@article{MTMT:34829424,
	title = {Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats},
	url = {https://m2.mtmt.hu/api/publication/34829424},
	author = {Kawamura, T. and Kerepesi, C. and Torma, Ferenc Gergely and Bori, Z. and Zhou, L. and Bakonyi, Péter and Radák, Zsolt},
	doi = {10.1101/2024.04.21.590009},
	journal = {bioRxive},
	volume = {2024},
	unique-id = {34829424},
	year = {2024},
	eissn = {2692-8205},
	orcid-numbers = {Bakonyi, Péter/0000-0002-6120-3384; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34776881,
	title = {Accelerated Fear Extinction by Regular Light-Intensity Exercise: A Possible Role of Hippocampal BDNF-TrkB Signaling},
	url = {https://m2.mtmt.hu/api/publication/34776881},
	author = {OKAMOTO, MASAHIRO and SHIMODA, RYO and AMAYA, YUKI and SOYA, SHINGO and SOYA, MARIKO and KOIZUMI, HIKARU and NAKAMURA, KENGO and HIRAGA, TAICHI and Torma, Ferenc Gergely and SOYA, HIDEAKI},
	doi = {10.1249/MSS.0000000000003312},
	journal-iso = {MED SCI SPORT EXER},
	journal = {MEDICINE AND SCIENCE IN SPORTS AND EXERCISE},
	volume = {56},
	unique-id = {34776881},
	issn = {0195-9131},
	year = {2024},
	eissn = {1530-0315},
	pages = {221-229}
}

@article{MTMT:34693196,
	title = {Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness},
	url = {https://m2.mtmt.hu/api/publication/34693196},
	author = {Torma, Ferenc Gergely and Kerepesi, Csaba and Jókai, Mátyás and Bábszky, Gergely and Koltai, Erika and Ligeti, Balázs and Kalcsevszki, Regina and McGreevy, Kristen M. and Horvath, Steve and Radák, Zsolt},
	doi = {10.1111/acel.14101},
	journal-iso = {AGING CELL},
	journal = {AGING CELL},
	unique-id = {34693196},
	issn = {1474-9718},
	abstract = {Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.},
	year = {2024},
	eissn = {1474-9726},
	orcid-numbers = {Kerepesi, Csaba/0000-0001-9541-246X; Bábszky, Gergely/0000-0002-5939-8434; Koltai, Erika/0000-0002-1370-2955; Horvath, Steve/0000-0002-4110-3589; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34110008,
	title = {Associations between cardiorespiratory fitness and lifestyle‐related factors with DNA methylation‐based ageing clocks in older men: WASEDA 'S Health Study},
	url = {https://m2.mtmt.hu/api/publication/34110008},
	author = {Kawamura, Takuji and Radák, Zsolt and Tabata, Hiroki and Akiyama, Hiroshi and Nakamura, Nobuhiro and Kawakami, Ryoko and Ito, Tomoko and Usui, Chiyoko and Jókai, Mátyás and Torma, Ferenc Gergely and Kim, Hyeon‐Ki and Miyachi, Motohiko and Torii, Suguru and Suzuki, Katsuhiko and Ishii, Kaori and Sakamoto, Shizuo and Oka, Koichiro and Higuchi, Mitsuru and Muraoka, Isao and McGreevy, Kristen M. and Horvath, Steve and Tanisawa, Kumpei},
	doi = {10.1111/acel.13960},
	journal-iso = {AGING CELL},
	journal = {AGING CELL},
	volume = {23},
	unique-id = {34110008},
	issn = {1474-9718},
	abstract = {DNA methylation‐based age estimators (DNAm ageing clocks) are currently one of the most promising biomarkers for predicting biological age. However, the relationships between cardiorespiratory fitness (CRF), measured directly by expiratory gas analysis, and DNAm ageing clocks are largely unknown. We investigated the relationships between CRF and the age‐adjusted value from the residuals of the regression of DNAm ageing clock to chronological age (DNAmAgeAcceleration: DNAmAgeAccel) and attempted to determine the relative contribution of CRF to DNAmAgeAccel in the presence of other lifestyle factors. DNA samples from 144 Japanese men aged 65–72 years were used to appraise first‐ (i.e., DNAmHorvath and DNAmHannum) and second‐ (i.e., DNAmPhenoAge, DNAmGrimAge, and DNAmFitAge) generation DNAm ageing clocks. Various surveys and measurements were conducted, including physical fitness, body composition, blood biochemical parameters, nutrient intake, smoking, alcohol consumption, disease status, sleep status, and chronotype. Both oxygen uptake at ventilatory threshold (VO 2 /kg at VT) and peak oxygen uptake (VO 2 /kg at Peak) showed a significant negative correlation with GrimAgeAccel, even after adjustments for chronological age and smoking and drinking status. Notably, VO 2 /kg at VT and VO 2 /kg at Peak above the reference value were also associated with delayed GrimAgeAccel. Multiple regression analysis showed that calf circumference, serum triglyceride, carbohydrate intake, and smoking status, rather than CRF, contributed more to GrimAgeAccel and FitAgeAccel. In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle‐related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.},
	year = {2024},
	eissn = {1474-9726},
	orcid-numbers = {Kawamura, Takuji/0000-0003-2110-8718; Radák, Zsolt/0000-0003-1297-6804; Akiyama, Hiroshi/0000-0002-9771-1823; Horvath, Steve/0000-0002-4110-3589}
}

@article{MTMT:34776890,
	title = {A possible contribution of the locus coeruleus to arousal enhancement with mild exercise: evidence from pupillometry and neuromelanin imaging},
	url = {https://m2.mtmt.hu/api/publication/34776890},
	author = {Yamazaki, Yudai and Suwabe, Kazuya and Nagano-Saito, Atsuko and Saotome, Kousaku and Kuwamizu, Ryuta and Hiraga, Taichi and Torma, Ferenc Gergely and Suzuki, Kenji and Sankai, Yoshiyuki and Yassa, Michael A and Soya, Hideaki},
	doi = {10.1093/texcom/tgad010},
	journal-iso = {CEREB CORTEX COMMUN},
	journal = {CEREBRAL CORTEX COMMUNICATIONS},
	volume = {4},
	unique-id = {34776890},
	abstract = {Acute mild exercise has been observed to facilitate executive function and memory. A possible underlying mechanism of this is the upregulation of the ascending arousal system, including the catecholaminergic system originating from the locus coeruleus (LC). Prior work indicates that pupil diameter, as an indirect marker of the ascending arousal system, including the LC, increases even with very light-intensity exercise. However, it remains unclear whether the LC directly contributes to exercise-induced pupil-linked arousal. Here, we examined the involvement of the LC in the change in pupil dilation induced by very light-intensity exercise using pupillometry and neuromelanin imaging to assess the LC integrity. A sample of 21 young males performed 10 min of very light-intensity exercise, and we measured changes in the pupil diameters and psychological arousal levels induced by the exercise. Neuromelanin-weighted magnetic resonance imaging scans were also obtained. We observed that pupil diameter and psychological arousal levels increased during very light-intensity exercise, which is consistent with previous findings. Notably, the LC contrast, a marker of LC integrity, predicted the magnitude of pupil dilation and psychological arousal enhancement with exercise. These relationships suggest that the LC-catecholaminergic system is a potential a mechanism for pupil-linked arousal induced by very light-intensity exercise.},
	year = {2023},
	eissn = {2632-7376},
	orcid-numbers = {Suwabe, Kazuya/0000-0001-9286-791X; Yassa, Michael A/0000-0002-8635-1498; Soya, Hideaki/0000-0002-3061-4375}
}

@article{MTMT:34477681,
	title = {Exercise combined with postbiotics treatment results in synergistic improvement of mitochondrial function in the brain of male transgenic mice for Alzheimer’s disease},
	url = {https://m2.mtmt.hu/api/publication/34477681},
	author = {Kolonics, Attila and Bori, Zoltán and Torma, Ferenc Gergely and Ábrahám, Dóra and Fehér, János and Radák, Zsolt},
	doi = {10.1186/s12868-023-00836-x},
	journal-iso = {BMC NEUROSCI},
	journal = {BMC NEUROSCIENCE},
	volume = {24},
	unique-id = {34477681},
	issn = {1471-2202},
	year = {2023},
	eissn = {1471-2202},
	orcid-numbers = {Kolonics, Attila/0000-0003-3990-5336; Bori, Zoltán/0000-0003-1253-060X; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:33866054,
	title = {DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation},
	url = {https://m2.mtmt.hu/api/publication/33866054},
	author = {Jókai, Mátyás and Torma, Ferenc Gergely and McGreevy, Kristen M. and Koltai, Erika and Bori, Zoltán and Bábszky, Gergely and Bakonyi, Péter and Gombos, Zoltán and György, Bernadett and Aczél, Dóra Tímea and Tóth, László and Osváth, Péter and Fridvalszki, Marcell Norbert and Téglás, Tímea and Pósa, Anikó and Kujach, Sylwester and Olek, Robert and Kawamura, Takuji and Seki, Yasuhiro and Suzuki, Katsuhiko and Tanisawa, Kumpei and Goto, Sataro and Kerepesi, Csaba and Boldogh, Istvan and Ba, Xueqing and Davies, Kelvin J. A. and Horvath, Steve and Radák, Zsolt},
	doi = {10.1007/s11357-023-00826-1},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {45},
	unique-id = {33866054},
	issn = {2509-2715},
	abstract = {DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ  = 0.2, p  = 6.4E − 4, r  = 0.19, p  = 1.2E − 3), Jumpmax ( p  = 0.11, p  = 5.5E − 2, r  = 0.13, p  = 2.8E − 2), Gripmax ( ρ  = 0.17, p  = 3.5E − 3, r  = 0.16, p  = 5.6E − 3), and HDL levels ( ρ  = 0.18, p  = 1.95E − 3, r  = 0.19, p  = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p  = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.},
	year = {2023},
	eissn = {2509-2723},
	pages = {2805-2817},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X; Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384; György, Bernadett/0000-0002-3787-7338; Tóth, László/0000-0001-9650-1202; Fridvalszki, Marcell Norbert/0000-0001-9445-9397; Pósa, Anikó/0000-0003-2167-2888; Kerepesi, Csaba/0000-0001-9541-246X; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:33745909,
	title = {Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing},
	url = {https://m2.mtmt.hu/api/publication/33745909},
	author = {Cikes, Domagoj and Elsayad, Kareem and Sezgin, Erdinc and Koltai, Erika and Torma, Ferenc Gergely and Orthofer, Michael and Yarwood, Rebecca and Heinz, Leonhard X. and Sedlyarov, Vitaly and Miranda, Nasser Darwish and Taylor, Adrian and Grapentine, Sophie and al-Murshedi, Fathiya and Abot, Anne and Weidinger, Adelheid and Kutchukian, Candice and Sanchez, Colline and Cronin, Shane J. F. and Novatchkova, Maria and Kavirayani, Anoop and Schuetz, Thomas and Haubner, Bernhard and Haas, Lisa and Hagelkruys, Astrid and Jackowski, Suzanne and Kozlov, Andrey V. and Jacquemond, Vincent and Knauf, Claude and Superti-Furga, Giulio and Rullman, Eric and Gustafsson, Thomas and McDermot, John and Lowe, Martin and Radák, Zsolt and Chamberlain, Jeffrey S. and Bakovic, Marica and Banka, Siddharth and Penninger, Josef M.},
	doi = {10.1038/s42255-023-00791-1},
	journal-iso = {NAT METAB},
	journal = {NATURE METABOLISM},
	volume = {2023},
	unique-id = {33745909},
	year = {2023},
	eissn = {2522-5812},
	pages = {495},
	orcid-numbers = {Cikes, Domagoj/0000-0003-0350-5672; Sezgin, Erdinc/0000-0002-4915-388X; Koltai, Erika/0000-0002-1370-2955; Miranda, Nasser Darwish/0000-0002-8821-8236; Grapentine, Sophie/0000-0003-2307-4363; Weidinger, Adelheid/0000-0002-2759-211X; Kutchukian, Candice/0000-0003-1142-7109; Kavirayani, Anoop/0000-0003-3874-3101; Schuetz, Thomas/0000-0001-9211-8345; Hagelkruys, Astrid/0000-0003-3015-4038; Kozlov, Andrey V./0000-0002-0834-4997; Jacquemond, Vincent/0000-0003-4944-270X; Knauf, Claude/0000-0001-5213-5378; Superti-Furga, Giulio/0000-0002-0570-1768; Rullman, Eric/0000-0003-2854-7262; Radák, Zsolt/0000-0003-1297-6804; Chamberlain, Jeffrey S./0000-0001-5299-0059; Banka, Siddharth/0000-0002-8527-2210; Penninger, Josef M./0000-0002-8194-3777}
}

@article{MTMT:33712726,
	title = {PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing},
	url = {https://m2.mtmt.hu/api/publication/33712726},
	author = {Cikes, Domagoj and Elsayad, Kareem and Sezgin, Erdinc and Koltai, Erika and Torma, Ferenc Gergely and Orthofer, Michael and Yarwood, Rebecca and Heinz, Leonhard X. and Sedlyarov, Vitaly and Miranda, Nasser Darwish and Taylor, Adrian and Grapentine, Sophie and al-Murshedi, Fathiya and Abot, Anne and Weidinger, Adelheid and Kutchukian, Candice and Sanchez, Colline and Cronin, Shane J. F. and Novatchkova, Maria and Kavirayani, Anoop and Schuetz, Thomas and Haubner, Bernhard and Haas, Lisa and Hagelkruys, Astrid and Jackowski, Suzanne and Kozlov, Andrey and Jacquemond, Vincent and Knauf, Claude and Superti-Furga, Giulio and Rullman, Eric and Gustafsson, Thomas and McDermot, John and Lowe, Martin and Radák, Zsolt and Chamberlain, Jeffrey S. and Bakovic, Marica and Banka, Siddharth and Penninger, Josef M.},
	doi = {10.1038/s42255-023-00766-2},
	journal-iso = {NAT METAB},
	journal = {NATURE METABOLISM},
	volume = {5},
	unique-id = {33712726},
	abstract = {Muscle degeneration is the most prevalent cause for frailty and dependency in inherited diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective treatments for muscle diseases, represents an important goal in improving human health. Here, we show that the lipid synthesis enzyme phosphatidylethanolamine cytidyltransferase (PCYT2/ECT) is critical to muscle health. Human deficiency in PCYT2 causes a severe disease with failure to thrive and progressive weakness. pcyt2-mutant zebrafish and muscle-specific Pcyt2-knockout mice recapitulate the participant phenotypes, with failure to thrive, progressive muscle weakness and accelerated ageing. Mechanistically, muscle Pcyt2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure and stability. PCYT2 activity declines in ageing muscles of mice and humans, and adeno-associated virus-based delivery of PCYT2 ameliorates muscle weakness in Pcyt2-knockout and old mice, offering a therapy for individuals with a rare disease and muscle ageing. Thus, PCYT2 plays a fundamental and conserved role in vertebrate muscle health, linking PCYT2 and PCYT2-synthesized lipids to severe muscle dystrophy and ageing.},
	keywords = {disease model; Ageing; Gene Therapy},
	year = {2023},
	eissn = {2522-5812},
	pages = {495-515},
	orcid-numbers = {Sezgin, Erdinc/0000-0002-4915-388X; Koltai, Erika/0000-0002-1370-2955; Miranda, Nasser Darwish/0000-0002-8821-8236; Grapentine, Sophie/0000-0003-2307-4363; Weidinger, Adelheid/0000-0002-2759-211X; Kutchukian, Candice/0000-0003-1142-7109; Kavirayani, Anoop/0000-0003-3874-3101; Schuetz, Thomas/0000-0001-9211-8345; Hagelkruys, Astrid/0000-0003-3015-4038; Kozlov, Andrey/0000-0002-0834-4997; Jacquemond, Vincent/0000-0003-4944-270X; Knauf, Claude/0000-0001-5213-5378; Superti-Furga, Giulio/0000-0002-0570-1768; Rullman, Eric/0000-0003-2854-7262; Radák, Zsolt/0000-0003-1297-6804; Chamberlain, Jeffrey S./0000-0001-5299-0059; Banka, Siddharth/0000-0002-8527-2210; Penninger, Josef M./0000-0002-8194-3777}
}

@article{MTMT:33668410,
	title = {DNAmFitAge: biological age indicator incorporating physical fitness},
	url = {https://m2.mtmt.hu/api/publication/33668410},
	author = {McGreevy, Kristen M. and Radák, Zsolt and Torma, Ferenc Gergely and Jókai, Mátyás and Lu, Ake T. and Belsky, Daniel W. and Binder, Alexandra and Marioni, Riccardo E. and Ferrucci, Luigi and Pośpiech, Ewelina and Branicki, Wojciech and Ossowski, Andrzej and Sitek, Aneta and Spólnicka, Magdalena and Raffield, Laura M. and Reiner, Alex P. and Cox, Simon and Kobor, Michael and Corcoran, David L. and Horvath, Steve},
	doi = {10.18632/aging.204538},
	journal-iso = {AGING-US},
	journal = {AGING-US},
	volume = {15},
	unique-id = {33668410},
	issn = {1945-4589},
	year = {2023},
	eissn = {1945-4589},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804}
}