@article{MTMT:2486869,
	title = {Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists},
	url = {https://m2.mtmt.hu/api/publication/2486869},
	author = {Muranyi, M and Cinar, Resat and Kékesi, Orsolya Sára and Birkás, Erika and Fábián, Gabriella and Bozó, Bea and Zentai, A and Tóth, Géza and Kicsi, EG and Macsai, M and Dochnal, Roberta and Szabó, Gyula and Szűcs, Mária},
	doi = {10.1155/2013/501086},
	journal-iso = {BIOMED RES INT},
	journal = {BIOMED RESEARCH INTERNATIONAL},
	volume = {2013},
	unique-id = {2486869},
	issn = {2314-6133},
	abstract = {Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles. We have shown previously that a new analogue, cis-1S,2R-aminocyclohexanecarboxylic acid(2)-endomorphin-2 (ACHC-EM2), had elevated mu-receptor affinity, selectivity, and proteolytic stability over the parent compound. In the present work, we have studied its antinociceptive effects and receptor regulatory processes. ACHC-EM2 displayed a somewhat higher (60%) acute antinociceptive response than the parent peptide, EM2 (45%), which peaked at 10 min after intracerebroventricular (icv) administration in the rat tail-flick test. Analgesic tolerance developed to the antinociceptive effect of ACHC-EM2 upon its repeated icv injection that was complete by a 10-day treatment. This was accompanied by attenuated coupling of mu-sites to G-proteins in subcellular fractions of rat brain. Also, the density of mu-receptors was upregulated by about 40% in the light membrane fraction, with no detectable changes in surface binding. Distinct receptor regulatory processes were noted in subcellular fractions of rat brains made tolerant by the prototypic full mu-agonist peptide, DAMGO, and its chloromethyl ketone derivative, DAMCK. These results are discussed in light of the recently discovered phenomenon, that is, the "so-called biased agonism" or "functional selectivity".},
	keywords = {IN-VIVO; RAT-BRAIN; DESENSITIZATION; TOLERANCE; MORPHINE; internalization; BIASED AGONISM; FUNCTIONAL SELECTIVITY; BETA-ARRESTIN; G-protein activation},
	year = {2013},
	eissn = {2314-6141},
	orcid-numbers = {Fábián, Gabriella/0000-0002-2323-4948; Szabó, Gyula/0000-0002-3409-5357}
}

@article{MTMT:1822624,
	title = {Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain},
	url = {https://m2.mtmt.hu/api/publication/1822624},
	author = {Fábián, Gabriella and Bozó, Bea and Szikszay, M and Horváth, Gyöngyi and Coscia, CJ and Szűcs, Mária},
	doi = {10.1124/jpet.1002.036152},
	journal-iso = {J PHARMACOL EXP THER},
	journal = {JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS},
	volume = {302},
	unique-id = {1822624},
	issn = {0022-3565},
	year = {2002},
	eissn = {1521-0103},
	pages = {774-780},
	orcid-numbers = {Fábián, Gabriella/0000-0002-2323-4948; Horváth, Gyöngyi/0000-0002-6025-4577}
}

@mastersthesis{MTMT:31259666,
	title = {Binding characteristics, G-protein activation and receptor regulatory mechanisms of opioid ligands},
	url = {https://m2.mtmt.hu/api/publication/31259666},
	author = {Bozó, Bea},
	publisher = {SZTE},
	unique-id = {31259666},
	year = {2000}
}

@article{MTMT:1910917,
	title = {Receptor binding and G-protein activation by new Met5-enkephalin-Arg6-Phe7 derived peptides},
	url = {https://m2.mtmt.hu/api/publication/1910917},
	author = {Bozó, Bea and Farkas, Judit and Tóth, Géza and Wollemann, Mária and Szűcs, Mária and Benyhe, Sándor},
	doi = {10.1016/S0024-3205(00)00429-X},
	journal-iso = {LIFE SCI},
	journal = {LIFE SCIENCES},
	volume = {66},
	unique-id = {1910917},
	issn = {0024-3205},
	year = {2000},
	eissn = {1879-0631},
	pages = {1241-1451}
}

@article{MTMT:1910735,
	title = {Ligand-specific regulation of μ-opioid receptors in rat brain},
	url = {https://m2.mtmt.hu/api/publication/1910735},
	author = {Szűcs, Mária and Bozó, Bea and KICSI, E and Fábián, Gabriella and MÁCSAI, M and Szabó, Gyula},
	journal-iso = {DOLOR},
	journal = {DOLOR-BARCELONA},
	volume = {14},
	unique-id = {1910735},
	issn = {0214-0659},
	year = {1999},
	pages = {15},
	orcid-numbers = {Fábián, Gabriella/0000-0002-2323-4948; Szabó, Gyula/0000-0002-3409-5357}
}

@article{MTMT:1232035,
	title = {Affinity labelling of opioid receptors in vivo and in vitro},
	url = {https://m2.mtmt.hu/api/publication/1232035},
	author = {Kicsi, Emese and Bozó, Bea and Farkas, Judit and Mácsai, M and Szabó, Gyula and Szűcs, Mária},
	journal-iso = {NEUROBIOLOGY},
	journal = {NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES},
	volume = {7},
	unique-id = {1232035},
	issn = {1216-8068},
	year = {1999},
	pages = {83-84},
	orcid-numbers = {Szabó, Gyula/0000-0002-3409-5357}
}

@article{MTMT:1910533,
	title = {A new assay for receptor mediated G-protein activation.},
	url = {https://m2.mtmt.hu/api/publication/1910533},
	author = {Bozó, Bea and Fábián, Gabriella and Szűcs, Mária},
	journal-iso = {NEUROBIOLOGY},
	journal = {NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES},
	volume = {6},
	unique-id = {1910533},
	issn = {1216-8068},
	year = {1998},
	pages = {173-174},
	orcid-numbers = {Fábián, Gabriella/0000-0002-2323-4948}
}

@article{MTMT:1910370,
	title = {Expression of G-Protein Subtypes in Cultured Cerebral Endothelial Cells},
	url = {https://m2.mtmt.hu/api/publication/1910370},
	author = {Fábián, Gabriella and Szabó, Andrea Csilla and Bozó, Bea and GREENWOOD, J and ADAMSON, P and Deli, Mária Anna and Joó, Ferenc and Krizbai, István Adorján and Szűcs, Mária},
	doi = {10.1016/S0197-0186(98)00008-4},
	journal-iso = {NEUROCHEM INT},
	journal = {NEUROCHEMISTRY INTERNATIONAL},
	volume = {33},
	unique-id = {1910370},
	issn = {0197-0186},
	keywords = {RAT-BRAIN; BINDING; IN-VITRO; ALPHA-THROMBIN; ADENYLATE-CYCLASE; RECEPTORS; G-PROTEINS; KINASE-C; RELAXING FACTOR; bradykinin; BLOOD-BRAIN-BARRIER; NEUROBLASTOMA SH-SY5Y CELLS; [S-35]GTP gamma S binding; beta-adrenergic receptors; cerebral endothelial cells},
	year = {1998},
	eissn = {1872-9754},
	pages = {179-185},
	orcid-numbers = {Fábián, Gabriella/0000-0002-2323-4948; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:1907580,
	title = {Specific alterations in the amount of heterotrimeric G-protein subtypes in morphine tolerant rat brain membranes.},
	url = {https://m2.mtmt.hu/api/publication/1907580},
	author = {Fábián, Gabriella and Bozó, Bea and TOMBOR, B and SZIKSZAY, M and Szűcs, Mária},
	journal-iso = {NEUROBIOLOGY},
	journal = {NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES},
	volume = {5},
	unique-id = {1907580},
	issn = {1216-8068},
	year = {1997},
	pages = {127},
	orcid-numbers = {Fábián, Gabriella/0000-0002-2323-4948}
}

@article{MTMT:1907579,
	title = {Chronic morphine induced changes of spinal and supraspinal mu opioid receptor binding in rat CNS.},
	url = {https://m2.mtmt.hu/api/publication/1907579},
	author = {Bozó, Bea and Tombor, Barbara and Fábián, Gabriella and SZIKSZAY, M and Szűcs, Mária},
	journal-iso = {NEUROBIOLOGY},
	journal = {NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES},
	volume = {5},
	unique-id = {1907579},
	issn = {1216-8068},
	year = {1997},
	pages = {113},
	orcid-numbers = {Fábián, Gabriella/0000-0002-2323-4948}
}