@CONFERENCE{MTMT:35191347,
	title = {PGC-1α activation boots exercise-dependent cellular response in the skeletal muscle},
	url = {https://m2.mtmt.hu/api/publication/35191347},
	author = {Mozaffaritabar, Soroosh and Zhou, Lei and Koltai, Erika and Radák, Zsolt},
	booktitle = {IX. SPORTTUDOMÁNYI PHD SZIMPÓZIUM},
	unique-id = {35191347},
	year = {2024},
	pages = {51-51},
	orcid-numbers = {Mozaffaritabar, Soroosh/0000-0003-1052-7140; Zhou, Lei/0000-0002-8152-7896; Koltai, Erika/0000-0002-1370-2955; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34850199,
	title = {Effect of the 35 nm and 70 nm Size Exclusion Chromatography (SEC) Column and Plasma Storage Time on Separated Extracellular Vesicles},
	url = {https://m2.mtmt.hu/api/publication/34850199},
	author = {György, Bernadett and Pálóczi, Krisztina and Balbisi, Mirjam and Turiák, Lilla and Drahos, László and Visnovitz, Tamás and Koltai, Erika and Radák, Zsolt},
	doi = {10.3390/cimb46050264},
	journal-iso = {CURR ISSUES MOL BIOL},
	journal = {CURRENT ISSUES IN MOLECULAR BIOLOGY},
	volume = {46},
	unique-id = {34850199},
	issn = {1467-3037},
	abstract = {The technical difficulty of separating extracellular vesicles (EVs) from plasma proteins in human blood presents a significant hurdle in EV research, particularly during nano ultra-high-performance liquid chromatography–tandem mass spectrometric (UHPLC-MS/MS) analysis, where detecting “vesicular” proteins among abundant plasma proteins is challenging. Standardisation is a pressing issue in EV research, prompting collaborative global efforts to address it. While the MISEV guidelines offer valuable recommendations, unanswered questions remain, particularly regarding sample storage. We compared size exclusion chromatography (SEC) columns with pore sizes of 35 nm and 70 nm to identify fractions with minimal contaminating proteins and the highest concentration of small EVs (sEVs). Following column selection, we explored potential differences in the quality and quantity of sEVs isolated from platelet-free plasma (PFP) after long-term storage at −80 °C (>2.5 years) compared to freshly drawn blood. Our methodologically rigorous study indicates that prolonged storage, under correct storage and processing conditions, does not compromise sEV quality. Both columns effectively isolated vesicles, with the 70 nm column exhibiting a higher abundance of “vesicular” proteins. We propose a relatively rapid and moderately efficient protocol for obtaining a comparatively pure sEV fraction from plasma, facilitating sEV processing in clinical trials.},
	year = {2024},
	eissn = {1467-3045},
	pages = {4337-4357},
	orcid-numbers = {György, Bernadett/0000-0002-3787-7338; Pálóczi, Krisztina/0000-0001-7065-3582; Balbisi, Mirjam/0000-0002-6917-6974; Turiák, Lilla/0000-0002-2139-8156; Drahos, László/0000-0001-9589-6652; Visnovitz, Tamás/0000-0002-7962-5083; Koltai, Erika/0000-0002-1370-2955; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34693196,
	title = {Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness},
	url = {https://m2.mtmt.hu/api/publication/34693196},
	author = {Torma, Ferenc Gergely and Kerepesi, Csaba and Jókai, Mátyás and Bábszky, Gergely and Koltai, Erika and Ligeti, Balázs and Kalcsevszki, Regina and McGreevy, Kristen M. and Horvath, Steve and Radák, Zsolt},
	doi = {10.1111/acel.14101},
	journal-iso = {AGING CELL},
	journal = {AGING CELL},
	volume = {23},
	unique-id = {34693196},
	issn = {1474-9718},
	abstract = {Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.},
	year = {2024},
	eissn = {1474-9726},
	orcid-numbers = {Kerepesi, Csaba/0000-0001-9541-246X; Bábszky, Gergely/0000-0002-5939-8434; Koltai, Erika/0000-0002-1370-2955; Horvath, Steve/0000-0002-4110-3589; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34539479,
	title = {PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle},
	url = {https://m2.mtmt.hu/api/publication/34539479},
	author = {Mozaffaritabar, Soroosh and Koltai, Erika and Zhou, Lei and Bori, Zoltán and Kolonics, Attila and Kujach, Sylwester and Gu, Yaodong and Koike, Atsuko and Boros, Anita and Radák, Zsolt},
	doi = {10.1007/s13105-024-01006-1},
	journal-iso = {J PHYSIOL BIOCHEM},
	journal = {JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY},
	volume = {80},
	unique-id = {34539479},
	issn = {1138-7548},
	abstract = {The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms of muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent fat metabolism. PGC-1α trained (PGC-1α Ex) and wild-trained (wt-ex) mice were trained for 10 weeks, five times a week at 30 min per day with 60 percent of their maximal running capacity. The PGC-1α overexpressed animals exhibited higher levels of Fibronectin type III domain-containing protein 5 (FNDC5), 5' adenosine monophosphate-activated protein kinase alpha (AMPK-α), the mammalian target of rapamycin (mTOR), Sirtuin 1 (SIRT1), Lon protease homolog 1 (LONP1), citrate synthase (CS), succinate dehydrogenase complex flavoprotein subunit A (SDHA), Mitofusin-1 (Mfn1), endothelial nitric oxide synthase (eNOS), Hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), G protein-coupled receptor 41 (GPR41), and Phosphatidylcholine Cytidylyltransferase 2 (PCYT2), and lower levels of Sirtuin 3 (SIRT3) compared to wild-type animals. Exercise training increased the protein content levels of SIRT1, HSL, and ATGL in both the wt-ex and PGC-1α trained groups. PGC-1α has a complex role in cellular signaling, including the upregulation of lipid metabolism-associated proteins. Our data reveals that although exercise training mimics the effects of PGC-1α overexpression, it incorporates some PGC-1α-independent adaptive mechanisms in fat uptake and cell signaling.},
	keywords = {skeletal muscle; lipid metabolism; Exercise; Mitochondrial function; PGC-1α overexpression},
	year = {2024},
	eissn = {1877-8755},
	pages = {329-335},
	orcid-numbers = {Mozaffaritabar, Soroosh/0000-0003-1052-7140; Koltai, Erika/0000-0002-1370-2955; Zhou, Lei/0000-0002-8152-7896; Bori, Zoltán/0000-0003-1253-060X; Kolonics, Attila/0000-0003-3990-5336; Kujach, Sylwester/0000-0001-5520-1748; Koike, Atsuko/0009-0002-2668-7114; Boros, Anita/0000-0001-5330-9050; Radák, Zsolt/0000-0003-1297-6804}
}

@CONFERENCE{MTMT:34053803,
	title = {The role of PGC1-A in inter-muscular lipid metabolism in exercised mice},
	url = {https://m2.mtmt.hu/api/publication/34053803},
	author = {Soroosh, Mozafffaritabar and Koltai, Erika and Radák, Zsolt},
	booktitle = {VIII. Sporttudományi PhD Szimpózium},
	unique-id = {34053803},
	year = {2023},
	pages = {47-48},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955}
}

@article{MTMT:33866054,
	title = {DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation},
	url = {https://m2.mtmt.hu/api/publication/33866054},
	author = {Jókai, Mátyás and Torma, Ferenc Gergely and McGreevy, Kristen M. and Koltai, Erika and Bori, Zoltán and Bábszky, Gergely and Bakonyi, Péter and Gombos, Zoltán and György, Bernadett and Aczél, Dóra Tímea and Tóth, László and Osváth, Péter and Fridvalszki, Marcell Norbert and Téglás, Tímea and Pósa, Anikó and Kujach, Sylwester and Olek, Robert and Kawamura, Takuji and Seki, Yasuhiro and Suzuki, Katsuhiko and Tanisawa, Kumpei and Goto, Sataro and Kerepesi, Csaba and Boldogh, Istvan and Ba, Xueqing and Davies, Kelvin J. A. and Horvath, Steve and Radák, Zsolt},
	doi = {10.1007/s11357-023-00826-1},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {45},
	unique-id = {33866054},
	issn = {2509-2715},
	abstract = {DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ  = 0.2, p  = 6.4E − 4, r  = 0.19, p  = 1.2E − 3), Jumpmax ( p  = 0.11, p  = 5.5E − 2, r  = 0.13, p  = 2.8E − 2), Gripmax ( ρ  = 0.17, p  = 3.5E − 3, r  = 0.16, p  = 5.6E − 3), and HDL levels ( ρ  = 0.18, p  = 1.95E − 3, r  = 0.19, p  = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p  = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.},
	year = {2023},
	eissn = {2509-2723},
	pages = {2805-2817},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X; Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384; György, Bernadett/0000-0002-3787-7338; Tóth, László/0000-0001-9650-1202; Fridvalszki, Marcell Norbert/0000-0001-9445-9397; Pósa, Anikó/0000-0003-2167-2888; Kerepesi, Csaba/0000-0001-9541-246X; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:33745909,
	title = {Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing},
	url = {https://m2.mtmt.hu/api/publication/33745909},
	author = {Cikes, Domagoj and Elsayad, Kareem and Sezgin, Erdinc and Koltai, Erika and Torma, Ferenc Gergely and Orthofer, Michael and Yarwood, Rebecca and Heinz, Leonhard X. and Sedlyarov, Vitaly and Miranda, Nasser Darwish and Taylor, Adrian and Grapentine, Sophie and al-Murshedi, Fathiya and Abot, Anne and Weidinger, Adelheid and Kutchukian, Candice and Sanchez, Colline and Cronin, Shane J. F. and Novatchkova, Maria and Kavirayani, Anoop and Schuetz, Thomas and Haubner, Bernhard and Haas, Lisa and Hagelkruys, Astrid and Jackowski, Suzanne and Kozlov, Andrey V. and Jacquemond, Vincent and Knauf, Claude and Superti-Furga, Giulio and Rullman, Eric and Gustafsson, Thomas and McDermot, John and Lowe, Martin and Radák, Zsolt and Chamberlain, Jeffrey S. and Bakovic, Marica and Banka, Siddharth and Penninger, Josef M.},
	doi = {10.1038/s42255-023-00791-1},
	journal-iso = {NAT METAB},
	journal = {NATURE METABOLISM},
	volume = {2023},
	unique-id = {33745909},
	year = {2023},
	eissn = {2522-5812},
	pages = {495},
	orcid-numbers = {Cikes, Domagoj/0000-0003-0350-5672; Sezgin, Erdinc/0000-0002-4915-388X; Koltai, Erika/0000-0002-1370-2955; Miranda, Nasser Darwish/0000-0002-8821-8236; Grapentine, Sophie/0000-0003-2307-4363; Weidinger, Adelheid/0000-0002-2759-211X; Kutchukian, Candice/0000-0003-1142-7109; Kavirayani, Anoop/0000-0003-3874-3101; Schuetz, Thomas/0000-0001-9211-8345; Hagelkruys, Astrid/0000-0003-3015-4038; Kozlov, Andrey V./0000-0002-0834-4997; Jacquemond, Vincent/0000-0003-4944-270X; Knauf, Claude/0000-0001-5213-5378; Superti-Furga, Giulio/0000-0002-0570-1768; Rullman, Eric/0000-0003-2854-7262; Radák, Zsolt/0000-0003-1297-6804; Chamberlain, Jeffrey S./0000-0001-5299-0059; Banka, Siddharth/0000-0002-8527-2210; Penninger, Josef M./0000-0002-8194-3777}
}

@article{MTMT:33712726,
	title = {PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing},
	url = {https://m2.mtmt.hu/api/publication/33712726},
	author = {Cikes, Domagoj and Elsayad, Kareem and Sezgin, Erdinc and Koltai, Erika and Torma, Ferenc Gergely and Orthofer, Michael and Yarwood, Rebecca and Heinz, Leonhard X. and Sedlyarov, Vitaly and Miranda, Nasser Darwish and Taylor, Adrian and Grapentine, Sophie and al-Murshedi, Fathiya and Abot, Anne and Weidinger, Adelheid and Kutchukian, Candice and Sanchez, Colline and Cronin, Shane J. F. and Novatchkova, Maria and Kavirayani, Anoop and Schuetz, Thomas and Haubner, Bernhard and Haas, Lisa and Hagelkruys, Astrid and Jackowski, Suzanne and Kozlov, Andrey and Jacquemond, Vincent and Knauf, Claude and Superti-Furga, Giulio and Rullman, Eric and Gustafsson, Thomas and McDermot, John and Lowe, Martin and Radák, Zsolt and Chamberlain, Jeffrey S. and Bakovic, Marica and Banka, Siddharth and Penninger, Josef M.},
	doi = {10.1038/s42255-023-00766-2},
	journal-iso = {NAT METAB},
	journal = {NATURE METABOLISM},
	volume = {5},
	unique-id = {33712726},
	abstract = {Muscle degeneration is the most prevalent cause for frailty and dependency in inherited diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective treatments for muscle diseases, represents an important goal in improving human health. Here, we show that the lipid synthesis enzyme phosphatidylethanolamine cytidyltransferase (PCYT2/ECT) is critical to muscle health. Human deficiency in PCYT2 causes a severe disease with failure to thrive and progressive weakness. pcyt2-mutant zebrafish and muscle-specific Pcyt2-knockout mice recapitulate the participant phenotypes, with failure to thrive, progressive muscle weakness and accelerated ageing. Mechanistically, muscle Pcyt2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure and stability. PCYT2 activity declines in ageing muscles of mice and humans, and adeno-associated virus-based delivery of PCYT2 ameliorates muscle weakness in Pcyt2-knockout and old mice, offering a therapy for individuals with a rare disease and muscle ageing. Thus, PCYT2 plays a fundamental and conserved role in vertebrate muscle health, linking PCYT2 and PCYT2-synthesized lipids to severe muscle dystrophy and ageing.},
	keywords = {disease model; Ageing; Gene Therapy},
	year = {2023},
	eissn = {2522-5812},
	pages = {495-515},
	orcid-numbers = {Sezgin, Erdinc/0000-0002-4915-388X; Koltai, Erika/0000-0002-1370-2955; Miranda, Nasser Darwish/0000-0002-8821-8236; Grapentine, Sophie/0000-0003-2307-4363; Weidinger, Adelheid/0000-0002-2759-211X; Kutchukian, Candice/0000-0003-1142-7109; Kavirayani, Anoop/0000-0003-3874-3101; Schuetz, Thomas/0000-0001-9211-8345; Hagelkruys, Astrid/0000-0003-3015-4038; Kozlov, Andrey/0000-0002-0834-4997; Jacquemond, Vincent/0000-0003-4944-270X; Knauf, Claude/0000-0001-5213-5378; Superti-Furga, Giulio/0000-0002-0570-1768; Rullman, Eric/0000-0003-2854-7262; Radák, Zsolt/0000-0003-1297-6804; Chamberlain, Jeffrey S./0000-0001-5299-0059; Banka, Siddharth/0000-0002-8527-2210; Penninger, Josef M./0000-0002-8194-3777}
}

@CONFERENCE{MTMT:33022430,
	title = {A több évtizedes testedzés hatása a humán vérből izolált extracelluláris vezikulák tartalmára},
	url = {https://m2.mtmt.hu/api/publication/33022430},
	author = {György, Bernadett and Pálóczi, Krisztina and Buzás, Edit and Koltai, Erika and Radák, Zsolt},
	booktitle = {VII. SPORTTUDOMÁNYI PHD SZIMPÓZIUM - PROGRAM- ÉS ABSZTRAKTFÜZET},
	unique-id = {33022430},
	year = {2022},
	pages = {24-24},
	orcid-numbers = {György, Bernadett/0000-0002-3787-7338; Koltai, Erika/0000-0002-1370-2955}
}

@article{MTMT:32259162,
	title = {Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes: A Longitudinal Study of Master Athletes},
	url = {https://m2.mtmt.hu/api/publication/32259162},
	author = {Ireland, Alex and Mittag, Uwe and Degens, Hans and Felsenberg, Dieter and Heinonen, Ari and Koltai, Erika and Korhonen, Marko T. and McPhee, Jamie S. and Mekjavic, Igor and Pisot, Rado and Rawer, Rainer and Radák, Zsolt and Simunic, Bostjan and Suominen, Harri and Rittweger, Jörn},
	doi = {10.1007/s00223-021-00907-3},
	journal-iso = {CALCIFIED TISSUE INT},
	journal = {CALCIFIED TISSUE INTERNATIONAL},
	volume = {110},
	unique-id = {32259162},
	issn = {0171-967X},
	year = {2022},
	eissn = {1432-0827},
	pages = {196-203},
	orcid-numbers = {Ireland, Alex/0000-0003-1094-9183; Koltai, Erika/0000-0002-1370-2955; Radák, Zsolt/0000-0003-1297-6804}
}