@article{MTMT:32570862,
	title = {Fehérje méretű molekulák humán sejtekbe juttatása lipid-raft mediált endocitózissal},
	url = {https://m2.mtmt.hu/api/publication/32570862},
	author = {Hetényi, Anasztázia and Imre, Norbert and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	journal-iso = {BIOKÉMIA},
	journal = {BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA},
	volume = {45},
	unique-id = {32570862},
	issn = {0133-8455},
	year = {2021},
	eissn = {2060-8152},
	pages = {67-83},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:32531953,
	title = {In Vitro Comparative Study of Solid Lipid and PLGA Nanoparticles Designed to Facilitate Nose-to-Brain Delivery of Insulin},
	url = {https://m2.mtmt.hu/api/publication/32531953},
	author = {Akel, Hussein and Pannonhalminé Csóka, Ildikó and Ambrus, Rita and Bocsik, Alexandra and Gróf, Ilona and Mészáros, Mária and Szecskó, Anikó and Kozma, Gábor and Veszelka, Szilvia and Deli, Mária Anna and Kónya, Zoltán and Katona, Gábor},
	doi = {10.3390/ijms222413258},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32531953},
	issn = {1661-6596},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Kozma, Gábor/0000-0003-2033-0720; Deli, Mária Anna/0000-0001-6084-6524; Kónya, Zoltán/0000-0002-9406-8596; Katona, Gábor/0000-0003-1564-4813}
}

@article{MTMT:31890902,
	title = {New Approach in Ocular Drug Delivery. In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations},
	url = {https://m2.mtmt.hu/api/publication/31890902},
	author = {Bíró, Tivadar and Bocsik, Alexandra and Jurišić Dukovski, Bisera and Gróf, Ilona and Lovrić, Jasmina and Pannonhalminé Csóka, Ildikó and Deli, Mária Anna and Aigner, Zoltán},
	doi = {10.2147/DDDT.S264745},
	journal-iso = {DRUG DES DEV THER},
	journal = {DRUG DESIGN DEVELOPMENT AND THERAPY},
	volume = {15},
	unique-id = {31890902},
	issn = {1177-8881},
	abstract = {Background: Optimal transcorneal penetration is necessary for ocular therapy; meanwhile, it is limited by the complex structure and defensive mechanisms of the eye. Antimicrobial stability of topical ophthalmic formulations is especially important. According to previous studies, the mostly used preservative, benzalkonium-chloride is irritative and toxic on corneal epithelial cells; therefore, novel non-toxic, antimicrobial agents are required. In this study, prednisolone-containing ophthalmic formulations were developed with expected optimal permeation without toxic or irritative effects. Methods: The toxicity and permeability of prednisolone-containing eye drops were studied on a human corneal epithelial cell line (HCE-T) and ex vivo cornea model. The lipophilic drug is dissolved by the formation of cyclodextrin inclusion complex. Zinc-containing mucoadhesive biopolymer was applied as an alternative preservative agent, whose toxicity was compared with benzalkonium-chloride. Results: As the results show, benzalkonium-chloride-containing samples were toxic on HCE-T cells. The biopolymer caused no cell damage after the treatment. This was confirmed by immunohistochemistry assay. The in vitro permeability was significantly higher in formulations with prednisolone-cyclodextrin complex compared with suspension formulation. According to the ex vivo permeability study, the biopolymer-containing samples had significantly lower permeability. Conclusion: Considering the mucoadhesive attribute of target formulations, prolonged absorption is expected after application with less frequent administration. It can be stated that the compositions are innovative approaches as novel non-toxic ophthalmic formulations with optimal drug permeability.},
	year = {2021},
	pages = {351-360},
	orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31978759,
	title = {Investigation of the permeability and cytotoxicity in novel topical ophthalmic formulations using in vitro and ex vivo models},
	url = {https://m2.mtmt.hu/api/publication/31978759},
	author = {Bíró, Tivadar and Bocsik, Alexandra and Gróf, Ilona and Bisera, Jurisic Dukowski and Jasmina, Lovric and Deli, Mária Anna and Aigner, Zoltán},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {90},
	unique-id = {31978759},
	issn = {0001-6659},
	year = {2020},
	eissn = {1587-1495},
	pages = {86-86},
	orcid-numbers = {Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31335512,
	title = {The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel},
	url = {https://m2.mtmt.hu/api/publication/31335512},
	author = {Gróf, Ilona and Bocsik, Alexandra and Harazin, András and Santa Maria, Anaraquel and Vizsnyiczai, Gaszton and Barna, Lilla and Kiss, Lóránd and Fűr, Gabriella and Rakonczay, Zoltán and Ambrus, Rita and Révész, Piroska and Gosselet, Fabien and Pongsiri, Jaikumpun and Szabó, Hajnalka and Zsembery, Ákos and Deli, Mária Anna},
	doi = {10.3390/ijms21114024},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31335512},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067},
	orcid-numbers = {Harazin, András/0000-0002-0904-5606; Santa Maria, Anaraquel/0000-0003-3505-5477; Vizsnyiczai, Gaszton/0000-0003-3245-3736; Rakonczay, Zoltán/0000-0002-1499-3416; Révész, Piroska/0000-0002-5336-6052; Pongsiri, Jaikumpun/0000-0001-9160-2645; Zsembery, Ákos/0000-0003-0253-9379; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31181444,
	title = {Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage.},
	url = {https://m2.mtmt.hu/api/publication/31181444},
	author = {Barna, Lilla and Walter, Fruzsina and Harazin, András and Bocsik, Alexandra and Kincses, András and Tubak, Vilmos and Jósvay, Katalin and Zvara, Ágnes and Campos-Bedolla, Patricia and Deli, Mária Anna},
	doi = {10.1186/s12987-019-0166-1},
	journal-iso = {FLUIDS BARRIERS CNS},
	journal = {FLUIDS AND BARRIERS OF THE CNS},
	volume = {17},
	unique-id = {31181444},
	issn = {2045-8118},
	abstract = {Excitotoxicity is a central pathological pathway in many neurological diseases with blood-brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, but the direct effect of kainate on brain endothelial cells has not been studied in detail. Our aim was to examine the direct effects of kainate on cultured cells of the BBB and to test three anti-inflammatory and antioxidant drugs used in clinical practice, simvastatin, edaravone and dexamethasone, to protect against kainate-induced changes.Primary rat brain endothelial cell, pericyte and astroglia cultures were used to study cell viability by impedance measurement. BBB permeability was measured on a model made from the co-culture of the three cell types. The production of nitrogen monoxide and reactive oxygen species was followed by fluorescent probes. The mRNA expression of kainate receptors and nitric oxide synthases were studied by PCR.Kainate damaged brain endothelial cells and made the immunostaining of junctional proteins claudin-5 and zonula occludens-1 discontinuous at the cell border indicating the opening of the barrier. The permeability of the BBB model for marker molecules fluorescein and albumin and the production of nitric oxide in brain endothelial cells were increased by kainate. Simvastatin, edaravone and dexamethasone protected against the reduced cell viability, increased permeability and the morphological changes in cellular junctions caused by kainate. Dexamethasone attenuated the elevated nitric oxide production and decreased the inducible nitric oxide synthase (NOS2/iNOS) mRNA expression increased by kainate treatment.Kainate directly damaged cultured brain endothelial cells. Simvastatin, edaravone and dexamethasone protected the BBB model against kainate-induced changes. Our results confirmed the potential clinical usefulness of these drugs to attenuate BBB damage.},
	keywords = {DEXAMETHASONE; Permeability; Blood-Brain Barrier; Reactive oxygen species; nitric oxide synthase; SIMVASTATIN; kainate; Edaravone; Brain endothelial cells},
	year = {2020},
	eissn = {2045-8118},
	orcid-numbers = {Walter, Fruzsina/0000-0001-8145-2823; Harazin, András/0000-0002-0904-5606; Tubak, Vilmos/0000-0002-6141-3920; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31126947,
	title = {Routing Nanomolar Protein Cargoes to Lipid Raft‐Mediated/Caveolar Endocytosis through a Ganglioside GM1‐Specific Recognition Tag},
	url = {https://m2.mtmt.hu/api/publication/31126947},
	author = {Imre, Norbert and Hetényi, Anasztázia and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	doi = {10.1002/advs.201902621},
	journal-iso = {ADV SCI},
	journal = {ADVANCED SCIENCE},
	volume = {7},
	unique-id = {31126947},
	year = {2020},
	eissn = {2198-3844},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:30912242,
	title = {Encapsulation in Polymeric Nanoparticles Enhances the Enzymatic Stability and the Permeability of the GLP-1 Analog, Liraglutide, Across a Culture Model of Intestinal Permeability},
	url = {https://m2.mtmt.hu/api/publication/30912242},
	author = {Ismail, Ruba and Bocsik, Alexandra and Katona, Gábor and Gróf, Ilona and Deli, Mária Anna and Pannonhalminé Csóka, Ildikó},
	doi = {10.3390/pharmaceutics11110599},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {11},
	unique-id = {30912242},
	issn = {1999-4923},
	year = {2019},
	eissn = {1999-4923},
	orcid-numbers = {Ismail, Ruba/0000-0002-5122-9513; Katona, Gábor/0000-0003-1564-4813; Deli, Mária Anna/0000-0001-6084-6524; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:30434125,
	title = {Dual Action of the PN159/KLAL/MAP Peptide. Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability.},
	url = {https://m2.mtmt.hu/api/publication/30434125},
	author = {Bocsik, Alexandra and Gróf, Ilona and Kiss, Lóránd and Ötvös, Ferenc and Zsíros, Ottó and Daruka, Lejla and Fülöp, Lívia and Vastag, Monika and Kittel, Ágnes and Imre, Norbert and Martinek, Tamás and Pál, Csaba and Révész, Piroska and Deli, Mária Anna},
	doi = {10.3390/pharmaceutics11020073},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {11},
	unique-id = {30434125},
	issn = {1999-4923},
	abstract = {The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study the 18-mer amphiphilic PN159 peptide was found to be an effective tight junction modulator on intestinal epithelial and blood⁻brain barrier models. PN159, also known as KLAL or MAP, was described to interact with biological membranes as a cell-penetrating peptide. In the present work we demonstrated that the PN159 peptide as a penetration enhancer has a dual action on intestinal epithelial cells. The peptide safely and reversibly enhanced the permeability of Caco-2 monolayers by opening the intercellular junctions. The penetration of dextran molecules with different size and four efflux pump substrate drugs was increased several folds. We identified claudin-4 and -7 junctional proteins by docking studies as potential binding partners and targets of PN159 in the opening of the paracellular pathway. In addition to the tight junction modulator action, the peptide showed cell membrane permeabilizing and antimicrobial effects. This dual action is not general for cell-penetrating peptides (CPPs), since the other three CPPs tested did not show barrier opening effects.},
	keywords = {Drug delivery; Claudin; Caco-2; Antimicrobial peptide; KLAL; PN159; absorption enhancer; cell-penetrating peptide (CPP); intestinal epithelial cells; tight junction modulator},
	year = {2019},
	eissn = {1999-4923},
	orcid-numbers = {Fülöp, Lívia/0000-0002-8010-0129; Martinek, Tamás/0000-0003-3168-8066; Révész, Piroska/0000-0002-5336-6052; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:30548713,
	title = {Formulation of steroid containing eye drops with cyclodextrin derivatives and mucoadhesive preservative system},
	url = {https://m2.mtmt.hu/api/publication/30548713},
	author = {Bíró, Tivadar and Horvát, Gabriella and Bocsik, Alexandra and Gróf, Ilona and Zsoldiné Urbán, Edit and Deli, Mária Anna and Csányi, Erzsébet and Révész, Piroska and Pannonhalminé Csóka, Ildikó and Aigner, Zoltán},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {88},
	unique-id = {30548713},
	issn = {0001-6659},
	year = {2018},
	eissn = {1587-1495},
	pages = {139-140},
	orcid-numbers = {Zsoldiné Urbán, Edit/0000-0002-9602-7552; Deli, Mária Anna/0000-0001-6084-6524; Csányi, Erzsébet/0000-0002-3010-1959; Révész, Piroska/0000-0002-5336-6052; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}