@article{MTMT:36919961,
	title = {UHPLC-MS-Based Analysis of Fluvoxamine in Rabbit Aqueous Humour and Serum: Method Development and Validation},
	url = {https://m2.mtmt.hu/api/publication/36919961},
	author = {Guba, Andrea and Takácsi-Nagy, Anna and Das, Sourav and Szokol, Bálint and Medveczki, Tímea and Vajna, Márton Antal and Kalló, Gergő and Fekete, Andrea and Hodrea, Judit and Csősz, Éva},
	doi = {10.3390/ph19020260},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {19},
	unique-id = {36919961},
	abstract = {Background/Objectives: Fluvoxamine (FLU) is a selective serotonin reuptake inhibitor and one of the most potent agonists of the sigma-1 receptor. Emerging evidence shows that FLU exerts protective effects in multiple organs, making it a promising candidate for topical ocular therapy. Developing an FLU eyedrop for glaucoma can address a significant treatment gap with potentially fewer side effects compared with conventional therapies. To optimise formulation development, precise quantification of FLU in ocular compartments such as aqueous humour, as well as systemic circulation, is essential to characterise drug absorption, ocular bioavailability, and safety. Methods: We developed and validated a UHPLC-MS method for FLU detection in aqueous humour and serum using simple sample preparation steps. Results: The 11-min-long reverse phase chromatography followed by SRM-based mass spectrometry detection provides a highly selective and sensitive FLU detection method. Our method was proved to be linear in the 0.0625–1.5 µg/mL range and was validated according to the EMA guidelines. Conclusions: The simplicity of sample preparation, the tolerable matrix effects, and the favourable detection parameters provide a robust tool for preclinical pharmacokinetic and pharmacodynamic studies of FLU’s ocular protective effects.},
	year = {2026},
	eissn = {1424-8247},
	orcid-numbers = {Guba, Andrea/0009-0009-0535-2025; Takácsi-Nagy, Anna/0000-0002-4756-9136; Das, Sourav/0000-0002-3753-9689; Szokol, Bálint/0000-0002-0196-6072; Medveczki, Tímea/0000-0002-3618-6690; Vajna, Márton Antal/0000-0001-5280-7533; Kalló, Gergő/0000-0002-5732-8758; Fekete, Andrea/0000-0002-0210-153X; Hodrea, Judit/0000-0002-6388-4021; Csősz, Éva/0000-0003-4373-2175}
}

@CONFERENCE{MTMT:36094044,
	title = {Új hatásmechanizmusú anti-glaukómás szemcsepp preklinikai fejlesztése},
	url = {https://m2.mtmt.hu/api/publication/36094044},
	author = {Medveczki, Tímea and Hodrea, Judit and Tran, Ngoc Minh and Takácsi-Nagy, Anna and Lakat, Tamás and Szokol, Bálint and Kovács, Illés and Török, György and Fekete, Andrea},
	booktitle = {Selye EKÖP Tudományos Fórum 2025},
	unique-id = {36094044},
	year = {2025},
	pages = {26-27},
	orcid-numbers = {Medveczki, Tímea/0000-0002-3618-6690; Hodrea, Judit/0000-0002-6388-4021; Tran, Ngoc Minh/0000-0002-6925-0871; Lakat, Tamás/0000-0001-9769-3728; Kovács, Illés/0000-0001-5763-0482; Fekete, Andrea/0000-0002-0210-153X}
}

@misc{MTMT:36094470,
	title = {Fluvoxamine, a Sigma-1 receptor agonist, is a new and innovative therapy for glaucoma},
	url = {https://m2.mtmt.hu/api/publication/36094470},
	author = {Medveczki, Tímea and Hodrea, Judit and Tran, Ngoc Minh and Anna, Takacsi-Nagy and Tóth, Ákos Roland and Lakat, Tamás and Őrfi, László and Szokol, Bálint and Kovács, Illés and Eva, Csosz and Gyorgy, Torok and Szabó, Attila and Fekete, Andrea},
	unique-id = {36094470},
	year = {2025},
	orcid-numbers = {Medveczki, Tímea/0000-0002-3618-6690; Hodrea, Judit/0000-0002-6388-4021; Tran, Ngoc Minh/0000-0002-6925-0871; Tóth, Ákos Roland/0000-0002-2516-0508; Lakat, Tamás/0000-0001-9769-3728; Őrfi, László/0000-0001-6149-2385; Kovács, Illés/0000-0001-5763-0482; Szabó, Attila/0000-0001-7321-9861; Fekete, Andrea/0000-0002-0210-153X}
}

@CONFERENCE{MTMT:36226133,
	title = {A newly developed fluvoxamine eyedrop for glaucoma treatment},
	url = {https://m2.mtmt.hu/api/publication/36226133},
	author = {Hodrea, Judit and Medveczki, Tímea and Lakat, Tamás and Tran, Ngoc Minh and Tóth, Ákos Roland and Takacsi-Nagy, A and Szokol, Bálint and Török, György and Szabó, Attila and Kovács, Illés and Prokai, L and Fekete, Andrea},
	booktitle = {5th European Symposium,1st Meeting of SIGMA-1 EUROPE - Physiopathology of Sigma-1 Receptors},
	unique-id = {36226133},
	year = {2025},
	pages = {46-46},
	orcid-numbers = {Hodrea, Judit/0000-0002-6388-4021; Medveczki, Tímea/0000-0002-3618-6690; Lakat, Tamás/0000-0001-9769-3728; Tran, Ngoc Minh/0000-0002-6925-0871; Tóth, Ákos Roland/0000-0002-2516-0508; Török, György/0000-0001-7616-5782; Szabó, Attila/0000-0001-7321-9861; Kovács, Illés/0000-0001-5763-0482; Fekete, Andrea/0000-0002-0210-153X}
}

@CONFERENCE{MTMT:36226170,
	title = {Age-specific anti-glaucomatous effect of a Fluvoxamine-containing eye drop},
	url = {https://m2.mtmt.hu/api/publication/36226170},
	author = {Medveczki, Tímea and Hodrea, Judit and Tran, Ngoc Minh and Takacsi-Nagy, A and Lakat, Tamás and Tóth, Ákos Roland and Szokol, Bálint and Kovács, Illés and Török, György and Szabó, Attila and Fekete, Andrea},
	booktitle = {5th European Symposium,1st Meeting of SIGMA-1 EUROPE - Physiopathology of Sigma-1 Receptors},
	unique-id = {36226170},
	year = {2025},
	pages = {94-94},
	orcid-numbers = {Medveczki, Tímea/0000-0002-3618-6690; Hodrea, Judit/0000-0002-6388-4021; Tran, Ngoc Minh/0000-0002-6925-0871; Lakat, Tamás/0000-0001-9769-3728; Tóth, Ákos Roland/0000-0002-2516-0508; Kovács, Illés/0000-0001-5763-0482; Török, György/0000-0001-7616-5782; Szabó, Attila/0000-0001-7321-9861; Fekete, Andrea/0000-0002-0210-153X}
}

@CONFERENCE{MTMT:36226195,
	title = {Protective effects of a novel Sigma-1 receptor agonist in renal ischemia/reperfusion injury},
	url = {https://m2.mtmt.hu/api/publication/36226195},
	author = {Tóth, Ákos Roland and Lakat, Tamás and Budai, András and Szokol, Bálint and Őrfi, László and Szabó, Attila and Fekete, Andrea and Hosszú, Ádám},
	booktitle = {5th European Symposium,1st Meeting of SIGMA-1 EUROPE - Physiopathology of Sigma-1 Receptors},
	unique-id = {36226195},
	year = {2025},
	pages = {98-98},
	orcid-numbers = {Tóth, Ákos Roland/0000-0002-2516-0508; Lakat, Tamás/0000-0001-9769-3728; Budai, András/0000-0002-4634-2140; Őrfi, László/0000-0001-6149-2385; Szabó, Attila/0000-0001-7321-9861; Fekete, Andrea/0000-0002-0210-153X; Hosszú, Ádám/0000-0002-8415-5637}
}

@article{MTMT:36370245,
	title = {Új Sigma-1 receptor agonista kezelés protektív hatású a renális iszkémia/reperfúzós károsodással szemben},
	url = {https://m2.mtmt.hu/api/publication/36370245},
	author = {Tóth, Ákos Roland and Lakat, Tamás and Budai, András and Szokol, Bálint and Őrfi, László and Kerkó, Marcell and Wagner, J. László and Szabó, Attila and Fekete, Andrea and Hosszú, Ádám},
	journal-iso = {HYPERTONIA NEPHROLOGIA},
	journal = {HYPERTONIA ÉS NEPHROLOGIA},
	volume = {29},
	unique-id = {36370245},
	issn = {1418-477X},
	year = {2025},
	eissn = {2498-6259},
	pages = {47-48},
	orcid-numbers = {Tóth, Ákos Roland/0000-0002-2516-0508; Lakat, Tamás/0000-0001-9769-3728; Őrfi, László/0000-0001-6149-2385; Szabó, Attila/0000-0001-7321-9861; Fekete, Andrea/0000-0002-0210-153X; Hosszú, Ádám/0000-0002-8415-5637}
}

@{MTMT:36384948,
	title = {IN VIVO TARGETING OF THERAPEUTIC MOLECULES TO THE RETINA VIA THE OPTICAL SYSTEM OF THE EYE},
	url = {https://m2.mtmt.hu/api/publication/36384948},
	author = {KOVÁCS, KRISZTIÁN ANDRÁS and KALESNYKAS, GIEDRIUS and Szokol, Bálint and ILLYÉS, ESZTER] and SZABADKAI, ISTVÁN},
	unique-id = {36384948},
	year = {2025}
}

@{MTMT:36435731,
	title = {NOVEL PHOTOINDUCIBLE KINASE INHIBITORS FOR TREATING PROLIFERATIVE AND VASOPROLIFERATIVE DISEASES},
	url = {https://m2.mtmt.hu/api/publication/36435731},
	author = {Krisztián, András KOVÁCS and Giedrius, KALESNYKAS and Szokol, Bálint and Eszter, ILLYÉS and István, SZABADKAI},
	unique-id = {36435731},
	year = {2025}
}

@article{MTMT:36437689,
	title = {Novel Sigma-1 receptor agonist alleviates renal ischemic injury by targeting apoptotic and inflammatory pathways},
	url = {https://m2.mtmt.hu/api/publication/36437689},
	author = {Tóth, Ákos Roland and Lakat, Tamás and Budai, András and Kállay, Hanga and Szokol, Bálint and Wágner, László József and Őrfi, László and Kreko, Marcell and Szabó, Attila and Fekete, Andrea and Hosszú, Ádám},
	doi = {10.1038/s41598-025-23459-0},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {15},
	unique-id = {36437689},
	abstract = {Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury, yet its mechanisms remain unclear, and effective treatments are lacking. We previously showed that the Sigma-1 receptor (S1R) agonist fluvoxamine protects against IRI and IRI-induced graft injury during transplantation. Here, we developed a novel compound, 'VCC904125', with potent S1R affinity and minimal blood-brain barrier penetration to mitigate renal IRI without psychoactive side effects. Mice were treated with VCC904125 before clamping the left renal pedicles, followed by contralateral nephrectomy. VCC904125 markedly alleviated BUN and serum creatinine levels, KIM-1 and NGAL expression, and structural damage at both 24 and 48 h after reperfusion. S1R activation by VCC904125 targets key pathways underlying IRI, including apoptosis and inflammation. VCC904125 treatment impeded the apoptotic p53-Bax pathway and influenced CaMKII-NF-κB signaling, resulting in diminished proinflammatory cytokine expression. In the ex vivo model, kidneys were perfused and stored in an HTK preservation solution supplemented with VCC904125 to simulate cold storage conditions before transplantation. VCC904125 ameliorated structural injury profoundly after cold ischemia. Taken together, S1R activation by VCC904125 decreases renal IRI via ameliorating apoptotic and inflammatory pathways. These results highlight the therapeutic promise of S1R activation in mitigating cold and warm ischemia and improving transplant outcomes.},
	keywords = {Inflammation; STIMULATION; APOPTOSIS; PROTECTS; ISCHEMIA/REPERFUSION INJURY; FACTOR-KAPPA-B; Fluvoxamine; p53; Sigma-1 receptor; RENAL ISCHEMIA/REPERFUSION INJURY},
	year = {2025},
	eissn = {2045-2322},
	orcid-numbers = {Tóth, Ákos Roland/0000-0002-2516-0508; Lakat, Tamás/0000-0001-9769-3728; Budai, András/0000-0002-4634-2140; Wágner, László József/0000-0001-6806-4076; Őrfi, László/0000-0001-6149-2385; Szabó, Attila/0000-0001-7321-9861; Fekete, Andrea/0000-0002-0210-153X; Hosszú, Ádám/0000-0002-8415-5637}
}