@article{MTMT:34748236,
	title = {A Molecular Hybrid of the GFP Chromophore and 2,2′-Bipyridine: An Accessible Sensor for Zn2+ Detection with Fluorescence Microscopy},
	url = {https://m2.mtmt.hu/api/publication/34748236},
	author = {Csomos, Attila and Madarász, Miklós and Turczel, Gábor and Cseri, Levente and Katona, Gergely and Rózsa J., Balázs and Kovács, Ervin and Mucsi, Zoltán},
	doi = {10.3390/ijms25063504},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34748236},
	issn = {1661-6596},
	abstract = {The few commercially available chemosensors and published probes for in vitro Zn2+ detection in two-photon microscopy are compromised by their flawed spectroscopic properties, causing issues in selectivity or challenging multistep syntheses. Herein, we present the development of an effective small molecular GFP chromophore-based fluorescent chemosensor with a 2,2′-bipyridine chelator moiety (GFZnP BIPY) for Zn2+ detection that has straightforward synthesis and uncompromised properties. Detailed experimental characterizations of the free and the zinc-bound compounds within the physiologically relevant pH range are presented. Excellent photophysical characteristics are reported, including a 53-fold fluorescence enhancement with excitation and emission maxima at 422 nm and 492 nm, respectively. A high two-photon cross section of 3.0 GM at 840 nm as well as excellent metal ion selectivity are reported. In vitro experiments on HEK 293 cell culture were carried out using two-photon microscopy to demonstrate the applicability of the novel sensor for zinc bioimaging.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Madarász, Miklós/0000-0001-7057-303X; Katona, Gergely/0000-0002-4173-0355; Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847}
}

@article{MTMT:34724516,
	title = {A GFP inspired 8-methoxyquinoline-derived fluorescent molecular sensor for the detection of Zn2+ by two-photon microscopy},
	url = {https://m2.mtmt.hu/api/publication/34724516},
	author = {Csomos, Attila and Madarász, Miklós and Turczel, Gábor and Cseri, Levente and Bodor, Andrea and Anett, Matuscsák and Katona, Gergely and Kovács, Ervin and Rózsa J., Balázs and Mucsi, Zoltán},
	doi = {10.1002/chem.202400009},
	journal-iso = {CHEM-EUR J},
	journal = {CHEMISTRY-A EUROPEAN JOURNAL},
	unique-id = {34724516},
	issn = {0947-6539},
	abstract = {An effective, GFP-inspired fluorescent Zn2+ sensor is developed for two-photon microscopy and related biological application that featured an 8-methoxyquinoline moiety. Excellent photophysical characteristics including a 37-fold fluorescence enhancement with excitation and emission maxima at 440 nm and 505 nm, respectively, as well as a high two-photon cross-section of 73 GM at 880 nm are reported. Based on the experimental data, the relationship between the structure and properties was elucidated and explained backed up by DFT calculations, particularly to the observed PeT phenomenon for the turn-on process. Biological validation and detailed experimental and theoretical characterization of the free and the zinc-bound compounds are presented.},
	year = {2024},
	eissn = {1521-3765},
	orcid-numbers = {Madarász, Miklós/0000-0001-7057-303X; Bodor, Andrea/0000-0002-7422-298X; Katona, Gergely/0000-0002-4173-0355; Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847}
}

@{MTMT:34561430,
	title = {Glikomikai alkalmazásra fejlesztett permanens töltéssel rendelkező fluoreszcens jelölővegyületek},
	url = {https://m2.mtmt.hu/api/publication/34561430},
	author = {Csomos, Attila and Kovács, Ervin and Barkai, Gyöngy and Váradi, Csaba and Mucsi, Zoltán and Viskolcz, Béla and Rózsa J., Balázs and Cseri, Levente and Dojcsák, Dalma},
	unique-id = {34561430},
	abstract = {A bejelentés új, glikoproteinek elemzésére alkalmazható új jelölővegyületekre és kimutatási eljárásokra vonatkozik. Az új vegyületek N-hidroxi-szukcinimidil-karbamáttal származékolt xanténvázas rodamin- vagy pironin-származékok, amelyek N-glikánok folyadék-kromatográfiás elválasztást követő fluoreszcens és tömegspektrometriás detektálására használhatók fel.},
	year = {2024},
	orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Váradi, Csaba/0000-0002-2672-095X; Mucsi, Zoltán/0000-0003-3224-8847}
}

@{MTMT:34561278,
	title = {Piránvázas fluoreszcens jelzővegyületek DNS kimutatására},
	url = {https://m2.mtmt.hu/api/publication/34561278},
	author = {Domahidy, Farkas László and Kovács, Ervin and Mucsi, Zoltán and Cseri, Levente and Rózsa J., Balázs},
	unique-id = {34561278},
	abstract = {Találmányunk tárgyát képezik új piránvázas fluoreszcens jelzővegyületek, amely töltéssel rendelkező pirángyűrűn 2 és 6 helyzetben kapcsolódó fenil csoportokhoz amino csoportok kapcsolódnak, amelyek nitrogénjei olyan 2-3 szénatomos lánccal vannak szubsztituálva, amelyek szekunder vagy tercier aminocsoportot tartalmaznak. Ezen szekunder amino csoportok hatására a találmányunk szerinti színezék a korábban ismertnél előnyösebb, jobb vízoldhatóságú, a DNS-hez jól kötődő és DNS jelenlétében meglepően jobb fluoreszcencia-kvantumhatásfokú színezékek.},
	year = {2024},
	orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847}
}

@article{MTMT:34191513,
	title = {Two-Photon Fluorescent Chemosensors Based on the GFP-Chromophore for the Detection of Zn2+ in Biological Samples – From Design to Application},
	url = {https://m2.mtmt.hu/api/publication/34191513},
	author = {Csomos, Attila and Kovács, Ervin and Madarász, Miklós and Fedor, Flóra Zsófia and Fülöp, Anna and Katona, Gergely and Rózsa J., Balázs and Mucsi, Zoltán},
	doi = {10.1016/j.snb.2023.134753},
	journal-iso = {SENSOR ACTUAT B CHEM},
	journal = {SENSORS AND ACTUATORS B-CHEMICAL},
	volume = {398},
	unique-id = {34191513},
	issn = {0925-4005},
	keywords = {FLUORESCENCE; chemosensor; two-photon; Zinc); GFP-chromophore},
	year = {2024},
	eissn = {0925-4005},
	orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Madarász, Miklós/0000-0001-7057-303X; Fedor, Flóra Zsófia/0000-0003-4085-1419; Katona, Gergely/0000-0002-4173-0355; Mucsi, Zoltán/0000-0003-3224-8847}
}

@article{MTMT:34205650,
	title = {Effective Synthesis, Development and Application of a Highly Fluorescent Cyanine Dye for Antibody Conjugation and Microscopy Imaging},
	url = {https://m2.mtmt.hu/api/publication/34205650},
	author = {Szepesi Kovács, Dénes and Kontra, Bence and Chiovini, Balázs and Müller, Dalma and Tóth, Estilla Zsófia and Ábrányi-Balogh, Péter and Wittner, Lucia and Várady, György and Turczel, Gábor and Farkas, Ödön and Owen, Michael Christopher and Katona, Gergely and Győrffy, Balázs and Keserű, György Miklós and Mucsi, Zoltán and Rózsa J., Balázs and Kovács, Ervin},
	doi = {10.1039/D3OB01471A},
	journal-iso = {ORG BIOMOL CHEM},
	journal = {ORGANIC & BIOMOLECULAR CHEMISTRY},
	volume = {21},
	unique-id = {34205650},
	issn = {1477-0520},
	abstract = {An asymmetric cyanine-type fluorescent dye was designed and synthesized via a versatile, multi-step process, aiming to conjugate with an Her2+ receptor specific antibody by an azide-alkyne click reaction. The aromaticity and the excitation and relaxation energetics of the fluorophore were characterized by computational methods. The synthesized dye exhibited excellent fluorescence properties for confocal microscopy, offering efficient applicability in in vitro imaging due to its merits such as a high molar absorption coefficient (36 816 M-1 cm-1), excellent brightness, optimal wavelength (627 nm), larger Stokes shift (26 nm) and appropriate photostability compared to cyanines. The conjugated cyanine-trastuzumab was constructed via an effective, metal-free, strain-promoted azide-alkyne click reaction leading to a regulated number of dyes being conjugated. This novel cyanine-labelled antibody was successfully applied for in vitro confocal imaging and flow cytometry of Her2+ tumor cells. An azido cyanine dye was synthesized and characterized by computational and experimental techniques and applied in tumor cell imaging.},
	keywords = {RECEPTOR; REAGENTS; FUTURE},
	year = {2023},
	eissn = {1477-0539},
	pages = {8829-8836},
	orcid-numbers = {Kontra, Bence/0000-0001-8293-3637; Wittner, Lucia/0000-0001-6800-0953; Várady, György/0000-0003-2012-9680; Farkas, Ödön/0000-0002-4217-0150; Katona, Gergely/0000-0002-4173-0355; Győrffy, Balázs/0000-0002-5772-3766; Mucsi, Zoltán/0000-0003-3224-8847; Kovács, Ervin/0000-0002-3939-6925}
}

@article{MTMT:34016504,
	title = {Láthatóvá tenni a ráksejteket. Új festék a mikroszkópos tumordiagnosztikábanLáthatóvá tenni a ráksejteket/ Új festék a mikroszkópos tumordiagnosztikában},
	url = {https://m2.mtmt.hu/api/publication/34016504},
	author = {Kovács, Ervin and Szepesi Kovács, Dénes and Mucsi, Zoltán},
	journal-iso = {TERMÉSZET VILÁGA},
	journal = {TERMÉSZET VILÁGA},
	volume = {154},
	unique-id = {34016504},
	issn = {0040-3717},
	year = {2023},
	pages = {259-263},
	orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847}
}

@article{MTMT:34015800,
	title = {Synthesis and Application of Two-Photon Active Fluorescent Rhodol Dyes for Antibody Conjugation and In Vitro Cell Imaging},
	url = {https://m2.mtmt.hu/api/publication/34015800},
	author = {Szepesi Kovács, Dénes and Chiovini, Balázs and Müller, Dalma and Tóth, Estilla Zsófia and Fülöp, Anna and Ábrányi-Balogh, Péter and Wittner, Lucia and Várady, György and Farkas, Ödön and Turczel, Gábor and Katona, Gergely and Győrffy, Balázs and Keserű, György Miklós and Mucsi, Zoltán and Rózsa J., Balázs and Kovács, Ervin},
	doi = {10.1021/acsomega.3c01796},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {8},
	unique-id = {34015800},
	issn = {2470-1343},
	year = {2023},
	eissn = {2470-1343},
	pages = {22836-22843},
	orcid-numbers = {Wittner, Lucia/0000-0001-6800-0953; Várady, György/0000-0003-2012-9680; Farkas, Ödön/0000-0002-4217-0150; Katona, Gergely/0000-0002-4173-0355; Győrffy, Balázs/0000-0002-5772-3766; Mucsi, Zoltán/0000-0003-3224-8847; Kovács, Ervin/0000-0002-3939-6925}
}

@article{MTMT:33700517,
	title = {Csizmadia Imre Gyulára emlékezve},
	url = {https://m2.mtmt.hu/api/publication/33700517},
	author = {Kovács, Ervin and Mucsi, Zoltán},
	journal-iso = {MAGY KEM LAP},
	journal = {MAGYAR KÉMIKUSOK LAPJA},
	volume = {78},
	unique-id = {33700517},
	issn = {0025-0163},
	year = {2023},
	eissn = {1588-1199},
	pages = {30-31},
	orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847}
}

@article{MTMT:33700427,
	title = {A szerves kémia digitalizációjának úttörője – Megemlékezés Csizmadia Imre Gyula professzorról},
	url = {https://m2.mtmt.hu/api/publication/33700427},
	author = {Kovács, Ervin and Mucsi, Zoltán},
	journal-iso = {TERMÉSZET VILÁGA},
	journal = {TERMÉSZET VILÁGA},
	volume = {154},
	unique-id = {33700427},
	issn = {0040-3717},
	year = {2023},
	pages = {102-107},
	orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847}
}