TY - JOUR AU - Marosvölgyi, Tamás AU - Mintál, Kitti AU - Borbásné Farkas, Kornélia AU - Sipos, Zoltán AU - Makszin, Lilla AU - Szabó, Éva AU - Tóth, Attila AU - Kocsis, Béla AU - Kovács, Krisztina AU - Hormay, Edina AU - Lénárd, László AU - Karádi, Zoltán György AU - Bufa, Anita TI - Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-024-57046-6 UR - https://m2.mtmt.hu/api/publication/34745300 ID - 34745300 N1 - * Megosztott szerzőség AB - Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on the detailed FA spectrum has not been explored yet. We investigated the effect of antibiotics (ABx) and/or probiotics, in four treatment groups on rat stool FA composition. Principal component analysis indicated that the chromatogram profiles of the treatment groups differ, which was also observed at different time points. Linear mixed effects models showed that in the parameters compared (sampling times, treatments. and their interactions), both the weight percentage and the concentration of FAs were affected by ABx and probiotic administration. This study found that the gut microbiome defines trans and branched saturated FAs, most saturated FAs, and unsaturated FAs with less carbon atoms. These results are among the first ones to demonstrate the restoring effects of a probiotic mixture on a substantial part of the altered total FA spectrum, and also revealed a previously unknown relationship between gut bacteria and a larger group of FAs. These findings suggest that intestinal bacteria produce not only SCFAs but also other FAs that may affect the host’s physiological processes. LA - English DB - MTMT ER - TY - CONF AU - Hormay, Edina AU - Mintál, Kitti AU - László, Bettina Réka AU - Szabó, István AU - Tóth, Attila AU - László, Kristóf AU - Győrfi, Nina Rubina AU - Lénárd, László AU - Karádi, Zoltán György TI - Different aspects of the taste reactivity test to interpret gustatory responses elicited organismic changes. T2 - 7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet PY - 2024 SP - 48 UR - https://m2.mtmt.hu/api/publication/34735416 ID - 34735416 LA - English DB - MTMT ER - TY - CONF AU - Hormay, Edina AU - Mintál, Kitti AU - László, Bettina Réka AU - Szabó, István AU - Tóth, Attila AU - László, Kristóf AU - Győrfi, Nina Rubina AU - Lénárd, László AU - Karádi, Zoltán György TI - Long term saccharose consumption associated activity of limbic forebrain glucose-monitoring neurons: A pilot study in the rat. T2 - International Neuroscience Conference, Pécs 2024 PY - 2024 SP - 129 UR - https://m2.mtmt.hu/api/publication/34735333 ID - 34735333 LA - English DB - MTMT ER - TY - JOUR AU - Vizvári, Zoltán Ákos AU - Klincsik, Mihály AU - Odry, Péter AU - Tadity, Vladimir AU - Győrfi, Nina Rubina AU - Tóth, Attila AU - Sári, Zoltán TI - Continuous Electrode Models and Application of Exact Schemes in Modeling of Electrical Impedance Measurements JF - ELECTRONICS (SWITZ) VL - 13 PY - 2024 IS - 1 PG - 17 SN - 2079-9292 DO - 10.3390/electronics13010066 UR - https://m2.mtmt.hu/api/publication/34448557 ID - 34448557 N1 - Export Date: 22 January 2024 Correspondence Address: Vizvari, Z.; Department of Environmental Engineering, Boszorkany Str. 2, Hungary; email: vizvari.zoltan@mik.pte.hu AB - The crucial issue in electrical impedance (EI) measurements lies in the galvanic interaction between the electrodes and the investigated material. This paper brings together the basic and applied research experience and combines their results with excellent properties. Consequently, innovative precise methodologies have emerged, enabling the direct modeling of EI measurements, free from the inaccuracies often associated with numerical approaches. As an outcome of the efficiency and robustness of the applied method, the conductivity of the material and the electrodes are represented by a common piecewise function, which is used to solve the differential equation modeling of the EI measurement. Moreover, this allows the possibility for modeling the conductivity of electrodes with continuous functions, providing an important generalization of the Complete Electrode Model (CEM), which has been widely used so far. The effectiveness of the novel approach was showcased through two distinct case studies. In the first case study, potential functions within both the material and the electrodes were computed using the CEM. In the second case study, calculations were performed utilizing the newly introduced continuous electrode model. The simulation results suggest that the new method is a powerful tool for biological research, from in vitro experiments to animal studies and human applications. LA - English DB - MTMT ER - TY - JOUR AU - Győrfi, Nina Rubina AU - Gál, Adrián Róbert AU - Fincsur, András AU - Kalmar-Nagy, Karoly AU - Mintál, Kitti AU - Hormay, Edina AU - Miseta, Attila János AU - Tornóczky, Tamás AU - Nemeth, Anita K. AU - Bogner, Péter AU - Kiss, Tamas AU - Helyes, Zsuzsanna AU - Sári, Zoltán AU - Klincsik, Mihály AU - Tadity, Vladimir AU - Lénárd, László AU - Vereczkei, András AU - Karádi, Zoltán György AU - Vizvári, Zoltán Ákos AU - Tóth, Attila TI - Novel Noninvasive Paraclinical Study Method for Investigation of Liver Diseases JF - BIOMEDICINES J2 - BIOMEDICINES VL - 11 PY - 2023 IS - 9 PG - 21 SN - 2227-9059 DO - 10.3390/biomedicines11092449 UR - https://m2.mtmt.hu/api/publication/34124226 ID - 34124226 N1 - Communication AB - Based on a prior university patent, the authors developed a novel type of bioimpedance-based test method to noninvasively detect nonalcoholic fatty liver disease (NAFLD). The development of a new potential NAFLD diagnostic procedure may help to understand the underlying mechanisms between NAFLD and severe liver diseases with a painless and easy-to-use paraclinical examination method, including the additional function to detect even the earlier stages of liver disease. The aim of this study is to present new results and the experiences gathered in relation to NAFLD progress during animal model and human clinical trials. LA - English DB - MTMT ER - TY - JOUR AU - Vörös, Dávid AU - Kiss, Orsolya AU - Ollmann, Tamás AU - Mintál, Kitti AU - Péczely, László AU - Zagorácz, Olga AU - Kertes, Erika AU - Kállai, Veronika AU - László, Bettina Réka AU - Marosné Berta, Beáta AU - Tóth, Attila AU - Lénárd, László AU - László, Kristóf TI - Intraamygdaloid Oxytocin Increases Time Spent on Social Interaction in Valproate-Induced Autism Animal Model JF - BIOMEDICINES J2 - BIOMEDICINES VL - 11 PY - 2023 IS - 7 PG - 12 SN - 2227-9059 DO - 10.3390/biomedicines11071802 UR - https://m2.mtmt.hu/api/publication/34081444 ID - 34081444 AB - Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that affects about 1.5% of children worldwide. One of the core symptoms is impaired social interaction. Since proper treatment has not been found yet, an investigation of the exact pathophysiology of autism is essential. The valproate (VPA)-induced rat model can be an appropriate way to study autism. Oxytocin (OT) may amend some symptoms of ASD since it plays a key role in developing social relationships. In the present study, we investigated the effect of the intraamygdaloid OT on sham and intrauterine VPA-treated rats' social interaction using Crawley's social interaction test. Bilateral guide cannulae were implanted above the central nucleus of the amygdala (CeA), and intraamygdaloid microinjections were carried out before the test. Our results show that male Wistar rats prenatally exposed to VPA spent significantly less time on social interaction. Bilateral OT microinjection increased the time spent in the social zone; it also reached the level of sham-control animals. OT receptor antagonist blocked this effect of the OT but in itself did not significantly influence the behavior of the rats. Based on our results, we can establish that intraamygdaloid OT has significantly increased time spent on social interaction in the VPA-induced autism model, and its effect is receptor-specific. LA - English DB - MTMT ER - TY - CHAP AU - Győrfi, Nina Rubina AU - Vizvári, Z AU - Tóth, Attila AU - Karádi, Zoltán György ED - Bali, C ED - Puskás, T ED - Kajos, Luca Fanni ED - Horváth-Polgár, P I ED - Kovács, E TI - Development of an impedance-based cell measuring plate. T2 - MedPECS - Medical Conference for PhD Students and Experts of Clinical Science PB - University of Pécs, Doctoral Student Association CY - Pécs SN - 9789636261177 PY - 2023 SP - 52 UR - https://m2.mtmt.hu/api/publication/34001599 ID - 34001599 LA - English DB - MTMT ER - TY - CHAP AU - Hormay, Edina AU - Mintál, Kitti AU - László, Bettina Réka AU - Szabó, István AU - Tóth, Attila AU - László, Kristóf AU - Győrfi, Nina Rubina AU - Karádi, Zoltán György ED - Bali, C ED - Puskás, T ED - Kajos, Luca Fanni ED - Horváth-Polgár, P I ED - Kovács, E TI - The complex relationship of glucose and neural activity in the light of limbic forebrain glucose-monitoring neurons. T2 - MedPECS - Medical Conference for PhD Students and Experts of Clinical Science PB - University of Pécs, Doctoral Student Association CY - Pécs SN - 9789636261177 PY - 2023 SP - 51 UR - https://m2.mtmt.hu/api/publication/34001582 ID - 34001582 LA - English DB - MTMT ER - TY - CHAP AU - Mintál, Kitti AU - Tóth, Attila AU - Hormay, Edina AU - Kocsis, B AU - László, Kristóf AU - Vízvári, Z AU - Lénárd, László AU - Karádi, Zoltán György ED - Bali, C ED - Puskás, T ED - Kajos, Luca Fanni ED - Horváth-Polgár, P I ED - Kovács, E TI - Modifications of the gastrointestinal microbiome have crucial role in the control of social behavioural processes. T2 - MedPECS - Medical Conference for PhD Students and Experts of Clinical Science PB - University of Pécs, Doctoral Student Association CY - Pécs SN - 9789636261177 PY - 2023 SP - 46 UR - https://m2.mtmt.hu/api/publication/34001562 ID - 34001562 LA - English DB - MTMT ER - TY - JOUR AU - Sári, Zoltán AU - Klincsik, Mihály AU - Odry, Péter AU - Tadity, Vladimir AU - Tóth, Attila AU - Vizvári, Zoltán Ákos TI - Lumped Element Method Based Conductivity Reconstruction Algorithm for Localization Using Symmetric Discrete Operators on Coarse Meshes JF - SYMMETRY (BASEL) J2 - SYMMETRY-BASEL VL - 15 PY - 2023 IS - 5 PG - 24 SN - 2073-8994 DO - 10.3390/sym15051008 UR - https://m2.mtmt.hu/api/publication/33787514 ID - 33787514 N1 - Department of Technical Informatics, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 6, Pecs, H-7624, Hungary Symbolic Methods in Material Analysis and Tomography Research Group, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 6, Pecs, H-7624, Hungary Cellular Bioimpedance Research Group, Szentagothai Research Centre, University of Pecs, Ifjusag Str. 20, Pecs, H-7624, Hungary Institute of Information Technology, University of Dunaujvaros, Tancsics M. Str. 1/A, Dunaujvaros, H-2401, Hungary John von Neumann Faculty of Informatics, University of Obuda, Becsi Str. 96/B, Budapest, H-1034, Hungary Institute of Physiology, Medical School, University of Pecs, Szigeti Str. 12, Pecs, H-7624, Hungary Department of Environmental Engineering, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 2, Pecs, H-7624, Hungary Cited By :1 Export Date: 7 November 2023 Correspondence Address: Vizvari, Z.; Symbolic Methods in Material Analysis and Tomography Research Group, Boszorkany Str. 6, Hungary; email: vizvari.zoltan@mik.pte.hu AB - The inverse conductivity problem in electrical impedance tomography involves the solving of a nonlinear and under-determined system of equations. This paper presents a new approach, which leads to a quadratic and overdetermined system of equations. The aim of the paper is to establish new research directions in handling of the inverse conductivity problem. The basis of the proposed method is that the material, which can be considered as an isotropic continuum, is modeled as a linear network with concentrated parameters. The weights of the obtained graph represent the properties of the discretized continuum. Further, the application of the developed procedure allows for the dielectric constant to be used in the multi-frequency approach, as a result of which the optimized system of equations always remains overdetermined. Through case studies, the efficacy of the reconstruction method by changing the mesh resolution applied for discretizing is presented and evaluated. The presented results show, that, due to the application of discrete, symmetric mathematical structures, the new approach even at coarse mesh resolution is capable of localizing the inhomogeneities of the material. LA - English DB - MTMT ER -