TY - JOUR AU - Abonyi-Tóth, Zsolt AU - Rokszin, György Aurél AU - Bajcsayné Fábián, Ibolya AU - Kiss, Zoltán AU - Jermendy, György AU - Kempler, Péter AU - Lengyel, Csaba Attila AU - Wittmann, István AU - Molnár, Gergő Attila AU - Sütő, Gábor TI - Incident Cancer Risk in Patients with Incident Type 2 Diabetes Mellitus in Hungary (Part 1) JF - CANCERS J2 - CANCERS VL - 16 PY - 2024 IS - 9 SN - 2072-6694 DO - 10.3390/cancers16091745 UR - https://m2.mtmt.hu/api/publication/34825468 ID - 34825468 N1 - * Megosztott szerzőség AB - Abstract (1) Background: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of cancer but how these two diseases associate is still debated. The goal of this study was the assessment of the overall incidence of cancer among patients with newly diagnosed T2DM in Hungary. (2) Methods: A nationwide, retrospective, longitudinal study was performed using a Hungarian database. After exclusion of cases of age < 18 years, with gestational diabetes, with polycystic ovary syndrome, and with type 1 and prevalent type 2 diabetes mellitus, the incident T2DM (approx. 50,000 cases yearly) and for comparison, the diabetes-free Hungarian adult population (approx. 7,000,000 cases yearly) was included in the study. The primary endpoints were the overall and site-specific incidence and annual percentage change of the incidence of cancer in both populations. (3) Results: The overall incidence of cancer in patients amounted to 29.4/1000 and 6.6/1000 with or without T2DM, respectively, and the OR (95%CI) of cancer of the T2DM group was 4.32 (4.14–4.53), p < 0.0001. The risk of having cancer was age dependent. The incidence of cancer was declining in the non-diabetic but was unchanged in the T2DM population. The average lag time of diagnosing cancer after the detection of T2DM was 3.86 months. (4) Conclusions: Incident T2DM is associated with a significantly higher overall risk of incident cancer, with a reverse correlation of age. Newly registered T2DM patients were suggested to be screened for cancer within 6 months. LA - English DB - MTMT ER - TY - JOUR AU - Csatordai, Márta AU - Benkő, Ria AU - Matuz, Mária AU - Engi, Zsófia AU - Csupor, Dezső AU - Lengyel, Csaba Attila AU - Doró, Péter TI - Trends and regional differences in antidiabetic medication use: a nationwide retrospective observational study JF - DIABETOLOGY AND METABOLIC SYNDROME J2 - DIABETOL METAB SYNDR VL - 16 PY - 2024 IS - 1 PG - 10 SN - 1758-5996 DO - 10.1186/s13098-024-01334-8 UR - https://m2.mtmt.hu/api/publication/34824725 ID - 34824725 N1 - Faculty of Pharmacy, Institute of Clinical Pharmacy, University of Szeged, Szikra utca 8, Szeged, 6725, Hungary Albert Szent-Györgyi Health Centre, Central Pharmacy, University of Szeged, Szeged, Hungary Albert Szent-Györgyi Health Centre, Department of Internal Medicine, University of Szeged, Szeged, Hungary Export Date: 3 May 2024 Correspondence Address: Doró, P.; Faculty of Pharmacy, Szikra utca 8, Hungary; email: doro.peter@szte.hu LA - English DB - MTMT ER - TY - JOUR AU - Nemes, Attila AU - Kormányos, Árpád AU - Orosz, Andrea AU - Ambrus, Nóra AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila TI - Autonomic function and specific right atrial functions - Is there a relationship? Correlations from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study JF - JOURNAL OF CLINICAL ULTRASOUND J2 - J CLIN ULTRASOUND PY - 2024 PG - 8 SN - 0091-2751 DO - 10.1002/jcu.23672 UR - https://m2.mtmt.hu/api/publication/34778284 ID - 34778284 N1 - Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Export Date: 23 April 2024 CODEN: JCULD Correspondence Address: Nemes, A.; Department of Medicine, H-6725 Szeged, emmelweis street 8, P.O. Box 427, Hungary; email: nemes.attila@med.u-szeged.hu AB - Similarly to the ventricles, the atria are under sympathetic/parasympathetic neural regulation. Accordingly, correlations were investigated between Ewing's standard cardiovascular reflex tests (SCRTs) and three-dimensional speckle-tracking echocardiography (3DSTE)-derived right atrial (RA) volumes and strains in healthy subjects.The study comprised 45 healthy adults, but 5 subjects were excluded due to inferior image quality for 3DSTE-derived RA assessments. The remaining 40 individuals being in sinus rhythm had a mean age of 35.1 ± 3.5 years (20 men). Two-dimensional, Doppler, 3DSTE and SCRTs were performed in all cases.RA maximum volume and total and passive RA stroke volumes correlated with the Valsalva ratio. Active RA stroke volume and emptying fraction showed correlations with 30/15 ratio. Peak global and mean segmental RA circumferential (CS) and longitudinal strains (LS) showed correlation with the Valsalva ratio. At atrial contraction, global RA-LS and mean segmental RA-CS showed correlations with the Valsalva ratio. Moreover, mean segmental RA-CS correlated with 30/15 ratio and mean segmental RA radial strain showed correlations with systolic blood pressure in response to standing. Autonomic neuropathy score correlated with peak global RA-LS.Autonomic function parameters have significant associations with specific RA functions in healthy adults, making the latter possible indicators of autonomic dysregulation. LA - English DB - MTMT ER - TY - CHAP AU - Nemes, Attila AU - Rácz, Gergely AU - Kormányos, Árpád AU - Ruzsa, Zoltán AU - Achim, Alexandru AU - Lengyel, Csaba Attila ED - Cristiana, Bustea ED - Delia, Mirela Tit TI - The Relationship between Tricuspid Annular Longitudinal and Sphincter-Like Features of Its Function in Healthy Adults: Insights from the MAGYAR-Healthy Study T2 - Cardiovascular Diseases: From Basic Research to Clinical Application PB - MDPI CY - Basel SN - 9783725806126 PY - 2024 SP - 155 EP - 164 PG - 10 UR - https://m2.mtmt.hu/api/publication/34768899 ID - 34768899 LA - English DB - MTMT ER - TY - JOUR AU - Nemes, Attila AU - Kormányos, Árpád AU - Ruzsa, Zoltán AU - Achim, Alexandru AU - Ambrus, Nóra AU - Lengyel, Csaba Attila TI - Right Ventricular Longitudinal Shortening is not Associated with Left Ventricular Rotational Mechanics in Healthy Adults - Insights from the Three-dimensional Speckle-tracking Echocardiographic MAGYAR-Healthy Study JF - REVIEWS IN CARDIOVASCULAR MEDICINE J2 - REV CARDIOVASC MED VL - 25 PY - 2024 IS - 2 PG - 9 SN - 1530-6550 DO - 10.31083/j.rcm2502053 UR - https://m2.mtmt.hu/api/publication/34557988 ID - 34557988 N1 - Export Date: 23 April 2024 CODEN: RCMEC Correspondence Address: Nemes, A.; Department of Medicine, Hungary; email: nemes.attila@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Anita AU - Hantosi, Dóra AU - Szabó, Nikoletta AU - Letoha, Annamária AU - Lengyel, Csaba Attila AU - Földesi, Imre AU - Burián, Katalin AU - Palkó, András AU - Veréb, Dániel AU - Kincses, Zsigmond Tamás TI - D-dimer levels to exclude pulmonary embolism and reduce the need for CT angiography in COVID-19 in an outpatient population JF - PLOS ONE J2 - PLOS ONE VL - 19 PY - 2024 IS - 1 PG - 11 SN - 1932-6203 DO - 10.1371/journal.pone.0297023 UR - https://m2.mtmt.hu/api/publication/34521238 ID - 34521238 N1 - Összes idézések száma a WoS-ban: 0 LA - English DB - MTMT ER - TY - JOUR AU - Nemes, Attila AU - Kormányos, Árpád AU - Orosz, Andrea AU - Ambrus, Nóra AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila TI - Correlations between vegetative autonomic function and specific left atrial functions in healthy adults: Insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study JF - JOURNAL OF CLINICAL ULTRASOUND J2 - J CLIN ULTRASOUND VL - 52 PY - 2024 IS - 2 SP - 178 EP - 185 PG - 8 SN - 0091-2751 DO - 10.1002/jcu.23603 UR - https://m2.mtmt.hu/api/publication/34400260 ID - 34400260 N1 - Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Cited By :2 Export Date: 23 April 2024 CODEN: JCULD Correspondence Address: Nemes, A.; Department of Medicine, Semmelweis Street 8, P.O. Box 427, Hungary; email: nemes.attila@med.u-szeged.hu AB - The functioning of the left atrium (LA) is partly controlled by the neural system. It was purposed to evaluate correlations between the result of Ewing's 5 standard cardiovascular reflex tests (SCRTs) characterizing autonomic function and LA volumetric and functional features as assessed by three-dimensional speckle-tracking echocardiography (3DSTE) in healthy individuals.The current study comprised 18 healthy volunteers being in sinus rhythm (mean age: 35 ± 12 years, 10 men). Measurement of blood pressure, ECG, 5 SCRTs, two-dimensional Doppler echocardiography and 3DSTE were performed. These parameters were in normal ranges in all cases.From LA volumetric parameters, only systolic total atrial emptying fraction (r = 0.559, p = 0.037) and early diastolic passive atrial emptying fraction (r = 0.539, p = 0.047) correlated with systolic blood pressure response to standing representing sympathetic autonomic function. From LA strains, peak mean segmental LA radial strain (RS) (r = -0.532, p = 0.050), global and mean segmental LA circumferential strain (CS) (r = 0.662, p = 0.010 and r = 0.635, p = 0.015, respectively) representing systolic LA function correlated with Valsalva ratio representing parasympathetic autonomic function. Global LA-RS (r = -0.713, p = 0.040) and LA-CS (r = 0.657, p = 0.011) and mean segmental LA-CS (r = 0.723, p = 0.003) at atrial contraction representing end-diastolic atrial contraction showed correlations with Valsalva ratio, as well. Peak global and mean segmental LA-CS (r = 0.532, p = 0.050 and r = 0.530, p = 0.050) and the same strains at atrial contraction (r = 0.704, p = 0.005 and r = 0.690, p = 0.006) representing systolic function and end-diastolic atrial contraction correlated with systolic blood pressure response to standing representing both parasympathetic and sympathetic autonomic functions.Significant correlations between features of vegetative autonomic function represented by Ewing's 5 SCRTs and specific LA functions represented by 3DSTE-derived LA volume-based functional properties and strains could be demonstrated in healthy adults. LA - English DB - MTMT ER - TY - JOUR AU - Fejes, Imola AU - Bajcsi, Dóra AU - Czakó, László AU - Turkevi-Nagy, Sándor AU - Iványi, Béla AU - Ábrahám, György AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila AU - Légrády, Péter TI - SGLT2-GÁTLÓ DAPAGLIFLOZIN EREDMÉNYES ALKALMAZÁSA NEPHROSIS SZINDRÓMÁVAL JÁRÓ, SZÖVETTANILAG IGAZOLT DIABETESES VESEBETEGSÉGBEN JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 306 EP - 306 PG - 1 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34560639 ID - 34560639 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Christofi, A AU - Kormányos, Árpád AU - Kalapos, Anita AU - Domsik, Péter AU - Gyenes, Nándor AU - Ambrus, Nóra AU - Gavallér, Edit Henriette AU - Csajbók, Éva AU - Julesz, János AU - Forster, Tamás AU - Csanády, Miklós AU - Horváth, Á AU - Lengyel, Csaba Attila AU - Nemes, Attila AU - Valkusz, Zsuzsanna TI - A NÖVEKEDÉSI HORMON HATÁSA A SZÍV FIZIOLÓGIÁJÁRA JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 303 EP - 303 PG - 1 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34559525 ID - 34559525 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Vágvölgyi, Anna AU - Nyiraty, Szabolcs AU - Máthéné, Köteless É AU - Korom, A AU - Ábrahám, Erzsébet Judit AU - Barnai, Mária AU - Szűcs, Mónika AU - Orosz, Andrea AU - Nemes, Attila AU - Baczkó, István AU - Kempler, Péter AU - Várkonyi, Tamás AU - Kósa, István AU - Lengyel, Csaba Attila TI - Három hónapos edzésprogram javítja a kardiovaszkuláris autonóm funkciót a metabolikus szindrómás páciensekben JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 338 EP - 339 PG - 2 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34519512 ID - 34519512 LA - Hungarian DB - MTMT ER -