TY  - JOUR
AU  - Muranyi, M
AU  - Cinar, Resat
AU  - Kékesi, Orsolya Sára
AU  - Birkás, Erika
AU  - Fábián, Gabriella
AU  - Bozó, Bea
AU  - Zentai, A
AU  - Tóth, Géza
AU  - Kicsi, EG
AU  - Macsai, M
AU  - Dochnal, Roberta
AU  - Szabó, Gyula
AU  - Szűcs, Mária
TI  - Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists
JF  - BIOMED RESEARCH INTERNATIONAL
J2  - BIOMED RES INT
VL  - 2013
PY  - 2013
PG  - 9
SN  - 2314-6133
DO  - 10.1155/2013/501086
UR  - https://m2.mtmt.hu/api/publication/2486869
ID  - 2486869
AB  - Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles. We have shown previously that a new analogue, cis-1S,2R-aminocyclohexanecarboxylic acid(2)-endomorphin-2 (ACHC-EM2), had elevated mu-receptor affinity, selectivity, and proteolytic stability over the parent compound. In the present work, we have studied its antinociceptive effects and receptor regulatory processes. ACHC-EM2 displayed a somewhat higher (60%) acute antinociceptive response than the parent peptide, EM2 (45%), which peaked at 10 min after intracerebroventricular (icv) administration in the rat tail-flick test. Analgesic tolerance developed to the antinociceptive effect of ACHC-EM2 upon its repeated icv injection that was complete by a 10-day treatment. This was accompanied by attenuated coupling of mu-sites to G-proteins in subcellular fractions of rat brain. Also, the density of mu-receptors was upregulated by about 40% in the light membrane fraction, with no detectable changes in surface binding. Distinct receptor regulatory processes were noted in subcellular fractions of rat brains made tolerant by the prototypic full mu-agonist peptide, DAMGO, and its chloromethyl ketone derivative, DAMCK. These results are discussed in light of the recently discovered phenomenon, that is, the "so-called biased agonism" or "functional selectivity".
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fábián, Gabriella
AU  - Bozó, Bea
AU  - Szikszay, M
AU  - Horváth, Gyöngyi
AU  - Coscia, CJ
AU  - Szűcs, Mária
TI  - Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain
JF  - JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
J2  - J PHARMACOL EXP THER
VL  - 302
PY  - 2002
IS  - 2
SP  - 774
EP  - 780
PG  - 7
SN  - 0022-3565
DO  - 10.1124/jpet.102.036152
UR  - https://m2.mtmt.hu/api/publication/1822624
ID  - 1822624
N1  - WoS:hiba:000176899200047 2019-03-03 09:45 cikkazonosító nem egyezik
LA  - English
DB  - MTMT
ER  - 

TY  - THES
AU  - Bozó, Bea
TI  - Binding characteristics, G-protein activation and receptor regulatory mechanisms of opioid ligands
PB  - Szegedi Tudományegyetem (SZTE)
PY  - 2000
SP  - 55
UR  - https://m2.mtmt.hu/api/publication/31259666
ID  - 31259666
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bozó, Bea
AU  - Farkas, Judit
AU  - Tóth, Géza
AU  - Wollemann, Mária
AU  - Szűcs, Mária
AU  - Benyhe, Sándor
TI  - Receptor binding and G-protein activation by new Met5-enkephalin-Arg6-Phe7 derived peptides
JF  - LIFE SCIENCES
J2  - LIFE SCI
VL  - 66
PY  - 2000
SP  - 1241
EP  - 1451
PG  - 211
SN  - 0024-3205
DO  - 10.1016/S0024-3205(00)00429-X
UR  - https://m2.mtmt.hu/api/publication/1910917
ID  - 1910917
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szűcs, Mária
AU  - Bozó, Bea
AU  - KICSI, E
AU  - Fábián, Gabriella
AU  - MÁCSAI, M
AU  - Szabó, Gyula
TI  - Ligand-specific regulation of μ-opioid receptors in rat brain
JF  - DOLOR-BARCELONA
J2  - DOLOR
VL  - 14
PY  - 1999
SP  - 15
SN  - 0214-0659
UR  - https://m2.mtmt.hu/api/publication/1910735
ID  - 1910735
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kicsi, Emese
AU  - Bozó, Bea
AU  - Farkas, Judit
AU  - Mácsai, M
AU  - Szabó, Gyula
AU  - Szűcs, Mária
TI  - Affinity labelling of opioid receptors in vivo and in vitro
JF  - NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES
J2  - NEUROBIOLOGY
VL  - 7
PY  - 1999
IS  - 1
SP  - 83
EP  - 84
PG  - 2
SN  - 1216-8068
UR  - https://m2.mtmt.hu/api/publication/1232035
ID  - 1232035
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bozó, Bea
AU  - Fábián, Gabriella
AU  - Szűcs, Mária
TI  - A new assay for receptor mediated G-protein activation.
JF  - NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES
J2  - NEUROBIOLOGY
VL  - 6
PY  - 1998
SP  - 173
EP  - 174
PG  - 2
SN  - 1216-8068
UR  - https://m2.mtmt.hu/api/publication/1910533
ID  - 1910533
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fábián, Gabriella
AU  - Szabó, Andrea Csilla
AU  - Bozó, Bea
AU  - GREENWOOD, J
AU  - ADAMSON, P
AU  - Deli, Mária Anna
AU  - Joó, Ferenc
AU  - Krizbai, István Adorján
AU  - Szűcs, Mária
TI  - Expression of G-Protein Subtypes in Cultured Cerebral Endothelial Cells
JF  - NEUROCHEMISTRY INTERNATIONAL
J2  - NEUROCHEM INT
VL  - 33
PY  - 1998
SP  - 179
EP  - 185
PG  - 7
SN  - 0197-0186
DO  - 10.1016/S0197-0186(98)00008-4
UR  - https://m2.mtmt.hu/api/publication/1910370
ID  - 1910370
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fábián, Gabriella
AU  - Bozó, Bea
AU  - TOMBOR, B
AU  - SZIKSZAY, M
AU  - Szűcs, Mária
TI  - Specific alterations in the amount of heterotrimeric G-protein subtypes in morphine tolerant rat brain membranes.
JF  - NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES
J2  - NEUROBIOLOGY
VL  - 5
PY  - 1997
SP  - 127
SN  - 1216-8068
UR  - https://m2.mtmt.hu/api/publication/1907580
ID  - 1907580
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bozó, Bea
AU  - Tombor, Barbara
AU  - Fábián, Gabriella
AU  - SZIKSZAY, M
AU  - Szűcs, Mária
TI  - Chronic morphine induced changes of spinal and supraspinal mu opioid receptor binding in rat CNS.
JF  - NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES
J2  - NEUROBIOLOGY
VL  - 5
PY  - 1997
SP  - 113
SN  - 1216-8068
UR  - https://m2.mtmt.hu/api/publication/1907579
ID  - 1907579
LA  - English
DB  - MTMT
ER  -