TY  - JOUR
AU  - Benyó, Dániel
AU  - Bato, Emese
AU  - Faragó, Dóra
AU  - Rigó, Gábor
AU  - Racskóné Domonkos, Ildikó
AU  - Labhane, Nitin
AU  - Zsigmond, Laura
AU  - Prasad, Melvin
AU  - Nagy, István
AU  - Szabados, László
TI  - The zinc finger protein 3 of Arabidopsis thaliana regulates vegetative growth and root hair development
JF  - FRONTIERS IN PLANT SCIENCE
J2  - FRONT PLANT SCI
VL  - 14
PY  - 2024
PG  - 16
SN  - 1664-462X
DO  - 10.3389/fpls.2023.1221519
UR  - https://m2.mtmt.hu/api/publication/34547379
ID  - 34547379
N1  - Funding Agency and Grant Number: Young Researcher Fellowship of the Hungarian Academy of Sciences [NKFI NN-118089, NKFI K-128728, NKFI K-143620, GINOP-2.3.3-15-2016-00023, TT_IN-2020-00034]; Tempus Fellowship
            Funding text: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. Research was supported by research grants NKFI NN-118089, NKFI K-128728, NKFI K-143620, GINOP-2.3.3-15-2016-00023. TET_IN-2020-00034. DB and DF were supported by Young Researcher Fellowship of the Hungarian Academy of Sciences. NL was supported by Tempus Fellowship.
AB  - Introduction Zinc finger protein 3 (ZFP3) and closely related C2H2 zinc finger proteins have been identified as regulators of abscisic acid signals and photomorphogenic responses during germination. Whether ZFP3 and related ZFP factors regulate plant development is, however, not known.Results ZFP3 overexpression reduced plant growth, limited cell expansion in leaves, and compromised root hair development. The T-DNA insertion zfp3 mutant and transgenic lines with silenced ZFP1, ZFP3, ZFP4, and ZFP7 genes were similar to wild-type plants or had only minor differences in plant growth and morphology, probably due to functional redundancy. RNAseq transcript profiling identified ZFP3-controlled gene sets, including targets of ABA signaling with reduced transcript abundance. The largest gene set that was downregulated by ZFP3 encoded regulatory and structural proteins in cell wall biogenesis, cell differentiation, and root hair formation. Chromatin immunoprecipitation confirmed ZFP3 binding to several target promoters.Discussion Our results suggest that ZFP3 and related ZnF proteins can modulate cellular differentiation and plant vegetative development by regulating the expression of genes implicated in cell wall biogenesis.
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Maár, Kitti
AU  - Neparáczki, Endre
AU  - Varga, Gergely István
AU  - Kovács, Bence
AU  - Maróti, Zoltán
AU  - Kalmár, Tibor
AU  - Nagy, István
AU  - Latinovics, Dóra
AU  - Tihanyi, Balázs
AU  - Marcsik, Antónia
AU  - Kustár, Ágnes
AU  - Pálfi, György
AU  - Raskó, István
AU  - Török, Tibor
ED  - Türk, Attila
ED  - Jancsik, Balázs
ED  - Sudár, Balázs
TI  - Honfoglalás kori köznépi temetők anyai vonalainak jellemzése, archeogenetikai módszerekkel
T2  - "Hadak útján" A népvándorláskor fiatal kutatóinak XXIX. konferenciája. = 29th Conference of scholars on the Migration Period
PB  - Martin Opitz Kiadó
CY  - Budapest
SN  - 9786156388353
T3  - Magyar Őstörténeti Kutatócsoport Kiadványok, ISSN 2786-1538 ; 4.2.
T3  - Studia ad Archaeologiam Pazmaniensia, ISSN 2064-8162 ; 24.2.
PY  - 2023
SP  - 159
EP  - 170
PG  - 12
DO  - 10.55722/Arpad.Kiad.2023.4.2_07
UR  - https://m2.mtmt.hu/api/publication/34493120
ID  - 34493120
AB  - A régészeti leletekből kinyerhető archaikus DNS vizsgálata fényt deríthet egyének, populációk eredetére és rokoni kapcsolataira. Korábbi munkánk során elsősorban a honfoglalás kori szállási temetők genetikai kapcsolatait derítettük fel régészeti genetikai módszerekkel. A karosi és kenézlői temető együttesek nagy felbontású teljes mitogenom analízise azt mutatta, hogy a honfoglalók anyai ágú vonalai visszavezethetők az eurázsiai sztyeppe távoli részeire: harmaduk Közép-Belső Ázsia területéről származott, kétharmaduk pedig a bronzkori pontusi-kaszpi sztyeppe Poltavka-Potakovka-Szrubnaja kultúráira vezethető vissza. Felvetődött a kérdés, hogy ezek az adatok milyen mértékben vonatkoztathatók a teljes honfoglaló populációra? Hogy ezt a kérdést megválaszoljuk, vizsgálatainkat kiterjesztettük a 10. századi nagyobb sírszámú falusi temetőkre, melyek a honfoglalás kori köznépet rejthetik. A kiválasztott 6 falusi temető mindegyikéből 20-30 egyén anyai vonalait vizsgáltuk. A mintaválasztást elsősorban régészeti és antropológiai adatok alapján végeztük. Mivel a temetők többsége átnyúlik az Árpád-korba és korábbi antropológiai vizsgálatok több temetőben lehetséges népességcserét jeleztek, ezért a korai és a későbbi sírok összehasonlításával a népességcsere kérdésére is választ remélhetünk. A projekt jelen állása szerint csaknem az összes szekvencia adat elkészült és most folyik az adatok filogenetikai és populációgenetikai kiértékelése, ezért az előzetes eredményeket tudjuk bemutatni.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Nagy, Bettina
AU  - Öktem, Ayşegül
AU  - Ferenc, Györgyi
AU  - Ungor, Ditta Anita
AU  - Kalac, Aladina
AU  - Kelemen-Valkony, Ildikó
AU  - Ayaydin-Fodor, Elfrieda
AU  - Nagy, István
AU  - Dudits, Dénes
AU  - Ayaydin, Ferhan
TI  - CRISPR/Cas9 Mutagenesis through Introducing a Nanoparticle Complex Made of a Cationic Polymer and Nucleic Acids into Maize Protoplasts
JF  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
J2  - INT J MOL SCI
VL  - 24
PY  - 2023
IS  - 22
PG  - 12
SN  - 1661-6596
DO  - 10.3390/ijms242216137
UR  - https://m2.mtmt.hu/api/publication/34288968
ID  - 34288968
N1  - Funding Agency and Grant Number: National Research, Development and Innovation Office of the Hungarian Government
            Funding text: No Statement Available
AB  - Presently, targeted gene mutagenesis attracts increasing attention both in plant research and crop improvement. In these approaches, successes are largely dependent on the efficiency of the delivery of gene editing components into plant cells. Here, we report the optimization of the cationic polymer poly(2-hydroxypropylene imine) (PHPI)-mediated delivery of plasmid DNAs, or single-stranded oligonucleotides labelled with Cyanine3 (Cy3) or 6-Carboxyfluorescein (6-FAM)-fluorescent dyes into maize protoplasts. Co-delivery of the GFP-expressing plasmid and the Cy3-conjugated oligonucleotides has resulted in the cytoplasmic and nuclear accumulation of the green fluorescent protein and a preferential nuclear localization of oligonucleotides. We show the application of nanoparticle complexes, i.e., “polyplexes” that comprise cationic polymers and nucleic acids, for CRISPR/Cas9 editing of maize cells. Knocking out the functional EGFP gene in transgenic maize protoplasts was achieved through the co-delivery of plasmids encoding components of the editing factors Cas9 (pFGC-pcoCas9) and gRNA (pZmU3-gRNA) after complexing with a cationic polymer (PHPI). Several edited microcalli were identified based on the lack of a GFP fluorescence signal. Multi-base and single-base deletions in the EGFP gene were confirmed using Sanger sequencing. The presented results support the use of the PHPI cationic polymer in plant protoplast-mediated genome editing approaches.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Luzics, Szabina
AU  - Tóth, Ákos
AU  - Barna, Teréz
AU  - Szabó, Erna
AU  - Nagy, I.
AU  - Horváth, B.
AU  - Nagy, István
AU  - Varecza, Zoltán
AU  - Batáné Vidács, Ildikó
AU  - Kukolya, József
TI  - Cloning, expression, and biochemical characterisation of a novel endomannanase from Thermobifida alba
JF  - ACTA ALIMENTARIA: AN INTERNATIONAL JOURNAL OF FOOD SCIENCE
J2  - ACTA ALIMENT
VL  - 52
PY  - 2023
IS  - 3
SP  - 502
EP  - 519
PG  - 18
SN  - 0139-3006
DO  - 10.1556/066.2023.00186
UR  - https://m2.mtmt.hu/api/publication/34129658
ID  - 34129658
N1  - Funding Agency and Grant Number: Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
            Funding text: Akos Toth was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - McLaughlin, Joseph
AU  - Nagy, István
AU  - Miliotis, Georgios
AU  - McDowell, Andrew
TI  - CUTIS-SEQ, a flexible bilocus sequence typing scheme that provides high resolution of Cutibacterium acnes strains across all subspecies
JF  - ANAEROBE
J2  - ANAEROBE
VL  - 79
PY  - 2023
PG  - 8
SN  - 1075-9964
DO  - 10.1016/j.anaerobe.2022.102671
UR  - https://m2.mtmt.hu/api/publication/33723348
ID  - 33723348
N1  - Funding Agency and Grant Number: British Skin Foundation [025/s/16]
            Funding text: J.M. is currently funded by a British Skin Foundation studentship to A.M.D (Grant Project No. 025/s/16). The study also made use of the C. acnes PubMLST database and we also thank Keith Jolley for assistance in setting up the CUTIS-SEQ isolate database within this site.
AB  - Objectives: A `high resolution' Single Locus Sequence Typing (SLST) scheme has been described for the anaerobic skin bacterium Cutibacterium acnes that seemingly discriminates sequence types (STs) to a level commensurate with previously described Multilocus Sequence Typing (MLST) methods (MLST4; MLST8; MLST9). However, no quantifiable evaluation of SLST versus MLST for differentiation of C. acnes strains, especially in relation to the subspecies of the bacterium, known as C. acnes subsp. acnes (type I), C. acnes subsp. defendens (type II) and C. acnes subsp. elongatum (type III), has been performed which is vital given its increasing use. To address this, we examined the discriminatory power of SLST versus MLST with a large group of isolates representative of all subspecies. Methods: Simpson's index of diversity (D) was used for quantitative comparison of the resolving power of the SLST and MLST schemes for 186 isolates of C. acnes covering all three subspecies. Results: When strains were considered collectively, SLST and all three MLST approaches had similar D values > 90%. However, at the subspecies level there were significant differences between the methods, most strikingly a reduced discrimination of type II and type III strains (D <80%) by SLST versus MLST8, and to a lesser extent MLST4. The MLST9 method also performed poorly for type II strains (D <70%), but did display the best results for type I (D= 90%). By combining the SLST locus with the camp2 gene sequence to create a novel and flexible high-resolution Bilocus Sequence Typing (BLST) scheme, known as CUTIS-SEQ typing (CUTIbacterium acneS BilocuS sEQuence Typing), we achieved improved resolution at both species and, critically, subspp. levels. Conclusions: CUTIS-SEQ provides an opportunity to improve differentiation of C. acnes isolates by SLST without significantly impacting laboratory workload, or compromising application to complex biological communities. A CUTIS-SEQ isolate database is now available as part of the C. acnes PubMLST database at https://pubmlst.org. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Imre, Gergely
AU  - Takács, Bertalan Vilmos
AU  - Czipa, Erik
AU  - Drubi, Andrea
AU  - Jaksa, Gábor
AU  - Latinovics, Dóra
AU  - Nagy, Andrea
AU  - Karkas, Réka
AU  - Hudoba, Liza
AU  - Vásárhelyi, Bálint Márk
AU  - Pankotai-Bodó, Gabriella
AU  - Blastyák, András
AU  - Hegedűs, Zoltán
AU  - Germán, Péter
AU  - Bálint, Balázs
AU  - Ahmed Abdullah, Khaldoon Sadiq
AU  - Kopasz, Anna Georgina
AU  - Kovács, Anita Kármen
AU  - Nagy, László
AU  - Sükösd, Farkas
AU  - Pintér, Lajos
AU  - Rülicke, Thomas
AU  - Barta, Endre
AU  - Nagy, István
AU  - Haracska, Lajos
AU  - Mátés, Lajos
TI  - Prolonged activity of the transposase helper may raise safety concerns during DNA transposon-based gene therapy
JF  - MOLECULAR THERAPY-METHODS AND CLINICAL DEVELOPMENT
J2  - MOL THER-METH CLIN D
VL  - 29
PY  - 2023
SP  - 145
EP  - 159
PG  - 15
SN  - 2329-0501
DO  - 10.1016/j.omtm.2023.03.003
UR  - https://m2.mtmt.hu/api/publication/33708483
ID  - 33708483
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Grézal, Gábor
AU  - Spohn, Réka
AU  - Méhi, Orsolya Katinka
AU  - Dunai, Anett
AU  - Lázár, Viktória
AU  - Bálint, Balázs
AU  - Nagy, István
AU  - Pál, Csaba
AU  - Papp, Balázs
TI  - Plasticity and stereotypic rewiring of the transcriptome upon bacterial evolution of antibiotic resistance
JF  - MOLECULAR BIOLOGY AND EVOLUTION
J2  - MOL BIOL EVOL
VL  - 40
PY  - 2023
IS  - 2
SN  - 0737-4038
DO  - 10.1093/molbev/msad020
UR  - https://m2.mtmt.hu/api/publication/33632100
ID  - 33632100
N1  - Funding Agency and Grant Number: Lendulet program of the Hungarian Academy of Sciences [LP-2009-013/2012, LP-2012-32/2018]; ELKH Lenduelet program [LP-2017-2010/2020]; Wellcome Trust WT [098016/Z/11/Z]; European Research Council [648364, 862077]; National Research, Development and Innovation Office; Ministry for Innovation and Technology [KKP KH125616, 126506, RRF-2.3.1-21-2022-00006, GINOP-2.3.2-15-2016-00026, GINOP-2.3.2-15-2 016-00014, GINOP-2.3.2-15-2 016-00020]; National Laboratory of Biotechnology Grant [2022-2.1.1-NL-2022-00008]; European Union [739593]; NKFIH [FK124254]; Janos Bolyai Research Fellowship from the Hungarian Academy of Sciences [BO/608/21]
            Funding text: This work was supported by the "Lendulet" program of the Hungarian Academy of Sciences LP-2009-013/2012 (B.P.), LP-2012-32/2018 (C.P.), the ELKH Lenduelet program LP-2017-2010/2020 (C.P.), the Wellcome Trust WT 098016/Z/11/Z (B.P.), The European Research Council H2020-ERC-2014-CoG 648364-Resistance Evolution (C.P.), and H2020-ERC-2019-PoC 862077-Aware (C.P.), the National Research, Development and Innovation Office and the Ministry for Innovation and Technology under the "Frontline" program KKP KH125616 and 126506 (B.P. and C.P.), RRF-2.3.1-21-2022-00006 (B.P.), GINOP-2.3.2-15-2016-00026 (iChamber, B.P.), GINOP-2.3.2-15-2 016-00014 (EVOMER, C.P. and B.P.), GINOP-2.3.2-15-2 016-00020 (MolMedEx TUMORDNS, C.P.), National Laboratory of Biotechnology Grant 2022-2.1.1-NL-2022-00008 (C.P. and B.P.), The European Union's Horizon 202 0 research and innovation program under grant agreement No 739593 (B.P.). NKFIH grant FK124254 (O.M.), the Janos Bolyai Research Fellowship from the Hungarian Academy of Sciences BO/608/21 (R.S.).
AB  - Bacterial evolution of antibiotic resistance frequently has deleterious side effects on microbial growth, virulence, and susceptibility to other antimicrobial agents. However, it is unclear how these trade-offs could be utilized for manipulating antibiotic resistance in the clinic, not least because the underlying molecular mechanisms are poorly understood. Using laboratory evolution, we demonstrate that clinically relevant resistance mutations in Escherichia coli constitutively rewire a large fraction of the transcriptome in a repeatable and stereotypic manner. Strikingly, lineages adapted to functionally distinct antibiotics and having no resistance mutations in common show a wide range of parallel gene expression changes that alter oxidative stress response, iron homeostasis, and the composition of the bacterial outer membrane and cell surface. These common physiological alterations are associated with changes in cell morphology and enhanced sensitivity to antimicrobial peptides. Finally, the constitutive transcriptomic changes induced by resistance mutations are largely distinct from those induced by antibiotic stresses in the wild-type. This indicates a limited role for genetic assimilation of the induced antibiotic stress response during resistance evolution. Our work suggests that diverse resistance mutations converge on similar global transcriptomic states that shape genetic susceptibility to antimicrobial compounds.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Boros, Éva
AU  - Hegedűs, Zoltán
AU  - Kellermayer, Zoltán
AU  - Balogh, Péter
AU  - Nagy, István
TI  - Global alteration of colonic microRNAome landscape associated with inflammatory bowel disease
JF  - FRONTIERS IN IMMUNOLOGY
J2  - FRONT IMMUNOL
VL  - 13
PY  - 2022
PG  - 14
SN  - 1664-3224
DO  - 10.3389/fimmu.2022.991346
UR  - https://m2.mtmt.hu/api/publication/33125064
ID  - 33125064
N1  - Seqomics Biotechnology Ltd, Mórahalom, Hungary            
            Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary            
            Institute of Biophysics, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary            
            Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary            
            Department of Immunology and Biotechnology, University of Pécs, Pécs, Hungary            
            Lymphoid Organogenesis Research Group, Szentágothai János Research Center, University of Pécs, Pécs, Hungary            
            Cited By :2            
            Export Date: 16 October 2023            
            Correspondence Address: Nagy, I.; Seqomics Biotechnology LtdHungary; email: nagyi@baygen.hu            
            Chemicals/CAS: collagenase 3, 175449-82-8; gamma interferon, 82115-62-6; myocyte enhancer factor 2, 148349-68-2; toll like receptor 9, 352486-49-8, 390883-32-6; Core Binding Factor Alpha 2 Subunit; Matrix Metalloproteinase 13; MicroRNAs            
            Manufacturers: Illumina; Macherey; Qiagen; Thermo            
            Funding details: European Commission, EC            
            Funding details: European Social Fund, ESF, A2-ELMH-12-0082, NTP-NFTÖ-19-B-0076            
            Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, GINOP-2.3.2-15-2016-00039            
            Funding details: National Research, Development and Innovation Office            
            Funding text 1: This work was funded, in part, by grant from the National Research, Development and Innovation Office (grant number GINOP-2.3.2-15-2016-00039). ÉB was funded by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of ‘National Excellence Program’ (grant number A2-ELMH-12-0082) and supported by NTP-NFTÖ-19-B (grant number NTP-NFTÖ-19-B-0076).
AB  - Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract that associates with, among others, increased risk of colorectal cancer. There is a growing evidence that miRNAs have important roles in pathological processes, such as inflammation or carcinogenesis. Understanding the molecular mechanisms such as alterations in microRNAome upon chronic intestinal inflammation is critical for understanding the exact pathomechanism of IBD. Hence, we conducted a genome wide microRNAome analysis by applying miRNA-Seq in a rat model of experimental colitis, validated the data by QPCR, examined the expression of a selection of precursor and mature miRNAs, performed in depth biological interpretation using Ingenuity Pathway Analysis and tested the obtained results on samples derived from human patients. We identified specific, interdependent expression pattern of activator/repressor transcription factors, miRNAs and their direct targets in the inflamed colon samples. Particularly, decreased expression of the miR-200 family members (miR-200a/b/c,-141, and -429) and miR-27b correlates with the reduced level of their enhancers (HNF1B, E2F1), elevated expression of their repressors (ZEB2, NFKB1) and increased expression of their target genes (ZEB2, RUNX1). Moreover, the marked upregulation of six miR-27b target genes (IFI16, GCA, CYP1B1, RUNX1, MEF2C and MMP13) in the inflamed colon tissues is a possible direct consequence of the lack of repression due to the downregulated miRNA-27b expression. Our data indicate that changes in microRNAome are associated with the pathophysiology of IBD, consequently, microRNAs offer potential targets for the diagnosis, prognosis and treatment of IBD.
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Maróti, Zoltán
AU  - Neparáczki, Endre
AU  - Schütz, Oszkár
AU  - Maár, Kitti
AU  - Varga, Gergely István
AU  - Kovács, Bence
AU  - Kalmár, Tibor
AU  - Nyerki, Emil
AU  - Nagy, István
AU  - Latinovics, Dóra
AU  - Tihanyi, Balázs
AU  - Marcsik, Antónia
AU  - Pálfi, György
AU  - Bernert, Zsolt
AU  - Gallina, József Zsolt
AU  - Horváth, Ciprian
AU  - Varga, Sándor
AU  - Költő, László
AU  - Raskó, István
AU  - L. Nagy, Péter
AU  - Balogh, Csilla
AU  - Zink, Albert
AU  - Maixner, Frank
AU  - Götherström, Anders
AU  - George, Robert
AU  - Szalontai, Csaba
AU  - Szenthe, Gergely Pál
AU  - Gáll, Erwin
AU  - P. Kiss, Attila
AU  - Rácz, Attila
AU  - Gulyás, Bence
AU  - Ny. Kovacsóczy, Bernadett
AU  - Gaál, Sándor Szilárd
AU  - Tomka, Péter
AU  - Török, Tibor
TI  - Whole genome analysis sheds light on the genetic origin of Huns, Avars and conquering Hungarians
PY  - 2022
SP  - 1
EP  - 26
PG  - 26
UR  - https://m2.mtmt.hu/api/publication/33074997
ID  - 33074997
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Maróti, Zoltán
AU  - Neparáczki, Endre
AU  - Schütz, Oszkár
AU  - Maár, Kitti
AU  - Varga, Gergely István
AU  - Kovács, Bence
AU  - Kalmár, Tibor
AU  - Nyerki, Emil
AU  - Nagy, István
AU  - Latinovics, Dóra
AU  - Tihanyi, Balázs
AU  - Marcsik, Antónia
AU  - Pálfi, György
AU  - Bernert, Zsolt
AU  - Gallina, József Zsolt
AU  - Horváth, Ciprian
AU  - Varga, Sándor
AU  - Költő, László
AU  - Raskó, István
AU  - Nagy, Péter L.
AU  - Balogh, Csilla
AU  - Zink, Albert
AU  - Maixner, Frank
AU  - Götherström, Anders
AU  - George, Robert
AU  - Szalontai, Csaba
AU  - Szenthe, Gergely Pál
AU  - Gáll, Erwin
AU  - Kiss P., Attila
AU  - Gulyás, Bence
AU  - Kovacsóczy, Bernadett
AU  - Gál, Szilárd Sándor
AU  - Tomka, Péter
AU  - Török, Tibor
TI  - The genetic origin of Huns, Avars, and conquering Hungarians
JF  - CURRENT BIOLOGY
J2  - CURR BIOL
VL  - 32
PY  - 2022
IS  - 13
SP  - 2858
EP  - 2870.e7
PG  - 13
SN  - 0960-9822
DO  - 10.1016/j.cub.2022.04.093
UR  - https://m2.mtmt.hu/api/publication/32853231
ID  - 32853231
N1  - Funding Agency and Grant Number: National Research, Development and Innovation Office [K-124350, TUDFO/5157-1/2019-ITM, TKP2020-NKA-23]; House ofArpad Programme (2018-2023) Scientific Subproject: V.1. Anthropological-Genetic portrayal of Hungarians in the Arpadian Age [VI/1878/2020]
            Funding text: Weare grateful to our archaeologist colleagues Gabriella M. Lezsak and Andrej Novicsihin for providing us with the Anapa samples, Gabor L}orinczy for his help regarding the Avar material, and Zsoia Racz for her help with the Hun period samples. We are thankful to all the museum curators and archaeologists who provided bone material for this study: Herman OttoMuseum Miskolc, LaczkoDezs}o Museum Veszprem, Budapest History Museum, Ferenczy Museum Szentendre, DoboIstvan Castle Museum Eger, Josa Andras Museum Nyiregyhaza, Katona Jozsef Museum Kecskemet, and Janus Pannonius Museum Pecs. This research was funded by grants from the National Research, Development and Innovation Office (K-124350 to T.T. and TUDFO/5157-1/2019-ITMand TKP2020-NKA-23 to E.N.), The House ofArpad Programme (2018-2023) Scientific Subproject: V.1. Anthropological-Genetic portrayal of Hungarians in theA ' rpadian Age to T.T. and no. VI/1878/2020. certificate number grants to E.N.
AB  - Huns, Avars, and conquering Hungarians were migration-period nomadic tribal confederations that arrived in three successive waves in the Carpathian Basin between the 5th and 9th centuries. Based on the historical data, each of these groups are thought to have arrived from Asia, although their exact origin and relation to other ancient and modern populations have been debated. Recently, hundreds of ancient genomes were analyzed from Central Asia, Mongolia, and China, from which we aimed to identify putative source populations for the above-mentioned groups. In this study, we have sequenced 9 Hun, 143 Avar, and 113 Hungarian conquest period samples and identified three core populations, representing immigrants from each period with no recent European ancestry. Our results reveal that this “immigrant core” of both Huns and Avars likely originated in present day Mongolia, and their origin can be traced back to Xiongnus (Asian Huns), as suggested by several historians. On the other hand, the “immigrant core” of the conquering Hungarians derived from an earlier admixture of Mansis, early Sarmatians, and descendants of late Xiongnus. We have also shown that a common “proto-Ugric” gene pool appeared in the Bronze Age from the admixture of Mezhovskaya and Nganasan people, supporting genetic and linguistic data. In addition, we detected shared Hun-related ancestry in numerous Avar and Hungarian conquest period genetic outliers, indicating a genetic link between these successive nomadic groups. Aside from the immigrant core groups, we identified that the majority of the individuals from each period were local residents harboring “native European” ancestry.
LA  - English
DB  - MTMT
ER  -