TY - JOUR AU - Bajor, Judit AU - Vereczkei, Zsófia AU - Bencs, Réka AU - Nagy, Enikő AU - Peresztegi, Míra Zsófia AU - Hegedűs, Ivett AU - Borbásné Farkas, Kornélia AU - Tárnok, András AU - Szigeti, Nóra AU - Szakács, Zsolt TI - Associations of Clinical Presentation of Coeliac Disease with Comorbidities and Complications: A Retrospective Single-Centre Analysis JF - JOURNAL OF PERSONALIZED MEDICINE J2 - J PERS MED VL - 15 PY - 2025 IS - 2 PG - 12 SN - 2075-4426 DO - 10.3390/jpm15020055 UR - https://m2.mtmt.hu/api/publication/35732301 ID - 35732301 N1 - First Department of Medicine, Medical School, University of Pécs, Ifjúság Str. 13, Pécs, H-7624, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Szigeti Str. 12, Pécs, H-7624, Hungary Department of Sport Nutrition and Hydration, Institute of Nutritional Science and Dietetics, Faculty of Health Sciences, University of Pécs, Vörösmarty Mihály Str. 4, Pécs, H-7621, Hungary Second Department of Internal Medicine and Nephrological Centre, Medical School, University of Pécs, Pacsirta Str. 1, Pécs, H-7624, Hungary Department of Emergency Medicine, Medical School, University of Pécs, Ifjúság Str. 13, Pécs, H-7624, Hungary Medical School, University of Pécs, Szigeti Str. 12, Pécs, H-7624, Hungary Department of Pathology, Medical School, University of Pécs, Szigeti Str. 12, Pécs, H-7624, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Szigeti Str. 12, Pécs, H-7624, Hungary Department of Paediatrics, Medical School, University of Pécs, József Attila Str. 7, Pécs, H-7623, Hungary Export Date: 19 March 2025; Correspondence Address: J. Bajor; First Department of Medicine, Medical School, University of Pécs, Pécs, Ifjúság Str. 13, H-7624, Hungary; email: bajor.judit@pte.hu AB - Background: The clinical presentation of coeliac disease (CD) is various and may influence disease course. We aimed to investigate the associations of clinical presentation with comorbidities and disease complications in a cohort of Hungarian coeliac patients. Methods: In this retrospective study, data of consecutive CD patients were analysed. Clinical presentation (classical vs. non-classical), extraintestinal manifestations and comorbidities (anaemia, metabolic bone disease, dermatitis herpetiformis, IgA deficiency, chromosomal abnormalities, autoimmune diseases and malignancy) were assessed. Student’s t-test (for age at diagnosis) and the Chi-squared test or Fisher’s exact test (for categorical variables) were applied as analyses. Results: A total of 738 patients were included. In classical vs. non-classical comparisons, classical presentation was significantly associated with metabolic bone disease (59 vs. 36%, respectively, p < 0.001), anaemia (47 vs. 38%, respectively, p = 0.027) and malignancy (6 vs. 2%, respectively, p = 0.006); however, autoimmune diseases and dermatitis herpetiformis were more common with non-classical presentation (23 vs. 31%, p = 0.02, and 5 vs. 16%, p = 0.014, respectively). Conclusions: Our findings confirm that clinical presentation is associated with certain comorbidities and complications in CD. More personalised follow-up may be recommended based on clinical presentation. LA - English DB - MTMT ER - TY - JOUR AU - Peresztegi, Míra Zsófia AU - Szakács, Zsolt AU - Vereczkei, Zsófia AU - Dakó, Eszter AU - Dakó, Sarolta AU - Lada, Szilvia AU - Lemes, Klára AU - Holczer, Miklós AU - Borbásné Farkas, Kornélia AU - Bajor, Judit TI - Mediterranean Diet Adherence in Celiac Patients : A Nested Cross-Sectional Study JF - NUTRIENTS J2 - NUTRIENTS VL - 17 PY - 2025 IS - 5 PG - 13 SN - 2072-6643 DO - 10.3390/nu17050788 UR - https://m2.mtmt.hu/api/publication/36015546 ID - 36015546 N1 - Export Date: 29 March 2025 AB - Background/Objectives: The Mediterranean diet (MD) reduces cardiovascular risk, which is higher in celiac disease (CD). We aimed to investigate adherence to the MD in newly diagnosed CD patients, CD patients on a gluten-free diet (GFD), and in a non-celiac control group. Additionally, we aimed to establish an association between GFD and MD adherence. Methods: In this nested, cross-sectional Hungarian study, MD adherence was assessed using the Mediterranean Diet Score (MDS), and GFD adherence was assessed using the Standardized Dietitian Evaluation (SDE). Results: A total of 215 subjects were enrolled, 128 of which were CD patients on a GFD for a minimum of 1 year, 24 were newly diagnosed CD patients, and 63 were non-CD healthy control subjects. Although the control subjects had a higher mean MDS, the groups did not differ statistically significantly from each other (CD on GFD: 5.55 ± 1.57, newly diagnosed CD: 5.35 ± 1.81, controls: 6.05 ± 1.73; p > 0.05)-all groups had suboptimal scores. Both CD groups consumed fewer whole grains than the controls (p < 0.001). Adequate GFD adherence was associated with higher MDS (5.62 ± 1.54 vs. 4.71 ± 1.21, respectively; p = 0.009). Conclusions: Our study highlights the low adherence to MD in celiac patients with insufficient consumption of whole grains. Adherence to GFD is associated with better MD adherence, which underlines the role of dietary education during follow-up. Targeted nutritional counseling could improve the quality of diet in CD patients to reduce cardiovascular risk. LA - English DB - MTMT ER - TY - JOUR AU - Simon, Orsolya Anna AU - Bajor, Judit TI - Hasmenés gyermek- és felnőttkorban JF - HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE J2 - HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE VL - 30 PY - 2025 IS - 4 SP - 257 EP - 261 PG - 5 SN - 1219-8641 UR - https://m2.mtmt.hu/api/publication/36197561 ID - 36197561 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szakács, Zsolt AU - Csiszár, Beáta AU - Nagy, Mátyás AU - Tőkés-Füzesi, Margit AU - Sarlós, Patrícia AU - Tóth, Kálmán AU - Hegyi, Péter AU - Alizadeh, Hussain AU - Bajor, Judit TI - Hemorheology in Inflammatory Bowel Disease: A Case–Control Study JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 14 PY - 2025 IS - 13 PG - 12 SN - 2077-0383 DO - 10.3390/jcm14134436 UR - https://m2.mtmt.hu/api/publication/36203548 ID - 36203548 N1 - Funding Agency and Grant Number: University of Pecs, Medical School; National Research, Development, and Innovation Office (NKFIH) [FK142942, FK132834]; NKFIH [TKP2021-EGA-17] Funding text: This research was funded by the University of Pecs, Medical School, and by the National Research, Development, and Innovation Office (NKFIH) (grant FK142942 to J.B. and FK132834 to P.S.) and supported by NKFIH within the framework of the University of Pecs project TKP2021-EGA-17 to T.K. AB - Background: Venous thromboembolism is more prevalent among patients with inflammatory bowel disease (IBD). This study aimed to identify prothrombotic hemorheological alterations in IBD. Methods: We conducted a case–control study with patients with ulcerative colitis, Crohn’s disease, and non-IBD control subjects. We measured hemorheological indicators including plasma viscosity (PV), whole blood viscosity (WBV), erythrocyte aggregation (EA), and erythrocyte deformability (ED). Uni- and multivariate tests were employed for analysis. Results: A total of 53 IBD patients and 77 control subjects were recruited. IBD patients showed significantly higher aggregation index (68.8% (35.3–83.5%) vs. 66.9% (35.2–83.5%), p = 0.003) and threshold shear rate (120 1/s (55–325 1/s) vs. 110 1/s (55–325 1/s), p < 0.001), with lower aggregation half-time (1.6 s (0.6–7.1 s) vs. 1.8 s (0.6–7.1 s), p = 0.004), indicating enhanced EA. However, after adjusting for covariates, including inflammatory markers, IBD no longer predicted EA. There were no significant differences in EA. PV, WBV, and ED between the groups. Fibrinogen, rather than the Crohn’s Disease Activity Index, was the strongest predictor of the outcomes. Conclusions: Our study demonstrates that IBD patients exhibit enhanced EA, predicted mainly by fibrinogen. These results confirm that inflammation plays the cardinal role in the increased tendency for venous thromboembolism in IBD. LA - English DB - MTMT ER - TY - JOUR AU - Simon, Orsolya Anna AU - Bajor, Judit TI - Hasmenés gyermek- és felnőttkorban. JF - GYÓGYSZERÉSZ TOVÁBBKÉPZÉS J2 - GYÓGYSZERÉSZ TOVÁBBKÉPZÉS VL - 19 PY - 2025 IS - 5 SP - 221 EP - 225 PG - 5 SN - 1788-9049 UR - https://m2.mtmt.hu/api/publication/36285102 ID - 36285102 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Peresztegi, Míra Zsófia AU - Szakács, Zsolt AU - Borbásné Farkas, Kornélia AU - Szekeres, Gábor AU - Faluhelyi, Nándor AU - Hagymási, Krisztina AU - Pásztor, Gyula AU - Vereczkei, Zsófia AU - Fülöp, Petra AU - Lada, Szilvia AU - Dakó, Sarolta AU - Dakó, Eszter AU - Bajor, Judit TI - Hepatic Steatosis and Diet in Adult Celiac Disease: A Cross-Sectional Study JF - NUTRIENTS J2 - NUTRIENTS VL - 17 PY - 2025 IS - 22 PG - 14 SN - 2072-6643 DO - 10.3390/nu17223577 UR - https://m2.mtmt.hu/api/publication/36464633 ID - 36464633 N1 - Funding Agency and Grant Number: University Research Grant Program EKP-25-3-I [EKP-25-3-I-PTE-832]; Ministry of Culture and Innovation, National Fund for Research, Development, and Innovation; University of Pcs Medical School; National Research, Development, and Innovation Office [FK142942] Funding text: This research was funded by the University of Pecs Medical School and by the National Research, Development, and Innovation Office (grant FK142942 to J.B.). This work was also supported by the Ministry of Culture and Innovation, National Fund for Research, Development, and Innovation, under the University Research Grant Program EKOP-25-3-I (EKOP-25-3-I-PTE-832 to M.Z.P.). AB - Background: Celiac disease (CD) is a chronic immune-mediated enteropathy that is treated exclusively with a lifelong gluten-free diet (GFD). Hepatic involvement, including hepatic steatosis (HS), is common in both newly diagnosed and long-term GFD-treated CD patients. Limited data exist regarding HS prevalence and risk factors in CD, and the effects of dietary patterns, including GFD and the Mediterranean diet (MD), remain unclear. Objective: This study investigated the prevalence and severity of HS in newly diagnosed, pre-GFD and GFD-treated CD patients compared to non-celiac control subjects, while assessing the influence of dietary adherence. Methods: In a nested cross-sectional study within the ARCTIC trial (NCT05530070), 290 Hungarian adults were enrolled (60 pre-GFD CD, 156 CD on GFD, and 74 control subjects). HS was assessed by ultrasonography, and dietary adherence was evaluated using the Standardized Dietitian Evaluation and Mediterranean Diet Score (MDS). Binary regression models were applied to identify predictors of HS. Results: HS was diagnosed in 34% of participants, most frequently in pre-GFD CD patients. BMI was the strongest predictor of HS both overall and within the CD cohort (OR = 1.27; 95% CI: 1.16, 1.42; p < 0.001). Neither adherence to GFD nor overall MD adherence significantly influenced the prevalence of HS. Severity of HS correlated with higher BMI, older age, and diabetes prevalence, while individual MD components, including olive oil consumption, were associated with milder HS. Conclusions: HS is more prevalent in CD patients, particularly pre-GFD patients, and is strongly associated with BMI. While overall dietary patterns did not significantly impact HS, certain diet components may modulate severity. LA - English DB - MTMT ER - TY - JOUR AU - Vereczkei, Zsófia AU - Szakács, Zsolt AU - Peresztegi, Míra Zsófia AU - Lemes, Klára AU - Hagymási, Krisztina AU - Dakó, Sarolta AU - Dakó, Eszter AU - Lada, Szilvia AU - Faluhelyi, Nándor AU - Szekeres, Gábor AU - Pásztor, Gyula AU - Borbásné Farkas, Kornélia AU - Pár, Gabriella AU - Mezősi, Emese AU - Bajor, Judit TI - Influence of a structured, 1-year-long dietary intervention regarding body composition and cardiovascular risk (ARCTIC) in coeliac disease: a protocol of a multicentre randomised controlled trial JF - BMJ OPEN J2 - BMJ OPEN VL - 14 PY - 2024 IS - 10 PG - 11 SN - 2044-6055 DO - 10.1136/bmjopen-2024-084365 UR - https://m2.mtmt.hu/api/publication/35453130 ID - 35453130 N1 - Protocol AB - Coeliac disease (CD) affects 1% of the population worldwide. The only available evidence-based treatment is a strict gluten-free diet (GFD), which can readily lead to weight gain and unfavourable metabolic changes (eg, dyslipidaemia, fatty liver disease and insulin resistance) if followed without adequate dietary control. That can lead to increased cardiovascular risk (CV). We planned a randomised controlled trial to test the effect of a group-based, structured, 1-year, advanced dietary education, per the proposal of a Mediterranean diet vs standard of care, regarding the most relevant CV risk factors (eg, metabolic parameters and body composition) in CD patients.Randomisation will occur after the baseline dietary education and interview in a 1:1 allocation ratio. Outcomes include anthropometric parameters (body composition analysis including weight, Body Mass Index, fat mass, per cent body fat, skeletal muscle mass, visceral fat area and total body water) and CV risk-related metabolic parameters (eg, lipid profile, homocysteine, fasting glucose, haemoglobin A1c, Homeostatic Model Assessment Index, metabolic hormones, waist circumference, blood pressure, liver function tests, liver steatosis rate and diet composition). In this study, we aim to draw attention to a new aspect regarding managing CD: dietary education can lead to a better quality of the GFD, thereby reducing the risk of potential metabolic and CV complications.The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (27521-5/2022/EÜIG). Findings will be disseminated at research conferences and in peer-reviewed journals.NCT05530070. LA - English DB - MTMT ER - TY - JOUR AU - Bajor, Judit AU - Peresztegi, Z. M. AU - Vereczkei, Zsófia AU - Hagymási, K. AU - Faluhelyi, Nándor AU - Szekeres, G. AU - Pásztor, G. AU - Szirmay, Balázs AU - Sipos, Zoltán AU - Lemes, K. AU - Papp, V. AU - Lénárt, Z. AU - Pár, Gabriella TI - HEPATIC STEATOSIS AND BODY COMPOSITION IN PATIENTS WITH CELIAC DISEASE. PRELIMINARY RESULTS OF A PROSPECTIVE, MULTICENTER, CASE-CONTROL STUDY (ARCTIC STUDY) JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 12 PY - 2024 IS - S8 SP - 232 EP - 233 PG - 2 SN - 2050-6406 UR - https://m2.mtmt.hu/api/publication/35499799 ID - 35499799 LA - English DB - MTMT ER - TY - JOUR AU - Peresztegi, Z. M. AU - Vereczkei, Zsófia AU - Sipos, Zoltán AU - Borbásné Farkas, Kornélia AU - Máth, B. AU - Lemes, K. AU - Lenart, Z. AU - Papp, V. AU - Dakó, E. AU - Dakó, S. AU - Bajor, Judit TI - INVESTIGATION OF BODY COMPOSITION PARAMETERS IN PATIENTS WITH CELIAC DISEASE ON A GLUTEN-FREE DIET. PROSPECTIVE, MULTICENTER, CASE-CONTROL STUDY (ARCTIC STUDY) JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 12 PY - 2024 IS - S8 SP - 356 EP - 356 PG - 1 SN - 2050-6406 UR - https://m2.mtmt.hu/api/publication/35499831 ID - 35499831 LA - English DB - MTMT ER - TY - JOUR AU - Vereczkei, Zsófia AU - Fülöp, P. AU - Lada, S. AU - Dakó, S. AU - Dakó, E. AU - Füstös, D. D. AU - Peresztegi, M. Z. AU - Bajor, Judit TI - BODY COMPOSITION AND MEDITERRANEAN DIET ADHERENCE OF COELIAC PATIENTS. A PROSPECTIVE, MULTICENTER STUDY (ARCTIC STUDY) JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 12 PY - 2024 IS - S8 SP - 828 EP - 828 PG - 1 SN - 2050-6406 UR - https://m2.mtmt.hu/api/publication/35499839 ID - 35499839 LA - English DB - MTMT ER -