@{MTMT:34731954, title = {Rákellenes gyógyszerhordozó gangliozid nanomicellák = Ganglioside nanomicelles for anticancer drug delivery}, url = {https://m2.mtmt.hu/api/publication/34731954}, author = {Rolya, Alexandra and Feczkó, Tivadar}, booktitle = {Műszaki Kémiai Napok 2023 Konferencia}, unique-id = {34731954}, abstract = {A gangliozidok komplex glikoszfingolipidek, amelyekben a szénhidrátrészben egy vagy több sziálsav van jelen. Létfontosságú szerepet játszanak a központi idegrendszer fenntartásában, valamint az idegi sérülések védelmében és megerősítésében. A külsőleg beadott gangliozidok képesek átjutni a vér-agy gáton, így fontos kutatási területet jelentenek a neurodegeneratív betegségek, például az Alzheimer-kór, a Parkinson-kór és a rák klinikai kezelésében. A kutatómunka egyik célja a GM1 gangliozidokkal előállított nanomicellák kémiai és fizikai stabilitásának vizsgálata. A kutatás további célja rákellenes gyógyszerek mikrokapszulázása gangliozidokkal, hogy nanomicellákat hozzunk létre a hatóanyagok bejuttatásának elősegítésére. A doxorubicint választottuk modell hatóanyagnak, hogy tanulmányozzuk a GM1 kölcsönhatását egy hidrofil hatóanyaggal. A paclitaxelt és a temozolomidot pedig, mint potenciális agydaganatok elleni, különböző hatásmechanizmussal rendelkező hatóanyagokként választottuk. Vizsgáltuk továbbá az előállított gyógyszer nanomicellák fizikai, kémiai és hatóanyag-felszabadulási tulajdonságait is. A paclitaxel vízben való alacsony oldhatósága miatt DMSO oldatokat alkalmaztunk a GM1 vizes oldatában való szolubilizálásához. Ezzel szemben a doxorubicin-hidroklorid és a temozolomid közvetlenül feloldódott a GM1- oldatban. A nanomicellák méreteloszlását, dinamikus fényszórás alapelvén működő készüléken - Malvern Zetasizer-en - mértem. A micellák által kötött hatóanyag meghatározásához a nem kötött hatóanyag oldatát dialízissel választottam el. Ezt követően a hatóanyag koncentrációját UV-látható spektrofotometriával határoztam meg. A bekapszulázott doxorubicin és paclitaxel rákellenes gyógyszerek hozzáadása nem befolyásolta a GM1 nanomicellák monodiszperz méreteloszlását jelentősen. A DLS segítségével kapott eredményeket a hatóanyagot tartalmazó micellák FEI Talos F200XG2 készülékkel végzett pásztázó/transzmissziós elektronmikroszkópos (S/TEM) képalkotása is alátámasztotta. A GM1 nanomicellák kapszulázási hatékonysága doxorubicin esetén 96,1-100 %, paclitaxel esetében 88,1-100 %-nak adódott. Gangliosides are complex glycosphingolipids that contain a ceramide lipid tail and a glycan headgroup with one or more sialic acid residues. They play a vital role in maintaining the central nervous system, as well as in the protection and strengthening of neural injuries. Externally administered gangliosides can cross the blood-brain barrier, making them an important area of research in the clinical treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease, and cancer. This study focuses on the synthesis and characterisation of GM1 nanomicelles under diverse conditions. Furthermore, gangliosides have emerged as promising drug carrier materials, which motivated the second aim of microencapsulating anticancer drugs. The drug concentration was quantified using UV-vis spectrophotometry. Doxorubicin hydrochloride, paclitaxel, and temozolomide anticancer drugs were entrapped by GM1. Due to the low solubility of paclitaxel in water, DMSO solutions were employed to solubilize it in the aqueous GM1 solution. In contrast, doxorubicin hydrochloride and temozolomide could be directly dissolved in the GM1 solution. In order to enhance the efficacy of anticancer drugs and potentially mitigate drug resistance, a combinatorial approach utilizing two drugs of different mechanism of action was implemented. The size of the nanomicelles was evaluated by Malvern Zetasizer instrument using dynamic light scattering. The entrapped doxorubicin and paclitaxel anticancer drugs did not significantly alter the size distribution of GM1. To ascertain the presence of drugs in GM1 micelles, the solutions underwent dialysis to separate the free drug from the entrapped active agent. The outcomes obtained by DLS were supported by scanning/transmission electron microscopy (S/TEM) imaging of the drug-loaded micelles using a FEI Talos F200XG2. The doxorubicin and paclitaxel encapsulation efficiencies of GM1 nanomicelles were 96.1-100 % and 88.1-100 %, respectively.}, year = {2023}, pages = {71} } @article{MTMT:34112909, title = {Biocatalytic synthesis of new polyesteramides from ε-caprolactam and hydroxy acids: Structural characterization, biodegradability, and suitability as drug nanocarriers}, url = {https://m2.mtmt.hu/api/publication/34112909}, author = {Benea, Ioana Cristina and Kántor, Izolda and Todea, Anamaria and Pellis, Alessandro and Bîtcan, Ioan and Nagy, Lajos and Kéki, Sándor and Dreavă, Diana Maria and Péter, Francisc and Feczkó, Tivadar}, doi = {10.1016/j.reactfunctpolym.2023.105702}, journal-iso = {REACT FUNCT POLYM}, journal = {REACTIVE & FUNCTIONAL POLYMERS}, volume = {191}, unique-id = {34112909}, issn = {1381-5148}, abstract = {The synthesis of polyesters and polyamides by enzyme-catalyzed processes in vitro was developed in the last decades as a green alternative to obtain biodegradable synthetic polymers with various applications, such as nanoparticle-sized carriers for drug delivery. Polyesteramides were much less studied in this respect, although having the presumable advantage of increased mechanical and thermic resistance brought by the amide moieties. In this work, polyesteramides were synthesized for the first time employing as raw materials epsilon-caprolactam and a hydroxy acid. L-malic, 3-hydroxybutyric, 12-hydroxystearic and 16-hydroxyhexadecanoic acid, respectively, were investigated as co-monomers in solventless or organic medium, using the immobilized lipase Novozyme 435 as catalyst. The short chain hydroxy acids holding secondary hydroxyl groups yielded oligomers with average degree of polymerization no higher than 4, while in the case of the long-chain 12-hydroxystearic acid this value increased to 7. The best results were achieved by using 16-hydroxyhexadecanoic acid in 2:1 M excess at 80. C, yielding a product with 75% copolymer content and average molecular weight higher than 3000 Da. The emulsion-solvent evaporation method allowed the efficient production of nanoparticles based on this copolymer, with sizes around 230 nm, used for the encapsulation of a model bioactive compound, the anticancer drug sorafenib. Production yields of >70% and encapsulation efficiencies of around 60% are very promising for further development of this approach.}, keywords = {BIOCATALYSIS; Polymer nanoparticle; Polyesteramide}, year = {2023}, eissn = {1873-166X} } @article{MTMT:33628997, title = {Power consumption of model houses with and without PCM plaster lining using different heating methods}, url = {https://m2.mtmt.hu/api/publication/33628997}, author = {Németh, Bence László and Ujhidy, Aurél and Tóth, Judit and Ferencz, Mónika and Kurdi, Róbert and Gyenis, János and Feczkó, Tivadar}, doi = {10.1016/j.enbuild.2023.112845}, journal-iso = {ENERG BUILDINGS}, journal = {ENERGY AND BUILDINGS}, volume = {284}, unique-id = {33628997}, issn = {0378-7788}, year = {2023}, eissn = {1872-6178}, orcid-numbers = {Ferencz, Mónika/0000-0002-1700-8880; Kurdi, Róbert/0000-0002-7845-2045; Gyenis, János/0000-0001-5928-0535} } @article{MTMT:33573245, title = {Nano-Spray-Dried Levocetirizine Dihydrochloride with Mucoadhesive Carriers and Cyclodextrins for Nasal Administration}, url = {https://m2.mtmt.hu/api/publication/33573245}, author = {Mirankó, Mirella and Tóth, Judit and Bartos, Csilla and Ambrus, Rita and Feczkó, Tivadar}, doi = {10.3390/pharmaceutics15020317}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {15}, unique-id = {33573245}, issn = {1999-4923}, abstract = {Antihistamines such as levocetirizine dihydrochloride (LC) are commercially used in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray-dried using three mucoadhesive polymers and four cyclodextrin species to form composite powders for nasal administration. The product was composed of hydroxypropyl methylcellulose polymer, including LC as a zwitterion, after neutralization by NaOH, and XRD investigations verified its amorphous state. This and a sulfobutylated-beta-cyclodextrin sodium salt-containing sample showed crystal peaks due to NaCl content as products of the neutralization reaction in the solutions before drying. The average particle size of the spherical microparticles was between 2.42 and 3.44 µm, except for those containing a polyvinyl alcohol excipient, which were characterized by a medium diameter of 29.80 µm. The drug was completely and immediately liberated from all the samples at pH 5.6 and 32 °C; i.e., the carriers did not change the good dissolution behavior of LC. A permeability test was carried out by dipping the synthetic cellulose ester membrane in isopropyl myristate using modified horizontal diffusion cells. The spray-dried powder with β-cyclodextrin showed the highest permeability (188.37 µg/cm2/h), as this additive was the least hydrophilic. Products prepared with other cyclodextrins (randomly methylated-beta-cyclodextrin, sulfobutylated-beta-cyclodextrin sodium salt and (hydroxypropyl)-beta-cyclodextrin) showed similar or slightly higher penetration abilities than LC. Other polymer excipients resulted in lower penetration of the active agent than the pure LC.}, year = {2023}, eissn = {1999-4923}, orcid-numbers = {Ambrus, Rita/0000-0001-5496-1710} } @article{MTMT:33140562, title = {Gelation elimination in eco-friendly preparation of double-layered calcium alginate-coconut oil latent heat energy storing microcapsules}, url = {https://m2.mtmt.hu/api/publication/33140562}, author = {Németh, Bence László and Ujhidy, Aurél and Tóth, Judit and Trif, László and Feczkó, Tivadar and Rauch, Renáta}, doi = {10.1016/j.matchemphys.2022.126889}, journal-iso = {MATER CHEM PHYS}, journal = {MATERIALS CHEMISTRY AND PHYSICS}, volume = {293}, unique-id = {33140562}, issn = {0254-0584}, year = {2023}, eissn = {1879-3312}, orcid-numbers = {Trif, László/0000-0002-3960-1829; Rauch, Renáta/0000-0002-1856-941X} } @{MTMT:33706576, title = {Microencapsulation of metronidazole by nano spray drying}, url = {https://m2.mtmt.hu/api/publication/33706576}, author = {Mirankó, Mirella and Trif, László and Judit, Tóth and Feczkó, Tivadar}, booktitle = {50. Műszaki Kémiai Napok Jubileumi Konferencia}, unique-id = {33706576}, year = {2022}, pages = {54}, orcid-numbers = {Trif, László/0000-0002-3960-1829} } @article{MTMT:33265157, title = {Topical formulation of nano spray-dried levocetirizine dihydrochloride against allergic edema}, url = {https://m2.mtmt.hu/api/publication/33265157}, author = {Mirankó, Mirella and Tóth, Judit and Fodorné Kardos, Andrea and Móricz , Krisztina and Szenes-Nagy, Antal Balázs and Gácsi, Attila and Spaits, Tamás and Gyenis, János and Feczkó, Tivadar}, doi = {10.3390/pharmaceutics14122577}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {33265157}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Szenes-Nagy, Antal Balázs/0000-0003-4623-0875; Gyenis, János/0000-0001-5928-0535} } @article{MTMT:33199936, title = {Immobilization of Metronidazole on Mesoporous Silica Materials}, url = {https://m2.mtmt.hu/api/publication/33199936}, author = {Szentmihályi, Klára and Klébert, Szilvia and May, Zoltán and Bódis, Eszter and Mohai, Miklós and Trif, László and Feczkó, Tivadar and Károly, Zoltán}, doi = {10.3390/pharmaceutics14112332}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {33199936}, issn = {1999-4923}, abstract = {Metronidazole (MTZ) is a widely used drug, but due to its many side effects, there is a growing trend today to use a minimum dose while maintaining high efficacy. One way to meet this demand is to reduce the size of the drug particles. A relatively new method of size reduction is attaching the drug molecules to a mesoporous carrier. In this paper, we studied the fixation of MTZ molecules on mesoporous silica carriers. The drug was immobilized on two mesoporous silica materials (Syloid, SBA-15) with the use of a variety of immersion techniques and solvents. The immobilized drug was subjected to physicochemical examinations (e.g., SEM, XPS, XRD, nitrogen uptake, DSC) and dissolution studies. A significantly higher immobilization was attained on SBA-15 than on a Syloid carrier. Among the processing parameters, the type of MTZ solvent had the highest influence on immobilization. Ultrasonic agitation had a lower but still significant impact, while the concentration of MTZ in the solution made no difference. Under optimal conditions, with the application of an ethyl acetate solution, the surface coverage on SBA-15 reached as much as 91%. The immobilized MTZ exhibited a ca. 10% faster dissolution rate as compared to the pure micron-sized drug particles.}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Klébert, Szilvia/0000-0002-3107-3371; Trif, László/0000-0002-3960-1829} } @article{MTMT:33193476, title = {Low temperature energy storage by bio-originated calcium alginate-octyl laurate microcapsules}, url = {https://m2.mtmt.hu/api/publication/33193476}, author = {Hajba-Horváth, Eszter and Németh, Bence László and Trif, László and May, Zoltán and Jakab, Miklós and Fodorné Kardos, Andrea and Feczkó, Tivadar}, doi = {10.1007/s10973-022-11678-w}, journal-iso = {J THERM ANAL CALORIM}, journal = {JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY}, volume = {147}, unique-id = {33193476}, issn = {1388-6150}, abstract = {Octyl laurate phase change material (PCM) was microencapsulated by calcium alginate for eco-friendly low temperature energy storage. The PCM microcapsules were prepared by repeated interfacial coacervation followed by crosslinking method. In order to enhance the antibacterial properties of the as prepared capsules, the calcium alginate shell was functionalized by Ag nanoparticles. Calcium alginate-octyl laurate microcapsules possessed high latent heat of fusion values (130.8 and 128.6 J g −1 on melting and cooling, respectively) which did not significantly change when Ag nanoparticles were entrapped in the shell (127.5 and 125.2 J g −1 for melting and freezing enthalpy changes). Based on these values 71.0 and 69.0% maximal PCM content in the microcapsules were determined by the differential scanning calorimetry method. Both of the Ag-loaded and unloaded calcium alginate-octyl laurate PCM capsules maintained the high heat storing capacity after 250 warming and cooling cycles, which proved they did not suffer from leakage after the accelerated thermal test.}, year = {2022}, eissn = {1572-8943}, pages = {13151-13160}, orcid-numbers = {Hajba-Horváth, Eszter/0000-0003-4662-5594; Trif, László/0000-0002-3960-1829} } @article{MTMT:33026129, title = {Halochromic Behavior and Anticancer Effect of New Synthetic Anthocyanidins Complexed with β-Cyclodextrin Derivatives}, url = {https://m2.mtmt.hu/api/publication/33026129}, author = {Păușescu, Iulia and Kántor, Izolda and Babos, György and May, Zoltán and Fodorné Kardos, Andrea and Miskolczy, Zsombor and Biczók, László and Péter, Francisc and Medeleanu, Mihai and Feczkó, Tivadar}, doi = {10.3390/ijms23158103}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33026129}, issn = {1661-6596}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Babos, György/0000-0003-2688-2227; Biczók, László/0000-0003-2568-5942; Péter, Francisc/0000-0001-7248-2641} }