. and Kis, Erika and Bottyán, Krisztina and Orlando, Antonio and de Terlizzi, Francesca and Mitsala, Grammatiki and Careri, Rosanna and Curatolo, Pietro and Snoj, Marko and Sersa, Gregor and Valpione, Sara and Quaglino, Pietro and Mowatt, David and Brizio, Matteo and Schepler, Hadrian}, doi = {10.1016/j.ijsu.2019.10.013}, journal-iso = {INT J SURG}, journal = {INTERNATIONAL JOURNAL OF SURGERY}, volume = {72}, unique-id = {31094270}, issn = {1743-9191}, abstract = {Background: Cutaneous angiosarcoma (cAS) is a highly aggressive malignancy that challenges the radicality of surgical treatment. Electrochemotherapy (ECT), a skin-directed treatment based on cytotoxic chemotherapy combined with local electric pulses, may be an intraoperative adjunct and a new opportunity in the therapeutic strategy. This cohort study reports the experience with ECT as an option.Methods: Data on patients with locally-advanced/metastatic cAS who underwent ECT between October 2013 and October 2018 at eight European centres were prospectively submitted to the InspECT (International network for sharing practices of ECT) register. Patients received therapy according to the European Standard Operating Procedures of ECT (ESOPE). Treatment feasibility was assessed based on tumour coverage with electrodes and recorded tissue current; treatment toxicity and tumour response were graded according to CTCAE v5.0 and RECIST v1.1 criteria, respectively; patient-reported outcomes (PRO) were evaluated using a visual analogue score (VAS) for pain, acceptance of retreatment and the EQ-5D questionnaire.Results: We enrolled 20 patients with advanced cAS in the scalp/face (n = 7), breast/trunk (n = 10) or limbs (n = 3). Target tumours (n = 51) had a median size of 2.3 cm (range, 1-20). We administered 24 ECT courses using 1-4 cm treatment safety margin around tumours. In five patients, ECT was combined/sequenced with surgery. Median tissue current was 3 A (range, 1.5-10), tumour margins coverage rate was 75% (15/20 patients). The objective response rate (ORR) was 80% (complete, 40%). Grade-3 toxicity included skin ulceration (15%) and pain (10%), with no significant change of PRO scores. Bleeding control was achieved in 13/14 patients with ulcerated tumours. With a median overall survival of 12.5 months, the local progression-free survival (LPFS) was 10.9 months.Conclusion: ECT produces sustained response rate with minimal side effects and should be considered an option for advanced cAS. Palliative benefits include patient tolerability, local haemostasis and durable local control. Definition of optimal timing, treatment safety margins and combination with surgery need further investigation.}, keywords = {ELECTROCHEMOTHERAPY; Cutaneous angiosarcoma; Skin metastases; Tumour control; Skin-directed therapies}, year = {2019}, eissn = {1743-9159}, pages = {34-42} } @article{MTMT:31068193, title = {Elektrokemoterápiával kezelt betegek életminőségének változása}, url = {https://m2.mtmt.hu/api/publication/31068193}, author = {Rózsa, Petra and Bottyán, Krisztina and Baltás, Eszter and Oláh, Judit Magdolna and Kemény, Lajos and Kis, Erika}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {95}, unique-id = {31068193}, issn = {0006-7768}, year = {2019}, eissn = {2064-261X}, pages = {284-284}, orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:31068085, title = {Cutan angiosarcoma elektrokemoterápiás kezelése az arc és a skalp területén}, url = {https://m2.mtmt.hu/api/publication/31068085}, author = {Bottyán, Krisztina}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {95}, unique-id = {31068085}, issn = {0006-7768}, year = {2019}, eissn = {2064-261X}, pages = {254-254} }