TY - JOUR AU - Thallinger, Christiane AU - Berzinec, Peter AU - Bicakcic, Emina AU - Dan, Adelina AU - Fábián, Gabriella AU - Gales, Laurentia Nicoletta AU - Kuhar, Cvetka Grasic AU - Janzic, Urska AU - Kahan, Zsusanna AU - Mencinger, Marina AU - Penthedourakis, George AU - Sgouros, Joseph AU - Simetic, Luka AU - Sirbu, Daniela AU - Vosmik, Milan AU - Wrona, Anna AU - Zielinski, Christoph TI - Establishment of a virtual transborder tumor board for cancer patients in Central and Southeastern Europe An initiative of the Central European Cooperative Oncology Group (CECOG) JF - WIENER KLINISCHE WOCHENSCHRIFT: MIDDLE EUROPEAN JOURNAL OF MEDICINE J2 - WIEN KLIN WOCHENSCHR VL - 134 PY - 2022 IS - 19-20 SP - 697 EP - 704 PG - 8 SN - 0043-5325 DO - 10.1007/s00508-022-02016-z UR - https://m2.mtmt.hu/api/publication/33449266 ID - 33449266 AB - Purpose To establish a transborder virtual tumor board (VTB) fostering state-of-the-art management of cancer patients by exchanging knowledge and expertise among oncologists in Central and Southeastern Europe (CEE). Methods We established and implemented a VTB based on the WebEx platform. This allowed for password-protected and secure upload of patient cases to be presented and discussed among colleagues from various oncology centers scattered throughout CEE in order to arrive at a recommendation for further diagnoses and/or treatment. Results A total of 73 cases from 16 oncology centers located in 11 CEE countries were uploaded by 22 physicians; 71 were discussed over the course of 17 virtual meetings between June 2018 and May 2019 and 12 different kinds of malignant diseases were discussed with lung cancer (46.6%), melanoma (19.2%) and bladder cancer (13.6%) being the most commonly presented tumor entities. Of the discussed patients, 93.3% had stage IV disease at the time of presentation, 62.6% received chemotherapy or targeted treatment and 67.1% were treated with immune checkpoint inhibitors (ICPIs). The most common causes for presentation and discussion of patient cases were related to the use of ICPIs (80%). Conclusion When the need for expertise exceeds locally available resources, web-based VTBs provide a feasible way to discuss patient cases and arrive at conclusions regarding diagnoses and/or treatment across large geographic distances. Moreover, VTBs provide an innovative way for proper, state-of-the-art management of patients with malignant diseases in times of social distancing and the resulting need for restricted interaction during the current SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) pandemic. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Mónika Gabriella AU - Kiscsatári, Laura AU - Varga, Zoltán AU - Kővári, Bence AU - Fábián, Gabriella AU - Cserni, Gábor AU - Thum, Thomas AU - Csont, Tamás Bálint AU - Bátkai, Sándor AU - Barnea, Eytan AU - Kahán, Zsuzsanna AU - Sárközy, Márta TI - The effect of the preimplantation factor on the cardiac expression of miR-21 in radiation-induced heart disease JF - ACTA PHYSIOLOGICA J2 - ACTA PHYSIOL VL - 227 PY - 2019 IS - Special Issue S718 SP - 166 EP - 167 PG - 2 SN - 1748-1708 UR - https://m2.mtmt.hu/api/publication/31290812 ID - 31290812 N1 - GINOP-2.3.2-15-2016-00040, FK129094,UNKP-19-3-SZTE-159, UNKP-19-4-SZTE-89), János Bolyai Research Fellowship of the Hungarian Academy of Sciences, EFOP-3.6.3-VEKOP-16-2017-00009 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Mónika Gabriella AU - Kiscsatári, Laura AU - Varga, Zoltán AU - Kővári, Bence AU - Fábián, Gabriella AU - Cserni, Gábor AU - Thomas, Thum AU - Csont, Tamás Bálint AU - Bátkai, Sándor AU - Eytan, Barnea AU - Kahán, Zsuzsanna AU - Sárközy, Márta TI - A preimplantációs faktor hatása a miR-21 kardiális expressziójára radiogén szívkárosodásban [The effect of preimplantation factor on the cardiac expression of miR-21 in radiation-induced heart disease] JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 49 PY - 2019 IS - Supplementum B SP - B29 EP - B30 PG - 1 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/31290227 ID - 31290227 N1 - ÚNKP- 17-4-I-SZTE-43, ÚNKP-17-2-I-SZTE-30, ÚNKP-18-4-SZTE-63, ÚNKP-18-3-II-SZTE-15, GINOP-2.3.2-15-2016-00040, NKFIH_FK129094 LA - English DB - MTMT ER - TY - GEN AU - Kovács, Mónika Gabriella AU - Kovács, Zsuzsanna AU - Varga, Zoltán AU - Fábián, Gabriella AU - Eytan, Barnea AU - Kahán, Zsuzsanna AU - Csont, Tamás Bálint AU - Sárközy, Márta TI - The potential anti-hypertrophic effect of the preimplantation factor in the development of radiation-induced heart disease in rats PY - 2019 PG - 1 UR - https://m2.mtmt.hu/api/publication/31289423 ID - 31289423 N1 - GINOP-2.3.2-15-2016-00040, NKFIH_FK129094,NKFIH K115990,EFOP 3.6.3-VEKOP-16-2007-00002,EFOP-3.6.2-16-2017-00006,ÚNKP-19-3-SZTE-160, ÚNKP-19-3-159, ÚNKP-19-4-SZTE-89 LA - English DB - MTMT ER - TY - CHAP AU - Kovács, Mónika Gabriella AU - Kiscsatári, Laura AU - Varga, Zoltán AU - Kővári, Bence AU - Fábián, Gabriella AU - Cserni, Gábor AU - Thomas, Thum AU - Csont, Tamás Bálint AU - Bátkai, Sándor AU - Eytan, Barnea AU - Kahán, Zsuzsanna AU - Sárközy, Márta ED - Bagdy, György TI - A preimplantációs faktor hatása a miR-21 kardiális expressziójára radiogén szívkárosodásban T2 - FAMÉ 2019 Magyar Kísérletes és Klinikai Farmakológiai Társaság; Magyar Anatómus Társaság; Magyar Mikrocirkulációs és Vaszkuláris Biológiai Társaság; Magyar Élettani Társaság PB - Expert-Quality Kongresszusi és Utazási Iroda CY - Budapest SN - 9786158129909 PY - 2019 SP - 72 EP - 72 PG - 1 UR - https://m2.mtmt.hu/api/publication/31289421 ID - 31289421 N1 - ÚNKP- 17-4-I-SZTE-43, ÚNKP-17-2-I-SZTE-30, ÚNKP-18-4-SZTE-63, ÚNKP-18-3-II-SZTE-15, GINOP-2.3.2-15-2016-00040, NKFIH_FK129094 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sárközy, Márta AU - Molnár-Gáspár, Renáta AU - Zvara, Ágnes AU - Kiscsatári, Laura AU - Varga, Zoltán AU - Kővári, Bence AU - Kovács, Mónika Gabriella AU - Szűcs, Gergő AU - Fábián, Gabriella AU - Diószegi, Petra AU - Cserni, Gábor AU - Puskás, László AU - Thum, Thomas AU - Kahán, Zsuzsanna AU - Csont, Tamás Bálint AU - Batkai, Sandor TI - Selective Heart Irradiation Induces Cardiac Overexpression of the Pro-hypertrophic miR-212 JF - FRONTIERS IN ONCOLOGY J2 - FRONT ONCOL VL - 9 PY - 2019 PG - 15 SN - 2234-943X DO - 10.3389/fonc.2019.00598 UR - https://m2.mtmt.hu/api/publication/30755535 ID - 30755535 N1 - Funding Agency and Grant Number: Ministry of Human Capacities [20391-3/2018/FEKUSTRAT]; New National Excellence Program of the Ministry of Human Capacities [UNKP-17-4-I-SZTE-43, UNKP-17-2-I-SZTE-30, UNKP-18-4-SZTE-63, UNKP-18-3-II-SZTE-15]; EU; Deutsche Forschungsgemeinschaft [KFO311]; Janos Bolyai Research Fellowship of the Hungarian Academy of Sciences; [GINOP-2.3.2-15-2016-00040]; [NKFIH K115990]; [FK129094]; [EFOP-3.6.2-16-2017-00006]; [EFOP 3.6.3-VEKOP-16-2017-00009] Funding text: The work and publication were supported by the projects GINOP-2.3.2-15-2016-00040, NKFIH K115990, and FK129094, EFOP-3.6.2-16-2017-00006 (LIVE LONGER) and by the Ministry of Human Capacities (20391-3/2018/FEKUSTRAT). MS and MK were supported by the New National Excellence Program of the Ministry of Human Capacities (UNKP-17-4-I-SZTE-43, UNKP-17-2-I-SZTE-30, UNKP-18-4-SZTE-63, and UNKP-18-3-II-SZTE-15). MS is supported by the Janos Bolyai Research Fellowship of the Hungarian Academy of Sciences. MK was supported by the EFOP 3.6.3-VEKOP-16-2017-00009. The study was also partly funded by the EU funded ERANET program EXPERT (to TT), and the Deutsche Forschungsgemeinschaft KFO311 (to TT). AB - Background: A deleterious, late-onset side effect of thoracic radiotherapy is the development of radiation-induced heart disease (RIHD). It covers a spectrum of cardiac pathology including also heart failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction. MicroRNA-212 (miR-212) is a crucial regulator of pathologic LVH via FOXO3-mediated pathways in pressure-overload-induced heart failure. We aimed to investigate whether miR-212 and its selected hypertrophy-associated targets play a role in the development of RIHD.Methods: RIHD was induced by selective heart irradiation (50Gy) in a clinically relevant rat model. One, three, and nineteen weeks after selective heart irradiation, transthoracic echocardiography was performed to monitor cardiac morphology and function. Cardiomyocyte hypertrophy and fibrosis were assessed by histology at week 19. qRT-PCR was performed to measure the gene expression changes of miR-212 and forkhead box O3 (FOXO3) in all follow-up time points. The cardiac transcript level of other selected hypertrophy-associated targets of miR-212 including extracellular signal-regulated kinase 2 (ERK2), myocyte enhancer factor 2a (MEF2a), AMP-activated protein kinase, (AMPK), heat shock protein 40 (HSP40), sirtuin 1, (SIRT1), calcineurin A-alpha and phosphatase and tensin homolog (PTEN) were also measured at week 19. Cardiac expression of FOXO3 and phospho-FOXO3 were investigated at the protein level by Western blot at week 19.Results: In RIHD, diastolic dysfunction was present at every time point. Septal hypertrophy developed at week 3 and a marked LVH with interstitial fibrosis developed at week 19 in the irradiated hearts. In RIHD, cardiac miR-212 was overexpressed at week 3 and 19, and FOXO3 was repressed at the mRNA level only at week 19. In contrast, the total FOXO3 protein level failed to decrease in response to heart irradiation at week 19. Other selected hypertrophy-associated target genes failed to change at the mRNA level in RIHD at week 19.Conclusions: LVH in RIHD was associated with cardiac overexpression of miR-212. However, miR-212 seems to play a role in the development of LVH via FOXO3-independent mechanisms in RIHD. As a central regulator of pathologic remodeling, miR-212 might become a novel target for RIHD-induced LVH and heart failure. LA - English DB - MTMT ER - TY - CONF AU - Sárközy, Márta AU - Molnár-Gáspár, Renáta AU - Ágnes, Zvara AU - Kiscsatári, Laura AU - Varga, Zoltán AU - Kővári, Bence AU - Kovács, Mónika Gabriella AU - Szűcs, Gergő AU - Fábián, Gabriella AU - Cserni, Gábor AU - László, G. Puskás AU - Thomas, Thum AU - Kahán, Zsuzsanna AU - Csont, Tamás Bálint AU - Sándor, Bátkai ED - Sáfrány, G. TI - Selective heart irradiation induces cardiac overexpression of the pro-hypertrophic miR-212 T2 - The 44th Annual Meeting of the European Radiation Research Society: Program and Abstract Book PY - 2018 SP - 160 EP - 160 PG - 1 UR - https://m2.mtmt.hu/api/publication/31289399 ID - 31289399 N1 - The work and publication were supported by the projects GINOP-2.3.2-15-2016-00040 and NKFIH K115990. M. Sarkozy and M.G. Kovács were supported by the New National Excellence Program of the Ministry of Human Capacities (UNKP-17-4-I-SZTE-43 and UNKP-17-2-I-SZTE-30). M. Sárközy is supported by the János Bolyai Research Grant of the Hungarian Academy of Sciences. AB - Poster session: Pre- and clinical research supporting human radiotherapy LA - English DB - MTMT ER - TY - CONF AU - Sárközy, Márta AU - Molnár-Gáspár, Renáta AU - Zvara, Ágnes AU - Kiscsatári, Laura AU - Varga, Zoltán AU - Kővári, Bence AU - Kovács, Mónika Gabriella AU - Szűcs, Gergő AU - Diószegi, Petra AU - Fábián, Gabriella AU - Cserni, Gábor AU - Puskás, G László AU - Thomas, Thum AU - Kahán, Zsuzsanna AU - Csont, Tamás Bálint AU - Bátkai, Sándor TI - A hipertrófiás miR-212/132 klaszter kardiális expressziója megemelkedik radiogén szívkárosodásban T2 - Magyar Élettani Társaság 2018. évi Vándorgyűlése : előadás és poszter absztraktok PY - 2018 SP - 83 EP - 83 PG - 1 UR - https://m2.mtmt.hu/api/publication/3399366 ID - 3399366 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sárközy, Márta AU - Molnár-Gáspár, Renáta AU - Zvara, Ágnes AU - Kiscsatári, Laura AU - Varga, Zoltán AU - Kővári, Bence AU - Kovács, Mónika Gabriella AU - Szűcs, Gergő AU - Fábián, Gabriella AU - Cserni, Gábor AU - László, G Puskás AU - Thomas, Thum AU - Kahán, Zsuzsanna AU - Csont, Tamás Bálint AU - Sándor, Bátkai TI - Selective heart irradiation induces left ventricular hypertrophy and diastolic dysfunction with overexpression of the miR-212/132 cluster JF - EUROPEAN JOURNAL OF HEART FAILURE J2 - EUR J HEART FAIL VL - 20 PY - 2018 IS - Suppl. 1 SP - 334 EP - 334 PG - 1 SN - 1388-9842 UR - https://m2.mtmt.hu/api/publication/3377886 ID - 3377886 LA - English DB - MTMT ER - TY - JOUR AU - Sárközy, Márta AU - Molnár-Gáspár, Renáta AU - Zvara, Ágnes AU - Kiscsatári, Laura AU - Varga, Zoltán AU - Kővári, Bence AU - Kovács, Mónika Gabriella AU - Szűcs, Gergő AU - Fábián, Gabriella AU - Cserni, Gábor AU - Puskás, G. László AU - Thum, Thomas AU - Kahán, Zsuzsanna AU - Csont, Tamás Bálint AU - Bátkai, Sándor TI - A pro-hipertrófiás miR-212/132 klaszter kardiális expressziója megemelkedik radiogén szívkárosodásban [Selective heart irradiation induces cardiac over-expression of the pro-hypertropic miR-212/132 cluster] JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 48 PY - 2018 IS - Supplementum C SP - C34 EP - C35 PG - 1 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/3370814 ID - 3370814 LA - English DB - MTMT ER -