TY - CHAP AU - Rolya, Alexandra AU - Feczkó, Tivadar TI - Rákellenes gyógyszerhordozó gangliozid nanomicellák = Ganglioside nanomicelles for anticancer drug delivery T2 - Műszaki Kémiai Napok 2023 Konferencia PB - Pannon Egyetem CY - Veszprém SN - 9789633962565 PY - 2023 SP - 71 UR - https://m2.mtmt.hu/api/publication/34731954 ID - 34731954 AB - A gangliozidok komplex glikoszfingolipidek, amelyekben a szénhidrátrészben egy vagy több sziálsav van jelen. Létfontosságú szerepet játszanak a központi idegrendszer fenntartásában, valamint az idegi sérülések védelmében és megerősítésében. A külsőleg beadott gangliozidok képesek átjutni a vér-agy gáton, így fontos kutatási területet jelentenek a neurodegeneratív betegségek, például az Alzheimer-kór, a Parkinson-kór és a rák klinikai kezelésében. A kutatómunka egyik célja a GM1 gangliozidokkal előállított nanomicellák kémiai és fizikai stabilitásának vizsgálata. A kutatás további célja rákellenes gyógyszerek mikrokapszulázása gangliozidokkal, hogy nanomicellákat hozzunk létre a hatóanyagok bejuttatásának elősegítésére. A doxorubicint választottuk modell hatóanyagnak, hogy tanulmányozzuk a GM1 kölcsönhatását egy hidrofil hatóanyaggal. A paclitaxelt és a temozolomidot pedig, mint potenciális agydaganatok elleni, különböző hatásmechanizmussal rendelkező hatóanyagokként választottuk. Vizsgáltuk továbbá az előállított gyógyszer nanomicellák fizikai, kémiai és hatóanyag-felszabadulási tulajdonságait is. A paclitaxel vízben való alacsony oldhatósága miatt DMSO oldatokat alkalmaztunk a GM1 vizes oldatában való szolubilizálásához. Ezzel szemben a doxorubicin-hidroklorid és a temozolomid közvetlenül feloldódott a GM1- oldatban. A nanomicellák méreteloszlását, dinamikus fényszórás alapelvén működő készüléken - Malvern Zetasizer-en - mértem. A micellák által kötött hatóanyag meghatározásához a nem kötött hatóanyag oldatát dialízissel választottam el. Ezt követően a hatóanyag koncentrációját UV-látható spektrofotometriával határoztam meg. A bekapszulázott doxorubicin és paclitaxel rákellenes gyógyszerek hozzáadása nem befolyásolta a GM1 nanomicellák monodiszperz méreteloszlását jelentősen. A DLS segítségével kapott eredményeket a hatóanyagot tartalmazó micellák FEI Talos F200XG2 készülékkel végzett pásztázó/transzmissziós elektronmikroszkópos (S/TEM) képalkotása is alátámasztotta. A GM1 nanomicellák kapszulázási hatékonysága doxorubicin esetén 96,1-100 %, paclitaxel esetében 88,1-100 %-nak adódott. Gangliosides are complex glycosphingolipids that contain a ceramide lipid tail and a glycan headgroup with one or more sialic acid residues. They play a vital role in maintaining the central nervous system, as well as in the protection and strengthening of neural injuries. Externally administered gangliosides can cross the blood-brain barrier, making them an important area of research in the clinical treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease, and cancer. This study focuses on the synthesis and characterisation of GM1 nanomicelles under diverse conditions. Furthermore, gangliosides have emerged as promising drug carrier materials, which motivated the second aim of microencapsulating anticancer drugs. The drug concentration was quantified using UV-vis spectrophotometry. Doxorubicin hydrochloride, paclitaxel, and temozolomide anticancer drugs were entrapped by GM1. Due to the low solubility of paclitaxel in water, DMSO solutions were employed to solubilize it in the aqueous GM1 solution. In contrast, doxorubicin hydrochloride and temozolomide could be directly dissolved in the GM1 solution. In order to enhance the efficacy of anticancer drugs and potentially mitigate drug resistance, a combinatorial approach utilizing two drugs of different mechanism of action was implemented. The size of the nanomicelles was evaluated by Malvern Zetasizer instrument using dynamic light scattering. The entrapped doxorubicin and paclitaxel anticancer drugs did not significantly alter the size distribution of GM1. To ascertain the presence of drugs in GM1 micelles, the solutions underwent dialysis to separate the free drug from the entrapped active agent. The outcomes obtained by DLS were supported by scanning/transmission electron microscopy (S/TEM) imaging of the drug-loaded micelles using a FEI Talos F200XG2. The doxorubicin and paclitaxel encapsulation efficiencies of GM1 nanomicelles were 96.1-100 % and 88.1-100 %, respectively. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Benea, Ioana Cristina AU - Kántor, Izolda AU - Todea, Anamaria AU - Pellis, Alessandro AU - Bîtcan, Ioan AU - Nagy, Lajos AU - Kéki, Sándor AU - Dreavă, Diana Maria AU - Péter, Francisc AU - Feczkó, Tivadar TI - Biocatalytic synthesis of new polyesteramides from ε-caprolactam and hydroxy acids: Structural characterization, biodegradability, and suitability as drug nanocarriers JF - REACTIVE & FUNCTIONAL POLYMERS J2 - REACT FUNCT POLYM VL - 191 PY - 2023 PG - 17 SN - 1381-5148 DO - 10.1016/j.reactfunctpolym.2023.105702 UR - https://m2.mtmt.hu/api/publication/34112909 ID - 34112909 AB - The synthesis of polyesters and polyamides by enzyme-catalyzed processes in vitro was developed in the last decades as a green alternative to obtain biodegradable synthetic polymers with various applications, such as nanoparticle-sized carriers for drug delivery. Polyesteramides were much less studied in this respect, although having the presumable advantage of increased mechanical and thermic resistance brought by the amide moieties. In this work, polyesteramides were synthesized for the first time employing as raw materials epsilon-caprolactam and a hydroxy acid. L-malic, 3-hydroxybutyric, 12-hydroxystearic and 16-hydroxyhexadecanoic acid, respectively, were investigated as co-monomers in solventless or organic medium, using the immobilized lipase Novozyme 435 as catalyst. The short chain hydroxy acids holding secondary hydroxyl groups yielded oligomers with average degree of polymerization no higher than 4, while in the case of the long-chain 12-hydroxystearic acid this value increased to 7. The best results were achieved by using 16-hydroxyhexadecanoic acid in 2:1 M excess at 80. C, yielding a product with 75% copolymer content and average molecular weight higher than 3000 Da. The emulsion-solvent evaporation method allowed the efficient production of nanoparticles based on this copolymer, with sizes around 230 nm, used for the encapsulation of a model bioactive compound, the anticancer drug sorafenib. Production yields of >70% and encapsulation efficiencies of around 60% are very promising for further development of this approach. LA - English DB - MTMT ER - TY - JOUR AU - Németh, Bence László AU - Ujhidy, Aurél AU - Tóth, Judit AU - Ferencz, Mónika AU - Kurdi, Róbert AU - Gyenis, János AU - Feczkó, Tivadar TI - Power consumption of model houses with and without PCM plaster lining using different heating methods JF - ENERGY AND BUILDINGS J2 - ENERG BUILDINGS VL - 284 PY - 2023 PG - 16 SN - 0378-7788 DO - 10.1016/j.enbuild.2023.112845 UR - https://m2.mtmt.hu/api/publication/33628997 ID - 33628997 N1 - Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar tudósok körútja 2., Budapest, H-1117, Hungary Faculty of Engineering, University of Pannonia, Egyetem u. 10, Veszprém, H-8200, Hungary Export Date: 23 March 2023 CODEN: ENEBD Correspondence Address: Feczkó, T.; University of Pannonia, Egyetem u. 10, Hungary; email: feczko.tivadar@ttk.hu LA - English DB - MTMT ER - TY - JOUR AU - Mirankó, Mirella AU - Tóth, Judit AU - Bartos, Csilla AU - Ambrus, Rita AU - Feczkó, Tivadar TI - Nano-Spray-Dried Levocetirizine Dihydrochloride with Mucoadhesive Carriers and Cyclodextrins for Nasal Administration JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 2 PG - 13 SN - 1999-4923 DO - 10.3390/pharmaceutics15020317 UR - https://m2.mtmt.hu/api/publication/33573245 ID - 33573245 AB - Antihistamines such as levocetirizine dihydrochloride (LC) are commercially used in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray-dried using three mucoadhesive polymers and four cyclodextrin species to form composite powders for nasal administration. The product was composed of hydroxypropyl methylcellulose polymer, including LC as a zwitterion, after neutralization by NaOH, and XRD investigations verified its amorphous state. This and a sulfobutylated-beta-cyclodextrin sodium salt-containing sample showed crystal peaks due to NaCl content as products of the neutralization reaction in the solutions before drying. The average particle size of the spherical microparticles was between 2.42 and 3.44 µm, except for those containing a polyvinyl alcohol excipient, which were characterized by a medium diameter of 29.80 µm. The drug was completely and immediately liberated from all the samples at pH 5.6 and 32 °C; i.e., the carriers did not change the good dissolution behavior of LC. A permeability test was carried out by dipping the synthetic cellulose ester membrane in isopropyl myristate using modified horizontal diffusion cells. The spray-dried powder with β-cyclodextrin showed the highest permeability (188.37 µg/cm2/h), as this additive was the least hydrophilic. Products prepared with other cyclodextrins (randomly methylated-beta-cyclodextrin, sulfobutylated-beta-cyclodextrin sodium salt and (hydroxypropyl)-beta-cyclodextrin) showed similar or slightly higher penetration abilities than LC. Other polymer excipients resulted in lower penetration of the active agent than the pure LC. LA - English DB - MTMT ER - TY - JOUR AU - Németh, Bence László AU - Ujhidy, Aurél AU - Tóth, Judit AU - Trif, László AU - Feczkó, Tivadar AU - Rauch, Renáta TI - Gelation elimination in eco-friendly preparation of double-layered calcium alginate-coconut oil latent heat energy storing microcapsules JF - MATERIALS CHEMISTRY AND PHYSICS J2 - MATER CHEM PHYS VL - 293 PY - 2023 PG - 8 SN - 0254-0584 DO - 10.1016/j.matchemphys.2022.126889 UR - https://m2.mtmt.hu/api/publication/33140562 ID - 33140562 LA - English DB - MTMT ER - TY - CHAP AU - Mirankó, Mirella AU - Trif, László AU - Judit, Tóth AU - Feczkó, Tivadar ED - Balogh, András ED - Klein, Mónika TI - Microencapsulation of metronidazole by nano spray drying T2 - 50. Műszaki Kémiai Napok Jubileumi Konferencia PB - Pannon Egyetem Mérnöki Kar CY - Veszprém SN - 9789633962343 PY - 2022 SP - 54 UR - https://m2.mtmt.hu/api/publication/33706576 ID - 33706576 LA - English DB - MTMT ER - TY - JOUR AU - Mirankó, Mirella AU - Tóth, Judit AU - Fodorné Kardos, Andrea AU - Móricz , Krisztina AU - Szenes-Nagy, Antal Balázs AU - Gácsi, Attila AU - Spaits, Tamás AU - Gyenis, János AU - Feczkó, Tivadar TI - Topical formulation of nano spray-dried levocetirizine dihydrochloride against allergic edema JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 12 PG - 11 SN - 1999-4923 DO - 10.3390/pharmaceutics14122577 UR - https://m2.mtmt.hu/api/publication/33265157 ID - 33265157 N1 - ISSN:1999-4923 LA - English DB - MTMT ER - TY - JOUR AU - Szentmihályi, Klára AU - Klébert, Szilvia AU - May, Zoltán AU - Bódis, Eszter AU - Mohai, Miklós AU - Trif, László AU - Feczkó, Tivadar AU - Károly, Zoltán TI - Immobilization of Metronidazole on Mesoporous Silica Materials JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 11 PG - 19 SN - 1999-4923 DO - 10.3390/pharmaceutics14112332 UR - https://m2.mtmt.hu/api/publication/33199936 ID - 33199936 N1 - Funding Agency and Grant Number: European Structural and Investments Funds; Hungarian Government [GINOP-2.2.1-15-2016-00023] Funding text: The authors would like to thank the European Structural and Investments Funds and the Hungarian Government for providing funding in the framework of the GINOP-2.2.1-15-2016-00023 project for this research, but the article processing charges (APC) were not funded. AB - Metronidazole (MTZ) is a widely used drug, but due to its many side effects, there is a growing trend today to use a minimum dose while maintaining high efficacy. One way to meet this demand is to reduce the size of the drug particles. A relatively new method of size reduction is attaching the drug molecules to a mesoporous carrier. In this paper, we studied the fixation of MTZ molecules on mesoporous silica carriers. The drug was immobilized on two mesoporous silica materials (Syloid, SBA-15) with the use of a variety of immersion techniques and solvents. The immobilized drug was subjected to physicochemical examinations (e.g., SEM, XPS, XRD, nitrogen uptake, DSC) and dissolution studies. A significantly higher immobilization was attained on SBA-15 than on a Syloid carrier. Among the processing parameters, the type of MTZ solvent had the highest influence on immobilization. Ultrasonic agitation had a lower but still significant impact, while the concentration of MTZ in the solution made no difference. Under optimal conditions, with the application of an ethyl acetate solution, the surface coverage on SBA-15 reached as much as 91%. The immobilized MTZ exhibited a ca. 10% faster dissolution rate as compared to the pure micron-sized drug particles. LA - English DB - MTMT ER - TY - JOUR AU - Hajba-Horváth, Eszter AU - Németh, Bence László AU - Trif, László AU - May, Zoltán AU - Jakab, Miklós AU - Fodorné Kardos, Andrea AU - Feczkó, Tivadar TI - Low temperature energy storage by bio-originated calcium alginate-octyl laurate microcapsules JF - JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY J2 - J THERM ANAL CALORIM VL - 147 PY - 2022 SP - 13151 EP - 13160 PG - 10 SN - 1388-6150 DO - 10.1007/s10973-022-11678-w UR - https://m2.mtmt.hu/api/publication/33193476 ID - 33193476 AB - Octyl laurate phase change material (PCM) was microencapsulated by calcium alginate for eco-friendly low temperature energy storage. The PCM microcapsules were prepared by repeated interfacial coacervation followed by crosslinking method. In order to enhance the antibacterial properties of the as prepared capsules, the calcium alginate shell was functionalized by Ag nanoparticles. Calcium alginate-octyl laurate microcapsules possessed high latent heat of fusion values (130.8 and 128.6 J g −1 on melting and cooling, respectively) which did not significantly change when Ag nanoparticles were entrapped in the shell (127.5 and 125.2 J g −1 for melting and freezing enthalpy changes). Based on these values 71.0 and 69.0% maximal PCM content in the microcapsules were determined by the differential scanning calorimetry method. Both of the Ag-loaded and unloaded calcium alginate-octyl laurate PCM capsules maintained the high heat storing capacity after 250 warming and cooling cycles, which proved they did not suffer from leakage after the accelerated thermal test. LA - English DB - MTMT ER - TY - JOUR AU - Păușescu, Iulia AU - Kántor, Izolda AU - Babos, György AU - May, Zoltán AU - Fodorné Kardos, Andrea AU - Miskolczy, Zsombor AU - Biczók, László AU - Péter, Francisc AU - Medeleanu, Mihai AU - Feczkó, Tivadar TI - Halochromic Behavior and Anticancer Effect of New Synthetic Anthocyanidins Complexed with β-Cyclodextrin Derivatives JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 15 PG - 18 SN - 1661-6596 DO - 10.3390/ijms23158103 UR - https://m2.mtmt.hu/api/publication/33026129 ID - 33026129 N1 - ISSN:1422-0067 LA - English DB - MTMT ER -