TY - JOUR AU - Eszlári, Nóra AU - Hullám, Gábor István AU - Gál, Zsófia AU - Török, Dóra AU - Nagy, Tamás AU - Millinghoffer, András Dániel AU - Baksa, Dániel AU - Gonda, Xénia AU - Antal, Péter AU - Bagdy, György AU - Juhász, Gabriella TI - Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine JF - TRANSLATIONAL PSYCHIATRY J2 - TRANSL PSYCHIAT VL - 14 PY - 2024 IS - 1 PG - 10 SN - 2158-3188 DO - 10.1038/s41398-024-02867-2 UR - https://m2.mtmt.hu/api/publication/34779723 ID - 34779723 N1 - Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Office [K 139330, K 143391, PD 146014, 2019-2.1.7-ERA-NET-2020-00005, ERAPERMED2019-108]; Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; Hungarian Brain Research Program 3.0 [NAP2022-I-4/2022, TKP2021-EGA-25]; Ministry of Innovation and Technology of Hungary National Research, Development and Innovation Fund [TKP2021-EGA-25]; National Research, Development, and Innovation Fund of Hungary [TKP2021-EGA-02]; European Union [RRF-2.3.1-21-2022-00004]; New National Excellence Program of the Ministry for Culture and Innovation National Research, Development and Innovation Fund [UNKP-23-4-II-SE-2]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; Semmelweis University; [UNKP-22-4-II-SE-1] Funding text: This study was supported by the Hungarian National Research, Development, and Innovation Office, with grants K 139330, K 143391, and PD 146014, as well as 2019-2.1.7-ERA-NET-2020-00005 under the frame of ERA PerMed (ERAPERMED2019-108); by the Hungarian Brain Research Program (grant: 2017-1.2.1-NKP-2017-00002) and the Hungarian Brain Research Program 3.0 (NAP2022-I-4/2022); and by TKP2021-EGA-25, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. It was also supported by the National Research, Development, and Innovation Fund of Hungary under Grant TKP2021-EGA-02 and the European Union project RRF-2.3.1-21-2022-00004 within the framework of the Artificial Intelligence National Laboratory. NE was supported by the UNKP-22-4-II-SE-1, and DB by the UNKP-23-4-II-SE-2 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. NE is supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work uses data provided by patients and collected by the NHS as part of their care and support. Copyright (c) (2019), NHS England. Re-used with the permission of the UK Biobank (Application Number 1602). All rights reserved.Open access funding provided by Semmelweis University. AB - Most current approaches to establish subgroups of depressed patients for precision medicine aim to rely on biomarkers that require highly specialized assessment. Our present aim was to stratify participants of the UK Biobank cohort based on three readily measurable common independent risk factors, and to investigate depression genomics in each group to discover common and separate biological etiology. Two-step cluster analysis was run separately in males ( n = 149,879) and females ( n = 174,572), with neuroticism (a tendency to experience negative emotions), body fat percentage, and years spent in education as input variables. Genome-wide association analyses were implemented within each of the resulting clusters, for the lifetime occurrence of either a depressive episode or recurrent depressive disorder as the outcome. Variant-based, gene-based, gene set-based, and tissue-specific gene expression test were applied. Phenotypically distinct clusters with high genetic intercorrelations in depression genomics were found. A two-cluster solution was the best model in each sex with some differences including the less important role of neuroticism in males. In females, in case of a protective pattern of low neuroticism, low body fat percentage, and high level of education, depression was associated with pathways related to olfactory function. While also in females but in a risk pattern of high neuroticism, high body fat percentage, and less years spent in education, depression showed association with complement system genes. Our results, on one hand, indicate that alteration of olfactory pathways, that can be paralleled to the well-known rodent depression models of olfactory bulbectomy, might be a novel target towards precision psychiatry in females with less other risk factors for depression. On the other hand, our results in multi-risk females may provide a special case of immunometabolic depression. LA - English DB - MTMT ER - TY - GEN AU - Gecse, Kinga AU - A., Németh AU - G. G., Fedor AU - C. S., Aranyi AU - M., Emri AU - Kökönyei, Gyöngyi AU - Bagdy, György AU - Juhász, Gabriella TI - Negative correlation between plasma kynurenine concentration and periaqueductal gray matter functional connectivity in migraine PY - 2024 UR - https://m2.mtmt.hu/api/publication/34631480 ID - 34631480 LA - English DB - MTMT ER - TY - JOUR AU - Kristóf, Zsüliet AU - Gál, Zsófia AU - Török, Dóra AU - Eszlári, Nóra AU - Sutori, Sara AU - Sperlágh, Beáta AU - Anderson, Ian M. AU - Deakin, Bill AU - Bagdy, György AU - Juhász, Gabriella AU - Gonda, Xénia TI - Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 2 PG - 17 SN - 1661-6596 DO - 10.3390/ijms25020865 UR - https://m2.mtmt.hu/api/publication/34496842 ID - 34496842 N1 - Department of Psychiatry and Psychotherapy, Semmelweis University, Balassa utca 6, Budapest, 1082, Hungary Laboratory of Molecular Pharmacology, HUN-REN Institute of Experimental Medicine, Szigony utca 43, Budapest, 1083, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4, Budapest, 1089, Hungary NAP3.0 Neuropsychopharmacology Research Group, Semmelweis University, Nagyvarad ter 4, Budapest, 1089, Hungary National Centre for Suicide Research and Prevention (NASP), Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Granits väg 4, Solna, 17165, Sweden Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, The University of Manchester, Manchester Academic Health Sciences Centre, 46 Grafton Street, Manchester, M13 9NT, United Kingdom Export Date: 3 May 2024 Correspondence Address: Gonda, X.; Department of Psychiatry and Psychotherapy, Balassa utca 6, Hungary; email: gonda.xenia@semmelweis.hu Chemicals/CAS: P2RX7 protein, human; Receptors, Purinergic P2X7 AB - Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders and P2RX7 gene encoding P2X7 receptors, which stimulate neuroinflammation. We investigated the effect of P2RX7 variation in interaction with early childhood adversities and traumas and recent stressors on lifetime suicide attempts and current suicide risk markers. Overall, 1644 participants completed questionnaires assessing childhood adversities, recent negative life events, and provided information about previous suicide attempts and current suicide risk-related markers, including thoughts of ending their life, death, and hopelessness. Subjects were genotyped for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered into logistic and linear regression models, followed by a clumping procedure to identify clumps of SNPs with a significant main and interaction effect. We identified two significant clumps with a main effect on current suicidal ideation with top SNPs rs641940 and rs1653613. In interaction with childhood trauma, we identified a clump with top SNP psy_rs11615992 and another clump on hopelessness containing rs78473339 as index SNP. Our results suggest that P2RX7 variation may mediate the effect of early childhood adversities and traumas on later emergence of suicide risk. LA - English DB - MTMT ER - TY - JOUR AU - Gecse, Kinga AU - Norbert, Károlyi AU - Angela, Hammer AU - Csaba, Sándor Aranyi AU - Miklos, Emri AU - Bagdy, György AU - Juhász, Gabriella TI - Inverse relationship between trait-anxiety and periaqueductal grey connectivity in migraineurs compared to tension-type headache patients JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - IHC Abstracts SP - 198 EP - 199 PG - 2 SN - 0333-1024 UR - https://m2.mtmt.hu/api/publication/34631933 ID - 34631933 LA - English DB - MTMT ER - TY - JOUR AU - Gecse, Kinga AU - Duc, Anh Nguyen AU - Juhász, Gabriella AU - Hiroshi, Mamitsuka AU - Petschner, Péter TI - Machine-learning based drug-drug interaction prediction identifies acetylsalicylic acid as risk for cardiovascular events during migraine treatment JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - IHC Abstracts SP - 76 SN - 0333-1024 UR - https://m2.mtmt.hu/api/publication/34631855 ID - 34631855 LA - English DB - MTMT ER - TY - JOUR AU - Kumar, Sahel AU - Gecse, Kinga AU - Baksa, Dániel AU - Bagdy, György AU - Juhász, Gabriella AU - Petschner, Péter TI - Uncovering Potential Interictal Suppression of ERK Cascade and miR-21 in Migraine Patients: Insights from RNA-Seq Analysis JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - IHC Abstracts SP - 76 EP - 77 PG - 2 SN - 0333-1024 UR - https://m2.mtmt.hu/api/publication/34631775 ID - 34631775 LA - English DB - MTMT ER - TY - JOUR AU - Dobos, Dóra AU - Gecse, Kinga AU - Szabó, Edina AU - Baksa, Dániel AU - Kocsel, Natália AU - Galambos, Attila AU - Kökönyei, Gyöngyi AU - Juhász, Gabriella TI - Headache-Related Quality of Life Associates Differently with Emotional Processing in Migraine and Tension-Type Headache Patients – an fMRI Study JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - IHC Abstracts SP - 196 EP - 197 PG - 2 SN - 0333-1024 UR - https://m2.mtmt.hu/api/publication/34631657 ID - 34631657 LA - English DB - MTMT ER - TY - JOUR AU - Hullám, Gábor István AU - Gál, Zsófia AU - Gonda, Xénia AU - Nagy, Tamás AU - Gézsi, András AU - Cano, Isaac AU - Van der Auwera, Sandra AU - Koukkanen, Mikko AU - Antal, Péter AU - Juhász, Gabriella TI - A sound mind in a sound body a novel concept unravelling heterogeneity of depression. JF - NEUROPSYCHOPHARMACOLOGIA HUNGARICA J2 - NEUROPSYCHOPHARM HUNG VL - 25 PY - 2023 IS - 4 SP - 183 EP - 193 PG - 11 SN - 1419-8711 UR - https://m2.mtmt.hu/api/publication/34478390 ID - 34478390 N1 - Export Date: 19 January 2024 Correspondence Address: Juhasz, G.; Department of Pharmacodynamics, Nagyvárad tér 4, Hungary; email: juhasz.gabriella@semmelweis.hu Funding details: 1602, SLD002/19/000002 Funding details: Academy of Finland, AKA Funding details: Bundesministerium für Bildung und Forschung, BMBF, 01KU2004 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI Funding details: National Research, Development and Innovation Office, 2019-2.1.7-ERA-NET-2020-00005 Funding text 1: The TRAJECTOME project (https://semmelweis.hu/TRAJECTOME/TRAJECTOME/) was supported by the ERA PerMed Joint Translational Call 2019 (application number: ERAPERMED2019-108). At national level the project was funded by the National Research, Development and Innovation Office (2019-2.1.7-ERANET-2020-00005), Hungary; by the Federal Ministry of Education and Research (BMBF, gr. No. 01KU2004), Germany; by the Academy of Finland under the frame of ERA PerMed (TRAJECTOME project, ERAPERMED2019-108), Finland; and by the Catalan Department of Health (SLD002/19/000002), Spain. The UK Biobank database resource was utilised under application number 1602, which includes medical and phenotypic data of recruited participants on the NHS patient registers of people aged 40–69 years [51]. Funding text 2: Acknowledgements: The TRAJECTOME project (https://semmelweis.hu/TRAJECTOME/TRAJECTOME/) was supported by the ERA PerMed Joint Translational Call 2019 (application number: ERAPERMED2019-108). At national level the project was funded by the National Research, Development and Innovation Offi ce (2019-2.1.7-ERA-NET-2020-00005), Hungary; by the Federal Ministry of Education and Research (BMBF, gr. No. 01KU2004), Germany; by the Academy of Finland under the frame of ERA PerMed (TRAJECTOME project, ERAPERMED2019-108), Finland; and by the Catalan Department of Health (SLD002/19/000002), Spain. The UK Biobank database resource was utilised under application number 1602, which includes medical and phenotypic data of recruited participants on the NHS patient registers of people aged 40–69 years [51]. AB - Depression is a highly prevalent and debilitating condition, yet we still lack both in-depth knowledge concerning its etiopathology and sufficiently efficacious treatment options. With approximately one third of patients resistant to currently available antidepressants there is a pressing need for a better understanding of depression, identifying subgroups within the highly heterogeneous illness category and to understand the divergent underlying biology of such subtypes, to help develop and personalise treatments. The TRAJECTOME project aims to address such challenges by (1) identifying depression-related multimorbidity subgroups and shared molecular pathways based on temporal disease profiles from healthcare systems and biobank data using machine learning approaches, and by (2) characterising these subgroups from multiple aspects including genetic variants, metabolic processes, lifestyle and environmental factors. Following the identification of multimorbidity trajectories, a disease burden score related to depression and adjusted for multimorbidity was established summarising the current state of the patient to weigh the molecular mechanisms associated with depression. In addition, the role of genetic and environmental factors, and also their interactions were identified for all subgroups. The project also attempted to identify potential metabolomic markers for the early diagnostics of these multimorbidity conditions. Finally, we prioritized molecular drug candidates matching the multimorbidity pathways indicated for the individual subgroups which would potentially offer personalised treatment simultaneously for the observable multimorbid conditions yet minimising polypharmacy and related side effects. The present paper overviews the TRAJECTOME project including its aims, tasks, procedures and accomplishments. (Neuropsychopharmacol Hung 2023; 25(4): 183-193) LA - English DB - MTMT ER - TY - JOUR AU - Dobos, Dóra AU - Kökönyei, Gyöngyi AU - Gyebnár, Gyula AU - Szabó, Edina AU - Kocsel, Natália AU - Galambos, Attila AU - Gecse, Kinga AU - Baksa, Dániel AU - Kozák, Lajos Rudolf AU - Juhász, Gabriella TI - Microstructural differences in migraine: A diffusion-tensor imaging study JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - 12 PG - 9 SN - 0333-1024 DO - 10.1177/03331024231216456 UR - https://m2.mtmt.hu/api/publication/34474549 ID - 34474549 LA - English DB - MTMT ER - TY - JOUR AU - Rimek, Adrienn Dóra AU - Gecse, Kinga AU - Juhász, Gabriella TI - A migrén és a táplálkozás kapcsolata JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 67 PY - 2023 IS - 8 SP - 420 EP - 426 PG - 7 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/34186094 ID - 34186094 LA - Hungarian DB - MTMT ER -