@article{MTMT:34763514,
	title = {Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development},
	url = {https://m2.mtmt.hu/api/publication/34763514},
	author = {Gödöny, Krisztina and Herczeg, Róbert and Gyenesei, Attila and Várnagy, Ákos and Bognár, Zoltán and Kovács, L. Gábor and Szekeres, Júlia and Mauchart, Péter and Nagy, Bernadett and Erostyák, János and Kovács, Kálmán András and Bódis, József},
	doi = {10.1159/000536358},
	journal-iso = {MED PRIN PRACT},
	journal = {MEDICAL PRINCIPLES AND PRACTICE},
	volume = {33},
	unique-id = {34763514},
	issn = {1011-7571},
	abstract = {<b><i>Objective:</i></b> Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). <b><i>Materials and Methods:</i></b> We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. <b><i>Results:</i></b> Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. <b><i>Conclusions:</i></b> The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety.},
	keywords = {blastocyst; abortion; intracytoplasmic sperm injection; In vitro fertilization; Live birth rate; light protection},
	year = {2024},
	eissn = {1423-0151},
	pages = {112-121},
	orcid-numbers = {Herczeg, Róbert/0000-0002-5903-0082; Kovács, L. Gábor/0000-0001-5298-5401}
}

@misc{MTMT:34525481,
	title = {Detection of Ultraweak Photon Emissions from Mouse Embryos with Implications for Assisted Reproduction},
	url = {https://m2.mtmt.hu/api/publication/34525481},
	author = {Bódis, József and Bognár, Zoltán and Csabai-Tanics, Tímea Judith and Berke, József and Gulyás, István Tibor and Mauchart, Péter and Hans-Rudolf, Tinneberg and Farkas, Bálint and Várnagy, Ákos and Kovács, Kálmán András},
	unique-id = {34525481},
	year = {2024},
	orcid-numbers = {Berke, József/0000-0002-0190-4197; Farkas, Bálint/0000-0003-0638-2057}
}

@misc{MTMT:34525317,
	title = {Unique algorithm for the evaluation of embryo photon emission and viability},
	url = {https://m2.mtmt.hu/api/publication/34525317},
	author = {Berke, József and Gulyás, István Tibor and Bognár, Zoltán and Dávid, Berke and Attila, Enyedi and Veronika, Kozma-Bognár and Mauchart, Péter and Nagy, Bernadett and Várnagy, Ákos and Kovács, Kálmán András and Bódis, József},
	unique-id = {34525317},
	year = {2024},
	orcid-numbers = {Berke, József/0000-0002-0190-4197}
}

@article{MTMT:34486045,
	title = {Follicular Fluid Proteomic Analysis of Women Undergoing Assisted Reproduction Suggests That Apolipoprotein A1 Is a Potential Fertility Marker},
	url = {https://m2.mtmt.hu/api/publication/34486045},
	author = {Kurdi, Csilla and Schmidt, János and Horváth-Szalai, Zoltán and Mauchart, Péter and Gödöny, Krisztina and Várnagy, Ákos and Kovács, L. Gábor and Kőszegi, Tamás},
	doi = {10.3390/ijms25010486},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34486045},
	issn = {1661-6596},
	abstract = {Infertility affects millions worldwide, posing a significant global health challenge. The proteomic analysis of follicular fluid provides a comprehensive view of the complex molecular landscape within ovarian follicles, offering valuable information on the factors influencing oocyte development and on the overall reproductive health. The follicular fluid is derived from the plasma and contains various proteins that can have different roles in oocyte health and infertility, and this fluid is a critical microenvironment for the developing oocytes as well. Using the high-performance liquid chromatography-mass spectrometry method, we investigated the protein composition of the follicular fluid, and after classification, we carried out relative quantification of the identified proteins in the pregnant (P) and non-pregnant (NP) groups. Based on the protein–protein interaction analysis, albumin and apolipoprotein A1 (ApoA1) were found to be hub proteins, and the quantitative comparison of the P and NP groups resulted in a significantly lower concentration of ApoA1 and high-density lipoprotein cholesterol in the P group. As both molecules are involved in the cholesterol transport, we also investigated their role in the development of oocytes and in the prediction of fertility.},
	keywords = {PREDICTIVE VALUE; Mass spectrometry; follicular fluid; proteomics; apolipoprotein A1; HDL CHOLESTEROL; assisted reproductive treatment},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Kovács, L. Gábor/0000-0001-5298-5401}
}

@article{MTMT:34106678,
	title = {Amino Acid Profiling of Follicular Fluid in Assisted Reproduction Reveals Important Roles of Several Amino Acids in Patients with Insulin Resistance},
	url = {https://m2.mtmt.hu/api/publication/34106678},
	author = {Kurdi, Csilla and Lelovics, Vanessza and Hesszenberger, Dávid and Lajtai, Anikó and Lakatos, Ágnes and Herczeg, Róbert and Gödöny, Krisztina and Mauchart, Péter and Várnagy, Ákos and Kovács, L. Gábor and Kőszegi, Tamás},
	doi = {10.3390/ijms241512458},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34106678},
	issn = {1661-6596},
	abstract = {The global prevalence of insulin resistance (IR) is increasing continuously, influencing metabolic parameters and fertility. The metabolic changes due to IR can alter the molecular composition of plasma and other body fluids. Follicular fluid (FF) is derived mainly from plasma, and it is a critical microenvironment for the developing oocytes. It contains various metabolites and amino acids, and the quality of the oocytes is linked at least partially to amino acid metabolism. Our goal was to quantitatively determine the amino acid (AA) profile of FF in IVF patients and to compare IR and non-insulin resistance (NIR) groups to investigate the AA changes in their FF. Using UHPLC-based methods, we quantified the main 20 amino acids from human FF samples in the IR and NIR groups. Several amino acids (aspartate, glycine, glutamate, and cysteine) differed significantly (p < 0.05 or less) between the two groups. The most significant alterations between the IR and NIR groups were related to the glutathione metabolic pathway involving glycine, serine, and threonine. Since insulin resistance alters the amino acid composition of the FF, the oocytes may undergo metabolism-induced changes resulting in poor oocyte quality and less fertility in the insulin resistance groups.},
	keywords = {PREDICTIVE VALUE; Insulin Resistance; follicular fluid; metabolomics; Amino acid profile; Assisted reproduction technology},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Herczeg, Róbert/0000-0002-5903-0082; Kovács, L. Gábor/0000-0001-5298-5401}
}

@article{MTMT:33667137,
	title = {Oxidative Stress in Assisted Reproductive Techniques, with a Focus on an Underestimated Risk Factor.},
	url = {https://m2.mtmt.hu/api/publication/33667137},
	author = {Mauchart, Péter and Vass, Réka Anna and Nagy, Bernadett and Sulyok, Endre and Bódis, József and Kovács, Kálmán András},
	doi = {10.3390/cimb45020083},
	journal-iso = {CURR ISSUES MOL BIOL},
	journal = {CURRENT ISSUES IN MOLECULAR BIOLOGY},
	volume = {45},
	unique-id = {33667137},
	issn = {1467-3037},
	abstract = {Based on current findings, the presence of oxidative stress has a significant impact on the quality of gametes and embryos when performing assisted reproductive techniques (ART). Unfortunately, in vitro manipulation of these cells exposes them to a higher level of reactive oxygen species (ROS). The primary goal of this review is to provide a comprehensive overview of the development of oxidative stress in female and male reproductive systems, as well as in the case of the pre-implantation embryo and its environment. This review also focuses on the origins of ROS and the mechanisms of oxidative stress-induced damage during ART procedures. A well-known but underestimated hazard, light exposure-related photo-oxidation, is particularly concerning. The effect of oxidative stress on ART outcomes, as well as the various strategies for preventing it, are also discussed. We emphasize the role and significance of antioxidants and light protection including forms, functions, and mechanisms in the development of gametes and embryos in vivo and in vitro.},
	keywords = {antioxidants; IVF; SPERM; embryo; oocyte; light protection},
	year = {2023},
	eissn = {1467-3045},
	pages = {1272-1286},
	orcid-numbers = {Vass, Réka Anna/0000-0002-0436-4261}
}

@article{MTMT:33667134,
	title = {Telomere Length and Telomerase Activity of Granulosa Cells and Follicular Fluid in Women Undergoing In Vitro Fertilization.},
	url = {https://m2.mtmt.hu/api/publication/33667134},
	author = {Péntek, Sándor Mátyás and Várnagy, Ákos and Farkas, Bálint and Mauchart, Péter and Gödöny, Krisztina and Varjas, Tímea and Kőszegi, Tamás and Kaltenecker, Péter and Jakabfi-Csepregi, Rita and Kovács, Kálmán András and Bódis, József and Sulyok, Endre},
	doi = {10.3390/antiox12020419},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {33667134},
	abstract = {This study aimed to evaluate the interrelationship between telomere length, telomerase activity and oxidative DNA damage in patients undergoing in vitro fertilization (IVF). This single-center, observational clinical study comprised 102 unselected, consecutive patients with various infertility diagnoses. Granulosa cells (GCs) and follicular fluid (FF) were analyzed simultaneously for telomere functions and for the marker of oxidative DNA damage, 8-hydroxy-2-deoxyguanosine (8-OHdG). An Absolute Human Telomere Lengths Quantification qPCR Assay kit and Telomerase Activity Quantification qPCR Assay kit (Nucleotestbio, Budapest, Hungary), as well as an 8-OHdG ELISA kit (Abbexa Ltd., Cambridge, United Kingdom) were used for analyses. Similar telomere lengths were found in GCs and FF, however telomerase activity was markedly depressed, while 8-OHdG levels were markedly elevated in FF compared with those in GCs (p < 0.01). Telomere lengths were independent of telomerase activity both in GCs and FF. However, GC 8-OHdG was inversely related to telomerase activity in GCs and FF (p < 0.05). Importantly, 8-OHdG levels both in GCs and FF had significant negative impact on the number of the retrieved and MII oocytes (p < 0.01), whereas FF 8-OHdG was negatively related further to the number of fertilized oocytes and blastocysts (p < 0.01). In conclusion, we could not confirm the direct association of telomere function and reproductive potential. However, oxidative DNA damage, as mainly reflected by 8-OHdG, adversely affected early markers of IVF outcome and clinical pregnancies.},
	keywords = {In vitro fertilization; Telomere length; oxidative DNA damage; Telomerase activity},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Farkas, Bálint/0000-0003-0638-2057; Varjas, Tímea/0000-0002-4950-0669}
}

@article{MTMT:32098656,
	title = {Pécsi innovációs technológiák a humán reprodukció szolgálatában : Embrióvédelemmel kapcsolatos vizsgálatok, hagyományos embriószelekciós eljárások, az embrió életképességének és betegségeinek genetikai markerei},
	url = {https://m2.mtmt.hu/api/publication/32098656},
	author = {Bódis, József and Szekeres, Júlia and Sulyok, Endre and Gombos, Katalin and Bognár, Zoltán and Gyenesei, Attila and Gödöny, Krisztina and Mauchart, Péter and Várnagy, Ákos and Ertl, Tibor and Nagy, Bernadett and Kovács, Kálmán András and Kovács, L. Gábor},
	journal-iso = {NŐGYÓGYÁSZATI ÉS SZÜLÉSZETI TOVÁBBKÉPZŐ SZEMLE},
	journal = {NŐGYÓGYÁSZATI ÉS SZÜLÉSZETI TOVÁBBKÉPZŐ SZEMLE},
	volume = {23},
	unique-id = {32098656},
	issn = {1585-8731},
	year = {2021},
	pages = {72-86},
	orcid-numbers = {Kovács, L. Gábor/0000-0001-5298-5401}
}

@article{MTMT:31802064,
	title = {No experimental evidence for vector-free, long-range, upstream dispersal of adult Asian clams [Corbicula fluminea (Müller, 1774)]},
	url = {https://m2.mtmt.hu/api/publication/31802064},
	author = {Pernecker, Bálint and Czirok, Attila and Mauchart, Péter and Boda, Pál and Móra, Arnold and Csabai, Zoltán Szabolcs},
	doi = {10.1007/s10530-020-02446-8},
	journal-iso = {BIOL INVASIONS},
	journal = {BIOLOGICAL INVASIONS},
	volume = {23},
	unique-id = {31802064},
	issn = {1387-3547},
	year = {2021},
	eissn = {1573-1464},
	pages = {1393-1404},
	orcid-numbers = {Pernecker, Bálint/0000-0003-0167-697X; Boda, Pál/0000-0002-1825-5744; Móra, Arnold/0000-0001-5878-8281; Csabai, Zoltán Szabolcs/0000-0003-1700-2574}
}

@article{MTMT:31432707,
	title = {What to do if streams go dry? Behaviour of Balkan Goldenring (Cordulegaster heros, Odonata) larvae in a simulated drought experiment in SW Hungary},
	url = {https://m2.mtmt.hu/api/publication/31432707},
	author = {Pernecker, Bálint and Mauchart, Péter and Csabai, Zoltán Szabolcs},
	doi = {10.1111/een.12931},
	journal-iso = {ECOL ENTOMOL},
	journal = {ECOLOGICAL ENTOMOLOGY},
	volume = {45},
	unique-id = {31432707},
	issn = {0307-6946},
	year = {2020},
	eissn = {1365-2311},
	pages = {1457-1465},
	orcid-numbers = {Pernecker, Bálint/0000-0003-0167-697X; Csabai, Zoltán Szabolcs/0000-0003-1700-2574}
}