@article{MTMT:34743321,
	title = {The Impact of C-3 Side Chain Modifications on Kynurenic Acid: A Behavioral Analysis of Its Analogs in the Motor Domain},
	url = {https://m2.mtmt.hu/api/publication/34743321},
	author = {Martos, Diána and Lőrinczi, Bálint and Szatmári, István and Vécsei, László and Tanaka, Masaru},
	doi = {10.3390/ijms25063394},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34743321},
	issn = {1661-6596},
	abstract = {The central nervous system (CNS) is the final frontier in drug delivery because of the blood–brain barrier (BBB), which poses significant barriers to the access of most drugs to their targets. Kynurenic acid (KYNA), a tryptophan (Trp) metabolite, plays an important role in behavioral functions, and abnormal KYNA levels have been observed in neuropsychiatric conditions. The current challenge lies in delivering KYNA to the CNS owing to its polar side chain. Recently, C-3 side chain-modified KYNA analogs have been shown to cross the BBB; however, it is unclear whether they retain the biological functions of the parent molecule. This study examined the impact of KYNA analogs, specifically, SZR-72, SZR-104, and the newly developed SZRG-21, on behavior. The analogs were administered intracerebroventricularly (i.c.v.), and their effects on the motor domain were compared with those of KYNA. Specifically, open-field (OF) and rotarod (RR) tests were employed to assess motor activity and skills. SZR-104 increased horizontal exploratory activity in the OF test at a dose of 0.04 μmol/4 μL, while SZR-72 decreased vertical activity at doses of 0.04 and 0.1 μmol/4 μL. In the RR test, however, neither KYNA nor its analogs showed any significant differences in motor skills at either dose. Side chain modification affects affective motor performance and exploratory behavior, as the results show for the first time. In this study, we showed that KYNA analogs alter emotional components such as motor-associated curiosity and emotions. Consequently, drug design necessitates the development of precise strategies to traverse the BBB while paying close attention to modifications in their effects on behavior.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Lőrinczi, Bálint/0000-0001-7773-0034; Szatmári, István/0000-0002-8571-5229; Vécsei, László/0000-0001-8037-3672}
}

@article{MTMT:34721105,
	title = {Synthesis of bioactive evodiamine and rutaecarpine analogues under a ball milling condition},
	url = {https://m2.mtmt.hu/api/publication/34721105},
	author = {Hu, Hao-Chun and Yu, Szu-Yin and Tsi, Yi-Hong and Hsieh, Pei-Wen and Wang, Hui-Chun and Chen, Yan-Ning and Chuang, Ya-Ting and Lee, Min-Yu and Chang, Hsueh-Wei and Hu, Hao-Chun and Wu, Yang-Chang and Chang, Fang-Rong and Szatmári, István and Fülöp, Ferenc},
	doi = {10.1039/D4OB00056K},
	journal-iso = {ORG BIOMOL CHEM},
	journal = {ORGANIC & BIOMOLECULAR CHEMISTRY},
	volume = {22},
	unique-id = {34721105},
	issn = {1477-0520},
	abstract = {Mechanochemical reactions achieved by processes such as milling and grinding offer a promising alternative to traditional solution-based chemistry. This approach not only eliminates the need for large quantities of solvents,...},
	year = {2024},
	eissn = {1477-0539},
	pages = {2620-2629},
	orcid-numbers = {Szatmári, István/0000-0002-8571-5229; Fülöp, Ferenc/0000-0003-1066-5287}
}

@article{MTMT:34715381,
	title = {Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells},
	url = {https://m2.mtmt.hu/api/publication/34715381},
	author = {Hegedűs, Dóra and Szemerédi, Nikoletta and Gábor, Maja and Sas, Judit and Belasri, Khadija and Szatmári, István and Spengler, Gabriella},
	doi = {10.21873/anticanres.16910},
	journal-iso = {ANTICANCER RES},
	journal = {ANTICANCER RESEARCH},
	volume = {44},
	unique-id = {34715381},
	issn = {0250-7005},
	year = {2024},
	eissn = {1791-7530},
	pages = {1149-1160},
	orcid-numbers = {Szatmári, István/0000-0002-8571-5229; Spengler, Gabriella/0000-0001-8085-0950}
}

@article{MTMT:34689790,
	title = {Tryptophanhydroxamic Acid-Stabilized Ultrasmall Gold Nanoclusters: Tuning the Selectivity for Metal Ion Sensing},
	url = {https://m2.mtmt.hu/api/publication/34689790},
	author = {Gombár, Gyöngyi and Ungor, Ditta Anita and Szatmári, István and Juhász, Ádám and Csapó, Edit},
	doi = {10.3390/nano14050434},
	journal-iso = {NANOMATERIALS-BASEL},
	journal = {NANOMATERIALS},
	volume = {14},
	unique-id = {34689790},
	abstract = {Sub-nanometer-sized gold nanoclusters (Au NCs) were prepared via the spontaneous reduction of [AuCl4]−- ions with a hydroxamate derivative of L-tryptophan (Trp) natural amino acid (TrpHA). The prepared TrpHA-Au NCs possess intense blue emission (λem = 470 nm; λex = 380 nm) with a 2.13% absolute quantum yield and 1.47 ns average lifetime. The Trp-stabilized noble metal NCs are excellent metal ion sensors for Fe3+, but in this work, we highlighted that the incorporation of the hydroxamate functional group with an excellent metal ion binding capability can tune the selectivity and sensitivity of these NCs, which is a promising way to design novel strategies for the detection of other metal ions as well. Moreover, their simultaneous identification can also be realized. By decreasing the sensitivity of our nano-sensor for Fe3+ (limit of detection (LOD) ~11 µM), it was clearly demonstrated that the selectivity for Cu2+-ions can be significantly increased (LOD = 3.16 µM) in an acidic (pH = 3–4) condition. The surface-bounded TrpHA molecules can coordinate the Cu2+ confirmed by thermodynamic data, which strongly generates the linking of the NCs via the Cu2+ ions in acidic pH, and a parallel fluorescence quenching occurs. In the case of Fe3+, the degree of quenching strongly depends on the metal ion concentration, and it only occurs when the NCs are not able to bind more Fe3+ (~10 µM) on the surface, causing the NCs’ aggregation.},
	year = {2024},
	eissn = {2079-4991},
	orcid-numbers = {Ungor, Ditta Anita/0000-0002-7659-0428; Szatmári, István/0000-0002-8571-5229; Juhász, Ádám/0000-0003-0033-7968; Csapó, Edit/0000-0002-6980-9524}
}

@article{MTMT:34394136,
	title = {Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats},
	url = {https://m2.mtmt.hu/api/publication/34394136},
	author = {Ibos, Katalin Eszter and Bodnár, Éva and Dinh, Hoa and Kis, Merse and Márványkövi, Fanni and Kovács, Zsuzsanna and Siska, Andrea and Földesi, Imre and Galla, Zsolt and Monostori, Péter and Szatmári, István and Simon, Péter and Sárközy, Márta and Csabafi, Krisztina},
	doi = {10.1007/s00424-023-02884-y},
	journal-iso = {PFLUG ARCH EUR J PHY},
	journal = {PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY},
	volume = {476},
	unique-id = {34394136},
	issn = {0031-6768},
	abstract = {Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study was to assess the effect of moderate CKD on anxiety in rats. 5/6 nephrectomy was performed in male Wistar rats. 7 weeks after, anxiety-like behavior was assessed by elevated plus maze (EPM), open field (OF), and marble burying (MB) tests. At weeks 8 and 9, urinalysis was performed, and blood and amygdala samples were collected, respectively. In the amygdala, the gene expression of Avp and the gene and protein expression of Crh , Crhr1 , and Crhr2 were analyzed. Furthermore, the plasma concentration of corticosterone, uremic toxins, and tryptophan metabolites was measured by UHPLC-MS/MS. Laboratory tests confirmed the development of CKD. In the CKD group, the closed arm time increased; the central time and the total number of entries decreased in the EPM. There was a reduction in rearing, central distance and time in the OF, and fewer interactions with marbles were detected during MB. CKD evoked an upregulation of gene expression of Crh , Crhr1 , and Crhr2 , but not Avp , in the amygdala. However, there was no alteration in protein expression. In the CKD group, plasma concentrations of p-cresyl-sulfate, indoxyl-sulfate, kynurenine, kynurenic acid, 3-hydroxykynurenine, anthranilic acid, xanthurenic acid, 5-hydroxyindoleacetic acid, picolinic acid, and quinolinic acid increased. However, the levels of tryptophan, tryptamine, 5-hydroxytryptophan, serotonin, and tyrosine decreased. In conclusion, moderate CKD evoked anxiety-like behavior that might be mediated by the accumulation of uremic toxins and metabolites of the kynurenine pathway, but the contribution of the amygdalar CRH system to the development of anxiety seems to be negligible at this stage.},
	year = {2024},
	eissn = {1432-2013},
	pages = {179-196},
	orcid-numbers = {Ibos, Katalin Eszter/0000-0001-5243-9945; Dinh, Hoa/0000-0001-5812-715X; Márványkövi, Fanni/0000-0002-5114-1319; Kovács, Zsuzsanna/0000-0002-4197-4579; Földesi, Imre/0000-0002-3329-8136; Galla, Zsolt/0000-0002-9166-1212; Monostori, Péter/0000-0003-3591-6054; Szatmári, István/0000-0002-8571-5229; Sárközy, Márta/0000-0002-5929-2146; Csabafi, Krisztina/0000-0002-2008-7604}
}

@article{MTMT:34109620,
	title = {Organorhodium complexes of 8-hydroxyquinoline derivatives with antibacterial and antitumor effect},
	url = {https://m2.mtmt.hu/api/publication/34109620},
	author = {Spengler, Gabriella and Pivarcsik, Tamás and Gergő, Egri and Ugrai, Imre and Szatmári, István and Enyedy, Éva Anna},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {70},
	unique-id = {34109620},
	issn = {1217-8950},
	year = {2023},
	eissn = {1588-2640},
	pages = {81-82},
	orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Szatmári, István/0000-0002-8571-5229; Enyedy, Éva Anna/0000-0002-8058-8128}
}

@article{MTMT:34067503,
	title = {Histidinehydroxamic acid as new biomolecule to produce molecular-like fluorescent gold nanoclusters: Possible mechanisms for metal ion sensing},
	url = {https://m2.mtmt.hu/api/publication/34067503},
	author = {Gombár, Gyöngyi and Simon, Péter and Ungor, Ditta Anita and Szatmári, István and Csapó, Edit},
	doi = {10.1016/j.molliq.2023.122597},
	journal-iso = {J MOL LIQ},
	journal = {JOURNAL OF MOLECULAR LIQUIDS},
	volume = {387},
	unique-id = {34067503},
	issn = {0167-7322},
	year = {2023},
	eissn = {1873-3166},
	orcid-numbers = {Ungor, Ditta Anita/0000-0002-7659-0428; Szatmári, István/0000-0002-8571-5229; Csapó, Edit/0000-0002-6980-9524}
}

@article{MTMT:34061805,
	title = {The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia},
	url = {https://m2.mtmt.hu/api/publication/34061805},
	author = {Szabó, Melinda and Biróné Lajkó, Noémi and Dulka, Karolina and Barczánfalvi, Gábor Attila and Lőrinczi, Bálint and Szatmári, István and Mihály, András and Vécsei, László and Gulya, Károly},
	doi = {10.1038/s41598-023-38107-8},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34061805},
	issn = {2045-2322},
	abstract = {We previously showed the anti-inflammatory effects of kynurenic acid (KYNA) and its brain-penetrable analog N -(2-(dimethylamino)ethyl)-3-(morpholinomethyl)-4-hydroxyquinoline-2-carboxamide (SZR104) both in vivo and in vitro. Here, we identified the cytomorphological effects of KYNA and SZR104 in secondary microglial cultures established from newborn rat forebrains. We quantitatively analyzed selected morphological aspects of microglia in control (unchallenged), lipopolysaccharide (LPS)-treated (challenged), KYNA- or SZR104-treated, and LPS + KYNA or LPS + SZR104-treated cultures. Multicolor immunofluorescence labeling followed by morphometric analysis (area, perimeter, transformation index, lacunarity, density, span ratio, maximum span across the convex hull, hull circularity, hull area, hull perimeter, max/min radii, mean radius, diameter of bounding circle, fractal dimension, roughness, circularity) on binary (digital) silhouettes of the microglia revealed their morphological plasticity under experimental conditions. SZR104 and, to a lesser degree, KYNA inhibited proinflammatory phenotypic changes. For example, SZR104 treatment resulted in hypertrophied microglia characterized by a swollen cell body, enlarged perimeter, increased transformation index/decreased circularity, increased convex hull values (area, perimeter, mean radius, maximum span, diameter of the bounding circle and hull circularity), altered box-counting parameters (such as fractal dimension), and increased roughness/decreased density. Taken together, analysis of cytomorphological features could contribute to the characterization of the anti-inflammatory activity of SZR104 on cultured microglia.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Szabó, Melinda/0000-0002-7161-6342; Dulka, Karolina/0000-0002-7368-8198; Lőrinczi, Bálint/0000-0001-7773-0034; Szatmári, István/0000-0002-8571-5229; Mihály, András/0000-0002-6802-0169; Vécsei, László/0000-0001-8037-3672}
}

@article{MTMT:34035454,
	title = {The synthesis of pharmacologically important oxindoles via the asymmetric aldol reaction of isatin and the investigation of the organocatalytic activity of new alicyclic β-amino acid derivatives},
	url = {https://m2.mtmt.hu/api/publication/34035454},
	author = {Faragó, Tünde and Remete, Attila Márió and Szatmári, István and Ambrus, Rita and Palkó, Márta},
	doi = {10.1039/D3RA03528J},
	journal-iso = {RSC ADV},
	journal = {RSC ADVANCES},
	volume = {13},
	unique-id = {34035454},
	issn = {2046-2069},
	abstract = {This work involves the synthesis and subsequent development of a number of novel organocatalysts generated from β-amino acids bearing diendo and diexo norbornene skeletons to improve their catalytic characteristics.},
	year = {2023},
	eissn = {2046-2069},
	pages = {19356-19365},
	orcid-numbers = {Faragó, Tünde/0000-0002-3052-8258; Remete, Attila Márió/0000-0001-6388-0197; Szatmári, István/0000-0002-8571-5229; Palkó, Márta/0000-0002-8265-7377}
}

@article{MTMT:33811528,
	title = {Novel Eco-friendly, One-Pot Method for the Synthesis of Kynurenic Acid Ethyl Esters},
	url = {https://m2.mtmt.hu/api/publication/33811528},
	author = {Simon, Péter and Lőrinczi, Bálint and Hetényi, Anasztázia and Szatmári, István},
	doi = {10.1021/acsomega.3c01170},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {8},
	unique-id = {33811528},
	issn = {2470-1343},
	year = {2023},
	eissn = {2470-1343},
	pages = {17966-17975},
	orcid-numbers = {Lőrinczi, Bálint/0000-0001-7773-0034; Hetényi, Anasztázia/0000-0001-8080-6992; Szatmári, István/0000-0002-8571-5229}
}