TY - GEN AU - Schneider-Patkó, Brigitta AU - Kovács, Krisztina AU - Zsoldiné Urbán, Edit AU - Lutz, Zsolt AU - Nyul, Adrienn AU - Fenyvesi, Hajnalka AU - Csontos, Csaba AU - Rauth, Erika AU - Sonnevend, Ágnes TI - Multirezisztens kórokozók szűrése egy egyetemi kórház központi intenzív osztályán PY - 2023 UR - https://m2.mtmt.hu/api/publication/34498239 ID - 34498239 LA - Hungarian DB - MTMT ER - TY - GEN AU - Meszéna, Réka AU - Schneider-Patkó, Brigitta AU - Halda-Kiss, Bernadett AU - Kovács, Krisztina AU - Zsoldiné Urbán, Edit AU - Lutz, Zsolt AU - Nyul, Adrienn AU - Fenyvesi, Hajnalka AU - Urbán, Péter AU - Gyenesei, Attila AU - Tóth, Ákos AU - Pál, Tibor AU - Sonnevend, Ágnes TI - NDM-5 termelő Escherichia coli ST361 megjelenése és terjedése Baranya vármegyében. PY - 2023 UR - https://m2.mtmt.hu/api/publication/34498236 ID - 34498236 LA - Hungarian DB - MTMT ER - TY - CONF AU - Kovács, Krisztina AU - Nyul, Adrienn AU - Lutz, Zsolt AU - Mestyán, Gyula AU - Gajdács, Márió AU - Zsoldiné Urbán, Edit AU - Sonnevend, Ágnes ED - Baráth, Zoltán Lajos ED - Stájer, Anette ED - Madléna, Melinda ED - Matusovits, Danica ED - Kárpáti, Krisztina ED - Gajdács, Márió TI - Anaerob baktériumok által okozott véráramfertőzések epidemiológiája egy egyetemi központban: 5-éves retrospektív, megfigyeléses vizsgálat T2 - Szegedi Fogorvosnapok 2022. Szegedi Fogorvos Találkozó és Tudományos Konferencia, Magyar Gyermekfogászati és Fogszabályozási Társaság IX. Tóth Pál Vándorgyűlés PB - Szegedi Tudományegyetem Fogorvostudományi Kar C1 - Szeged SN - 9786150161211 PY - 2022 SP - 40 EP - 41 PG - 2 UR - https://m2.mtmt.hu/api/publication/33118493 ID - 33118493 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Krisztina AU - Nyul, Adrienn AU - Lutz, Zsolt AU - Mestyán, Gyula AU - Gajdács, Márió AU - Zsoldiné Urbán, Edit AU - Sonnevend, Ágnes TI - Incidence and Clinical Characteristics of Anaerobic Bacteremia at a University Hospital in Hungary: A 5-Year Retrospective Observational Study JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 11 PY - 2022 IS - 10 PG - 10 SN - 2079-6382 DO - 10.3390/antibiotics11101326 UR - https://m2.mtmt.hu/api/publication/33116337 ID - 33116337 LA - English DB - MTMT ER - TY - JOUR AU - Pertics, Botond Zsombor AU - Cox, Alysia AU - Nyul, Adrienn AU - Szamek, Nóra AU - Kovács, Tamás AU - Schneider, György TI - Isolation and Characterization of a Novel Lytic Bacteriophage against the K2 Capsule-Expressing Hypervirulent Klebsiella pneumoniae Strain 52145, and Identification of Its Functional Depolymerase JF - MICROORGANISMS J2 - MICROORGANISMS VL - 9 PY - 2021 IS - 3 PG - 20 SN - 2076-2607 DO - 10.3390/microorganisms9030650 UR - https://m2.mtmt.hu/api/publication/31926267 ID - 31926267 AB - Klebsiella pneumoniae is among the leading bacteria that cause nosocomial infections. The capsule of this Gram-negative bacterium is a dominant virulence factor, with a prominent role in defense and biofilm formation. Bacteriophages, which are specific for one bacterial strain and its capsule type, can evoke the lysis of bacterial cells, aided by polysaccharide depolymerase enzymes. In this study, we isolated and characterized a bacteriophage against the nosocomial K. pneumoniae 52145 strain with K2 capsular serotype. The phage showed a narrow host range and stable lytic activity, even when exposed to different temperatures or detergents. Preventive effect of the phage in a nasal colonization model was investigated in vivo. Phlyogenetic analysis showed that the newly isolated Klebsiella phage B1 belongs to the Webervirus genus in Drexlerviridae family. We identified the location of the capsule depolymerase gene of the new phage, which was amplified, cloned, expressed, and purified. The efficacy of the recombinant B1dep depolymerase was tested by spotting on K. pneumoniae strains and it was confirmed that the extract lowers the thickness of the bacterium lawn as it degrades the protective capsule on bacterial cells. As K. pneumoniae strains possessing the K2 serotype have epidemiological importance, the B1 phage and its depolymerase are promising candidates for use as possible antimicrobial agents. LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Németh, Anita AU - Knausz, Márta AU - Barrak, Ibrahim Ádám AU - Stájer, Anette AU - Mestyán, Gyula AU - Melegh, Szilvia Zsóka AU - Nyul, Adrienn AU - Tóth, Ákos AU - Ágoston, Zsuzsanna AU - Zsoldiné Urbán, Edit TI - Streptococcus suis: An Underestimated Emerging Pathogen in Hungary? JF - MICROORGANISMS J2 - MICROORGANISMS VL - 8 PY - 2020 IS - 9 PG - 18 SN - 2076-2607 DO - 10.3390/microorganisms8091292 UR - https://m2.mtmt.hu/api/publication/31408959 ID - 31408959 N1 - Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6., Szeged, 6720, Hungary Institute of Medical Microbiology, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4., Budapest, 1089, Hungary Microbiology Laboratory, Petz Aladár County Teaching Hospital, Vasvári Pál utca 2–4., Győr, 9023, Hungary Department of Prosthodontics, Faculty of Dentistry, University of Szeged, Tiszta Lajos körút 62–64., Szeged, 6720, Hungary Department of Periodontology, Faculty of Dentistry, University of Szeged, Tiszta Lajos körút 62–64, Szeged, 6720, Hungary Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Szigeti út 12., Pécs, 7624, Hungary Department of Bacteriology, Mycology and Parasitology, National Public Health Center, Albert Flórián út 2–6., Budapest, 1097, Hungary Department of Anaesthesiology and Intensive Therapy, Faculty of Medicine, University of Szeged, Semmelweis utca 6., Szeged, 6725, Hungary Institute of Translational Medicine, Faculty of Medicine, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary Cited By :14 Export Date: 7 September 2023 Correspondence Address: Gajdács, M.; Department of Pharmacodynamics and Biopharmacy, Eötvös utca 6., Hungary; email: gajdacs.mario@pharm.u-szeged.hu Correspondence Address: Gajdács, M.; Institute of Medical Microbiology, Nagyvárad tér 4., Hungary; email: gajdacs.mario@pharm.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Sipos, Dávid AU - Nyul, Adrienn AU - Kovács, Krisztina AU - Alizadeh, Hussain AU - Péterfi, Zoltán TI - Kórokozóspektrum egy hematológiai osztályon JF - HEMATOLÓGIA-TRANSZFUZIOLÓGIA J2 - HEMATOLÓGIA-TRANSZFUZIOLÓGIA VL - 52 PY - 2019 IS - 1 SP - 57 EP - 61 PG - 5 SN - 1786-5913 DO - 10.1556/2068.2019.52.1.11 UR - https://m2.mtmt.hu/api/publication/30637910 ID - 30637910 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Melegh, Szilvia Zsóka AU - Nyul, Adrienn AU - Kovács, Krisztina AU - Kovács, Tamás AU - Ghidán, Ágoston AU - Dombrádi, Zsuzsanna Rita AU - Szabó, Judit AU - Berta, B AU - Lesinszki, V AU - Paszti, J AU - Tóth, Ákos AU - Mestyán, Gyula TI - Dissemination of VanA-Type Enterococcus faecium Isolates in Hungary. JF - MICROBIAL DRUG RESISTANCE J2 - MICROB DRUG RESIST VL - 24 PY - 2018 IS - 9 SP - 1376 EP - 1390 PG - 15 SN - 1076-6294 DO - 10.1089/mdr.2017.0296 UR - https://m2.mtmt.hu/api/publication/3371681 ID - 3371681 N1 - Department of Medical Microbiology and Immunology, University of Pécs, 12 Szigeti Street, Pécs, H-7624, Hungary Enviroinvest Co, Pécs, Hungary Department of Medical Microbiology, Semmelweis University, Budapest, Hungary Department of Medical Microbiology, University of Debrecen, Debrecen, Hungary National Public Health Institute, Budapest, Hungary Cited By :3 Export Date: 7 September 2023 CODEN: MDREF Correspondence Address: Melegh, S.; Department of Medical Microbiology and Immunology, 12 Szigeti Street, Hungary; email: melegh.szilvia@pte.hu AB - Although vanA carrying Enterococcus faecium human clinical isolates have been rarely found in Hungary before 2012, they have been detected in continuously increasing numbers since then. To identify factors associated with their dissemination, we investigated the clonal relatedness and plasmids of 30 vanA carrying E. faecium isolates originating from different Hungarian healthcare institutions from 2012 to 2014. Molecular typing of the isolates (n = 30) was performed with pulsed-field gel electrophoresis (PFGE), multilocus sequence typing, Tn1546 polymerase chain reaction mapping, plasmid restriction fragment length polymorphism analysis, and sequencing. A single Tn1546 variant was detected in all of the isolates. It harbored IS1251 in the vanS-vanH intergenic region, had an entire deletion of the transposase gene and a partial deletion of the resolvase gene, and was located on a pRUM-like plasmid. Based on PFGE, the isolates could be grouped into 13 pulsotypes. Representative strains of these pulsotypes belonged to ST17, ST18, ST80, ST117, and ST203, which are known to be part of the hospital-adapted clades. The increase in the number of vanA carrying E. faecium clinical isolates in Hungary could be explained by the dissemination of pRUM-like vancomycin resistance plasmids in hospital-adapted clonal lineages. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Krisztina AU - Nyul, Adrienn AU - Mestyan, G AU - Melegh, Szilvia Zsóka AU - Fenyvesi, H AU - Jakab, G AU - Szabo, H AU - Janvari, L AU - Damjanova, I AU - Tóth, Ákos TI - Emergence and interhospital spread of OXA-48-producing Klebsiella pneumoniae ST395 clone in Western Hungary. JF - INFECTIOUS DISEASES J2 - INFECT DIS-NOR VL - 49 PY - 2017 IS - 3 SP - 231 EP - 233 PG - 3 SN - 2374-4235 DO - 10.1080/23744235.2016.1207252 UR - https://m2.mtmt.hu/api/publication/3097563 ID - 3097563 N1 - Letter to the Editor LA - English DB - MTMT ER - TY - JOUR AU - Melegh, Szilvia Zsóka AU - Kovács, Krisztina AU - Gám, T AU - Nyul, Adrienn AU - Patkó, B AU - Tóth, Ákos AU - Damjanova, I AU - Mestyán, G TI - Emergence of VIM-4 metallo-β-lactamase-producing Klebsiella pneumoniae ST15 clone in the Clinical Centre University of Pécs, Hungary JF - CLINICAL MICROBIOLOGY AND INFECTION J2 - CLIN MICROBIOL INFEC VL - 20 PY - 2014 IS - 1 SP - O27 EP - O29 SN - 1198-743X DO - 10.1111/1469-0691.12293 UR - https://m2.mtmt.hu/api/publication/2540197 ID - 2540197 N1 - Research Note LA - English DB - MTMT ER -