TY - JOUR AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, Mihály AU - Perlaki, Gábor AU - Pál, József AU - Steier, Roy AU - Lénárd, László AU - Karádi, Zoltán György TI - Identifying non-toxic doses of manganese for manganese-enhanced magnetic resonance imaging to map brain areas activated by operant behavior in trained rats. JF - MAGNETIC RESONANCE IMAGING J2 - MAGN RESON IMAGING VL - 37 PY - 2017 SP - 122 EP - 133 PG - 12 SN - 0730-725X DO - 10.1016/j.mri.2016.11.017 UR - https://m2.mtmt.hu/api/publication/3148677 ID - 3148677 N1 - Case report Funding Agency and Grant Number: PTE [AOK-KA 2013/34039/1]; [SROP-4.2.2/B-10/1-2010-0029]; [SCROP-4.2.1.B-10/2/KONV-2010-002] Funding text: Authors wish to thank Attila Schwartz for his technical support. We would like to thank Mrs. Iren Takacs, Mrs. Erzsebet Kovacs and Ildiko Fuchs for their technical assistance. This study was supported by SROP-4.2.2/B-10/1-2010-0029, SCROP-4.2.1.B-10/2/KONV-2010-002 and by PTE AOK-KA 2013/34039/1. AB - Manganese-enhanced magnetic resonance imaging (MEMRI) offers unique advantages such as studying brain activation in freely moving rats, but its usefulness has not been previously evaluated during operant behavior training. Manganese in a form of MnCl2, at a dose of 20mg/kg, was intraperitoneally infused. The administration was repeated and separated by 24h to reach the dose of 40mg/kg or 60mg/kg, respectively. Hepatotoxicity of the MnCl2 was evaluated by determining serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, albumin and protein levels. Neurological examination was also carried out. The animals were tested in visual cue discriminated operant task. Imaging was performed using a 3T clinical MR scanner. T1 values were determined before and after MnCl2 administrations. Manganese-enhanced images of each animal were subtracted from their baseline images to calculate decrease in the T1 value (DeltaT1) voxel by voxel. The subtracted T1 maps of trained animals performing visual cue discriminated operant task, and those of naive rats were compared. The dose of 60mg/kg MnCl2 showed hepatotoxic effect, but even these animals did not exhibit neurological symptoms. The dose of 20 and 40mg/kg MnCl2 increased the number of omissions and did not affect the accuracy of performing the visual cue discriminated operant task. Using the accumulated dose of 40mg/kg, voxels with a significant enhanced DeltaT1 value were detected in the following brain areas of the visual cue discriminated operant behavior performed animals compared to those in the controls: the visual, somatosensory, motor and premotor cortices, the insula, cingulate, ectorhinal, entorhinal, perirhinal and piriform cortices, hippocampus, amygdala with amygdalohippocampal areas, dorsal striatum, nucleus accumbens core, substantia nigra, and retrorubral field. In conclusion, the MEMRI proved to be a reliable method to accomplish brain activity mapping in correlation with the operant behavior of freely moving rodents. LA - English DB - MTMT ER - TY - CONF AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, Mihály AU - Pál, József AU - Perlaki, Gábor AU - Karádi, Zoltán György AU - Lénárd, László TI - Application of activation induced manganese-enhanced magnetic resonance imaging (MEMRI) for mapping of brain structures involved in operant responses in rats. T2 - FAMÉ 2016 PY - 2016 UR - https://m2.mtmt.hu/api/publication/3079594 ID - 3079594 LA - English DB - MTMT ER - TY - JOUR AU - Perlaki, Gábor AU - Orsi, Gergely AU - Schwarcz, Attila AU - BODI, P AU - Plózer, Enikő AU - BICZO, K AU - Aradi, Mihály AU - Dóczi, Tamás Péter AU - Komoly, Sámuel AU - Hejjel, László AU - Kovács, Norbert AU - Janszky, József Vladimír TI - Pain-Related Autonomic Response Is Modulated By The Medial Prefrontal Cortex: An ECG-FMRI Study In Men JF - JOURNAL OF THE NEUROLOGICAL SCIENCES J2 - J NEUROL SCI VL - 349 PY - 2015 IS - 1-2 SP - 202 EP - 208 PG - 7 SN - 0022-510X DO - 10.1016/j.jns.2015.01.019 UR - https://m2.mtmt.hu/api/publication/2811986 ID - 2811986 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Erdélyi-Bótor, Szilvia AU - Aradi, Mihály AU - Kamson Olayinka, Dávid AU - Kovács, Norbert AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Schwarcz, Attila AU - Dóczi, Tamás Péter AU - Komoly, Sámuel AU - Deli, Gabriella AU - Trauninger, Anita AU - Pfund, Zoltán TI - Changes of Migraine-Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study. JF - HEADACHE J2 - HEADACHE VL - 55 PY - 2015 IS - 1 SP - 55 EP - 70 PG - 16 SN - 0017-8748 DO - 10.1111/head.12459 UR - https://m2.mtmt.hu/api/publication/2758889 ID - 2758889 AB - OBJECTIVE/BACKGROUND: The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes. Since in this patient group the repeated migraine attacks were the only known risk factors for the development of white matter hyperintensities, the remeasurements of migraineurs after a 3-year long follow-up may show changes in the status of these structural abnormalities as the effects of the repeated headaches. METHODS: The same patient group was reinvestigated in 2012 using the same MRI scanner and acquisition protocol. MR measurements were performed on a 3.0-Tesla clinical MRI scanner. Beyond the routine T1-, T2-weighted, and fluid-attenuated inversion recovery imaging, diffusion and perfusion-weighted imaging, proton magnetic resonance spectroscopy, and T1 and T2 relaxation time measurements were also performed. Findings of the baseline and follow-up studies were compared with each other. RESULTS: The follow-up proton magnetic resonance spectroscopy studies of white matter hyperintensities showed significantly decreased N-acetyl-aspartate (median values 8.133 vs 7.153 mmol/L, P = .009) and creatine/phosphocreatine (median values 4.970 vs 4.641 mmol/L, P = .015) concentrations compared to the baseline, indicating a more severe axonal loss and glial hypocellularity with decreased intracellular energy production. The diffusion values, the T1 and T2 relaxation times, and the cerebral blood flow and volume measurements presented only mild changes between the studies. The number (median values 21 vs 25, P < .001) and volume (median values 0.896 vs 1.140 mL, P < .001) of hyperintensities were significantly higher in the follow-up study. No changes were found in the hemispheric and lobar distribution of hyperintensities. An increase in the hyperintensity size of preexisting lesions was much more common than a decrease (median values 14 vs 5, P = .004). A higher number of newly developed hyperintensities were detected than disappeared ones (130 vs 22), and most of them were small (<.034 mL). Small white matter hyperintensities in patients with a low migraine attack frequency had a higher chance to disappear than large white matter hyperintensities or white matter hyperintensities in patients with a high attack frequency (coefficient: -0.517, P = .034). CONCLUSIONS: This longitudinal MRI study found clinically silent brain white matter hyperintensities to be predominantly progressive in nature. The absence of a control group precludes definitive conclusions about the nature of these changes or if their degree is beyond normal aging. LA - English DB - MTMT ER - TY - JOUR AU - Orsi, Gergely AU - Aradi, Mihály AU - Nagy, Szilvia Anett AU - Perlaki, Gábor AU - Trauninger, Anita AU - Bogner, Péter AU - Janszky, József Vladimír AU - Illés, Zsolt László AU - Dóczi, Tamás Péter AU - Pfund, Zoltán AU - Schwarcz, Attila TI - Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements. JF - JOURNAL OF MAGNETIC RESONANCE IMAGING J2 - JMRI - J MAGN RESON IM VL - 41 PY - 2015 IS - 3 SP - 676 EP - 683 PG - 8 SN - 1053-1807 DO - 10.1002/jmri.24580 UR - https://m2.mtmt.hu/api/publication/2598820 ID - 2598820 AB - PURPOSE: To compare the white matter lesions seen in multiple sclerosis and migraine using monoexponential and high b-value biexponential diffusion measurements. MATERIALS AND METHODS: Diffusion-weighted images were acquired on a 3.0-Tesla magnetic resonance imaging system. Diffusion parameters were estimated using monoexponential (0-1000 s/mm2 ) and biexponential (0-5000 s/mm2 ) approaches from 15 multiple sclerosis patients, 15 patients with migraine and 15 healthy control subjects. The study was performed in accordance with the approval of the Regional Research Ethics Committee. The apparent diffusion coefficient (ADC) values were measured in the lesions and the normal-appearing white matter of patients and in the white matter of controls. RESULTS: High lesional ADCmono values were detected in both patient groups without significant differences between the groups (10.72 and 9.86 x 10-4 mm2 /s for MS and migraine respectively, P = 0.2134). The biexponential measurements showed significantly higher ADCfast , ADCslow , and Pslow values in the migraine lesions than in the multiple sclerosis lesions (16.47 versus 14.29, 1.41 versus 0.76, and 20.34 versus 12.01 all values in 10-4 mm2 /s; P = 0.0344, P = 0.0019, P = 0.0021, respectively). CONCLUSION: Biexponential diffusion analysis may help to differentiate multiple sclerosis-related white matter lesions from migraine-related ones.J. Magn. Reson. Imaging 2014. (c) 2014 Wiley Periodicals, Inc. LA - English DB - MTMT ER - TY - CONF AU - Varga, Eszter AU - Schnell, Zsuzsanna AU - Perlaki, Gábor AU - Orsi, Gergely AU - Aradi, Mihály AU - Auer, T AU - John, F AU - Dóczi, Tamás Péter AU - Komoly, Sámuel AU - Kovács, Norbert AU - Schwarcz, Attila AU - Tényi, Tamás AU - Herold, Róbert AU - Janszky, József Vladimír AU - Horváth, Réka ED - Nick, Campbell ED - Dafydd, Gibbon ED - Daniel, Hirst TI - Hemispheric lateralization of sentence intonation in left handed subjects with typical and atypical language lateralization: An fMRI study T2 - 7th International Conference on Speech Prosody, SP 2014 PB - International Speech Communication Association (ISCA) C1 - Dublin T3 - Proceedings of the International Conference on Speech Prosody, ISSN 2333-2042 PY - 2014 SP - 1130 EP - 1133 PG - 4 UR - https://m2.mtmt.hu/api/publication/2715253 ID - 2715253 AB - Prosody (as the melody of speech) is an important component of human social interactions. More specifically, linguistic prosody conveys meaning of speech through syllable, word, or sentence level stress and intonation. In the modern neuroimaging era the hemispheric representation of sentence intonation is widely investigated. Most of these studies suggest bilateral activations predominantly in the perisylvian language areas and in the subdominant homologues. However, there are some inconsistencies about the hemispheric representation and lateralization of linguistic prosody. These inconsistencies could be due to the lack of attention on the language lateralization of the subjects. The present study aims to investigate the hemispheric representation and lateralization of linguistic prosody with a sentence intonation task in two groups of left handed subjects with typical and atypical language lateralization. Functional MRI was used to test the assumption that - according to the functional lateralization hypothesis - the representation of sentence intonation is predominantly lateralized within the language dominant hemisphere and the lateralization of sentence intonation is associated with language lateralization in both groups. Left handers were examined to create two groups of subjects with typical and atypical language lateralization. In all, 32 healthy subjects were evaluated with a standard verbal fluency task with fMRI in order to assess functional hemispheric language lateralization. In our final investigation the atypical group consisted of 8 subjects with right hemispheric language dominance (LI<-0.2) and the typical group also consisted of 8 subjects with left hemispheric language dominance (LI>0.2). Sentence intonation task was utilized to test linguistic prosody skills with fMRI. 49 pairs of sentences (18 pairs of neutral-neutral sentences, 10 pairs of interrogativeinterrogative sentences, and 1 pair of interrogative-neutral sentence) were presented with an event-related design. Sentences were matched in terms of syntactic structure, semantic complexity and length and all were affectively neutral. In the fMRI data analysis interrogative pairs were compared to neutral pairs. One of the main findings of our study is that subjects with typical language lateralization activated the middle temporal gyrus (MTG) on the right side. The activation of the MTG in the right hemisphere is classically associated with the encoding of prosodic information. Furthermore, both groups recruited the frontal and temporal language areas predominantly in the language-dominant hemisphere. Moreover, between-group comparison showed significantly stronger activations in subjects with typical language lateralization only in left sided language areas: pars triangularis of the inferior frontal gyrus, the superior frontal gyrus and the inferior parietal lobule. This finding is in accordance with the functional lateralization hypothesis of prosody, and suggests a correlation between linguistic prosody lateralization and language lateralization. LA - English DB - MTMT ER - TY - CONF AU - Horváth, Andrea AU - Nagy, Szilvia Anett AU - Perlaki, Gábor AU - Tóth, A AU - Orsi, Gergely AU - Aradi, Mihály AU - Komáromy, H AU - Dóczi, Tamás Péter AU - Bogner, Péter ED - Patuzzi, Julia TI - A quantitative approach in characterization of epidermoid cyst and middle ear cholesteatoma: T1 and T2 mapping T2 - European Congress of Radiology, ECR 2014 PY - 2014 DO - 10.1594/ecr2014/C-1947 UR - https://m2.mtmt.hu/api/publication/2533570 ID - 2533570 LA - English DB - MTMT ER - TY - GEN AU - Orsi, Gergely AU - Aradi, Mihály AU - Nagy, Szilvia Anett AU - Perlaki, Gábor AU - Trauninger, A AU - Bogner, Péter AU - Janszky, József Vladimír AU - Illes, Zs AU - Dóczi, Tamás Péter AU - Pfund, Zoltán AU - Schwarcz, A TI - Differentiating White Matter Lesions in Multiple Sclerosis and Migraine Using Monoexponential and Biexponential Diffusion Measurements PY - 2013 UR - https://m2.mtmt.hu/api/publication/3228173 ID - 3228173 N1 - [Poszter prezentáció] LA - English DB - MTMT ER - TY - GEN AU - Orsi, Gergely AU - Aradi, Mihály AU - Nagy, Szilvia Anett AU - Bogner, Péter AU - Janszky, József Vladimír AU - Illés, Zsolt László AU - Perlaki, Gábor AU - Dóczi, Tamás Péter AU - Pfund, Zoltán AU - Schwarcz, Attila TI - Biexponenciális diffúziós jelcsökkenés migrénben és sclerosis multiplexben PY - 2013 UR - https://m2.mtmt.hu/api/publication/3013125 ID - 3013125 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Horváth, Andrea AU - Aradi, Mihály AU - Perlaki, Gábor AU - Orsi, Gergely AU - Szalay, Csaba AU - Schwarcz, Attila AU - Büki, András AU - Kövér, Ferenc AU - Dóczi, Tamás Péter AU - Bogner, Péter TI - A kómás agy strukturális és funkcionális vizsgálata multiparametrikus MR-technikával JF - MAGYAR RADIOLÓGIA J2 - MAGYAR RADIOLÓGIA VL - 87 PY - 2013 IS - 2 SP - 32 EP - 39 PG - 8 SN - 0025-0287 UR - https://m2.mtmt.hu/api/publication/2533567 ID - 2533567 LA - Hungarian DB - MTMT ER -