TY - JOUR AU - Mozaffaritabar, Soroosh AU - Koltai, Erika AU - Zhou, Lei AU - Bori, Zoltán AU - Kolonics, Attila AU - Kujach, Sylwester AU - Gu, Yaodong AU - Koike, Atsuko AU - Boros, Anita AU - Radák, Zsolt TI - PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle JF - JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY J2 - J PHYSIOL BIOCHEM VL - 2024 PY - 2024 SN - 1138-7548 DO - 10.1007/s13105-024-01006-1 UR - https://m2.mtmt.hu/api/publication/34539479 ID - 34539479 N1 - Received25 August 2023 Accepted10 January 2024 Published23 January 2024 AB - The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms of muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent fat metabolism. PGC-1α trained (PGC-1α Ex) and wild-trained (wt-ex) mice were trained for 10 weeks, five times a week at 30 min per day with 60 percent of their maximal running capacity. The PGC-1α overexpressed animals exhibited higher levels of Fibronectin type III domain-containing protein 5 (FNDC5), 5' adenosine monophosphate-activated protein kinase alpha (AMPK-α), the mammalian target of rapamycin (mTOR), Sirtuin 1 (SIRT1), Lon protease homolog 1 (LONP1), citrate synthase (CS), succinate dehydrogenase complex flavoprotein subunit A (SDHA), Mitofusin-1 (Mfn1), endothelial nitric oxide synthase (eNOS), Hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), G protein-coupled receptor 41 (GPR41), and Phosphatidylcholine Cytidylyltransferase 2 (PCYT2), and lower levels of Sirtuin 3 (SIRT3) compared to wild-type animals. Exercise training increased the protein content levels of SIRT1, HSL, and ATGL in both the wt-ex and PGC-1α trained groups. PGC-1α has a complex role in cellular signaling, including the upregulation of lipid metabolism-associated proteins. Our data reveals that although exercise training mimics the effects of PGC-1α overexpression, it incorporates some PGC-1α-independent adaptive mechanisms in fat uptake and cell signaling. LA - English DB - MTMT ER - TY - JOUR AU - Kolonics, Attila AU - Bori, Zoltán AU - Torma, Ferenc Gergely AU - Ábrahám, Dóra AU - Fehér, János AU - Radák, Zsolt TI - Exercise combined with postbiotics treatment results in synergistic improvement of mitochondrial function in the brain of male transgenic mice for Alzheimer’s disease JF - BMC NEUROSCIENCE J2 - BMC NEUROSCI VL - 24 PY - 2023 IS - 1 SN - 1471-2202 DO - 10.1186/s12868-023-00836-x UR - https://m2.mtmt.hu/api/publication/34477681 ID - 34477681 N1 - Összes idézések száma a WoS-ban: 0 LA - English DB - MTMT ER - TY - JOUR AU - Jókai, Mátyás AU - Torma, Ferenc Gergely AU - McGreevy, Kristen M. AU - Koltai, Erika AU - Bori, Zoltán AU - Bábszky, Gergely AU - Bakonyi, Péter AU - Gombos, Zoltán AU - György, Bernadett AU - Aczél, Dóra Tímea AU - Tóth, László AU - Osváth, Péter AU - Fridvalszki, Marcell Norbert AU - Téglás, Tímea AU - Pósa, Anikó AU - Kujach, Sylwester AU - Olek, Robert AU - Kawamura, Takuji AU - Seki, Yasuhiro AU - Suzuki, Katsuhiko AU - Tanisawa, Kumpei AU - Goto, Sataro AU - Kerepesi, Csaba AU - Boldogh, Istvan AU - Ba, Xueqing AU - Davies, Kelvin J. A. AU - Horvath, Steve AU - Radák, Zsolt TI - DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 45 PY - 2023 IS - 5 SP - 2805 EP - 2817 PG - 13 SN - 2509-2715 DO - 10.1007/s11357-023-00826-1 UR - https://m2.mtmt.hu/api/publication/33866054 ID - 33866054 AB - DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ = 0.2, p = 6.4E − 4, r = 0.19, p = 1.2E − 3), Jumpmax ( p = 0.11, p = 5.5E − 2, r = 0.13, p = 2.8E − 2), Gripmax ( ρ = 0.17, p = 3.5E − 3, r = 0.16, p = 5.6E − 3), and HDL levels ( ρ = 0.18, p = 1.95E − 3, r = 0.19, p = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life. LA - English DB - MTMT ER - TY - JOUR AU - Fulop, A. AU - Budai, A. AU - Radak, Z. AU - Bori, Zoltán AU - Koltai, Erika AU - Tretter, L. AU - Horvath, G. AU - Lukats, A. AU - Szijarto, A. TI - Analyses of mitochondrial biogenesis and function after Associating Liver Partition and Portal vein Ligation for Staged hepatectomy (ALPPS) JF - HPB J2 - HPB VL - 21 PY - 2019 SP - S668 EP - S669 SN - 1365-182X DO - 10.1016/j.hpb.2019.10.463 UR - https://m2.mtmt.hu/api/publication/31305681 ID - 31305681 LA - English DB - MTMT ER - TY - JOUR AU - Budai, András AU - Horváth, Gergő AU - Tretter, László AU - Radák, Zsolt AU - Koltai, Erika AU - Bori, Zoltán AU - Torma, Ferenc Gergely AU - Lukáts, Ákos AU - Röhlich, Pál AU - Szijártó, Attila AU - Fülöp, András TI - Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model JF - BRITISH JOURNAL OF SURGERY J2 - BRIT J SURG VL - 106 PY - 2019 IS - 1 SP - 120 EP - 131 PG - 12 SN - 0007-1323 DO - 10.1002/bjs.10978 UR - https://m2.mtmt.hu/api/publication/3426954 ID - 3426954 LA - English DB - MTMT ER - TY - JOUR AU - Koltai, Erika AU - Bori, Zoltán AU - Osváth, Péter AU - Ihász, Ferenc AU - Szablics, Péter AU - Toth, Geza AU - Degens, Hans AU - Rittweger, Jörn AU - Boldogh, Istvan AU - Radák, Zsolt TI - Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls JF - REDOX BIOLOGY J2 - REDOX BIOL VL - 19 PY - 2018 IS - October SP - 46 EP - 51 PG - 6 SN - 2213-2317 DO - 10.1016/j.redox.2018.07.022 UR - https://m2.mtmt.hu/api/publication/3411071 ID - 3411071 LA - English DB - MTMT ER - TY - JOUR AU - Koltai, Erika AU - Bori, Zoltán AU - Chabert, C AU - Dubouchaud, H AU - Naito, H AU - Machida, S AU - Davies, KJ AU - Murlasits, Zsolt AU - Fry, AC AU - Boldogh, I AU - Radák, Zsolt TI - SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 595 PY - 2017 IS - 11 SP - 3361 EP - 3376 PG - 16 SN - 0022-3751 DO - 10.1113/JP273774 UR - https://m2.mtmt.hu/api/publication/3202563 ID - 3202563 AB - Significant skeletal muscle mass guarantees functional wellbeing and is important for high level performance in many sports. Although the molecular mechanism for skeletal muscle hypertrophy has been well-studied, it still is not completely understood. In the present study, we used a functional overload model to induce plantaris muscle hypertrophy by surgically removing the soleus, and gastrocnemius muscles in rats. Two weeks of muscle ablation resulted in a 40% increase in muscle mass, which was associated with a significant increase in SIRT1 content and activity (P < 0.001). SIRT1-regulated Akt, eNOS, GLUT4 levels were also induced in hypertrophied muscles, and SIRT1 levels correlated with muscle mass, paired box protein 7 (Pax7), proliferating cell nuclear antigen (PCNA) and nicotinamide phosphoribosyltransferase (Nampt) levels. Alternatively, decreased FOXO1 and increased K48 polyubiquitination also suggest that SIRT1 could also be involved in the catabolic process of hypertrophy. Furthermore, increased levels of K63 and muscle RING finger 2 (MuRF2) protein could also be important enhancers of muscle mass. We report here that the levels of miR1 and miR133a decrease in hypertrophy and negatively correlate with muscle mass, SIRT1, and Nampt levels. Our results reveal a strong agreement between SIRT1 levels and activity, SIRT1 regulated pathways, and overload-induced hypertrophy. These findings, along with the well-known regulatory roles that SIRT1 plays in modulating both anabolic and catabolic pathways, allow us to propose the hypothesis that SIRT1 may actually play a crucial causal role in overload induced hypertrophy of skeletal muscle. This hypothesis will now require rigorous direct and functional testing. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Torma, Ferenc Gergely AU - Bori, Zoltán AU - Koltai, Erika AU - Felszeghy, Klára AU - Vácz, Gabriella AU - Koch, Lauren AU - Britton, Steven AU - Boldogh, Istvan AU - Radak, Zsolt TI - Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats JF - FREE RADICAL BIOLOGY AND MEDICINE J2 - FREE RADICAL BIO MED VL - 96 PY - 2016 IS - S1 SP - S34 EP - S35 SN - 0891-5849 DO - 10.1016/j.freeradbiomed.2016.04.069 UR - https://m2.mtmt.hu/api/publication/3207700 ID - 3207700 LA - English DB - MTMT ER - TY - CHAP AU - Radák, Zsolt AU - Acs, Zoltan AU - Bori, Zoltán AU - Taylor, Albert W. AU - Yang, Hu ED - Laher, I TI - The Effects of High-Altitude Exposure on Reactive Oxygen and Nitrogen Species T2 - Systems Biology of Free Radicals and Antioxidants PB - Springer Netherlands CY - Berlin CY - Heidelberg SN - 9783642300172 PY - 2014 SP - 407 EP - 416 PG - 10 DO - 10.1007/978-3-642-30018-9_28 UR - https://m2.mtmt.hu/api/publication/31281655 ID - 31281655 LA - English DB - MTMT ER - TY - JOUR AU - Torma, Ferenc Gergely AU - Bori, Zoltán AU - Koltai, Erika AU - Felszeghy, Klára AU - Vácz, Gabriella AU - Koch, L AU - Britton, S AU - Boldogh, I AU - Radák, Zsolt TI - Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats JF - BRAIN RESEARCH BULLETIN J2 - BRAIN RES BULL VL - 107 PY - 2014 SP - 54 EP - 60 PG - 7 SN - 0361-9230 DO - 10.1016/j.brainresbull.2014.07.003 UR - https://m2.mtmt.hu/api/publication/2736493 ID - 2736493 AB - Exercise capacity and dietary restriction (DR) are linked to improved quality of life, including enhanced brain function and neuro-protection. Brain derived neurotrophic factor (BDNF) is one of the key proteins involved in the beneficial effects of exercise on brain. Low capacity runner (LCR) and high capacity runner (HCR) rats were subjected to DR in order to investigate the regulation of BDNF. HCR-DR rats out-performed other groups in a passive avoidance test. BDNF content increased significantly in the hippocampus of HCR-DR groups compared to control groups (p<0.05). The acetylation of H3 increased significantly only in the LCR-DR group. However, chip-assay revealed that the specific binding between acetylated histone H3 and BNDF promoter was increased in both LCR-DR and HCR-DR groups. In spite of these increases in binding, at the transcriptional level only, the LCR-DR group showed an increase in BDNF mRNA content. Additionally, DR also induced the activity of cAMP response element-binding protein (CREB), while the content of SIRT1 was not altered. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) was elevated in HCR-DR groups. But, based on the levels of nuclear respiratory factor-1 and cytocrome c oxidase, it appears that DR did not cause mitochondrial biogenesis. The data suggest that DR-mediated induction of BDNF levels includes chromatin remodeling. Moreover, DR does not induce mitochondrial biogenesis in the hippocampus of LCR/HCR rats. DR results in different responses to a passive avoidance test, and BDNF regulation in LCR and HCR rats. LA - English DB - MTMT ER -