@article{MTMT:33449266, title = {Establishment of a virtual transborder tumor board for cancer patients in Central and Southeastern Europe An initiative of the Central European Cooperative Oncology Group (CECOG)}, url = {https://m2.mtmt.hu/api/publication/33449266}, author = {Thallinger, Christiane and Berzinec, Peter and Bicakcic, Emina and Dan, Adelina and Fábián, Gabriella and Gales, Laurentia Nicoletta and Kuhar, Cvetka Grasic and Janzic, Urska and Kahan, Zsusanna and Mencinger, Marina and Penthedourakis, George and Sgouros, Joseph and Simetic, Luka and Sirbu, Daniela and Vosmik, Milan and Wrona, Anna and Zielinski, Christoph}, doi = {10.1007/s00508-022-02016-z}, journal-iso = {WIEN KLIN WOCHENSCHR}, journal = {WIENER KLINISCHE WOCHENSCHRIFT: MIDDLE EUROPEAN JOURNAL OF MEDICINE}, volume = {134}, unique-id = {33449266}, issn = {0043-5325}, abstract = {Purpose To establish a transborder virtual tumor board (VTB) fostering state-of-the-art management of cancer patients by exchanging knowledge and expertise among oncologists in Central and Southeastern Europe (CEE). Methods We established and implemented a VTB based on the WebEx platform. This allowed for password-protected and secure upload of patient cases to be presented and discussed among colleagues from various oncology centers scattered throughout CEE in order to arrive at a recommendation for further diagnoses and/or treatment. Results A total of 73 cases from 16 oncology centers located in 11 CEE countries were uploaded by 22 physicians; 71 were discussed over the course of 17 virtual meetings between June 2018 and May 2019 and 12 different kinds of malignant diseases were discussed with lung cancer (46.6%), melanoma (19.2%) and bladder cancer (13.6%) being the most commonly presented tumor entities. Of the discussed patients, 93.3% had stage IV disease at the time of presentation, 62.6% received chemotherapy or targeted treatment and 67.1% were treated with immune checkpoint inhibitors (ICPIs). The most common causes for presentation and discussion of patient cases were related to the use of ICPIs (80%). Conclusion When the need for expertise exceeds locally available resources, web-based VTBs provide a feasible way to discuss patient cases and arrive at conclusions regarding diagnoses and/or treatment across large geographic distances. Moreover, VTBs provide an innovative way for proper, state-of-the-art management of patients with malignant diseases in times of social distancing and the resulting need for restricted interaction during the current SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) pandemic.}, keywords = {immune checkpoint inhibitors; malignant diseases; Central and Southeastern Europe; Remote tumor board; CECOG}, year = {2022}, eissn = {1613-7671}, pages = {697-704}, orcid-numbers = {Fábián, Gabriella/0000-0002-2323-4948} } @article{MTMT:31290812, title = {The effect of the preimplantation factor on the cardiac expression of miR-21 in radiation-induced heart disease}, url = {https://m2.mtmt.hu/api/publication/31290812}, author = {Kovács, Mónika Gabriella and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Fábián, Gabriella and Cserni, Gábor and Thum, Thomas and Csont, Tamás Bálint and Bátkai, Sándor and Barnea, Eytan and Kahán, Zsuzsanna and Sárközy, Márta}, journal-iso = {ACTA PHYSIOL}, journal = {ACTA PHYSIOLOGICA}, volume = {227}, unique-id = {31290812}, issn = {1748-1708}, year = {2019}, eissn = {1748-1716}, pages = {166-167}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Csont, Tamás Bálint/0000-0001-5792-2768; Kahán, Zsuzsanna/0000-0002-5021-8775; Sárközy, Márta/0000-0002-5929-2146} } @article{MTMT:31290227, title = {A preimplantációs faktor hatása a miR-21 kardiális expressziójára radiogén szívkárosodásban [The effect of preimplantation factor on the cardiac expression of miR-21 in radiation-induced heart disease]}, url = {https://m2.mtmt.hu/api/publication/31290227}, author = {Kovács, Mónika Gabriella and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Fábián, Gabriella and Cserni, Gábor and Thomas, Thum and Csont, Tamás Bálint and Bátkai, Sándor and Eytan, Barnea and Kahán, Zsuzsanna and Sárközy, Márta}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {49}, unique-id = {31290227}, issn = {0133-5596}, year = {2019}, eissn = {1588-0230}, pages = {B29-B30}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Csont, Tamás Bálint/0000-0001-5792-2768; Kahán, Zsuzsanna/0000-0002-5021-8775; Sárközy, Márta/0000-0002-5929-2146} } @misc{MTMT:31289423, title = {The potential anti-hypertrophic effect of the preimplantation factor in the development of radiation-induced heart disease in rats}, url = {https://m2.mtmt.hu/api/publication/31289423}, author = {Kovács, Mónika Gabriella and Kovács, Zsuzsanna and Varga, Zoltán and Fábián, Gabriella and Eytan, Barnea and Kahán, Zsuzsanna and Csont, Tamás Bálint and Sárközy, Márta}, unique-id = {31289423}, year = {2019}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662; Kovács, Zsuzsanna/0000-0002-4197-4579; Varga, Zoltán/0000-0001-8537-6282; Fábián, Gabriella/0000-0002-2323-4948; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768; Sárközy, Márta/0000-0002-5929-2146} } @{MTMT:31289421, title = {A preimplantációs faktor hatása a miR-21 kardiális expressziójára radiogén szívkárosodásban}, url = {https://m2.mtmt.hu/api/publication/31289421}, author = {Kovács, Mónika Gabriella and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Fábián, Gabriella and Cserni, Gábor and Thomas, Thum and Csont, Tamás Bálint and Bátkai, Sándor and Eytan, Barnea and Kahán, Zsuzsanna and Sárközy, Márta}, booktitle = {FAMÉ 2019 Magyar Kísérletes és Klinikai Farmakológiai Társaság; Magyar Anatómus Társaság; Magyar Mikrocirkulációs és Vaszkuláris Biológiai Társaság; Magyar Élettani Társaság}, unique-id = {31289421}, year = {2019}, pages = {72-72}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Csont, Tamás Bálint/0000-0001-5792-2768; Kahán, Zsuzsanna/0000-0002-5021-8775; Sárközy, Márta/0000-0002-5929-2146} } @article{MTMT:30755535, title = {Selective Heart Irradiation Induces Cardiac Overexpression of the Pro-hypertrophic miR-212}, url = {https://m2.mtmt.hu/api/publication/30755535}, author = {Sárközy, Márta and Molnár-Gáspár, Renáta and Zvara, Ágnes and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Kovács, Mónika Gabriella and Szűcs, Gergő and Fábián, Gabriella and Diószegi, Petra and Cserni, Gábor and Puskás, László and Thum, Thomas and Kahán, Zsuzsanna and Csont, Tamás Bálint and Batkai, Sandor}, doi = {10.3389/fonc.2019.00598}, journal-iso = {FRONT ONCOL}, journal = {FRONTIERS IN ONCOLOGY}, volume = {9}, unique-id = {30755535}, issn = {2234-943X}, abstract = {Background: A deleterious, late-onset side effect of thoracic radiotherapy is the development of radiation-induced heart disease (RIHD). It covers a spectrum of cardiac pathology including also heart failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction. MicroRNA-212 (miR-212) is a crucial regulator of pathologic LVH via FOXO3-mediated pathways in pressure-overload-induced heart failure. We aimed to investigate whether miR-212 and its selected hypertrophy-associated targets play a role in the development of RIHD.Methods: RIHD was induced by selective heart irradiation (50Gy) in a clinically relevant rat model. One, three, and nineteen weeks after selective heart irradiation, transthoracic echocardiography was performed to monitor cardiac morphology and function. Cardiomyocyte hypertrophy and fibrosis were assessed by histology at week 19. qRT-PCR was performed to measure the gene expression changes of miR-212 and forkhead box O3 (FOXO3) in all follow-up time points. The cardiac transcript level of other selected hypertrophy-associated targets of miR-212 including extracellular signal-regulated kinase 2 (ERK2), myocyte enhancer factor 2a (MEF2a), AMP-activated protein kinase, (AMPK), heat shock protein 40 (HSP40), sirtuin 1, (SIRT1), calcineurin A-alpha and phosphatase and tensin homolog (PTEN) were also measured at week 19. Cardiac expression of FOXO3 and phospho-FOXO3 were investigated at the protein level by Western blot at week 19.Results: In RIHD, diastolic dysfunction was present at every time point. Septal hypertrophy developed at week 3 and a marked LVH with interstitial fibrosis developed at week 19 in the irradiated hearts. In RIHD, cardiac miR-212 was overexpressed at week 3 and 19, and FOXO3 was repressed at the mRNA level only at week 19. In contrast, the total FOXO3 protein level failed to decrease in response to heart irradiation at week 19. Other selected hypertrophy-associated target genes failed to change at the mRNA level in RIHD at week 19.Conclusions: LVH in RIHD was associated with cardiac overexpression of miR-212. However, miR-212 seems to play a role in the development of LVH via FOXO3-independent mechanisms in RIHD. As a central regulator of pathologic remodeling, miR-212 might become a novel target for RIHD-induced LVH and heart failure.}, keywords = {left ventricular hypertrophy; Heart failure with preserved ejection fraction (HFpEF); FOXO3; thoracic irradiation; miRNA-212}, year = {2019}, eissn = {2234-943X}, orcid-numbers = {Sárközy, Márta/0000-0002-5929-2146; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Kovács, Mónika Gabriella/0000-0002-5756-4662; Szűcs, Gergő/0000-0003-1874-2718; Fábián, Gabriella/0000-0002-2323-4948; Diószegi, Petra/0000-0001-8109-2266; Cserni, Gábor/0000-0003-1344-7744; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768} } @CONFERENCE{MTMT:31289399, title = {Selective heart irradiation induces cardiac overexpression of the pro-hypertrophic miR-212}, url = {https://m2.mtmt.hu/api/publication/31289399}, author = {Sárközy, Márta and Molnár-Gáspár, Renáta and Ágnes, Zvara and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Kovács, Mónika Gabriella and Szűcs, Gergő and Fábián, Gabriella and Cserni, Gábor and László, G. Puskás and Thomas, Thum and Kahán, Zsuzsanna and Csont, Tamás Bálint and Sándor, Bátkai}, booktitle = {The 44th Annual Meeting of the European Radiation Research Society: Program and Abstract Book}, unique-id = {31289399}, abstract = {Poster session: Pre- and clinical research supporting human radiotherapy}, year = {2018}, pages = {160-160}, orcid-numbers = {Sárközy, Márta/0000-0002-5929-2146; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Kovács, Mónika Gabriella/0000-0002-5756-4662; Szűcs, Gergő/0000-0003-1874-2718; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768} } @CONFERENCE{MTMT:3399366, title = {A hipertrófiás miR-212/132 klaszter kardiális expressziója megemelkedik radiogén szívkárosodásban}, url = {https://m2.mtmt.hu/api/publication/3399366}, author = {Sárközy, Márta and Molnár-Gáspár, Renáta and Zvara, Ágnes and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Kovács, Mónika Gabriella and Szűcs, Gergő and Diószegi, Petra and Fábián, Gabriella and Cserni, Gábor and Puskás, G László and Thomas, Thum and Kahán, Zsuzsanna and Csont, Tamás Bálint and Bátkai, Sándor}, booktitle = {Magyar Élettani Társaság 2018. évi Vándorgyűlése : előadás és poszter absztraktok}, unique-id = {3399366}, year = {2018}, pages = {83-83}, orcid-numbers = {Sárközy, Márta/0000-0002-5929-2146; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Kovács, Mónika Gabriella/0000-0002-5756-4662; Szűcs, Gergő/0000-0003-1874-2718; Diószegi, Petra/0000-0001-8109-2266; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768} } @article{MTMT:3377886, title = {Selective heart irradiation induces left ventricular hypertrophy and diastolic dysfunction with overexpression of the miR-212/132 cluster}, url = {https://m2.mtmt.hu/api/publication/3377886}, author = {Sárközy, Márta and Molnár-Gáspár, Renáta and Zvara, Ágnes and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Kovács, Mónika Gabriella and Szűcs, Gergő and Fábián, Gabriella and Cserni, Gábor and László, G Puskás and Thomas, Thum and Kahán, Zsuzsanna and Csont, Tamás Bálint and Sándor, Bátkai}, journal-iso = {EUR J HEART FAIL}, journal = {EUROPEAN JOURNAL OF HEART FAILURE}, volume = {20}, unique-id = {3377886}, issn = {1388-9842}, year = {2018}, eissn = {1879-0844}, pages = {334-334}, orcid-numbers = {Sárközy, Márta/0000-0002-5929-2146; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Kovács, Mónika Gabriella/0000-0002-5756-4662; Szűcs, Gergő/0000-0003-1874-2718; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768} } @article{MTMT:3370814, title = {A pro-hipertrófiás miR-212/132 klaszter kardiális expressziója megemelkedik radiogén szívkárosodásban [Selective heart irradiation induces cardiac over-expression of the pro-hypertropic miR-212/132 cluster]}, url = {https://m2.mtmt.hu/api/publication/3370814}, author = {Sárközy, Márta and Molnár-Gáspár, Renáta and Zvara, Ágnes and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Kovács, Mónika Gabriella and Szűcs, Gergő and Fábián, Gabriella and Cserni, Gábor and Puskás, G. László and Thum, Thomas and Kahán, Zsuzsanna and Csont, Tamás Bálint and Bátkai, Sándor}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {48}, unique-id = {3370814}, issn = {0133-5596}, year = {2018}, eissn = {1588-0230}, pages = {C34-C35}, orcid-numbers = {Sárközy, Márta/0000-0002-5929-2146; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Kovács, Mónika Gabriella/0000-0002-5756-4662; Szűcs, Gergő/0000-0003-1874-2718; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768} }