TY - JOUR AU - Zsila, Ágnes AU - McCutcheon, Lynn E. AU - Horváth, Rita AU - Urbán, Róbert AU - Paksi, Borbála AU - Darnai, Gergely AU - Janszky, József Vladimír AU - Demetrovics, Zsolt TI - Prevalence of celebrity worship: Development and application of the short version of the Celebrity Attitude Scale (CAS-7) on a large-scale representative sample JF - JOURNAL OF BEHAVIORAL ADDICTIONS J2 - J BEHAV ADDICT PY - 2024 SN - 2062-5871 DO - 10.1556/2006.2024.00019 UR - https://m2.mtmt.hu/api/publication/34800559 ID - 34800559 LA - English DB - MTMT ER - TY - JOUR AU - Áfra, Eszter AU - Janszky, József Vladimír AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Arató, Ákos AU - Szente, Anna Tímea AU - Alhour, Husamalddin Ali Mohammad AU - Kis-Jakab, Gréta AU - Darnai, Gergely TI - Altered functional brain networks in problematic smartphone and social media use: resting-state fMRI study JF - BRAIN IMAGING AND BEHAVIOR J2 - BRAIN IMAGING BEHAV PY - 2024 PG - 10 SN - 1931-7557 DO - 10.1007/s11682-023-00825-y UR - https://m2.mtmt.hu/api/publication/34420912 ID - 34420912 N1 - Funding Agency and Grant Number: University of Pecs from the National Research, Development and Innovation Fund of Hungary under the TKP2021-EGA funding scheme [TKP2021-EGA-16]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; National Laboratory of Translational Neuroscience (NLTN) [RRF-2.3.1-21-2022-00011] Funding text: Open access funding provided by University of Pecs. Project no. TKP2021-EGA-16 has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the TKP2021-EGA funding scheme. SAN was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Project no. RRF-2.3.1-21-2022-00011 were supported from the National Laboratory of Translational Neuroscience (NLTN). AB - Nowadays, the limitless availability to the World Wide Web can lead to general Internet misuse and dependence. Currently, smartphone and social media use belong to the most prevalent Internet-related behavioral addiction forms. However, the neurobiological background of these Internet-related behavioral addictions is not sufficiently explored. In this study, these addiction forms were assessed with self-reported questionnaires. Resting-state functional magnetic resonance imaging was acquired for all participants ( n = 59, 29 males) to examine functional brain networks. The resting-state networks that were discovered using independent component analysis were analyzed to estimate within network differences. Significant negative associations with social media addiction and smartphone addiction were found in the language network, the lateral visual networks, the auditory network, the sensorimotor network, the executive network and the frontoparietal network. These results suggest that problematic smartphone and social media use are associated with sensory processing and higher cognitive functioning . LA - English DB - MTMT ER - TY - JOUR AU - Matuz, András AU - Darnai, Gergely AU - Zsidó, András Norbert AU - Janszky, József Vladimír AU - Csathó, Árpád TI - Structural neural correlates of mental fatigue and reward-induced improvement in performance JF - BIOLOGIA FUTURA J2 - BIOL FUTURA PY - 2024 PG - 12 SN - 2676-8615 DO - 10.1007/s42977-023-00187-y UR - https://m2.mtmt.hu/api/publication/34226087 ID - 34226087 N1 - Funding Agency and Grant Number: New National Excellence Program of the Ministry for Innovation and Technology [NKP-19-3]; National Research, Development and Innovation Office, NKFIH grant [K142321] Funding text: AM was supported by the & Uacute;NKP-19-3 New National Excellence Program of the Ministry for Innovation and Technology. AM, AZ, GD, and AC were supported by the National Research, Development and Innovation Office, NKFIH grant (K142321). AB - Neuroimaging studies investigating the association between mental fatigue (henceforth fatigue) and brain physiology have identified many brain regions that may underly the cognitive changes induced by fatigue. These studies focused on the functional changes and functional connectivity of the brain relating to fatigue. The structural correlates of fatigue, however, have received little attention. To fill this gap, this study explored the associations of fatigue with cortical thickness of frontal and parietal regions. In addition, we aimed to explore the associations between reward-induced improvement in performance and neuroanatomical markers in fatigued individuals. Thirty-nine healthy volunteers performed the psychomotor vigilance task for 15 min (i.e., 3 time-on-task blocks of 5 min) out of scanner; followed by an additional rewarded block of the task lasting 5 min. Baseline high-resolution T1-weigthed MR images were obtained. Reaction time increased with time-on-task but got faster again in the rewarded block. Participants’ subjective fatigue increased during task performance. In addition, we found that higher increase in subjective mental fatigue was associated with the cortical thickness of the following areas: bilateral precuneus, right precentral gyrus; right pars triangularis and left superior frontal gyrus. Our results suggest that individual differences in subjective mental fatigue may be explained by differences in the degree of cortical thickness of areas that are associated with motor processes, executive functions, intrinsic alertness and are parts of the default mode network. LA - English DB - MTMT ER - TY - JOUR AU - Perlaki, Gábor AU - Darnai, Gergely AU - Arató, Ákos AU - Alhour, Husamalddin Ali Mohammad AU - Szente, Anna Tímea AU - Áfra, Eszter AU - Nagy, Szilvia Anett AU - Horváth, Réka AU - Kovács, Norbert AU - Dóczi, Tamás Péter AU - Orsi, Gergely AU - Janszky, József Vladimír TI - Gray Matter Changes Following Mild COVID-19 : An MR Morphometric Study in Healthy Young People JF - JOURNAL OF MAGNETIC RESONANCE IMAGING J2 - JMRI - J MAGN RESON IM PY - 2024 SN - 1053-1807 DO - 10.1002/jmri.28970 UR - https://m2.mtmt.hu/api/publication/34113102 ID - 34113102 AB - Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.Prospective.Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η2 p = 0.102/2.50 ± 0.06 mm vs. 2.54 ± 0.07 mm, η2 p = 0.101), lower subcortical gray matter (57881 ± 3998 mm3 vs. 60470 ± 5211 mm3 , η2 p = 0.100) and lower right olfactory bulb volume (52.28 ± 13.55 mm3 vs. 60.98 ± 15.8 mm3 , η2 p = 0.078) were found. In patients with moderate to severe anosmia, cortical thickness was significantly lower bilaterally, as compared to patients without olfactory function loss (left/right-hemisphere: 2.50 ± 0.06 mm vs. 2.56 ± 0.05 mm, η2 = 0.173/2.49 ± 0.06 mm vs. 2.55 ± 0.05 mm, η2 = 0.189). Using further exploratory analysis, significantly reduced cortical thickness was detected locally in the right lateral orbitofrontal cortex in the COVID group (2.53 ± 0.10 mm vs. 2.60 ± 0.09 mm, η2 p = 0.112).Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.2 TECHNICAL EFFICACY: Stage 3. LA - English DB - MTMT ER - TY - GEN AU - Pintér, Dávid AU - Harmat, Márk AU - Rohonczi, Mirtill AU - Aschermann, Zsuzsanna AU - Janszky, József Vladimír AU - Kovács, Norbert TI - Amikor a haszon (még) ellensúlyozza a kockázatot: Egy LECIG kezelésben részesülő Parkinson-kóros beteg esete PY - 2023 UR - https://m2.mtmt.hu/api/publication/34123923 ID - 34123923 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Norbert AU - Aschermann, Zsuzsanna AU - Harmat, Márk AU - Rohonczi, Mirtill AU - Janszky, József Vladimír AU - Pintér, Dávid TI - Comment on “Summing MDS-UPDRS Parts 1 + 2 (Nonmotor and Motor Experience of Daily Living): The Patient's Voice” JF - MOVEMENT DISORDERS J2 - MOVEMENT DISORD VL - 38 PY - 2023 IS - 8 SP - 1563 EP - 1564 PG - 2 SN - 0885-3185 DO - 10.1002/mds.29512 UR - https://m2.mtmt.hu/api/publication/34106202 ID - 34106202 N1 - Comment LA - English DB - MTMT ER - TY - GEN AU - Izsó, Lujza AU - Aschermann, Zsuzsanna AU - Járdaházi, Evelyn AU - Harmat, Márk AU - Janszky, József Vladimír AU - Kovács, Norbert AU - Pintér, Dávid TI - Applicability of imaging-guided programming during initiating deep brain stimulation for Parkinson’s disease PY - 2023 UR - https://m2.mtmt.hu/api/publication/34078356 ID - 34078356 LA - English DB - MTMT ER - TY - JOUR AU - Hernádi, Gabriella AU - Perlaki, Gábor AU - Kovács, Márton AU - Pintér, Dávid AU - Orsi, Gergely AU - Janszky, József Vladimír AU - Kovács, Norbert TI - White matter hyperintensities associated with impulse control disorders in Parkinson's Disease JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-023-37054-8 UR - https://m2.mtmt.hu/api/publication/34050785 ID - 34050785 N1 - * Megosztott szerzőség AB - Impulse control disorders (ICDs) in Parkinson's disease (PD) are increasingly recognized as clinically significant non-motor features that potentially impair the quality of life. White matter hyperintensities (WMHs), detected by magnetic resonance imaging, are frequently observed in PD and can be associated with both motor- and certain non-motor symptoms. Given the limited number of non-motor features studied in this context, our aim was to reveal the potential association between the severity of WMHs and ICDs in PD. Fluid-attenuated inversion recovery magnetic resonance images were retrospectively evaluated in 70 patients with PD (48 males; 59.3 ± 10.1 years). The severity of WMHs was assessed by Fazekas scores and by the volume and number of supratentorial WMHs. ICDs were evaluated using the modified Minnesota Impulsive Disorders Interview. Significant interaction between age and the severity of WMHs was present for ICDs. In our younger patients (< 60.5 years), severity of WMHs was positively associated with ICDs (p = 0.004, p = 0.021, p < 0.001 and p < 0.001, respectively for periventricular white matter and total Fazekas scores and the volume and number of WMHs). Our study supports the hypothesis that WMHs of presumed vascular origin may contribute to ICDs in PD. Future prospective studies are needed to assess the prognostic relevance of this finding. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Dávid AU - Ruszin-Perecz, Brigitta AU - Fülöp, Krisztina AU - Sipos, Andrea AU - Janszky, József Vladimír AU - Hajdú, Nándor AU - Pál, Endre TI - Urinary titin in myotonic dystrophy type 1 JF - MUSCLE & NERVE J2 - MUSCLE NERVE VL - 68 PY - 2023 IS - 2 SP - 215 EP - 218 PG - 4 SN - 0148-639X DO - 10.1002/mus.27917 UR - https://m2.mtmt.hu/api/publication/34012838 ID - 34012838 AB - Urinary titin, an easy-to-obtain marker, has been investigated in muscular dystrophies, but not in myotonic dystrophy type 1 (DM1). We investigated the role of titin as a biomarker of muscle injury in DM1.We compared the urinary titin N-fragment/creatinine ratio in 29 patients with DM1 vs. 30 healthy controls. We also recorded clinical data such as muscle strength, serum creatine kinase, DM1-related outcome measures, and the 20-item DM1-activ questionnaire. The severity of the disease was graded using the Muscular Impairment Rating Scale (MIRS).The titin/creatinine ratio was significantly higher in the urine samples of DM1 patients than of healthy controls (median ± mean absolute deviation [MAD]: 39.313 ± 26.546 vs. 6.768 ± 5.245 pmol/mg creatinine; P < .001), and was related to muscle impairment graded by MIRS (τ = 0.503, P = .038).Urinary titin may be a biomarker for DM1. Long-term follow-up of DM1 patients is needed to investigate the potential role of titin as a biomarker for disease activity and progression. LA - English DB - MTMT ER - TY - GEN AU - Kovács, Márton AU - Hernádi, Gabriella AU - Perlaki, Gábor AU - Pintér, Dávid AU - Orsi, Gergely AU - Janszky, József Vladimír AU - Kovács, Norbert TI - Fehérállományi hiperintenzitások és impulzus kontroll zavarok kapcsolata Parkinson-kórban PY - 2023 UR - https://m2.mtmt.hu/api/publication/34012058 ID - 34012058 LA - Hungarian DB - MTMT ER -