TY - JOUR AU - Gál, Márton AU - Samaniego Andrade, Samantha Kathiuska AU - Fehér, Anna Éva AU - Farkas, Attila AU - Madarász, János AU - Horváth, Lili AU - Gordon, Péter AU - Kovács, Róbert Sándor AU - Nagyné László, Krisztina TI - Thermal diffusity in copper benzene-1,3,5-tricarboxylate–reduced graphite oxide mechanical composites JF - JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY J2 - J THERM ANAL CALORIM PY - 2024 PG - 13 SN - 1388-6150 DO - 10.1007/s10973-024-13021-x UR - https://m2.mtmt.hu/api/publication/34772009 ID - 34772009 AB - Metal organic frameworks (MOFs) and particularly copper benzene-1,3,5-tricarboxylate (HKUST-1) are excellent materials for gas storage (e.g., CH 4 , N 2 , H 2 adsorption) and gas separation. In this work, reduced graphene oxide (RGO)–HKUST-1 mechanical mixtures were studied in order to reveal the effect of RGO content on the pressure tolerance of the texture and heat conductivity. HKUST-1 was obtained by two different synthesis routes. Air-dried MOF and RGO were thoroughly mixed prior to the compression. Powder XRD and Raman spectroscopy were used to characterize the response of the crystal structure, while low-temperature nitrogen adsorption was used the follow the adsorption properties of the pellets. Finally, the "flash" heat pulse method was used to assess the thermal properties. The gas adsorption isotherms revealed that the adsorption capacity decreases when RGO is added. Based on Raman and XRD results, we found that the synthesis route has an effect on multiple scales. We experimentally confirmed that evaluation of the thermal diffusivity requires a model more complex than the simple Fourier equation, due to the inherent heterogeneous structure of the material. A good approximation of the Fourier coefficient of thermal diffusivity was obtained using the parameters of the Guyer–Krumhansl equation. The heat pulse experiments also revealed possible size-dependent behavior. LA - English DB - MTMT ER - TY - JOUR AU - Borkovits, B. AU - Kontsek, Endre AU - Pesti, Adrián István AU - Gordon, Péter AU - Gergely, Szilveszter AU - Csabai, I. AU - Kiss, András AU - Pollner, Péter TI - Classification of colorectal primer carcinoma from normal colon with mid‐infrared spectra JF - JOURNAL OF CHEMOMETRICS J2 - J CHEMOMETR PY - 2024 PG - 15 SN - 0886-9383 DO - 10.1002/cem.3542 UR - https://m2.mtmt.hu/api/publication/34745108 ID - 34745108 AB - In this project, we used formalin‐fixed paraffin‐embedded (FFPE) tissue samples to measure thousands of spectra per tissue core with Fourier transform mid‐infrared spectroscopy using an FT‐IR imaging system. These cores varied between normal colon (NC) and colorectal primer carcinoma (CRC) tissues. We created a database to manage all the multivariate data obtained from the measurements. Then, we applied classifier algorithms to identify the tissue based on its yielded spectra. For classification, we used the random forest, a support vector machine, XGBoost, and linear discriminant analysis methods, as well as three deep neural networks. We compared two data manipulation techniques using these models and then applied filtering. In the end, we compared model performances via the sum of ranking differences (SRD). LA - English DB - MTMT ER - TY - JOUR AU - MAGRAMANE, Sabrina AU - Vlahovic, Kristina AU - Gordon, Péter AU - Kállai-Szabó, Nikolett AU - Zelkó, Romána AU - Antal, István AU - Farkas, Dóra TI - Inhalation Dosage Forms: A Focus on Dry Powder Inhalers and Their Advancements JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 16 PY - 2023 IS - 12 PG - 48 SN - 1424-8247 DO - 10.3390/ph16121658 UR - https://m2.mtmt.hu/api/publication/34405975 ID - 34405975 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes Str. 7, Budapest, H-1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, Budapest, H-1111, Hungary Department of Pharmacy Administration, Semmelweis University, Hőgyes Str. 7–9, Budapest, H-1092, Hungary Export Date: 14 March 2024 Correspondence Address: Kállai-Szabó, N.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: kallai.nikolett@semmelweis.hu Correspondence Address: Farkas, D.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: farkas.dora@semmelweis.hu AB - In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary delivery were investigated, as well as the significance of the particle size in drug deposition. The preparation of DPI formulations was also comprehensively explored, including physico-chemical characterization of powders, powder processing techniques, and formulation considerations. In addition to manufacturing procedures, testing methods were also discussed, providing insights into the development and evaluation of DPI formulations. This review also explores the design basics and critical attributes specific to DPIs, highlighting the significance of their optimization to achieve an effective inhalation therapy. Additionally, the morphology and stability of 3 DPI capsules (Spiriva, Braltus, and Onbrez) were investigated, offering valuable insights into the properties of these formulations. Altogether, these findings contribute to a deeper understanding of DPIs and their development, performance, and optimization of inhalation dosage forms. LA - English DB - MTMT ER - TY - JOUR AU - Gyarmati, Benjámin Sándor AU - Stankovits, József Gergely AU - Szilágyi, Barnabás Áron AU - Galata, Dorián László AU - Gordon, Péter AU - Szilágyi, András Ferenc TI - A robust mucin-containing poly(vinyl alcohol) hydrogel model for the in vitro characterization of mucoadhesion of solid dosage forms JF - COLLOIDS AND SURFACES B: BIOINTERFACES J2 - COLLOID SURFACE B VL - 213 PY - 2022 SN - 0927-7765 DO - 10.1016/j.colsurfb.2022.112406 UR - https://m2.mtmt.hu/api/publication/32765035 ID - 32765035 N1 - Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Department of Electronics Technology, Faculty of Electrical Engineering and Informatics, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, H-111, Hungary Export Date: 6 April 2022 CODEN: CSBBE Correspondence Address: Gyarmati, B.; Department of Physical Chemistry and Materials Science, Műegyetem rkp. 3, Hungary; email: gyarmati.benjamin@vbk.bme.hu Funding details: FK 125074, FK 138029 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Innovációs és Technológiai Minisztérium Funding details: National Research, Development and Innovation Office Funding text 1: The research reported in this paper is part of project no. TKP2021-EGA-02 , implemented with the support provided by the Ministry for Innovation and Technology of Hungary from the National Research , Development and Innovation (NRDI) Fund , financed under the TKP2021 funding scheme. We would like to thank Dr. János Móczó for his help in particle size measurements. Further support was provided by the NRDI Office via grant FK 125074 and FK 138029 . B. Gyarmati acknowledges the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . The work was also supported by the ÚNKP-21–5 New National Excellence Program of the Ministry for Innovation and Technology from the source of the NRDI Fund . LA - English DB - MTMT ER - TY - JOUR AU - Illés, Balázs György AU - Gordon, Péter TI - Filtering efficiency measurement of respirators by laser-based particle counting method JF - MEASUREMENT J2 - MEASUREMENT VL - 176 PY - 2021 SN - 0263-2241 DO - 10.1016/j.measurement.2021.109173 UR - https://m2.mtmt.hu/api/publication/31891742 ID - 31891742 N1 - Cited By :1 Export Date: 16 June 2022 CODEN: MSRMD Correspondence Address: Illés, B.; Department of Electronics Technology, Műegyetem rkp. 3-9, Hungary; email: billes@ett.bme.hu Funding details: 2020-2.1.1-ED-2020-00019 Funding details: National Research, Development and Innovation Office Funding text 1: This research was partially financed by the National Research, Development and Innovation Office in Hungary, NRDI fund, project code 2020-2.1.1-ED-2020-00019. LA - English DB - MTMT ER - TY - JOUR AU - Sántha, Konrád AU - Kállai-Szabó, Nikolett AU - Fülöp, Viktor AU - Jakab, Géza AU - Gordon, Péter AU - Kállai-Szabó, Barnabás AU - Bertalanné Balogh, Emese AU - Antal, István TI - Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 22 PY - 2021 IS - 1 PG - 10 SN - 1530-9932 DO - 10.1208/s12249-020-01902-x UR - https://m2.mtmt.hu/api/publication/31793659 ID - 31793659 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7, Budapest, 1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, Budapest, 1111, Hungary ViteCer Ltd., Ipartelepi Str. 8/b, Cegléd, 2700, Hungary Cited By :3 Export Date: 23 September 2022 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Str. 7, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu AB - Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as the release of the active ingredient depends on the integrity of the coating. In the present study, polymer-coated pellets tableted with different types of excipients (powder, granules, pellets) then were investigated by various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray; microCT) imaging methods. The information obtained from the independent evaluation of the in vitro drug release profiles model is confirmed by the results obtained by image analysis, regardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets were used for image analysis. The results of this study show that the novel easy-to-use, fast, and non-destructive MFX method is a good alternative to the already used microscopic image analysis methods regarding the characterization of particulates, compressed into tablets. LA - English DB - MTMT ER - TY - CHAP AU - Hurtony, Tamás József AU - Krammer, Olivér AU - Illés, Balázs György AU - Gordon, Péter TI - Investigation of the Microstructure of Mn-doped Tin-Silver-Copper Solder Alloys Solidified with Different Cooling Rates T2 - 2019 22ND EUROPEAN MICROELECTRONICS AND PACKAGING CONFERENCE & EXHIBITION (EMPC) PB - IEEE CY - New York, New York CY - Piscataway (NJ) SN - 9780956808660 PY - 2019 PG - 5 DO - 10.23919/EMPC44848.2019.8951866 UR - https://m2.mtmt.hu/api/publication/31576179 ID - 31576179 AB - Due to the moderate price and the non-toxicity, manganese is considered as an ideal dopant for the SAC (SnAgCu) solder alloys. Manganese refines the grain of solder joints, yielding better thermomechanical properties. In present research, the microstructure of the manganese-doped alloys solidified with different technological parameters had been investigated. Sn/Ag0.3./Cu0.7 based solder alloy with three different Mn content (0.1, 0.4, 0.7% wt%) were rejlowed on a copper substrate with tempered hot plate. They were solidified with different cooling rates from 0.3 to 4.5 K/s. Cross-sections have been prepared from the solder samples and the metallographic properties of the solder samples was investigated with optical and scanning electron microscopes. The characteristic features of the samples have been compared to conventionally used SAC305 (Sn/Ag3/Cu0.5) solder alloys, solidified with the same rates of cooling. Results showed that besides the grain refinement, the Mn content might also have effect on the evolution of intermetallic layer between the substrate and the solder alloy. The IMC grains of the layer were more elongated and more spalled grains had been obsen,ed close to the layer. However, independently of the cooling rate, the microstructure of the Mn containing solder alloys remained the same. This suggests that the macroscopic properties are also expected to be less sensitive to the cooling rate of the solidification. LA - English DB - MTMT ER - TY - JOUR AU - Hurtony, Tamás József AU - Szakál, Alex AU - Almásy, László AU - Len, Adél AU - Kugler, Sándor AU - Bonyár, Attila AU - Gordon, Péter TI - Characterization of the microstructure of tin-silver lead free solder JF - JOURNAL OF ALLOYS AND COMPOUNDS J2 - J ALLOY COMPD VL - 672 PY - 2016 SP - 13 EP - 19 PG - 7 SN - 0925-8388 DO - 10.1016/j.jallcom.2016.02.177 UR - https://m2.mtmt.hu/api/publication/3046261 ID - 3046261 LA - English DB - MTMT ER - TY - CHAP AU - Hurtony, Tamás József AU - Gordon, Péter ED - Franz, M ED - Krammer, O ED - Nicolics, J ED - Wohlrabe, H TI - The correlation between the mechanical and electrochemical properties of solder joints T2 - 38th International Spring Seminar on Electronics Technology (ISSE) PB - IEEE CY - Piscataway (NJ) SN - 9781479988600 T3 - International Spring Seminar on Electronics Technology ISSE, ISSN 2161-2536 PY - 2015 SP - 70 EP - 74 PG - 5 DO - 10.1109/ISSE.2015.7247965 UR - https://m2.mtmt.hu/api/publication/3029273 ID - 3029273 LA - English DB - MTMT ER - TY - CHAP AU - Gordon, Péter AU - Hurtony, Tamás József ED - Franz, M ED - Krammer, O ED - Nicolics, J ED - Wohlrabe, H TI - Investigation of the wetting properties of Cu6Sn5 intermetallic compound T2 - 38th International Spring Seminar on Electronics Technology (ISSE) PB - IEEE CY - Piscataway (NJ) SN - 9781479988600 T3 - International Spring Seminar on Electronics Technology ISSE, ISSN 2161-2536 PY - 2015 SP - 315 EP - 319 PG - 5 DO - 10.1109/ISSE.2015.7248013 UR - https://m2.mtmt.hu/api/publication/3029272 ID - 3029272 LA - English DB - MTMT ER -