@article{MTMT:33615942,
	title = {Anti-glutamatergic effects of three lignan compounds: arctigenin, matairesinol and trachelogenin - An ex vivo study on rat brain slices},
	url = {https://m2.mtmt.hu/api/publication/33615942},
	author = {Koech, Peter Kiplang'at and Jócsák, Gergely and Boldizsár, Imre and Moldován, Kinga Réka and Borbély, Sándor and Világi, Ildikó and Dobolyi, Árpád and Varró, Petra},
	doi = {10.1055/a-2005-5497},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {89},
	unique-id = {33615942},
	issn = {0032-0943},
	abstract = {Arctigenin is a bioactive dibenzylbutyrolactone-type lignan exhibiting various pharmacological activities. The neuroprotective effects of arctigenin were demonstrated to be mediated via inhibition of AMPA and KA type glutamate receptors in the somatosensory cortex of the rat brain. The aim of this study was to compare the effects of arctigenin with matairesinol and trachelogenin on synaptic activity in ex vivo rat brain slices. Arctigenin, matairesinol and trachelogenin were isolated from Arctium lappa, Centaurea scabiosa and Cirsium arvense, respectively, and applied on brain slices via perfusion medium at the concentration range of 0.5-40 µM. The effects of the lignans were examined in the CA1 hippocampus and the somatosensory cortex by recording electrically evoked field potentials. Arctigenin and trachelogenin caused a significant dose-dependent decrease in the amplitude of hippocampal population spikes (POPS) and the slope of excitatory postsynaptic potentials (EPSPs), whereas matairesinol (1 µM and 10 µM) decreased EPSP slope but had no effect on POPS amplitude. Trachelogenin effect (0.5 µM, 10 µM, 20 µM) was comparable to arctigenin (1 µM, 20 µM, 40 µM) (p ˃ 0.05). In the neocortex, arctigenin (10 µM, 20 µM) and trachelogenin (10 µM) significantly decreased the amplitude of evoked potential early component, while matairesinol (1 µM and 10 µM) had no significant effect (p>0.05). The results suggest that trachelogenin and arctigenin act via inhibition of AMPA and KA receptors in the brain and trachelogenin has a higher potency than arctigenin. Thus, trachelogenin and arctigenin could serve as lead compounds in the development of neuroprotective drugs.},
	keywords = {hippocampus; ASTERACEAE; GLUTAMATE RECEPTORS; Lignans; Cirsium arvense; neocortex; neuronal excitability; Arctium lappa; Centaurea scabiosa},
	year = {2022},
	eissn = {1439-0221},
	pages = {879-889},
	orcid-numbers = {Boldizsár, Imre/0000-0001-7852-8364; Moldován, Kinga Réka/0000-0001-5734-8110; Borbély, Sándor/0000-0002-5025-1778; Világi, Ildikó/0000-0002-1301-6568; Dobolyi, Árpád/0000-0003-0397-2991; Varró, Petra/0000-0001-7945-2672}
}

@article{MTMT:32475357,
	title = {Differential production of interleukin‐6 and tumor necrosis factor‐α in primary rat astrocyte cultures using two distinct methods of microglia elimination},
	url = {https://m2.mtmt.hu/api/publication/32475357},
	author = {Bárány, Zoltán Balázs and Tóth, István and Jócsák, Gergely and Frenyó V., László and Bartha, Tibor and Sterczer, Ágnes and Kiss, Dávid Sándor},
	doi = {10.1111/cen3.12650},
	journal-iso = {CLIN EXP NEUROIMMUNOLOGY},
	journal = {CLINICAL AND EXPERIMENTAL NEUROIMMUNOLOGY},
	volume = {12},
	unique-id = {32475357},
	issn = {1759-1961},
	year = {2021},
	pages = {192-201},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}

@article{MTMT:31801333,
	title = {A neuroinflammáció kórfolyamata és egyes terápiás vonatkozásai : Irodalmi összefoglaló},
	url = {https://m2.mtmt.hu/api/publication/31801333},
	author = {Kerek, Ádám and Bárány, Zoltán Balázs and Sterczer, Ágnes and Jócsák, Gergely},
	journal-iso = {MAGY ALLATORVOSOK},
	journal = {MAGYAR ÁLLATORVOSOK LAPJA},
	volume = {142},
	unique-id = {31801333},
	issn = {0025-004X},
	year = {2020},
	pages = {755-767}
}

@article{MTMT:31399182,
	title = {Functional Aspects of Hypothalamic Asymmetry},
	url = {https://m2.mtmt.hu/api/publication/31399182},
	author = {Kiss, Dávid Sándor and Tóth, István and Jócsák, Gergely and Bárány, Zoltán Balázs and Bartha, Tibor and Frenyó V., László and Horvath, Tamas L. and Zsarnovszky, Attila},
	doi = {10.3390/brainsci10060389},
	journal-iso = {BRAIN SCI},
	journal = {BRAIN SCIENCES},
	volume = {10},
	unique-id = {31399182},
	abstract = {Anatomically, the brain is a symmetric structure. However, growing evidence suggests that certain higher brain functions are regulated by only one of the otherwise duplicated (and symmetric) brain halves. Hemispheric specialization correlates with phylogeny supporting intellectual evolution by providing an ergonomic way of brain processing. The more complex the task, the higher are the benefits of the functional lateralization (all higher functions show some degree of lateralized task sharing). Functional asymmetry has been broadly studied in several brain areas with mirrored halves, such as the telencephalon, hippocampus, etc. Despite its paired structure, the hypothalamus has been generally considered as a functionally unpaired unit, nonetheless the regulation of a vast number of strongly interrelated homeostatic processes are attributed to this relatively small brain region. In this review, we collected all available knowledge supporting the hypothesis that a functional lateralization of the hypothalamus exists. We collected and discussed findings from previous studies that have demonstrated lateralized hypothalamic control of the reproductive functions and energy expenditure. Also, sporadic data claims the existence of a partial functional asymmetry in the regulation of the circadian rhythm, body temperature and circulatory functions. This hitherto neglected data highlights the likely high-level ergonomics provided by such functional asymmetry.},
	year = {2020},
	eissn = {2076-3425},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}

@article{MTMT:31260011,
	title = {Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States},
	url = {https://m2.mtmt.hu/api/publication/31260011},
	author = {Kiss, Dávid Sándor and Tóth, István and Jócsák, Gergely and Bartha, Tibor and Frenyó V., László and Bárány, Zoltán Balázs and Horváth, Tamás and Zsarnovszky, Attila},
	doi = {10.1007/s43032-019-00131-3},
	journal-iso = {REPROD SCI},
	journal = {REPRODUCTIVE SCIENCES},
	volume = {27},
	unique-id = {31260011},
	issn = {1933-7191},
	year = {2020},
	eissn = {1933-7205},
	pages = {1197-1205},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}

@article{MTMT:31194217,
	title = {Endocrine Disruptors Induced Distinct Expression of Thyroid and Estrogen Receptors in Rat versus Mouse Primary Cerebellar Cell Cultures},
	url = {https://m2.mtmt.hu/api/publication/31194217},
	author = {Jócsák, Gergely and Ioja, Enikő and Kiss, Dávid Sándor and Tóth, István and Bárány, Zoltán Balázs and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila},
	doi = {10.3390/brainsci9120359},
	journal-iso = {BRAIN SCI},
	journal = {BRAIN SCIENCES},
	volume = {9},
	unique-id = {31194217},
	year = {2019},
	eissn = {2076-3425},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}

@{MTMT:30659394,
	title = {Az oxidatív stressz és a tumor nekrózis faktor alfa (TNF-alfa) -termelés vizsgálata hepatikus encephalopathiában},
	url = {https://m2.mtmt.hu/api/publication/30659394},
	author = {Bárány, Zoltán Balázs and Kiss, Dávid Sándor and Tóth, István and Jócsák, Gergely and Frenyó V., László and Bartha, Tibor Zsarnovszky Attila and Sterczer, Ágnes},
	booktitle = {Akadémiai beszámolók},
	unique-id = {30659394},
	year = {2019},
	pages = {8-9},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}

@techreport{MTMT:30412858,
	title = {Az endokrin diszruptorkezelés indukálta ösztrogén- és pajzsmirigyhormon receptor expressziós változások összehasonlítása patkány és egér modellben},
	url = {https://m2.mtmt.hu/api/publication/30412858},
	author = {Jócsák, Gergely and Kiss, Dávid Sándor and Tóth, István and Bárány, Zoltán Balázs and Frenyó V., László and Bartha, Tibor and Zsarnovszky, Attila},
	unique-id = {30412858},
	year = {2019},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}

@techreport{MTMT:30412856,
	title = {Az oxidatív stressz és a tumor nekrózis faktor alfa (TNF-α)-termelés vizsgálata hepaticus encephalopathiaban},
	url = {https://m2.mtmt.hu/api/publication/30412856},
	author = {Bárány, Zoltán Balázs and Kiss, Dávid Sándor and Tóth, István and Jócsák, Gergely and Frenyó V., László and Bartha, Tibor and Zsarnovszky, Attila and Sterczer, Ágnes},
	unique-id = {30412856},
	year = {2019},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}

@article{MTMT:30412849,
	title = {Examination of the oxidative stress and the tumor necrosis factor (tnf)-α-production in hepatic encephalopathy},
	url = {https://m2.mtmt.hu/api/publication/30412849},
	author = {Bárány, Zoltán Balázs and Kiss, Dávid Sándor and Tóth, István and Jócsák, Gergely and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila and Sterczer, Ágnes},
	journal-iso = {GLIA},
	journal = {GLIA},
	volume = {67},
	unique-id = {30412849},
	issn = {0894-1491},
	year = {2019},
	eissn = {1098-1136},
	pages = {E549-E550},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}