@article{MTMT:35732301, title = {Associations of Clinical Presentation of Coeliac Disease with Comorbidities and Complications: A Retrospective Single-Centre Analysis}, url = {https://m2.mtmt.hu/api/publication/35732301}, author = {Bajor, Judit and Vereczkei, Zsófia and Bencs, Réka and Nagy, Enikő and Peresztegi, Míra Zsófia and Hegedűs, Ivett and Borbásné Farkas, Kornélia and Tárnok, András and Szigeti, Nóra and Szakács, Zsolt}, doi = {10.3390/jpm15020055}, journal-iso = {J PERS MED}, journal = {JOURNAL OF PERSONALIZED MEDICINE}, volume = {15}, unique-id = {35732301}, abstract = {Background: The clinical presentation of coeliac disease (CD) is various and may influence disease course. We aimed to investigate the associations of clinical presentation with comorbidities and disease complications in a cohort of Hungarian coeliac patients. Methods: In this retrospective study, data of consecutive CD patients were analysed. Clinical presentation (classical vs. non-classical), extraintestinal manifestations and comorbidities (anaemia, metabolic bone disease, dermatitis herpetiformis, IgA deficiency, chromosomal abnormalities, autoimmune diseases and malignancy) were assessed. Student’s t-test (for age at diagnosis) and the Chi-squared test or Fisher’s exact test (for categorical variables) were applied as analyses. Results: A total of 738 patients were included. In classical vs. non-classical comparisons, classical presentation was significantly associated with metabolic bone disease (59 vs. 36%, respectively, p < 0.001), anaemia (47 vs. 38%, respectively, p = 0.027) and malignancy (6 vs. 2%, respectively, p = 0.006); however, autoimmune diseases and dermatitis herpetiformis were more common with non-classical presentation (23 vs. 31%, p = 0.02, and 5 vs. 16%, p = 0.014, respectively). Conclusions: Our findings confirm that clinical presentation is associated with certain comorbidities and complications in CD. More personalised follow-up may be recommended based on clinical presentation.}, year = {2025}, eissn = {2075-4426}, orcid-numbers = {Vereczkei, Zsófia/0000-0002-8144-4628; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Tárnok, András/0000-0001-7019-2755; Szakács, Zsolt/0000-0002-7035-941X} } @article{MTMT:36015546, title = {Mediterranean Diet Adherence in Celiac Patients : A Nested Cross-Sectional Study}, url = {https://m2.mtmt.hu/api/publication/36015546}, author = {Peresztegi, Míra Zsófia and Szakács, Zsolt and Vereczkei, Zsófia and Dakó, Eszter and Dakó, Sarolta and Lada, Szilvia and Lemes, Klára and Holczer, Miklós and Borbásné Farkas, Kornélia and Bajor, Judit}, doi = {10.3390/nu17050788}, journal-iso = {NUTRIENTS}, journal = {NUTRIENTS}, volume = {17}, unique-id = {36015546}, abstract = {Background/Objectives: The Mediterranean diet (MD) reduces cardiovascular risk, which is higher in celiac disease (CD). We aimed to investigate adherence to the MD in newly diagnosed CD patients, CD patients on a gluten-free diet (GFD), and in a non-celiac control group. Additionally, we aimed to establish an association between GFD and MD adherence. Methods: In this nested, cross-sectional Hungarian study, MD adherence was assessed using the Mediterranean Diet Score (MDS), and GFD adherence was assessed using the Standardized Dietitian Evaluation (SDE). Results: A total of 215 subjects were enrolled, 128 of which were CD patients on a GFD for a minimum of 1 year, 24 were newly diagnosed CD patients, and 63 were non-CD healthy control subjects. Although the control subjects had a higher mean MDS, the groups did not differ statistically significantly from each other (CD on GFD: 5.55 ± 1.57, newly diagnosed CD: 5.35 ± 1.81, controls: 6.05 ± 1.73; p > 0.05)-all groups had suboptimal scores. Both CD groups consumed fewer whole grains than the controls (p < 0.001). Adequate GFD adherence was associated with higher MDS (5.62 ± 1.54 vs. 4.71 ± 1.21, respectively; p = 0.009). Conclusions: Our study highlights the low adherence to MD in celiac patients with insufficient consumption of whole grains. Adherence to GFD is associated with better MD adherence, which underlines the role of dietary education during follow-up. Targeted nutritional counseling could improve the quality of diet in CD patients to reduce cardiovascular risk.}, keywords = {celiac disease; GLUTEN-FREE DIET; Mediterranean diet}, year = {2025}, eissn = {2072-6643}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Vereczkei, Zsófia/0000-0002-8144-4628; Dakó, Eszter/0000-0003-0000-1575; Lada, Szilvia/0009-0001-9556-4778; Borbásné Farkas, Kornélia/0000-0002-5349-6527} } @article{MTMT:36197561, title = {Hasmenés gyermek- és felnőttkorban}, url = {https://m2.mtmt.hu/api/publication/36197561}, author = {Simon, Orsolya Anna and Bajor, Judit}, journal-iso = {HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE}, journal = {HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE}, volume = {30}, unique-id = {36197561}, issn = {1219-8641}, year = {2025}, pages = {257-261} } @article{MTMT:36203548, title = {Hemorheology in Inflammatory Bowel Disease: A Case–Control Study}, url = {https://m2.mtmt.hu/api/publication/36203548}, author = {Szakács, Zsolt and Csiszár, Beáta and Nagy, Mátyás and Tőkés-Füzesi, Margit and Sarlós, Patrícia and Tóth, Kálmán and Hegyi, Péter and Alizadeh, Hussain and Bajor, Judit}, doi = {10.3390/jcm14134436}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {14}, unique-id = {36203548}, abstract = {Background: Venous thromboembolism is more prevalent among patients with inflammatory bowel disease (IBD). This study aimed to identify prothrombotic hemorheological alterations in IBD. Methods: We conducted a case–control study with patients with ulcerative colitis, Crohn’s disease, and non-IBD control subjects. We measured hemorheological indicators including plasma viscosity (PV), whole blood viscosity (WBV), erythrocyte aggregation (EA), and erythrocyte deformability (ED). Uni- and multivariate tests were employed for analysis. Results: A total of 53 IBD patients and 77 control subjects were recruited. IBD patients showed significantly higher aggregation index (68.8% (35.3–83.5%) vs. 66.9% (35.2–83.5%), p = 0.003) and threshold shear rate (120 1/s (55–325 1/s) vs. 110 1/s (55–325 1/s), p < 0.001), with lower aggregation half-time (1.6 s (0.6–7.1 s) vs. 1.8 s (0.6–7.1 s), p = 0.004), indicating enhanced EA. However, after adjusting for covariates, including inflammatory markers, IBD no longer predicted EA. There were no significant differences in EA. PV, WBV, and ED between the groups. Fibrinogen, rather than the Crohn’s Disease Activity Index, was the strongest predictor of the outcomes. Conclusions: Our study demonstrates that IBD patients exhibit enhanced EA, predicted mainly by fibrinogen. These results confirm that inflammation plays the cardinal role in the increased tendency for venous thromboembolism in IBD.}, keywords = {AGGREGATION; THROMBOSIS; Inflammatory bowel disease; Viscosity; ulcerative colitis; Crohn's disease; Hemorheology; anticoagulant}, year = {2025}, eissn = {2077-0383}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Sarlós, Patrícia/0000-0002-5086-9455; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:36285102, title = {Hasmenés gyermek- és felnőttkorban.}, url = {https://m2.mtmt.hu/api/publication/36285102}, author = {Simon, Orsolya Anna and Bajor, Judit}, journal-iso = {GYÓGYSZERÉSZ TOVÁBBKÉPZÉS}, journal = {GYÓGYSZERÉSZ TOVÁBBKÉPZÉS}, volume = {19}, unique-id = {36285102}, issn = {1788-9049}, year = {2025}, pages = {221-225} } @article{MTMT:36464633, title = {Hepatic Steatosis and Diet in Adult Celiac Disease: A Cross-Sectional Study}, url = {https://m2.mtmt.hu/api/publication/36464633}, author = {Peresztegi, Míra Zsófia and Szakács, Zsolt and Borbásné Farkas, Kornélia and Szekeres, Gábor and Faluhelyi, Nándor and Hagymási, Krisztina and Pásztor, Gyula and Vereczkei, Zsófia and Fülöp, Petra and Lada, Szilvia and Dakó, Sarolta and Dakó, Eszter and Bajor, Judit}, doi = {10.3390/nu17223577}, journal-iso = {NUTRIENTS}, journal = {NUTRIENTS}, volume = {17}, unique-id = {36464633}, abstract = {Background: Celiac disease (CD) is a chronic immune-mediated enteropathy that is treated exclusively with a lifelong gluten-free diet (GFD). Hepatic involvement, including hepatic steatosis (HS), is common in both newly diagnosed and long-term GFD-treated CD patients. Limited data exist regarding HS prevalence and risk factors in CD, and the effects of dietary patterns, including GFD and the Mediterranean diet (MD), remain unclear. Objective: This study investigated the prevalence and severity of HS in newly diagnosed, pre-GFD and GFD-treated CD patients compared to non-celiac control subjects, while assessing the influence of dietary adherence. Methods: In a nested cross-sectional study within the ARCTIC trial (NCT05530070), 290 Hungarian adults were enrolled (60 pre-GFD CD, 156 CD on GFD, and 74 control subjects). HS was assessed by ultrasonography, and dietary adherence was evaluated using the Standardized Dietitian Evaluation and Mediterranean Diet Score (MDS). Binary regression models were applied to identify predictors of HS. Results: HS was diagnosed in 34% of participants, most frequently in pre-GFD CD patients. BMI was the strongest predictor of HS both overall and within the CD cohort (OR = 1.27; 95% CI: 1.16, 1.42; p < 0.001). Neither adherence to GFD nor overall MD adherence significantly influenced the prevalence of HS. Severity of HS correlated with higher BMI, older age, and diabetes prevalence, while individual MD components, including olive oil consumption, were associated with milder HS. Conclusions: HS is more prevalent in CD patients, particularly pre-GFD patients, and is strongly associated with BMI. While overall dietary patterns did not significantly impact HS, certain diet components may modulate severity.}, keywords = {celiac disease; GLUTEN-FREE DIET; hepatic steatosis; Mediterranean diet}, year = {2025}, eissn = {2072-6643}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Hagymási, Krisztina/0000-0002-5859-1320; Pásztor, Gyula/0009-0001-6000-4885; Vereczkei, Zsófia/0000-0002-8144-4628; Lada, Szilvia/0009-0001-9556-4778; Dakó, Eszter/0000-0003-0000-1575} } @article{MTMT:35453130, title = {Influence of a structured, 1-year-long dietary intervention regarding body composition and cardiovascular risk (ARCTIC) in coeliac disease: a protocol of a multicentre randomised controlled trial}, url = {https://m2.mtmt.hu/api/publication/35453130}, author = {Vereczkei, Zsófia and Szakács, Zsolt and Peresztegi, Míra Zsófia and Lemes, Klára and Hagymási, Krisztina and Dakó, Sarolta and Dakó, Eszter and Lada, Szilvia and Faluhelyi, Nándor and Szekeres, Gábor and Pásztor, Gyula and Borbásné Farkas, Kornélia and Pár, Gabriella and Mezősi, Emese and Bajor, Judit}, doi = {10.1136/bmjopen-2024-084365}, journal-iso = {BMJ OPEN}, journal = {BMJ OPEN}, volume = {14}, unique-id = {35453130}, issn = {2044-6055}, abstract = {Coeliac disease (CD) affects 1% of the population worldwide. The only available evidence-based treatment is a strict gluten-free diet (GFD), which can readily lead to weight gain and unfavourable metabolic changes (eg, dyslipidaemia, fatty liver disease and insulin resistance) if followed without adequate dietary control. That can lead to increased cardiovascular risk (CV). We planned a randomised controlled trial to test the effect of a group-based, structured, 1-year, advanced dietary education, per the proposal of a Mediterranean diet vs standard of care, regarding the most relevant CV risk factors (eg, metabolic parameters and body composition) in CD patients.Randomisation will occur after the baseline dietary education and interview in a 1:1 allocation ratio. Outcomes include anthropometric parameters (body composition analysis including weight, Body Mass Index, fat mass, per cent body fat, skeletal muscle mass, visceral fat area and total body water) and CV risk-related metabolic parameters (eg, lipid profile, homocysteine, fasting glucose, haemoglobin A1c, Homeostatic Model Assessment Index, metabolic hormones, waist circumference, blood pressure, liver function tests, liver steatosis rate and diet composition). In this study, we aim to draw attention to a new aspect regarding managing CD: dietary education can lead to a better quality of the GFD, thereby reducing the risk of potential metabolic and CV complications.The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (27521-5/2022/EÜIG). Findings will be disseminated at research conferences and in peer-reviewed journals.NCT05530070.}, keywords = {randomized controlled trial; clinical trial; risk management; health education; coeliac disease; Nutrition & Dietetics}, year = {2024}, eissn = {2044-6055}, orcid-numbers = {Vereczkei, Zsófia/0000-0002-8144-4628; Szakács, Zsolt/0000-0002-7035-941X; Hagymási, Krisztina/0000-0002-5859-1320; Dakó, Eszter/0000-0003-0000-1575; Pásztor, Gyula/0009-0001-6000-4885; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Mezősi, Emese/0000-0001-9367-3877} } @article{MTMT:35499799, title = {HEPATIC STEATOSIS AND BODY COMPOSITION IN PATIENTS WITH CELIAC DISEASE. PRELIMINARY RESULTS OF A PROSPECTIVE, MULTICENTER, CASE-CONTROL STUDY (ARCTIC STUDY)}, url = {https://m2.mtmt.hu/api/publication/35499799}, author = {Bajor, Judit and Peresztegi, Z. M. and Vereczkei, Zsófia and Hagymási, K. and Faluhelyi, Nándor and Szekeres, G. and Pásztor, G. and Szirmay, Balázs and Sipos, Zoltán and Lemes, K. and Papp, V. and Lénárt, Z. and Pár, Gabriella}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {12}, unique-id = {35499799}, issn = {2050-6406}, year = {2024}, eissn = {2050-6414}, pages = {232-233}, orcid-numbers = {Vereczkei, Zsófia/0000-0002-8144-4628; Sipos, Zoltán/0000-0001-7845-8116} } @article{MTMT:35499831, title = {INVESTIGATION OF BODY COMPOSITION PARAMETERS IN PATIENTS WITH CELIAC DISEASE ON A GLUTEN-FREE DIET. PROSPECTIVE, MULTICENTER, CASE-CONTROL STUDY (ARCTIC STUDY)}, url = {https://m2.mtmt.hu/api/publication/35499831}, author = {Peresztegi, Z. M. and Vereczkei, Zsófia and Sipos, Zoltán and Borbásné Farkas, Kornélia and Máth, B. and Lemes, K. and Lenart, Z. and Papp, V. and Dakó, E. and Dakó, S. and Bajor, Judit}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {12}, unique-id = {35499831}, issn = {2050-6406}, year = {2024}, eissn = {2050-6414}, pages = {356-356}, orcid-numbers = {Vereczkei, Zsófia/0000-0002-8144-4628; Sipos, Zoltán/0000-0001-7845-8116; Borbásné Farkas, Kornélia/0000-0002-5349-6527} } @article{MTMT:35499839, title = {BODY COMPOSITION AND MEDITERRANEAN DIET ADHERENCE OF COELIAC PATIENTS. A PROSPECTIVE, MULTICENTER STUDY (ARCTIC STUDY)}, url = {https://m2.mtmt.hu/api/publication/35499839}, author = {Vereczkei, Zsófia and Fülöp, P. and Lada, S. and Dakó, S. and Dakó, E. and Füstös, D. D. and Peresztegi, M. Z. and Bajor, Judit}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {12}, unique-id = {35499839}, issn = {2050-6406}, year = {2024}, eissn = {2050-6414}, pages = {828-828}, orcid-numbers = {Vereczkei, Zsófia/0000-0002-8144-4628} }