@article{MTMT:35739403,
	title = {Repetitive stability study of remdesivir/cyclodextrin complex on the international space station},
	url = {https://m2.mtmt.hu/api/publication/35739403},
	author = {Dormán, György and Buchholcz, Balázs and Puskás, István and Szabó, Pál Tamás and Varga, Erzsébet and Szente, Lajos and Keserű, György Miklós and Darvas, Ferenc},
	doi = {10.1038/s41598-024-81428-5},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {15},
	unique-id = {35739403},
	abstract = {Stability assessment of drugs in space is particularly important for future missions. In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and reproducibility of the data. Therefore, we investigated the stability of an anti-Covid drug formulation, Remdesivir (RDV) sulfobutylether-beta-cyclodextrin (SBECD) complex, in two separate flight experiments on the International Space Station (ISS). While HPLC/MS studies revealed no degradation of the cyclodextrin excipient in any of the samples investigated in both missions, RDV purity analysis of the RDV/SBECD complex after the first mission revealed different stabilities and altered degradation in space and on Earth. This latter interesting finding was not supported by the second mission, where no differences in the drug stabilities were identified. This anomaly highlighted the importance of standardization together with increased control of the variable parameters during the entire space missions and the terrestrial control experiments.},
	year = {2025},
	eissn = {2045-2322},
	orcid-numbers = {Dormán, György/0000-0001-7702-2206; Puskás, István/0000-0002-7879-2920; Szabó, Pál Tamás/0000-0003-2260-4641}
}

@article{MTMT:36097455,
	title = {A comprehensive nomenclature system for cyclodextrins},
	url = {https://m2.mtmt.hu/api/publication/36097455},
	author = {Anderson, Amelia and O'Connor, Matthew S. and Pipkin, James and Malanga, Milo and Sohajda, Tamás and Loftsson, Thorsteinn and Szente, Lajos and García-Fandiño, Rebeca and Piñeiro, Ángel},
	doi = {10.1016/j.carbpol.2025.123600},
	journal-iso = {CARBOHYD POLYM},
	journal = {CARBOHYDRATE POLYMERS},
	volume = {360},
	unique-id = {36097455},
	issn = {0144-8617},
	year = {2025},
	eissn = {1879-1344},
	pages = {123600}
}

@article{MTMT:36113345,
	title = {Degree of polymerization and spatial distributions of acyclic and cyclic oligohexoses in soybean root nodules uncovered by MALDI and nanophotonic laser desorption ionization mass spectrometry},
	url = {https://m2.mtmt.hu/api/publication/36113345},
	author = {Corning, Chloe and Dolatmoradi, Marjan and Tran, Tina H. and Stacey, Gary and Szente, Lajos and Samarah, Laith Z. and Vertes, Akos},
	doi = {10.1016/j.mtbio.2025.101776},
	journal-iso = {MATER TODAY BIO},
	journal = {MATERIALS TODAY BIO},
	volume = {32},
	unique-id = {36113345},
	issn = {2590-0064},
	year = {2025},
	eissn = {2590-0064},
	pages = {101776},
	orcid-numbers = {Vertes, Akos/0000-0001-5186-5352}
}

@article{MTMT:36118511,
	title = {Rapid test for identification of heptakis (2,6-di-O-methyl) β-cyclodextrin in isomeric mixtures},
	url = {https://m2.mtmt.hu/api/publication/36118511},
	author = {Szente, Lajos and Tuza, Kata and Herr, Dominika Mária and Varga, Erzsébet and Szőcs, Levente and Fenyvesi, Éva and Puskás, István},
	doi = {10.1007/s10847-025-01304-1},
	journal-iso = {J INCL PHENOM MACRO CHEM},
	journal = {JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY},
	volume = {105},
	unique-id = {36118511},
	issn = {1388-3127},
	year = {2025},
	eissn = {1573-1111},
	pages = {513-523},
	orcid-numbers = {Herr, Dominika Mária/0009-0003-7538-2752; Szőcs, Levente/0000-0002-9521-3628; Puskás, István/0000-0002-7879-2920}
}

@article{MTMT:36216612,
	title = {Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome},
	url = {https://m2.mtmt.hu/api/publication/36216612},
	author = {Benkő, Beáta Mária and Szabó, B.-I. and Kádár, Szabina and Szabó, Edina and Tóth, Gergő and Szente, Lajos and Tonka-Nagy, P. and Zelkó, Romána and Sebe, István},
	doi = {10.3390/pharmaceutics17070849},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {17},
	unique-id = {36216612},
	abstract = {Background/Objectives: Early diagnosis and oral or, in severe cases, intravenous antibiotics are usually effective for Lyme disease, but some patients have persistent symptoms unresponsive to standards of care, requiring alternative therapies. Disulfiram (DIS), a drug for alcoholism, is under investigation as a potential adjunctive treatment, but its low bioavailability, rapid metabolism, and safety concerns urge the development of improved formulations for clinical translation. Methods: Screening dissolution and permeation studies were investigated for vehicle and excipient selection, following the pharmacopeia perspectives to develop and optimize the low-dose DIS rectal suppository intended for application in post-treatment Lyme disease syndrome (PTLDS). Further characterizations were carried out by differential scanning calorimetry, X-ray diffraction, and infrared spectroscopy. Results: Cyclodextrin (CD) encapsulation was investigated to improve the aqueous solubility of the hydrophobic drug. The dissolution of DIS from fatty base suppository was very slow; it was remarkably improved by the molecular encapsulation of the drug with CDs. The dissolution of DIS from a water-soluble base was more favorable, but incomplete. In the polyethylene glycol (PEG) based suppositories, the addition of CDs already in a physical mixture ensured the dissolution of the drug. The presented drug delivery system relates to a novel preparation for rectal administration comprising a low-dose disulfiram with improved solubility and permeability by the PEG and hydroxypropyl-β-cyclodextrin (HPBCD) synergistic matrix. Conclusions: The rectal dosage form containing the drug and CD in the physical mixture is advantageous, avoiding the hepatic first-pass effect, minimizing dose-limiting toxicity, simplifying production, and fasting the availability of the repositioned drug.},
	year = {2025},
	eissn = {1999-4923},
	orcid-numbers = {Benkő, Beáta Mária/0000-0002-3608-6219; Szabó, Edina/0000-0001-9616-5122; Tóth, Gergő/0000-0001-5341-319X; Zelkó, Romána/0000-0002-5419-9137; Sebe, István/0000-0003-0752-781X}
}

@article{MTMT:36286982,
	title = {Cyclodextrins in Action: Modulating Candida albicans Biofilm Formation and Morphology},
	url = {https://m2.mtmt.hu/api/publication/36286982},
	author = {Márton, Rita and Hermann, Hanna and Kiss, Virág Tünde and Fenyvesi, Éva and Szente, Lajos and Molnár, Mónika},
	doi = {10.1016/j.btre.2025.e00912},
	journal-iso = {BIOTECHNOLOGY REP},
	journal = {BIOTECHNOLOGY REPORTS},
	volume = {47},
	unique-id = {36286982},
	issn = {2215-017X},
	abstract = {The primary objective of this research was to explore the bioactive potential of cyclodextrins in attenuating biofilm formation in C. albicans. The concentration-dependent effects of both native cyclodextrins and specific derivatives were studied at concentrations ranging from 0.1 to 12.5 mM, to determine the mechanisms by which the extent of biofilm formation can be reduced. Besides, the efficiency of various combinations of cyclodextrins and farnesol, as an antifungal substance, were examined. The present study revealed both stimulatory and inhibitory effects of cyclodextrins on biofilm formation, depending on the structure and concentration. The bioactive potential of randomly methylated α- and γ-CD showed significant antifungal properties, as evidenced by a reduction in the biofilm formation. In addition, randomly methylated cyclodextrins were found to significantly enhance the antifungal activity of farnesol against C. albicans. Consequently, their synergistic effect may provide an excellent opportunity to produce a lower dose but more effective anticandidal formulation. © 2025 Elsevier B.V., All rights reserved.},
	keywords = {CYCLODEXTRINS; Biofilm formation; Candida albicans; farnesol; quorum sensing},
	year = {2025},
	orcid-numbers = {Molnár, Mónika/0000-0001-5296-7924}
}

@article{MTMT:36292080,
	title = {Főszerkesztői levél},
	url = {https://m2.mtmt.hu/api/publication/36292080},
	author = {Szente, Lajos and Balogh, György Tibor},
	journal-iso = {MAGY KÉM FOLY KÉM KÖZL},
	journal = {MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-)},
	volume = {131},
	unique-id = {36292080},
	issn = {1418-9933},
	year = {2025},
	eissn = {1418-8600},
	pages = {3},
	orcid-numbers = {Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:36292084,
	title = {Gyászhír: Görög Sándor},
	url = {https://m2.mtmt.hu/api/publication/36292084},
	author = {Szente, Lajos and Balogh, György Tibor},
	journal-iso = {MAGY KÉM FOLY KÉM KÖZL},
	journal = {MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-)},
	volume = {131},
	unique-id = {36292084},
	issn = {1418-9933},
	year = {2025},
	eissn = {1418-8600},
	pages = {4},
	orcid-numbers = {Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:36344249,
	title = {Special Issue “A Commemorative Issue in Honor of József Szejtli: Advances in Cyclodextrin Chemistry and Its Applications”},
	url = {https://m2.mtmt.hu/api/publication/36344249},
	author = {Szente, Lajos and Fenyvesi, Éva},
	doi = {10.3390/ijms26189246},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {26},
	unique-id = {36344249},
	issn = {1661-6596},
	abstract = {This Special Issue is dedicated to the memory of the late Dr [...]},
	year = {2025},
	eissn = {1422-0067},
	pages = {9246}
}

@article{MTMT:36411197,
	title = {Synthesis and use of heptakis(2,6-di-O-methyl)-beta-cyclodextrin related to therapeutic applications: Patent and literature review},
	url = {https://m2.mtmt.hu/api/publication/36411197},
	author = {Puskás, István and Szente, Lajos and Ürögi, Zsolt and Szakály, Péter Soma and Varga, Erzsébet and Fenyvesi, Éva},
	doi = {10.1016/j.ijpharm.2025.126305},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {686},
	unique-id = {36411197},
	issn = {0378-5173},
	abstract = {The heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DIMEB), a methylated beta-cyclodextrin isomer has gained special interest due to its outstanding properties including high solubility and excellent solubilizing effect. It was found to enhance the pertussis toxin production in 1980s and has been used as an auxiliary material in manufacturing acellular pertussis vaccine since then. This vaccine applied world-wide against whooping cough has maintained the demand for DIMEB. In the meantime, further applications were discovered in other biotechnologies, drug delivery and tissue imaging. The high potential in the use as a therapeutic agent was also studied by several research groups. The increasing amount of knowledge concerning DIMEB calls for a systematic review.
		In this work we give the background based on the scientific literature and patents on the synthesis, effect and mechanism of action of this special cyclodextrin derivative. In relation to its applications, also, suitable analytical methods are enumerated to distinguish various methylated species of beta-cyclodextrins.
		Industrially produced DIMEB is a mixture of methylated cyclodextrin isomers containing at least 40 % of the specific single isomer heptakis(2,6-di-O-methyl)-beta-cyclodextrin. It was proved that this special methylation pattern has several advantages over the other methylated beta-cyclodextrin isomers including enhanced solubilizing and stabilizing effect, increased catalytic activity in various biotechnologies and special cellular effects with a potential in the therapy of various diseases.},
	year = {2025},
	eissn = {1873-3476},
	orcid-numbers = {Puskás, István/0000-0002-7879-2920; Szakály, Péter Soma/0009-0009-2510-6067}
}