@article{MTMT:34064351,
	title = {A Preliminary Study Indicating Improvement in the Median Survival Time of Glioblastoma Multiforme Patients by the Application of Deuterium Depletion in Combination with Conventional Therapy},
	url = {https://m2.mtmt.hu/api/publication/34064351},
	author = {Somlyai, Gábor and Kovács, Beáta Zsuzsanna and Papp, András and Somlyai, Ildikó},
	doi = {10.3390/biomedicines11071989},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {11},
	unique-id = {34064351},
	abstract = {Glioblastoma multiforme (GBM) and malignant gliomas are the most common primary malignant brain tumors. Temozolomide (TMZ) chemotherapy plus radiation therapy (RT), admi-mistered after debulking surgery, increased the median survival time (MST) from 12.1 months with RT alone merely to 14.6 months, respectively. In this study, the actions of deuterium-depleted water (DDW) on the survival of GBM patients who also received conventional therapies was investigated. Without changing the conventional treatment, the daily fluid intake of the patients was wholly replaced with DDW in 1.5–2 L per day volume to reduce the D concentration in their bodies. The primary endpoint was the MST. The 55 patients involved in this study, who received conventional treatment and consumed DDW, showed a longer MST (30 months) compared to the historical control (12.1–14.6 months). There was a massive difference between the two genders in the calculated MST values; it was 25 months in the male subgroup (n = 33) and 42 months in the female subgroup (n = 22), respectively. The MST was 27 months without TMZ treatment (38 patients) and 42 months in the TMZ-treated group (17 patients), respectively. For the selected 31 patients, who consumed DDW in the correct way in addition to their conventional treatments, their MST was calculated as 30 months. Within this group, the 20 subjects who had relapsed before DDW treatment had 30 months of MST, but in those 10 subjects who were in remission when DDW treatment started, their MST was 47 months. In the subgroup of patients who began their DDW treatment parallel with radiotherapy, their MST was again 47 months, and it was 25 months when their DDW treatment was started at 8 weeks or later after the completion of radiotherapy. Altogether, these survival times were substantially prolonged compared to the prospective clinical data of patients with primary GBM. Consequently, if conventional therapies are supplemented with D depletion, better survival can be achieved in the advanced stage of GBM than with the known targeted or combination therapies. Application of DDW is recommended in all stages of the disease before surgery and in parallel with radiotherapy, and repeated DDW courses are advised when remission has been achieved.},
	year = {2023},
	eissn = {2227-9059},
	orcid-numbers = {Somlyai, Gábor/0000-0001-9116-6417; Papp, András/0000-0003-0485-0806}
}

@article{MTMT:33609188,
	title = {Female Sexual Dysfunction in Association with Sexual History, Sexual Abuse and Satisfaction. A Cross-Sectional Study in Hungary},
	url = {https://m2.mtmt.hu/api/publication/33609188},
	author = {Erdős, Csaba and Kelemen, Oguz and Pócs, Dávid and Horváth, Edina and Dudás, Nóra and Papp, András and Paulik, Edit},
	doi = {10.3390/jcm12031112},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {12},
	unique-id = {33609188},
	abstract = {Female sexual dysfunction (FSD) has a negative impact on women’s quality of life, self-esteem, and physical health. The aim of the present study was to explore the prevalence and the factors associated with FSD using an online questionnaire. A cross-sectional survey was conducted among young adults (18−35 years old) in Hungary using the DSM-5 criteria. The participants (n = 5942) were divided into three major groups: FSD (20.3%), an intermediate group (43.9%), and a control group (35.6%). Most of the women showing FSD were affected with female orgasmic disorder (9.2%) and genito-pelvic pain/penetration disorder (4.6%), while female sexual interest/arousal disorder was found in altogether 100 women (1.7%); 4.8% of women were affected by more than one definite disorder. The occurrence of female sexual dysfunction was related to the women’s previous sexual history (first sexual experience, sexual education, early encounter with pornographic content, and sexual abuse), their self-satisfaction (with their own body, genitalia, and sexual attraction), and their sexual orientation. Sexual dysfunction showed a strong association with abuse, sexually transmitted diseases, and self-esteem. The present study identified the relationship between sexual dysfunctions and other health conditions, which can be the basis for some form of screening and early assistance programs for FSD.},
	year = {2023},
	eissn = {2077-0383},
	orcid-numbers = {Kelemen, Oguz/0000-0002-4522-9904; Pócs, Dávid/0000-0001-6544-5148; Papp, András/0000-0003-0485-0806; Paulik, Edit/0000-0002-3446-4327}
}

@article{MTMT:33038747,
	title = {Deuterium Content of the Organic Compounds in Food Has an Impact on Tumor Growth in Mice},
	url = {https://m2.mtmt.hu/api/publication/33038747},
	author = {Somlyai, G and Nagy, LI and Puskás, LG and Papp, András and Kovács, BZ and Fórizs, István and Czuppon, György and Somlyai, I},
	doi = {10.3390/cimb45010005},
	journal-iso = {CURR ISSUES MOL BIOL},
	journal = {CURRENT ISSUES IN MOLECULAR BIOLOGY},
	volume = {45},
	unique-id = {33038747},
	issn = {1467-3037},
	abstract = {Research with deuterium-depleted water (DDW) in the last two decades proved that the deuterium/hydrogen ratio has a key role in cell cycle regulation and cellular metabolism. The present study aimed to investigate the possible effect of deuterium-depleted yolk (DDyolk) alone and in combination with DDW on cancer growth in two in vivo mouse models. To produce DDyolk, the drinking water of laying hens was replaced with DDW (25 ppm) for 6 weeks, resulting in a 60 ppm D level in dried egg yolk that was used as a deuterium-depleted food additive. In one model, 4T1, a cell line with a high metastatic capacity to the lung was inoculated in the mice’s mammary pad. After three weeks of treatment with DDW and/or DDyolk, the tumor volume in the lungs was smaller in all treated groups vs. controls with natural D levels. Tumor growth and survival in mice transplanted with an MCF-7 breast cancer cell line showed that the anticancer effect of DDW was enhanced by food containing the deuterium-depleted yolk. The study confirmed the importance of the D/H ratio in consumed water and in metabolic water produced by the mitochondria while oxidizing nutrient molecules. This is in line with the concept that the initiation of cell growth requires the cells to generate a higher D/H ratio, but DDW, DDyolk, or the naturally low-D lipids in a ketogenic diet, have a significant effect on tumor growth by preventing the cells from raising the D/H ratio to the threshold.},
	year = {2023},
	eissn = {1467-3045},
	pages = {66-77},
	orcid-numbers = {Papp, András/0000-0003-0485-0806; Fórizs, István/0000-0003-0813-6079; Czuppon, György/0000-0002-7231-6042}
}

@article{MTMT:33213419,
	title = {Origin, environmental presence and health effects of microplastics},
	url = {https://m2.mtmt.hu/api/publication/33213419},
	author = {Papp, András and Tanaka, Manami and Máté, Zsuzsanna and Paulik, Edit},
	doi = {10.14232/abs.2022.1.75-84},
	journal-iso = {ACTA BIOL SZEGED},
	journal = {ACTA BIOLOGICA SZEGEDIENSIS},
	volume = {66},
	unique-id = {33213419},
	issn = {1588-385X},
	year = {2022},
	eissn = {1588-4082},
	pages = {75-84},
	orcid-numbers = {Papp, András/0000-0003-0485-0806; Máté, Zsuzsanna/0000-0003-0446-5422; Paulik, Edit/0000-0002-3446-4327}
}

@article{MTMT:32604745,
	title = {Blocking the Increase of Intracellular Deuterium Concentration Prevents the Expression of Cancer-Related Genes, Tumor Development, and Tumor Recurrence in Cancer Patients},
	url = {https://m2.mtmt.hu/api/publication/32604745},
	author = {Kovács, BZs and Puskás, LG and Nagy, LI and Papp, András and Gyöngyi, Zoltán and Fórizs, István and Czuppon, György and Somlyai, I and Somlyai, G},
	doi = {10.1177/10732748211068963},
	journal-iso = {CANCER CONTROL},
	journal = {CANCER CONTROL},
	volume = {29},
	unique-id = {32604745},
	issn = {1073-2748},
	abstract = {The possible role of the naturally occurring deuterium in the regulation of cell division was first described in the 1990s. To investigate the mechanism of influence of deuterium (D) on cell growth, expression of 236 cancer-related and 536 kinase genes were tested in deuterium-depleted (40 and 80 ppm) and deuterium-enriched (300 ppm) media compared to natural D level (150 ppm). Among genes with expression changes exceeding 30% and copy numbers over 30 (124 and 135 genes, respectively) 97.3% of them was upregulated at 300 ppm D-concentration. In mice exposed to chemical carcinogen, one-year survival data showed that deuterium-depleted water (DDW) with 30 ppm D as drinking water prevented tumor development. One quarter of the treated male mice survived 344 days, the females 334 days, while one quarter of the control mice survived only 188 and 156 days, respectively. In our human retrospective study 204 previously treated cancer patients with disease in remission, who consumed DDW, were followed. Cumulative follow-up time was 1024 years, and average follow-up time per patient, 5 years (median: 3.6 years). One hundred and fifty-six patients out of 204 (77.9%) did not relapse during their 803 years cumulative follow-up time. Median survival time (MST) was not calculable due to the extremely low death rate (11 cancer-related deaths, 5.4% of the study population). Importantly, 8 out of 11 deaths occurred several years after stopping DDW consumption, confirming that regular consumption of DDW can prevent recurrence of cancer. These findings point to the likely mechanism in which consumption of DDW keeps D-concentration below natural levels, preventing the D/H ratio from increasing to the threshold required for cell division. This in turn can serve as a key to reduce the relapse rate of cancer patients and/or to reduce cancer incidence in healthy populations.},
	keywords = {metabolism; Gene Expression; cancer recurrence; cancer prevention; NanoString technology; D/H ratio; anticancer drug development; deuterium-depleted water (DDW); median survival time (MST); production of metabolic water},
	year = {2022},
	eissn = {1526-2359},
	orcid-numbers = {Papp, András/0000-0003-0485-0806; Gyöngyi, Zoltán/0000-0001-9330-9119; Fórizs, István/0000-0003-0813-6079; Czuppon, György/0000-0002-7231-6042}
}

@article{MTMT:32617921,
	title = {Deuterium-depleted water delayed hormone therapy of prostate cancer},
	url = {https://m2.mtmt.hu/api/publication/32617921},
	author = {Kovács, Beáta Zs. and Somlyai, Ildikó and Papp, András and Somlyai, Gábor},
	journal-iso = {JOURNAL OF CLINICAL REVIEW & CASE REPORTS},
	journal = {JOURNAL OF CLINICAL REVIEW & CASE REPORTS},
	volume = {6},
	unique-id = {32617921},
	issn = {2573-9565},
	year = {2021},
	pages = {747-749},
	orcid-numbers = {Papp, András/0000-0003-0485-0806}
}

@article{MTMT:32529207,
	title = {Cause and effect relationship between application of deuterium-depleted water and improvement of chronic lymphocytic leukemia},
	url = {https://m2.mtmt.hu/api/publication/32529207},
	author = {Beáta, Zs. Kovács and Ildikó, Somlyai and Papp, András and Gábor, Somlyai},
	journal-iso = {JOURNAL OF CLINICAL REVIEW & CASE REPORTS},
	journal = {JOURNAL OF CLINICAL REVIEW & CASE REPORTS},
	volume = {6},
	unique-id = {32529207},
	issn = {2573-9565},
	year = {2021},
	pages = {724-728},
	orcid-numbers = {Papp, András/0000-0003-0485-0806}
}

@article{MTMT:32472188,
	title = {Deuterium depletion inhibits lung cancer cell growth and migration in vitro and results in severalfold increase of median survival time of non-small cell lung cancer patients receiving conventional therapy},
	url = {https://m2.mtmt.hu/api/publication/32472188},
	author = {Somlyai, Gábor and Kovács, Beáta Zs. and Somlyai, Ildikó and Papp, András and Nagy, Lajos I. and Puskás, László G.},
	doi = {10.14312/2052-4994.2021-2},
	journal-iso = {J CANC RES THER},
	journal = {JOURNAL OF CANCER RESEARCH AND THERAPY},
	volume = {9},
	unique-id = {32472188},
	keywords = {lung cancer; non-small cell lung cancer; A549 lung cancer cells; Deuterium depletion; deuterium depleted water (ddw)},
	year = {2021},
	eissn = {2052-4994},
	pages = {12-19},
	orcid-numbers = {Papp, András/0000-0003-0485-0806}
}

@{MTMT:32012616,
	title = {Preliminary Study on the Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome-Related and Other Blood Parameters in Humans},
	url = {https://m2.mtmt.hu/api/publication/32012616},
	author = {Somlyai, G and Somlyai, I and Fórizs, István and Czuppon, György and Papp, András and Molnár, M},
	booktitle = {Current Advances in Chemistry and Biochemistry},
	doi = {10.9734/bpi/cacb/v4/7563D},
	unique-id = {32012616},
	year = {2021},
	pages = {61-71},
	orcid-numbers = {Fórizs, István/0000-0003-0813-6079; Czuppon, György/0000-0002-7231-6042; Papp, András/0000-0003-0485-0806}
}

@article{MTMT:31720738,
	title = {Presence of Titanium and Toxic Effects Observed in Rat Lungs, Kidneys, and Central Nervous System in vivo and in Cultured Astrocytes in vitro on Exposure by Titanium Dioxide Nanorods},
	url = {https://m2.mtmt.hu/api/publication/31720738},
	author = {Papp, András and Horváth, Tamara and Igaz, Nóra and Gopisetty, Mohana Krishna and Csontné Kiricsi, Mónika and Berkesi, Dániel Simon and Kozma, Gábor and Kónya, Zoltán and Wilhelm, Imola Mária and Patai, Roland and Polgár, Tamás Ferenc and Bellák, Tamás and Tiszlavicz, László and Rázga, Zsolt and Vezér, Tünde},
	doi = {10.2147/IJN.S275937},
	journal-iso = {INT J NANOMED},
	journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE},
	volume = {15},
	unique-id = {31720738},
	issn = {1176-9114},
	year = {2020},
	eissn = {1178-2013},
	pages = {9939-9960},
	orcid-numbers = {Papp, András/0000-0003-0485-0806; Horváth, Tamara/0000-0003-4437-9924; Igaz, Nóra/0000-0003-1580-4397; Gopisetty, Mohana Krishna/0000-0002-4310-3478; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Kozma, Gábor/0000-0003-2033-0720; Kónya, Zoltán/0000-0002-9406-8596; Wilhelm, Imola Mária/0000-0003-2366-7337; Patai, Roland/0000-0002-5302-2815; Polgár, Tamás Ferenc/0000-0002-6287-1093; Bellák, Tamás/0000-0001-9276-4734; Tiszlavicz, László/0000-0003-1134-6587; Rázga, Zsolt/0000-0003-4717-8482; Vezér, Tünde/0000-0003-3878-0789}
}