TY - JOUR AU - Lőrincz, Katalin AU - Bóné, Beáta AU - Karádi, Kázmér AU - Kis-Jakab, Gréta AU - Tóth, Natália AU - Halász, László AU - Erőss, Loránd AU - Balás, István AU - Faludi, Béla AU - Jordán, Zsófia AU - Zoltan, Chadaide AU - Trischlerné Gyimesi, Csilla AU - Fabó, Dániel AU - Janszky, József Vladimír TI - Effects of anterior thalamic nucleus DBS on interictal heart rate variability in patients with refractory epilepsy JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 147 PY - 2023 SP - 17 EP - 30 PG - 14 SN - 1388-2457 DO - 10.1016/j.clinph.2022.11.020 UR - https://m2.mtmt.hu/api/publication/33420086 ID - 33420086 LA - English DB - MTMT ER - TY - JOUR AU - Kaufmann, E. AU - Peltola, J. AU - Colon, A. AU - Bóné, Beáta AU - Bentes, C. AU - Coenen, V. AU - Gil-Nagel, A. AU - Goncalves-Ferreira, A. AU - Lehtimaki, K. AU - Ryvlin, P. AU - Taylor, R. AU - Brionne, T. AU - Gielen, F. AU - Song, S. AU - Boon, P. TI - Multicenter long-term evaluation of safety and efficacy aspects of anterior thalamic deep brain stimulation JF - EPILEPSIA J2 - EPILEPSIA VL - 63 PY - 2022 SP - 225 EP - 226 PG - 2 SN - 0013-9580 UR - https://m2.mtmt.hu/api/publication/33117632 ID - 33117632 LA - English DB - MTMT ER - TY - JOUR AU - Tényi, Dalma AU - Tényi, Tamás AU - Tényiné Csábi, Györgyi AU - Bóné, Beáta AU - Janszky, József Vladimír TI - Increased prevalence of minor physical anomalies in patients with epilepsy – results with the Méhes Scale JF - EPILEPSIA J2 - EPILEPSIA VL - 63 PY - 2022 IS - Suppl. 2 SP - 71 EP - 71 PG - 1 SN - 0013-9580 UR - https://m2.mtmt.hu/api/publication/33106785 ID - 33106785 LA - English DB - MTMT ER - TY - JOUR AU - Tényi, Dalma AU - Tényi, Tamás AU - Tényiné Csábi, Györgyi AU - Jeges, Sára AU - Bóné, Beáta AU - Lőrincz, Katalin AU - Kovács, Norbert AU - Janszky, József Vladimír TI - Increased prevalence of minor physical anomalies in patients with epilepsy JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 9 SN - 2045-2322 DO - 10.1038/s41598-022-17853-1 UR - https://m2.mtmt.hu/api/publication/33050343 ID - 33050343 AB - Our aim was to investigate the rate and topological profile of minor physical anomalies (MPAs) in adult patients with epilepsy with the use of the Méhes Scale, a comprehensive modern scale of dysmorphology. Consecutive epilepsy patients admitted for outpatient evaluation were included. Patients with comorbidities of neurodevelopmental origin (such as autism, severe intellectual disability, attention deficit hyperactivity disorder, schizophrenia, tic disorder, Tourette syndrome, bipolar disorder, specific learning disorder and specific language impairment) were excluded. All participants underwent physical examination with the use of the Méhes Scale for evaluation of MPAs, including 57 minor signs. The frequency and topological profile of MPAs were correlated to clinical patient data using Kruskal–Wallis, chi2 tests and logistic regression model. 235 patients were included, according to the following subgroups: acquired epilepsy (non-genetic, non-developmental etiology) [N = 63], temporal lobe epilepsy with hippocampal sclerosis (TLE with HS) [N = 27], epilepsy with cortical dysgenesis etiology [N = 29], cryptogenic epilepsy [N = 69] and idiopathic generalized epilepsy (IGE) [N = 47]. As controls, 30 healthy adults were recruited. The frequency of MPAs were significantly affected by the type of epilepsy [H(6) = 90.17; p < 0.001]. Pairwise comparisons showed that all patient groups except for acquired epilepsy were associated with increased frequency of MPAs (p < 0.001 in all cases). Furrowed tongue and high arched palate were more common compared to controls in all epilepsy subgroup except for TLE (p < 0.001 or p = 0.001 in all cases). A positive association was detected between the occurrence of MPAs and antiepileptic drug therapy resistance [Exp(B) = 4.19; CI 95% 1.37–12.80; p = 0.012]. MPAs are more common in patients with epilepsy, which corroborates the emerging concept of epilepsy as a neurodevelopmental disorder. Assessment of these signs may contribute to the clarification of the underlying etiology. Moreover, as increased frequency of MPAs may indicate pharmacoresistance, the identification of patients with high number of MPAs could allow evaluation for non-pharmacological treatment in time. LA - English DB - MTMT ER - TY - JOUR AU - Kaufmann, E. AU - Peltola, J. AU - Colon, A. AU - Bóné, Beáta AU - Bentes, C. AU - Coenen, V. AU - Gil-Nagel, A. AU - Goncalves-Ferreira, A. AU - Lehtimaki, K. AU - Ryvlin, P. AU - Taylor, R. AU - Brionne, T. AU - Gielen, F. AU - Song, S. AU - Boon, P. TI - Insights from long-term clinical routine use of thalamic deep brain stimulation for epilepsy (MORE) JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 29 PY - 2022 SP - 264 EP - 265 PG - 2 SN - 1351-5101 UR - https://m2.mtmt.hu/api/publication/33030727 ID - 33030727 LA - English DB - MTMT ER - TY - JOUR AU - Trischlerné Gyimesi, Csilla AU - Barsi, Péter AU - Bóné, Beáta AU - Dóczi, Tamás Péter AU - Horváth, Réka AU - Horváth, Zsolt AU - Komoly, Sámuel AU - Lőrincz, Katalin Nóra AU - Tóth, Márton AU - Janszky, József Vladimír TI - Epilepsziasebészet a pécsi epilepsziacentrumban JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 17 EP - 17 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32893951 ID - 32893951 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, Márton AU - Barsi, Péter AU - Tóth, Zoltán AU - Borbély, Katalin AU - Lückl, János AU - Emri, Miklós AU - Repa, Imre AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Horváth, Zsolt AU - Halász, Péter AU - Juhos, Vera AU - Trischlerné Gyimesi, Csilla AU - Bóné, Beáta AU - Kuperczkó, Diána AU - Horváth, Réka AU - Nagy, Ferenc AU - Kelemen, Anna AU - Jordán, Zsófia AU - Újvári, Ákos AU - Hagiwara, Koichi AU - Isnard, Jean AU - Pál, Endre AU - Fekésházy, Attila AU - Fabó, Dániel AU - Vajda, Zsolt TI - The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy JF - BMC NEUROLOGY J2 - BMC NEUROL VL - 21 PY - 2021 IS - 1 PG - 20 SN - 1471-2377 DO - 10.1186/s12883-021-02352-z UR - https://m2.mtmt.hu/api/publication/32219141 ID - 32219141 N1 - * Megosztott szerzőség AB - When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20-65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients.In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI.The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention.The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.Trial registry: Scientific Research Ethics Committee of the Medical Research Council of Hungary.008899/2016/OTIG . Date of registration: 08 February 2016. LA - English DB - MTMT ER - TY - JOUR AU - Bóné, Beáta AU - Kovács, Norbert AU - Balás, István AU - Horváth, Réka AU - Dóczi, Tamás Péter AU - Janszky, József Vladimír TI - Pregnancy and deep brain stimulation therapy for epilepsy JF - EPILEPTIC DISORDERS J2 - EPILEPTIC DISORD VL - 23 PY - 2021 IS - 4 SP - 633 EP - 638 PG - 6 SN - 1294-9361 DO - 10.1684/epd.2021.1304 UR - https://m2.mtmt.hu/api/publication/32107761 ID - 32107761 N1 - Funding Agency and Grant Number: Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; NKFIH [EFOP-3.6.2-16-2017-00008]; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765/3/2018/FEKUSTRAT] Funding text: This article was supported by the Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002), NKFIH EFOP-3.6.2-16-2017-00008 government-based funds. Our research was partly financed by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the 5th thematic program of the University of Pecs, Hungary (20765/3/2018/FEKUSTRAT). AB - Neuromodulation therapy -vagus nerve stimulation (VNS) and deep brain stimulation (DBS)- is one of the therapeutic options for drug-resistant epilepsy. With the increasing number of DBS implantations in women with epilepsy, it has become a burning issue whether DBS is safe in pregnancy. We report here two women with epilepsy who gave birth to healthy children with DBS therapy. We describe two cases, a 30-year-old woman and a 37-year-old woman. Both were implanted with DBS due to drug-resistant epilepsy. Both of our patients showed a significant improvement after DBS implantation and thereafter gave birth to a healthy child with DBS treatment. The severity and frequency of epileptic seizures did not change during pregnancy and after childbirth. Although a Caesarean section was performed in one case, pregnancies and births were essentially problem-free. At present, the two- and four-year-old children are healthy. Considering these cases, previously described VNS cases, and DBS cases with non-epileptic indications; we suggest that pregnancy and childbirth are safe in epilepsy patients with DBS, moreover, DBS treatment has probably no effect on foetal abnormalities or breastfeeding. LA - English DB - MTMT ER - TY - JOUR AU - Hayden, Zsófia AU - Erdő-Bonyár, Szabina AU - Bóné, Beáta AU - Balázs, Noémi AU - Bodó, Kornélia AU - Illés, Zsolt László AU - Berki, Tímea AU - Simon, Diána TI - Toll-Like Receptor Homolog CD180 Expression Is Diminished on Natural Autoantibody-Producing B Cells of Patients with Autoimmune CNS Disorders JF - JOURNAL OF IMMUNOLOGY RESEARCH J2 - J IMMUNOL RES VL - 2021 PY - 2021 PG - 11 SN - 2314-8861 DO - 10.1155/2021/9953317 UR - https://m2.mtmt.hu/api/publication/32070950 ID - 32070950 AB - Decreased expression of TLR homolog CD180 in peripheral blood B cells and its potential role in antibody production have been described in autoimmune diseases. Effectiveness of anti-CD20 therapy in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) strengthens the role of B cells in the pathogenesis. Therefore, we aimed to investigate the CD180 expression of peripheral blood B cell subsets in NMOSD and MS patients and analyze the levels of natural anti-citrate synthase (CS) IgG autoantibodies and IgG antibodies induced by bacterial infections reported to play a role in the pathogenesis of NMOSD or MS.We analyzed the distribution and CD180 expression of peripheral blood B cell subsets, defined by CD19/CD27/IgD staining, and measured anti-CS IgM/G natural autoantibody and antibacterial IgG serum levels in NMOSD, RRMS, and healthy controls (HC).We found decreased naïve and increased memory B cells in NMOSD compared to MS. Among the investigated four B cell subsets, CD180 expression was exclusively decreased in CD19+CD27+IgD+ nonswitched (NS) memory B cells in both NMOSD and MS compared to HC. Furthermore, the anti-CS IgM natural autoantibody serum level was lower in both NMOSD and MS. In addition, we found a tendency of higher anti-CS IgG natural autoantibody levels only in anti-Chlamydia IgG antibody-positive NMOSD and MS patients.Our results suggest that reduced CD180 expression of NS B cells could contribute to the deficient natural IgM autoantibody production in NMOSD and MS, whereas natural IgG autoantibody levels show an association with antibacterial antibodies. LA - English DB - MTMT ER - TY - GEN AU - Balás, István AU - Dóczi, Tamás Péter AU - Büki, András AU - Llumiguano Zaruma, Segundo Carlos AU - Nagy, Máté AU - Berta, Balázs AU - Komoly, Sámuel AU - Janszky, József Vladimír AU - Aschermann, Zsuzsanna AU - Deli, Gabriella AU - Juhász, Annamária AU - Harmat, Márk AU - Karádi, Kázmér AU - Pintér, Dávid AU - Bóné, Beáta AU - Kovács, Norbert TI - Húsz éves a mély agyi stimuláció Pécsett PY - 2021 UR - https://m2.mtmt.hu/api/publication/32041092 ID - 32041092 LA - Hungarian DB - MTMT ER -