TY - JOUR AU - Mosaferi Ziaaldini, Mohammad AU - Koltai, Erika AU - Csende, Zsolt AU - Goto, Sataro AU - Boldogh, Istvan AU - Taylor, Albert W AU - Radák, Zsolt TI - Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats JF - EXPERIMENTAL GERONTOLOGY J2 - EXP GERONTOL VL - 67 PY - 2015 SP - 9 EP - 14 PG - 6 SN - 0531-5565 DO - 10.1016/j.exger.2015.04.008 UR - https://m2.mtmt.hu/api/publication/2883904 ID - 2883904 AB - Abstract Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training. LA - English DB - MTMT ER - TY - JOUR AU - Béres, Sándor AU - Csende, Zsolt AU - Adrian, Lees AU - Tihanyi, József TI - Prediction of jumping distance using a short approach model JF - KINESIOLOGY J2 - KINESIOLOGY VL - 46 PY - 2014 IS - 1 SP - 88 EP - 96 PG - 9 SN - 1331-1441 UR - https://m2.mtmt.hu/api/publication/2704733 ID - 2704733 AB - Recent evidence has suggested that relationship between approach speed and distance jumped may not be linear. The aims of this study were (1) to test the hypothesis that using a short approach (6-8-10-12 strides) of increasing length, performance variables will be non-linearly related to distance jumped, (2) to investigate the nature of these relationships for a group of long jumpers and individuals within the group, and (3) to use the regression analysis to determine the optimum number of run-up strides and predict the jumping distance that would be achieved with an optimum length run-up for an individual jumper. Eight male long jumpers with different skill levels (body mass: 75.2±2.2 kg and body height: 188.0±4.2 cm) performed a series of short-approach maximal jumps and the full-length approach in a competition. Kinematic data were collected from video analysis. The relationship between the number of approach strides and velocity, and distance jumped were shown to be best represented by second order polynomial equations. When applied on an individual basis, the predicted jump distances (6.95±.61 m) agreed very well with those found in actual competition (6.96±.58m). As a result, these individual relationships were used to comment on individual optimal approach lengths and to evaluate an individual’s potential for performance in the long jump event. It was concluded that the short approach model of performance is a valuable paradigm for investigating long jump behaviour and the performance potential of individuals. The findings also supported the simplified mathematical model proposed in the literature for the study of long jump performance. LA - English DB - MTMT ER - TY - JOUR AU - Hart, Nikolett AU - Szűcs (Sárga), Linda AU - Csende, Zsolt AU - Koch, Lauren G AU - Britton, Steven L AU - Davies, Kelvin J A AU - Radák, Zsolt TI - Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance JF - DOSE-RESPONSE J2 - DOSE RESP VL - 12 PY - 2014 IS - 1 SP - 57 EP - 71 PG - 15 SN - 1559-3258 DO - 10.2203/dose-response.13-010.Radak UR - https://m2.mtmt.hu/api/publication/2597018 ID - 2597018 LA - English DB - MTMT ER - TY - JOUR AU - Kopper, Bence AU - Csende, Zsolt AU - Trzaskoma, Lukasz AU - Tihanyi, József TI - Stretch-shortening cycle characteristics during vertical jumps carried out with small and large range of motion. JF - JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY J2 - J ELECTROMYOGR KINES VL - 24 PY - 2014 IS - 2 SP - 233 EP - 239 PG - 7 SN - 1050-6411 DO - 10.1016/j.jelekin.2014.01.001 UR - https://m2.mtmt.hu/api/publication/2530023 ID - 2530023 AB - In the present study we investigated kinematical characteristics of the knee and ankle extensors to estimate the length change properties of the contractile and the passive elements in countermovement jumps (CMJ) and drop jumps (DJ) performed with small (40 degrees ) and large (80 degrees ) range of joint motion (SRM and LRM). At SRM the accelerations at maximal muscle lengths compared with the last phase of joint flexion were greater for the gastrocnemius and the soleus (124.9% and 79.4%) and also were greater than at the beginning of joint extension, while no difference was measured at LRM. The differences suggest that at LRM the length change of the serial passive elements from the end of joint flexion to the beginning of joint extension is minimal and simultaneously the length change of the contractile elements is significant, but at SRM - especially in the plantar flexors - the length change of the contractile elements is minimal while in the passive elements significant. It can be presumed that for SRM at the end of joint flexion significant elastic energy is stored and at the beginning of joint extension reused, while for LRM elastic energy storage is not dominant. LA - English DB - MTMT ER - TY - JOUR AU - Hart, Nikolett AU - Szűcs (Sárga), Linda AU - Csende, Zsolt AU - Koltai, Erika AU - Koch, LG AU - Britton, SL AU - Davies, KJA AU - Kouretas, D AU - Wessner, B AU - Radák, Zsolt TI - Resveratrol enhances exercise training responses in rats selectively bred for high running performance JF - FOOD AND CHEMICAL TOXICOLOGY J2 - FOOD CHEM TOXICOL VL - 61 PY - 2013 SP - 53 EP - 59 PG - 7 SN - 0278-6915 DO - 10.1016/j.fct.2013.01.051 UR - https://m2.mtmt.hu/api/publication/2237194 ID - 2237194 N1 - Megjegyzés-23542230 N1 Funding Details: RO1 DK077200, NIH, National Institutes of Health Megjegyzés-23543273 N1 Funding Details: RO1 DK077200, NIH, National Institutes of Health Megjegyzés-23644230 N1 Funding Details: RO1 DK077200, NIH, National Institutes of Health AB - High Capacity Runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p<0.05). The changes in mitochondrial fission/fusion and Lon protease/HSP78 levels suggest that exercise training does not significantly induce damage of proteins. Moreover, neither exercise training nor resveratrol supplementation altered the content of protein carbonyls. Changes in the levels of forkhead transcription factor 1 and SIRT4 could suggest increased fat utilization and improved insulin sensitivity. These data indicate, that resveratrol supplementation enhances aerobic performance due to the activation of the AMPK-SIRT1-PGC-1alpha pathway. LA - English DB - MTMT ER - TY - JOUR AU - Kopper, Bence AU - Csende, Zsolt AU - Sáfár, Sándor AU - Hortobágyi, Tibor AU - Tihanyi, József TI - Muscle activation history at different vertical jumps and its influence on vertical velocity JF - JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY J2 - J ELECTROMYOGR KINES VL - 23 PY - 2013 IS - 1 SP - 132 EP - 139 PG - 8 SN - 1050-6411 DO - 10.1016/j.jelekin.2012.09.005 UR - https://m2.mtmt.hu/api/publication/2137602 ID - 2137602 AB - In the present study we investigated displacement, time, velocity and acceleration history of center of mass (COM) and electrical activity of knee extensors to estimate the dominance of the factors influencing the vertical velocity in squat jumps (SJs), countermovement jumps (CMJs) and drop jumps (DJs) performed with small (40°) and large (80°) range of joint motion (SROM and LROM). The maximum vertical velocity (v4) was 23.4% (CMJ) and 7.8% (DJ) greater when the jumps were performed with LROM compared with SROM (p < 0.05). These differences are considerably less than it could be expected from the greater COM and knee angular displacement and duration of active state. This small difference can be attributed to the greater deceleration during eccentric phase (CMJ:32.1%, DJ:91.5%) in SROM than that in LROM. v4 was greater for SJ in LROM than for SJ in SROM indicating the significance of the longer active state and greater activation level (p < 0.001). The difference in v4 was greater between SJ and CMJ in SROM (38.6%) than in LROM (9.0%), suggesting that elastic energy storage and re-use can be a dominant factor in the enhancement of vertical velocity of CMJ and DJ compared with SJ performed with SROM. © 2012 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Váczi, Márk AU - Tihanyi, József AU - Hortobágyi, Tibor AU - Rácz, Levente AU - Csende, Zsolt AU - Costa, Andreas AU - Pucsok, József TI - Mechanical, Biochemical, and Electromyographic Responses to Short-term Eccentric-Concentric Knee Extensor Training in Humans JF - JOURNAL OF STRENGTH AND CONDITIONING RESEARCH J2 - J STRENGTH CONDIT RES VL - 25 PY - 2011 IS - 4 SP - 922 EP - 932 PG - 11 SN - 1064-8011 DO - 10.1519/JSC.0b013e3181c1fa47 UR - https://m2.mtmt.hu/api/publication/1881645 ID - 1881645 N1 - Accession Number: 60170223; Author: VÁCZI, MÁRK: 1 email: mvaczi@freemail.hu. Author: TIHANYI, JÓZSEF: 1 Author: HORTOBÁGYI, TIBOR: 2 Author: RÁCZ, LEVENTE: 1 Author: CSENDÉ, ZSOLT: 1 Author: COSTA, ANDREAS: 1 Author: PUCSOK, JÓZSEF: 3 ; Author Affiliation: 1 Biomechanics Laboratory, Department of Biomechanics, Semmelweis University, Faculty of Physical Education and Sport Science, Budapest, Hungary.: 2 Biomechanics Laboratory, East Carolina University, Greenville, North Carolina.: 3 Research Institute, National Institute for Sport Mediane, Budapest, Hungary.; No. of Pages: 11; Language: English; Publication Type: Journal Article; Update Code: 20110504 DP: EBSCOhost DB: s3h AB - The article describes a study that examined the effects that short-term eccentric-concentric knee extensor training in humans had on their biomechanical and biochemical variables, muscle soreness, and electromyographic activity. It was found that the training caused immediate reductions in maximal voluntary force. LA - English DB - MTMT ER - TY - JOUR AU - Barna, Gábor AU - Mihalik, Rudolf AU - Timár, Botond AU - Tombol, J AU - Csende, Zsolt AU - Sebestyén, Anna AU - Bödör, Csaba AU - Csernus, Balázs AU - Reiniger, Lilla AU - Peták, István AU - Matolcsy, András TI - ROR1 expression is not a unique marker of CLL JF - HEMATOLOGICAL ONCOLOGY J2 - HEMATOL ONCOL VL - 29 PY - 2011 IS - 1 SP - 17 EP - 21 PG - 5 SN - 0278-0232 DO - 10.1002/hon.948 UR - https://m2.mtmt.hu/api/publication/1815999 ID - 1815999 N1 - Faculty of Medicine, 1st Department of Pathology, Experimental Cancer Research, Budapest, Hungary Cooperation Research Center, Semmelweis University, Budapest, Hungary Faculty of Medicine, Department of Biomechanics, Budapest, Hungary Cited By :60 Export Date: 16 January 2024 CODEN: HAOND Correspondence Address: Barna, G.; Faculty of Medicine, H-1085 Üllodouble acutei út 26, Budapest, Hungary; email: gbarna@korb1.sote.hu LA - English DB - MTMT ER - TY - JOUR AU - Mayer, Ágnes Andrea AU - Tihanyi, József AU - Bretz, Károly AU - Csende, Zsolt AU - Bretz, É AU - Horváth, Mónika TI - Adaptation to altered balance conditions in unilateral amputees due to atherosclerosis: A randomized controlled study JF - BMC MUSCULOSKELETAL DISORDERS J2 - BMC MUSCULOSKEL DIS VL - 12 PY - 2011 PG - 7 SN - 1471-2474 DO - 10.1186/1471-2474-12-118 UR - https://m2.mtmt.hu/api/publication/1713490 ID - 1713490 AB - Background: Amputation impairs the ability to balance. We examined adaptation strategies in balance following dysvascularity-induced unilateral tibial amputation in skilled prosthetic users (SPU) and first fitted amputees (FFA) (N = 28). Methods. Excursions of center of pressure (COP) were determined during 20 s quiet standing using a stabilometry system with eyes-open on both legs or on the non-affected leg(s). Main measures: COP trajectories and time functions; distribution of reaction forces between the two legs; inclination angles obtained through second order regression analysis using stabilogram data. Results: FFA vs SPU demonstrated 27.8% greater postural sway in bilateral stance (p = 0.0004). Postural sway area was smaller in FFA standing on the non-affected leg compared with SPU (p = 0.028). The slope of the regression line indicating postural stability was nearly identical in FFA and SPU and the direction of regression line was opposite for the left and right leg amputees. Conclusion: Of the two adaptation strategies in balance, the first appears before amputation due to pain and fatigue in the affected leg. This strategy appears in the form of reduced postural sway while standing on the non-affected leg. The second adaptation occurs during rehabilitation and regular use of the prosthesis resulting in normal weightbearing associated with reduced postural sway on two legs and return to the normal postural stability on one leg. © 2011 Mayer et al; licensee BioMed Central Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Barna, Gábor AU - Mihalik, Rudolf AU - Timár, Botond AU - Csende, Zsolt AU - Sebestyén, Anna AU - Tombol, J AU - Bödör, Csaba AU - Csernus, Balázs AU - Matolcsy, András TI - ROR1 EXPRESSION IS NOT A UNIQUE MARKER OF CLL JF - CYTOMETRY PART B-CLINICAL CYTOMETRY J2 - CYTOM PART B-CLIN CY VL - 78B PY - 2010 IS - 6 SP - 436 EP - 436 PG - 1 SN - 1552-4949 UR - https://m2.mtmt.hu/api/publication/1822327 ID - 1822327 LA - English DB - MTMT ER -