@article{MTMT:34779369,
	title = {Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting.},
	url = {https://m2.mtmt.hu/api/publication/34779369},
	author = {Prosz, Aurel and Sahgal, Pranshu and Huffman, Brandon M and Sztupinszki, Zsofia and Morris, Clare X and Chen, David and Börcsök, Judit and Diossy, Miklos and Tisza, Viktoria and Spisák, Sándor and Likasitwatanakul, Pornlada and Rusz, Orsolya and Csabai, István and Cecchini, Michael and Baca, Yasmine and Elliot, Andrew and Enzinger, Peter and Singh, Harshabad and Ubellaker, Jessalyn and Lazaro, Jean-Bernard and Cleary, James M and Szállási, Zoltán and Sethi, Nilay S},
	doi = {10.1038/s41698-024-00561-6},
	journal-iso = {NPJ PRECIS ONCOL},
	journal = {NPJ PRECISION ONCOLOGY},
	volume = {8},
	unique-id = {34779369},
	abstract = {Homologous recombination (HR) and nucleotide excision repair (NER) are the two most frequently disabled DNA repair pathways in cancer. HR-deficient breast, ovarian, pancreatic and prostate cancers respond well to platinum chemotherapy and PARP inhibitors. However, the frequency of HR deficiency in gastric and esophageal adenocarcinoma (GEA) still lacks diagnostic and functional validation. Using whole exome and genome sequencing data, we found that a significant subset of GEA, but very few colorectal adenocarcinomas, show evidence of HR deficiency by mutational signature analysis (HRD score). High HRD gastric cancer cell lines demonstrated functional HR deficiency by RAD51 foci assay and increased sensitivity to platinum chemotherapy and PARP inhibitors. Of clinical relevance, analysis of three different GEA patient cohorts demonstrated that platinum treated HR deficient cancers had better outcomes. A gastric cancer cell line with strong sensitivity to cisplatin showed HR proficiency but exhibited NER deficiency by two photoproduct repair assays. Single-cell RNA-sequencing revealed that, in addition to inducing apoptosis, cisplatin treatment triggered ferroptosis in a NER-deficient gastric cancer, validated by intracellular GSH assay. Overall, our study provides preclinical evidence that a subset of GEAs harbor genomic features of HR and NER deficiency and may therefore benefit from platinum chemotherapy and PARP inhibitors.},
	year = {2024},
	eissn = {2397-768X},
	orcid-numbers = {Rusz, Orsolya/0000-0001-5726-4072; Csabai, István/0000-0001-9232-9898; Szállási, Zoltán/0000-0001-5395-7509}
}

@article{MTMT:33814839,
	title = {Genomic Landscape of Normal and Breast Cancer Tissues in a Hungarian Pilot Cohort},
	url = {https://m2.mtmt.hu/api/publication/33814839},
	author = {Pipek, Orsolya Anna and Alpár, Donát and Rusz, Orsolya and Bödör, Csaba and Udvarnoki, Zoltán András and Medgyes-Horváth, Anna and Csabai, István and Szállási, Zoltán and Madaras, Lilla and Kahán, Zsuzsanna and Cserni, Gábor and Kővári, Bence and Kulka, Janina and Tőkés, Anna-Mária},
	doi = {10.3390/ijms24108553},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {33814839},
	issn = {1661-6596},
	abstract = {A limited number of studies have focused on the mutational landscape of breast cancer in different ethnic populations within Europe and compared the data with other ethnic groups and databases. We performed whole-genome sequencing of 63 samples from 29 Hungarian breast cancer patients. We validated a subset of the identified variants at the DNA level using the Illumina TruSight Oncology (TSO) 500 assay. Canonical breast-cancer-associated genes with pathogenic germline mutations were CHEK2 and ATM. Nearly all the observed germline mutations were as frequent in the Hungarian breast cancer cohort as in independent European populations. The majority of the detected somatic short variants were single-nucleotide polymorphisms (SNPs), and only 8% and 6% of them were deletions or insertions, respectively. The genes most frequently affected by somatic mutations were KMT2C (31%), MUC4 (34%), PIK3CA (18%), and TP53 (34%). Copy number alterations were most common in the NBN, RAD51C, BRIP1, and CDH1 genes. For many samples, the somatic mutational landscape was dominated by mutational processes associated with homologous recombination deficiency (HRD). Our study, as the first breast tumor/normal sequencing study in Hungary, revealed several aspects of the significantly mutated genes and mutational signatures, and some of the copy number variations and somatic fusion events. Multiple signs of HRD were detected, highlighting the value of the comprehensive genomic characterization of breast cancer patient populations.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Pipek, Orsolya Anna/0000-0001-8109-0340; Rusz, Orsolya/0000-0001-5726-4072; Bödör, Csaba/0000-0002-0729-692X; Udvarnoki, Zoltán András/0000-0001-7086-235X; Medgyes-Horváth, Anna/0000-0003-4435-5797; Csabai, István/0000-0001-9232-9898; Szállási, Zoltán/0000-0001-5395-7509; Madaras, Lilla/0000-0002-4137-4696; Kahán, Zsuzsanna/0000-0002-5021-8775; Cserni, Gábor/0000-0003-1344-7744; Kővári, Bence/0000-0002-4498-8781; Kulka, Janina/0000-0001-6498-5943; Tőkés, Anna-Mária/0000-0002-9581-7536}
}

@article{MTMT:32793328,
	title = {Investigating the Prognostic Relevance of Tumor Immune Microenvironment and Immune Gene Assembly in Breast Carcinoma Subtypes},
	url = {https://m2.mtmt.hu/api/publication/32793328},
	author = {Szeitz, Beáta and Pipek, Orsolya Anna and Kulka, Janina and Szundi, Csilla and Rusz, Orsolya and Tőkés, Tímea and Szász, Attila Marcell and Kovács, Attila and Pesti, Adrián István and Ben Arie, Taya Beri and Gángó, Ambrus and Fülöp, Zsolt and Drágus, Emőke and Vári-Kakas, Stefan A. and Tőkés, Anna-Mária},
	doi = {10.3390/cancers14081942},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {14},
	unique-id = {32793328},
	year = {2022},
	eissn = {2072-6694},
	orcid-numbers = {Szeitz, Beáta/0000-0001-6414-0537; Pipek, Orsolya Anna/0000-0001-8109-0340; Kulka, Janina/0000-0001-6498-5943; Rusz, Orsolya/0000-0001-5726-4072; Tőkés, Tímea/0000-0002-5456-1706; Szász, Attila Marcell/0000-0003-2739-4196; Pesti, Adrián István/0000-0001-6706-6221; Gángó, Ambrus/0000-0001-9127-5015; Fülöp, Zsolt/0000-0002-0854-5617; Tőkés, Anna-Mária/0000-0002-9581-7536}
}

@article{MTMT:32110177,
	title = {Efficacy of Clarithromycin Depends on the Bacterial Density in Clarithromycin-Heteroresistant Helicobacter pylori Infections: An In Situ Detected Susceptibility and Quantitative Morphometry-Based Retrospective Study},
	url = {https://m2.mtmt.hu/api/publication/32110177},
	author = {Kim, Jewel Ju Ea and Kocsmár, Ildikó and Buzás, György Miklós and Szirtes, Ildikó and Rusz, Orsolya and Diczházi, Csaba and Szijártó, Attila and Hritz, István and Schaff, Zsuzsa and Kiss, András and Kocsmár, Éva and Lotz, Gábor},
	doi = {10.3389/pore.2021.1609863},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {27},
	unique-id = {32110177},
	issn = {1219-4956},
	year = {2021},
	eissn = {1532-2807},
	orcid-numbers = {Szirtes, Ildikó/0000-0001-5853-6324; Rusz, Orsolya/0000-0001-5726-4072; Hritz, István/0000-0002-8763-6006; Schaff, Zsuzsa/0000-0002-6429-8059; Kiss, András/0000-0002-7453-3163; Lotz, Gábor/0000-0002-6921-8978}
}

@article{MTMT:32076418,
	title = {A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures},
	url = {https://m2.mtmt.hu/api/publication/32076418},
	author = {Diossy, Miklos and Sztupinszki, Zsófia and Borcsok, Judit and Krzystanek, Marcin and Tisza, Viktoria and Spisák, Sándor and Rusz, Orsolya and Tímár, József and Csabai, István and Fillinger, János and Moldvay, Judit and Pedersen, Anders Gorm and Szüts, Dávid and Szállási, Zoltán},
	doi = {10.1038/s41698-021-00199-8},
	journal-iso = {NPJ PRECIS ONCOL},
	journal = {NPJ PRECISION ONCOLOGY},
	volume = {5},
	unique-id = {32076418},
	year = {2021},
	eissn = {2397-768X},
	orcid-numbers = {Diossy, Miklos/0000-0003-0308-6615; Borcsok, Judit/0000-0002-3290-3971; Rusz, Orsolya/0000-0001-5726-4072; Tímár, József/0000-0001-9183-0859; Szüts, Dávid/0000-0001-7985-0136; Szállási, Zoltán/0000-0001-5395-7509}
}

@article{MTMT:31781512,
	title = {Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer},
	url = {https://m2.mtmt.hu/api/publication/31781512},
	author = {Börcsök, Judit and Sztupinszki, Zsófia and Bekele, Raie and Gao, Sizhi P and Diossy, Miklos and Samant, Amruta S and Dillon, Kasia M and Tisza, Viktoria and Spisák, Sándor and Rusz, Orsolya and Csabai, Istvan and Pappot, Helle and Frazier, Zoe J and Konieczkowski, David J and Liu, David and Vasani, Naresh and Rodrigues, James A and Solit, David B and Hoffman-Censits, Jean H and Plimack, Elizabeth R. and Rosenberg, Jonathan E and Lazaro, Jean-Bernard and Taplin, Mary-Ellen and Iyer, Gopa and Brunak, Søren and Lózsa, Rita Bernadett and Van Allen, Eliezer M and Szüts, Dávid and Mouw, Kent W and Szállási, Zoltán},
	doi = {10.1158/1078-0432.CCR-20-3316},
	journal-iso = {CLIN CANCER RES},
	journal = {CLINICAL CANCER RESEARCH},
	volume = {27},
	unique-id = {31781512},
	issn = {1078-0432},
	year = {2021},
	eissn = {1557-3265},
	pages = {2011-2022},
	orcid-numbers = {Rusz, Orsolya/0000-0001-5726-4072; Lózsa, Rita Bernadett/0000-0001-5957-906X; Szállási, Zoltán/0000-0001-5395-7509}
}

@article{MTMT:31194960,
	title = {Detection of molecular signatures of homologous recombination deficiency in prostate cancer with or without BRCA1/2 mutations},
	url = {https://m2.mtmt.hu/api/publication/31194960},
	author = {Sztupinszki, Zsófia and Diossy, Miklos and Krzystanek, Marcin and Börcsök, Judit and Pomerantz, Mark M and Tisza, Viktoria and Spisák, Sándor and Rusz, Orsolya and Csabai, István and Freedman, Matthew L and Szállási, Zoltán},
	doi = {10.1158/1078-0432.CCR-19-2135},
	journal-iso = {CLIN CANCER RES},
	journal = {CLINICAL CANCER RESEARCH},
	volume = {26},
	unique-id = {31194960},
	issn = {1078-0432},
	year = {2020},
	eissn = {1557-3265},
	pages = {2673-2680},
	orcid-numbers = {Rusz, Orsolya/0000-0001-5726-4072; Csabai, István/0000-0001-9232-9898; Szállási, Zoltán/0000-0001-5395-7509}
}

@article{MTMT:31171249,
	title = {Cognitive Functioning and Psychological Well-being in Breast Cancer Patients on Endocrine Therapy},
	url = {https://m2.mtmt.hu/api/publication/31171249},
	author = {Biró, Edit Magdolna and Kahán, Zsuzsanna and Kálmán, János and Rusz, Orsolya and Pákáski, Magdolna and Irinyi, Tamás and Kelemen, Gyöngyi and Dudás, Rita and Drótos, Gergely and Hamvai, Csaba},
	doi = {10.21873/invivo.11615},
	journal-iso = {IN VIVO},
	journal = {IN VIVO},
	volume = {33},
	unique-id = {31171249},
	issn = {0258-851X},
	year = {2019},
	eissn = {1791-7549},
	pages = {1381-1392},
	orcid-numbers = {Kahán, Zsuzsanna/0000-0002-5021-8775; Kálmán, János/0000-0001-5319-5639; Rusz, Orsolya/0000-0001-5726-4072; Pákáski, Magdolna/0000-0001-8067-5435}
}

@article{MTMT:30923894,
	title = {Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents.},
	url = {https://m2.mtmt.hu/api/publication/30923894},
	author = {Póti, Ádám and Gyergyák, Hella and Németh, Eszter and Rusz, Orsolya and Tóth, Szilárd and Kovácsházi, Csenger and Chen, Dan and Szikriszt, Bernadett and Spisák, Sándor and Takeda, Shunichi and Szakács, Gergely and Szállási, Zoltán and Richardson, Andrea L and Szüts, Dávid},
	doi = {10.1186/s13059-019-1867-0},
	journal-iso = {GENOME BIOL},
	journal = {GENOME BIOLOGY},
	volume = {20},
	unique-id = {30923894},
	issn = {1474-7596},
	abstract = {Homologous recombination (HR) repair deficiency arising from defects in BRCA1 or BRCA2 is associated with characteristic patterns of somatic mutations. In this genetic study, we ask whether inactivating mutations in further genes of the HR pathway or the DNA damage checkpoint also give rise to somatic mutation patterns that can be used for treatment prediction.Using whole genome sequencing of an isogenic knockout cell line panel, we find a universal HR deficiency-specific base substitution signature that is similar to COSMIC signature 3. In contrast, we detect different deletion phenotypes corresponding to specific HR mutants. The inactivation of BRCA2 or PALB2 leads to larger deletions, typically with microhomology, when compared to the disruption of BRCA1, RAD51 paralogs, or RAD54. Comparison with the deletion spectrum of Cas9 cut sites suggests that most spontaneously arising genomic deletions are not the consequence of double-strand breaks. Surprisingly, the inactivation of checkpoint kinases ATM and CHK2 has no mutagenic consequences. Analysis of tumor exomes with biallelic inactivating mutations in the investigated genes confirms the validity of the cell line models. We present a comprehensive analysis of sensitivity of the investigated mutants to 13 therapeutic agents for the purpose of correlating genomic mutagenic phenotypes with drug sensitivity.Our results suggest that no single genomic mutational class shows perfect correlation with sensitivity to common treatments, but the contribution of COSMIC signature 3 to base substitutions, or a combined measure of different features, may be reasonably good at predicting platinum and PARP inhibitor sensitivity.},
	keywords = {PALB2; BRCA2; BRCA1; ATM; RAD51C; Rad52; Mutation signature; CHEK2; PARP inhibitor; Microhomology deletion},
	year = {2019},
	eissn = {1474-760X},
	orcid-numbers = {Rusz, Orsolya/0000-0001-5726-4072; Kovácsházi, Csenger/0000-0003-0283-9486; Szállási, Zoltán/0000-0001-5395-7509}
}

@article{MTMT:30658783,
	title = {Influence of mutagenic versus non-mutagenic pre-operative chemotherapy on the immune infiltration of residual breast cancer},
	url = {https://m2.mtmt.hu/api/publication/30658783},
	author = {Tőkés, Anna-Mária and Rusz, Orsolya and Cserni, Gábor and Tóth, Erika and Rubovszky, Gábor and Tőkés, Tímea and Vízkeleti, Laura and Reiniger, Lilla and Kószó, Renáta Lilla and Kahán, Zsuzsanna and Kulka, Janina and Donia, Marco and Vörös, András and Szállási, Zoltán},
	doi = {10.1080/0284186X.2019.1633015},
	journal-iso = {ACTA ONCOL},
	journal = {ACTA ONCOLOGICA},
	volume = {58},
	unique-id = {30658783},
	issn = {0284-186X},
	year = {2019},
	eissn = {1651-226X},
	pages = {1603-1611},
	orcid-numbers = {Tőkés, Anna-Mária/0000-0002-9581-7536; Rusz, Orsolya/0000-0001-5726-4072; Cserni, Gábor/0000-0003-1344-7744; Tóth, Erika/0000-0003-2054-8447; Rubovszky, Gábor/0000-0003-1723-5589; Tőkés, Tímea/0000-0002-5456-1706; Vízkeleti, Laura/0000-0001-6870-3499; Reiniger, Lilla/0000-0003-2248-4264; Kószó, Renáta Lilla/0000-0002-1958-7839; Kahán, Zsuzsanna/0000-0002-5021-8775; Kulka, Janina/0000-0001-6498-5943; Vörös, András/0000-0001-6837-0567; Szállási, Zoltán/0000-0001-5395-7509}
}