@article{MTMT:34405846, title = {A tünetmentes állapot fenntartásáért felelős szerkezeti és immunológiai aspektusok azonosítása a pikkelysömörös nem léziós bőrben}, url = {https://m2.mtmt.hu/api/publication/34405846}, author = {Danis, Judit and Kelemen, Evelyn and Bozó, Renáta and Konczné Gubán, Barbara and Csörgő Sándorné Bata, Zsuzsanna and Kemény, Lajos and Széll, Márta}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {15}, unique-id = {34405846}, issn = {2061-0203}, year = {2023}, pages = {73-79}, orcid-numbers = {Danis, Judit/0000-0002-0270-5309; Bozó, Renáta/0000-0003-4242-2474; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Kemény, Lajos/0000-0002-2119-9501; Széll, Márta/0000-0002-0730-714X} } @article{MTMT:34085614, title = {Herpes Simplex Virus Infection Alters the Immunological Properties of Adipose-Tissue-Derived Mesenchymal-Stem Cells}, url = {https://m2.mtmt.hu/api/publication/34085614}, author = {Kun-Varga, Anikó and Konczné Gubán, Barbara and Miklós, Vanda and Parvaneh, Shahram and Guba, Melinda and Szűcs, Diána and Monostori, Tamás and Varga, János and Varga, Ákos and Rázga, Zsolt and Csörgő Sándorné Bata, Zsuzsanna and Kemény, Lajos and Megyeri, Klára and Veréb, Zoltán}, doi = {10.3390/ijms241511989}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34085614}, issn = {1661-6596}, abstract = {The proper functioning of mesenchymal stem cells (MSCs) is of paramount importance for the homeostasis of the body. Inflammation and infection can alter the function of MSCs, which can also affect the regenerative potential and immunological status of tissues. It is not known whether human herpes simplex viruses 1 and 2 (HSV1 and HSV2), well-known human pathogens that can cause lifelong infections, can induce changes in MSCs. In non-healing ulcers, HSV infection is known to affect deeper tissue layers. In addition, HSV infection can recur after initially successful cell therapies. Our aim was to study the response of adipose-derived MSCs (ADMSCs) to HSV infection in vitro. After confirming the phenotype and differentiation capacity of the isolated cells, we infected the cells in vitro with HSV1-KOS, HSV1-532 and HSV2 virus strains. Twenty-four hours after infection, we examined the gene expression of the cells via RNA-seq and RT-PCR; detected secreted cytokines via protein array; and determined autophagy via Western blot, transmission electron microscopy (TEM) and fluorescence microscopy. Infection with different HSV strains resulted in different gene-expression patterns. In addition to the activation of pathways characteristic of viral infections, distinct non-immunological pathways (autophagy, tissue regeneration and differentiation) were also activated according to analyses with QIAGEN Ingenuity Pathway Analysis, Kyoto Encyclopedia of Genes and Genome and Genome Ontology Enrichment. Viral infections increased autophagy, as confirmed via TEM image analysis, and also increased levels of the microtubule-associated protein light chain 3 (LC3B) II protein. We identified significantly altered accumulation for 16 cytokines involved in tissue regeneration and inflammation. Our studies demonstrated that HSV infection can alter the viability and immunological status of ADMSCs, which may have implications for ADMSC-based cell therapies. Alterations in autophagy can affect numerous processes in MSCs, including the inhibition of tissue regeneration as well as pathological differentiation.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Rázga, Zsolt/0000-0003-4717-8482; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155} } @article{MTMT:33261227, title = {Abnormal type VII collagen expression in non-lesional psoriatic skin}, url = {https://m2.mtmt.hu/api/publication/33261227}, author = {Konczné Gubán, Barbara and Flink, Lili Borbála and Bozó, Renáta and Danis, Judit and Rázga, Zsolt and Koncz, Balázs and Széll, Márta and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna}, doi = {10.1016/j.jid.2022.09.386}, journal-iso = {J INVEST DERMATOL}, journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY}, volume = {142}, unique-id = {33261227}, issn = {0022-202X}, year = {2022}, eissn = {1523-1747}, pages = {S244-S244}, orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Danis, Judit/0000-0002-0270-5309; Rázga, Zsolt/0000-0003-4717-8482; Széll, Márta/0000-0002-0730-714X; Kemény, Lajos/0000-0002-2119-9501; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743} } @article{MTMT:33190130, title = {Abnormal type VII collagen expression in non-lesional psoriatic skin}, url = {https://m2.mtmt.hu/api/publication/33190130}, author = {Konczné Gubán, Barbara and Flink, Lili Borbála and Bozó, Renáta and Danis, Judit and Rázga, Zsolt and Koncz, Balázs and Széll, Márta and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {98}, unique-id = {33190130}, issn = {0006-7768}, year = {2022}, eissn = {2064-261X}, pages = {190-190}, orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Danis, Judit/0000-0002-0270-5309; Rázga, Zsolt/0000-0003-4717-8482; Széll, Márta/0000-0002-0730-714X; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743} } @article{MTMT:31798342, title = {Could basement membrane alterations, resembling micro-wounds at the dermo-epidermal junction in psoriatic non-lesional skin, make the skin susceptible to lesion formation?}, url = {https://m2.mtmt.hu/api/publication/31798342}, author = {Bozó, Renáta and Flink, Lili Borbála and Belső, Nóra and Konczné Gubán, Barbara and Széll, Márta and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna}, doi = {10.1111/exd.14267}, journal-iso = {EXP DERMATOL}, journal = {EXPERIMENTAL DERMATOLOGY}, volume = {30}, unique-id = {31798342}, issn = {0906-6705}, abstract = {Current data suggest that tissue microenvironment control immune functions. Therefore, understanding the tissue environment in which immune activation occurs will enhance our capability to interfere with abnormal immune pathology. Here, we argue that studying the constitutively abnormal functions of clinically uninvolved psoriatic skin in patients with plaque type psoriasis is very important to better understand psoriasis pathobiology, because non-lesional skin provides the tissue environment in which the psoriatic lesion develops. A key question in psoriasis is what initiates the abnormal, uncontrolled immune activation in the first place and the answer may lie in the skin. In light of this concept, we summarize abnormalities at the dermal-epidermal junction region which shows a special "nonhealing-like" micro-wound phenotype in the psoriatic non-lesional skin that may act as a crucial susceptibility factor in the development of the disease.}, keywords = {Basement Membrane; Wound healing; psoriasis; dermal-epidermal junction; Non-lesional skin}, year = {2021}, eissn = {1600-0625}, pages = {765-772}, orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Széll, Márta/0000-0002-0730-714X; Kemény, Lajos/0000-0002-2119-9501; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743} } @article{MTMT:31655754, title = {Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model}, url = {https://m2.mtmt.hu/api/publication/31655754}, author = {Brunner, Szilvia and Tőkés, Tünde and Szabó, Emilia Rita and Polanek, Róbert and Szabó, Zoltán Imre and Reisz, Zita and Konczné Gubán, Barbara and Szijártó, András Lajos and Michael, Brand and Stefan, Hans and Leonhard, Karsch and Elisabeth, Lessmann and Jörg, Pawelke and Michael, Schürer and Elke, Beyreuther and Hideghéty, Katalin}, doi = {10.21873/anticanres.14633}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {40}, unique-id = {31655754}, issn = {0250-7005}, year = {2020}, eissn = {1791-7530}, pages = {6123-6135}, orcid-numbers = {Tőkés, Tünde/0000-0002-0587-7886; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Szabó, Zoltán Imre/0000-0001-8278-8038; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:31180746, title = {Cartilage Oligomeric Matrix Protein Negatively Influences Keratinocyte Proliferation Via α5β1-Integrin. Potential Relevance of Altered Cartilage Oligomeric Matrix Protein Expression in Psoriasis}, url = {https://m2.mtmt.hu/api/publication/31180746}, author = {Bozó, Renáta and Szél, Edit and Danis, Judit and Konczné Gubán, Barbara and Csörgő Sándorné Bata, Zsuzsanna and Szabó, Kornélia Ágnes and Kemény, Lajos and Groma, Gergely}, doi = {10.1016/j.jid.2019.12.037}, journal-iso = {J INVEST DERMATOL}, journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY}, volume = {140}, unique-id = {31180746}, issn = {0022-202X}, year = {2020}, eissn = {1523-1747}, pages = {1733-1742.e7}, orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Szél, Edit/0000-0001-9102-5542; Danis, Judit/0000-0002-0270-5309; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:31068156, title = {A porc oligomer mátrix fehérje (COMP) potenciális szerepe a pikkelysömörös tünetmentes bőrben}, url = {https://m2.mtmt.hu/api/publication/31068156}, author = {Bozó, Renáta and Szél, Edit and Danis, Judit and Konczné Gubán, Barbara and Szabó, Kornélia Ágnes and Bata-Csörgő, Zsuzsanna and Kemény, Lajos}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {95}, unique-id = {31068156}, issn = {0006-7768}, year = {2019}, eissn = {2064-261X}, pages = {271-271}, orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Szél, Edit/0000-0001-9102-5542; Danis, Judit/0000-0002-0270-5309} } @article{MTMT:30879468, title = {Cartilage oligomeric matrix protein (COMP) negatively influences keratinocyte proliferation via α5β1-integrin: Potential relevance of eltered COMP expression in psoriasis}, url = {https://m2.mtmt.hu/api/publication/30879468}, author = {Bozó, Renáta and Szél, Edit and Danis, Judit and Konczné Gubán, Barbara and Csörgő Sándorné Bata, Zsuzsanna and Szabó, Kornélia Ágnes and Kemény, Lajos and Groma, Gergely}, doi = {10.1016/j.jid.2019.07.412}, journal-iso = {J INVEST DERMATOL}, journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY}, volume = {139}, unique-id = {30879468}, issn = {0022-202X}, year = {2019}, eissn = {1523-1747}, pages = {S285-S285}, orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Szél, Edit/0000-0001-9102-5542; Danis, Judit/0000-0002-0270-5309; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:30401772, title = {Differential role of D cyclins in the regulation of cell cycle by influencing Ki67 expression in HaCaT cells}, url = {https://m2.mtmt.hu/api/publication/30401772}, author = {Belső, Nóra and Konczné Gubán, Barbara and Manczinger, Máté and Kormos, Bernadett and Bebes, Attila and Németh, István Balázs and Veréb, Zoltán and Széll, Márta and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna}, doi = {10.1016/j.yexcr.2018.11.030}, journal-iso = {EXP CELL RES}, journal = {EXPERIMENTAL CELL RESEARCH}, volume = {374}, unique-id = {30401772}, issn = {0014-4827}, year = {2019}, eissn = {1090-2422}, pages = {290-303}, orcid-numbers = {Manczinger, Máté/0000-0003-0831-9617; Bebes, Attila/0000-0002-8316-5622; Veréb, Zoltán/0000-0002-9518-2155; Széll, Márta/0000-0002-0730-714X; Kemény, Lajos/0000-0002-2119-9501; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743} }